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Performance of liver stiffness measurements by transient elastography in chronic hepatitis

World Journal of Gastroenterology 2013年第1期19卷 49-56页

作者： Giovanna Ferraioli Carmine Tinelli Barbara Dal Bello Mabel Zicchetti Raffaella Lissandrin Gaetano Filice Carlo Filice Elisabetta Above Giorgio Barbarini Enrico Brunetti Willy Calderon Marta Di gregorio Roberto Gulminetti Paolo Lanzarini Serena Ludovisi Laura Maiocchi Antonello Malfitano Giuseppe Michelone Lorenzo Minoli Mario Mondelli Stefano novati Savino FA Patruno Alessandro Perretti Gianluigi Poma Paolo Sacchi Domenico Zanaboni Marco Zaramella Ultrasound Unit Department of Infectious DiseasesFondazione IRCCS Policlinico San MatteoMedical School University of Pavia27100 PaviaItaly Clinical Epidemiology and Biometric Unit Fondazione IRCCS Policlinico San Matteo27100 PaviaItaly Department of Pathology Fondazione IRCCS Policlinico San Matteo27100 PaviaItaly Department of Infectious Diseases Fondazione IRCCS Policlinico San MatteoMedical School University of Pavia27100 PaviaItaly Department of Infectious Diseases Fondazione IRCCS Policlinico San Matteo27100 PaviaItaly

AIM:To compare results of liver stiffness measurements by transient elastography(TE) obtained in our patients population with that used in a recently published ***:This was a single center cross-sectional *** patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were *** was carried out by using FibroScan(Echosens,Paris,France).Liver biopsy was performed on the same day as TE,as day case *** was staged according to the Metavir scoring *** diagnostic performance of TE was assessed by using receiver operating characteristic(ROC) curves and the area under the ROC curve ***:Two hundred and fifty-two patients met the inclusion ***(2%) patients were excluded due to unreliable TE ***,246(171 men and 75 women) patients were *** hundred and ninety-five(79.3%) patients had chronic hepatitis C,41(16.7%) had chronic hepatitis B,and 10(4.0%) were coinfected with human immunodeficiency *** curve analysis identified optimal cut-off value of TE as high as 6.9 kPa forF ≥ 2;7.9 kPa forF ≥ 3;9.6 kPa for F = 4 in all patients(n = 246),and as high as 6.9 kPa for F ≥ 2;7.3 kPa for F ≥ 3;9.3 kPa for F = 4 in patients with hepatitis C(n = 195).Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2;9.6 kPa for F ≥ 3;12.2 kPa for F = 4 in all patients(n = 246),and as high as 7.0 kPa forF ≥ 2;9.3 kPa forF ≥ 3;12.3 kPa forF = 4 in patients with hepatitis C(n = 195).COnCLUSIOn:The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies.

关键词： Chronic viral hepatitis Hepatitis C Liver Liver biopsy Liver fibrosis Elastography Transient elastography FibroScan Ultrasound

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new Approach for Lead, Zinc and Copper Ions Elimination in Cyanidation Process to Improve the Quality of the Precipitate

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Materials Sciences and Applications 2015年第2期6卷 117-129页

作者： José R. Parga Jesús V. Valdés Jesús L. Valenzuela gregorio Gonzalez L. María de J. Pérez T. Francisco Cepeda Department of Materials Science and Metallurgy Technological Institute of Saltillo Saltillo M&eacute xico Departament of Chemical Engineering and Metallurgy University of Sonora Hermosillo M&eacute xico Faculty of Metallurgy University of Coahuila Monclova M&eacute xico

The Merrill-Crowe zinc-precipitation process has been applied worldwide on a large number of operations for recovering gold and silver from cyanide solutions. However, in some of the large plants this precipitate is of low quality, because copper and especially lead are precipitated along with gold and silver resulting in a higher consumption of zinc powder, fluxes in the smelting of the precipitate, formation of mate and short life for crucibles. In this research, a method is proposed to recover lead, zinc and copper cyanide ions from barren solutions, from the Merrill-Crowe process with hydroxyapatite before the filter press. This technology is based on inducing nucleated precipitation of zinc, copper and silver ions in a serpentine reactor, using sodium sulfide as the precipitator and sulfuric acid for pH control. This procedure was successfully applied at WILLIAM Mining and BACIS Mining Group in México.

关键词： Gold-Silver Recovery Hydroxyapatite Merrill-Crowe Sulphide Precipitation

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Liver-first approach of colorectal cancer with synchronous hepatic metastases: A reverse strategy

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World Journal of Hepatology 2015年第11期7卷 1444-1449页

作者： Jaques Waisberg Ivan gregorio Ivankovics Department of Surgery ABC Medical School Department of Medicine Rondonia Federal University

Recently, there has been a change in the strategy of how synchronous colorectal hepatic metastases are attributed to the development of more valuable protocols of chemotherapy and radiotherapy for neoadjuvant treatment of colorectal neoplasms and their hepatic metastases. There is a consensus that patients with synchronous colorectal hepatic metastases have lower survival than those with metachronous colorectal hepatic metastases. Currently, controversy remains concerning the best approach is sequence in a patient with colorectal cancer and synchronous hepatic metastases resection. To obtain a better patient selection, the authors have suggested the initial realization of systemic chemotherapy in the circumstance of patients with colorectal tumor stage Ⅳ, since these patients have a systemic disease. The rationale behind this liver-first strategy is initially the control of synchronous hepatic metastases of colorectal carcinoma, which can optimize a potentially curative hepatic resection and longstanding survival. The liver-first strategy procedure is indicated for patients with colorectal hepatic metastases who require downstaging therapy to make a curative liver resection possible. Thus, the liver-first strategy is considered an option in cases of rectal carcinoma in the early stage and with limited or advanced synchronous colorectal hepatic metastases or in case of patients with asymptomatic colorectal carcinoma, but with extensive liver metastases. Patients undergoing systemic chemotherapy and with progression of neoplastic disease should not undergo hepatic resection, because it does not change the prognosis and may even make it worse. To date, there have been no randomized controlled trials on surgical approach of colorectal synchronous hepatic metastases, despite the relatively high number of available manuscripts on this subject. All of these published studies are observational, usually retrospective, and often non-comparative. The patient selection criteria

关键词： Colorectal neoplasms neoplasm metastasis Liver neoplasms Liver/surgery Hepatectomy Drug therapy Survival Prognosis

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电信、雷达和电子战系统中的先进微波信号处理

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现代雷达 1989年第1期11卷 79-86页

作者： Fulvio Ananasso Paolo De Gasparis Giuseppe Miccoli C.Di gregorio 刘肖滨

静磁波集成分系统在象色散和非色散延迟线、可调滤波器、频谱分析仪、脉冲压缩器以及卷积器/相关器这样一些应用中能发挥重要作用。

关键词：静磁波器件微波信号处理电信

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The effect of temperature on load partitioning evolution in magnesium metal matrix composite reinforced with Ti particles using in-situ synchrotron radiation diffraction experiments

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Journal of Magnesium and Alloys 2023年第2期11卷 706-719页

作者： G.Garces J.Medina P.Perez A.Stark n.Schell P.Adeva Department of Physical Metallurgy CSICAvenida Gregorio del Amo 8Madrid E-28040Spain Institute of Materials Physics Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany

The load partitioning between the magnesium and titanium phases in an extruded Mg-15%Ti(vol.%) composite from room temperature up to 300 ℃ using synchrotron radiation diffraction during in-situ compression tests. During compression, the magnesium matrix composite deforms mainly by the activation of the extension twinning system up to 200 ℃. The volume fraction of twins increases with the plastic strain but decrease with the compression temperature. Hard titanium particles bear an additional load transferred by the soft magnesium matrix from room temperature up to 300 ℃. This effect is amplified after yield stress during plastic deformation. Additionally, twins within magnesium grains behaves as an additional reinforcement at low temperature(below 200 ℃) inducing an increase in the work hardening of the composite.

关键词： Magnesium alloys In-situ synchrotron radiationdiffraction Plasticity Precipitation Dislocationslip Twinning

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国内需求下降时货币贬值可以提高国外需求(上)

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金融发展研究 2016年第12期 32-34页

作者：何塞.德格雷戈里奥王宇美国彼得森国际经济研究所中国人民银行研究局

本文就20世纪70年代以来货币的大幅贬值事件,分析有关货币贬值的频度和幅度,及其与通货膨胀的关系。认为就涉及的国家数目、贬值程度或持续时间而言,当前货币贬值事件并不是最严重的。汇率对通胀的传递影响已经下降,贬值对通货膨胀的影... 详细信息

本文就20世纪70年代以来货币的大幅贬值事件,分析有关货币贬值的频度和幅度,及其与通货膨胀的关系。认为就涉及的国家数目、贬值程度或持续时间而言,当前货币贬值事件并不是最严重的。汇率对通胀的传递影响已经下降,贬值对通货膨胀的影响相对时间较短。在国内需求下降的情况下,货币贬值可以提高国外需求,从而促进国内经济增长。

关键词：汇率贬值通货膨胀货币政策需求

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在国内需求下降时,货币贬值可以提高国外需求(下)

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金融发展研究 2017年第1期 38-41页

作者：何塞.德格雷戈里奥王宇美国彼得森国际经济研究所中国人民银行研究局

关键词：汇率贬值通货膨胀货币政策需求

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High temperature mechanical behaviour of Mg-6Zn-1Y alloy with 1 wt.% calcium addition:Reinforcing effect due to I-(Mg3Zn6Yi)and Mg6Zn3Ca2 phases

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Journal of Magnesium and Alloys 2020年第4期8卷 1047-1060页

作者： J.Medina G.Garces P.Perez A.Stark n.Schell P.Adeva Department of Physical Metallurgy National Center for Metallurgical Research(CENIM-CSIC)Avenida Gregorio del Amo 828040 MadridSpain Institute of Materials Research Helmholtz-Zentrum GeesthachtMax-Planck-Str.121502 GeesthachtGermany Structural Research on new Materials Helmholtz-Zentrum Geesthacht Outstation at DESYNotkestrafie 8522607 HamburgGermany

The infiuence of small calcium additions on the high-temperature mechanical behaviour in an extruded Mg-6Zn-l Y(wt.%)alloy reinforced by the I-phase has been *** promotes the formation of the intermetallic Mg6Zn3Ca2 phase instead of 1-phase,which results in a noticeable improvement of the yield strength and ultimate tensile strength of the alloy above 100℃.The strength of the alloys was analysed taking into account the contribution due to the grain size,the crystallographic texture and the volume fraction and nature of second phase *** situ synchrotron radiation diffraction experiments have been used to evaluate the load partitioning between the magnesium matrix and the second phase particles(1-and MgezgCa?phases)in both *** load transfer from the magnesium matrix towards the MgezihCa?phase is markedly more effective than that for the I-phase over the entire temperature range,especially at 200°C,temperature at which the reinforcement effect of the I-phase is null.

关键词： Magnesium alloys I-phase Synchrotron radiation diffraction High temperature mechanical properties.

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Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TEnOSIMP-B study

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World Journal of Gastroenterology 2017年第41期23卷 7459-7469页

作者： Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 Division of Gastroenterology and Hepatology.Hospital Universitario Central de Asturias Unit for the Clinical Management of Digestive Diseases IBISHospital Universitario Virgen del Rocío Liver Transplantation and Hepatology Unit Gastroenterology ServiceHospital Universitario Reina Sofía Digestive Medicine Service Hospital Universitario Miguel Servet Hepatology Unit Digestive Medicine ServiceHospital Universitari i Politècnic La Fe Hepatology Unit Hospital Universitario Rio Hortega Liver Unit Hospital Universitario Puerta de Hierro de MajadahondaUniversidad Autónoma de Madrid Digestive Medicine Service Hospital Clínico de Santiago de Compostela Liver Unit Hospital Universitario de La Princesa Digestive Medicine Service Hospital General Universitario Gregorio Maranon Digestive Medicine Unit Complejo Hospitalario de Granada Digestive Medicine Service Hospital Universitario Son Espases Hepatology Unit IMIB Hospital Universitario Virgen de la Arrixaca Digestive Medicine Service Hospital Clínico Universitario de Valladolid Pharmacoeconomics and Outcomes Research Iberia Division of Gastroenterology and Hepatology Complejo Asistencial Universitario de León the TEnOSIMP-B Research Group

AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with *** This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were *** Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DnA(HBV-DnA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). no significant changes were observed in creatinine or serum phosphorus values in either group. no significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P nCLUSIOn TDF monotherapy proved to be safe

关键词： Tenofovir Lamivudine+Adefovir Efficacy Safety Adherence Costs Hepatitis B

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Human immunodeficiency virus type-1 induces a regulatory B cell-like phenotype in vitro

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Cellular & Molecular Immunology 2018年第10期15卷 917-933页

作者： Jacobo Lopez-Abente Adrián Prieto-Sanchez Maria-Ángeles Muñoz-Fernandez Rafael Correa-Rocha Marjorie Pion Laboratorio de Inmuno-Regulación Immunology DepartmentPabellón de Medicina y Cirugía ExperimentalHospital General Universitario Gregorio MarañónInstituto de Investigación Sanitaria Gregorio Marañón(IiSGM)Calle Máiquez9Madrid 28009Spain Laboratorio de Inmuno-Biología Molecular Immunology DepartmentHospital General Universitario Gregorio MarañónInstituto de Investigación Sanitaria Gregorio Marañón(IiSGM)C/Dr.Esquerdo 46Madrid 28007Spain networking Research Center on Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)C/Monforte de Lemos 3-5Pabellón 11Madrid 28029Spain

Individuals infected with human immunodeficiency virus type-1(HIV-1)usually show a general dysregulation and hyper-activation of the immune system.A direct influence of HIV-1 particles on B-cell phenotypes and functions has been previously ***,the consequences of B-cell dysregulation are still poorly *** evaluated the phenotypic changes in primary B cells after direct contact with HIV-1 particles in comparison with different types of *** functionality of treated B cells was challenged in co-culture experiments with autologous CD4+and CD8+T *** demonstrated that HIV-1 induces a phenotypic change in B cells towards a regulatory B-cell phenotype,showing a higher level of IL-10,TGF-β1,EBI3 or IL-12(p35)mRnA expression and acquiring an immunosuppressive *** acquisition of a Breg phenotype was confirmed by co-culture experiments where HIVtreated B cells reduced the proliferation and the TnFαproduction of CD4+or CD8+T *** suppressive ability of HIV-treated B cells was dependent on cell-to-cell contact between these B cells and effector *** our knowledge,these data provide the first evidence that HIV-1 can directly induce a regulatory B cell-like immunosuppressive phenotype,which could have the ability to impair specific immune *** dysregulation could constitute one of the mechanisms underlying unsuccessful efforts to develop an efficient vaccine against HIV-1.

关键词： HIV-1 immune hyper-activation regulatory B cells

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