检索结果-南通市图书馆

Spectral reflectance response to nitrogen fertilization in field grown corn

在线全文

学校读者我要写书评

暂无评论

International Journal of Agricultural and Biological Engineering 2018年第4期11卷 118-126页

作者： Chuanqi Xie Ce Yang Alexander Hummel Jr gregg A Johnson Forrest t Izuno Department of Bioproducts and Biosystems Engineering University of MinnesotaSaint PaulMN 55108United States Farm Nutrients Inc. 4949 Hwy 71RembrandtIA 50576United States Department of Agronomy and Plant Genetics University of MinnesotaSaint PaulMN 55108United States Southern Research and Outreach Center University of MinnesotaWasecaMN 56093United States

this study was carried out to analyze the spectral reflectance response of different nitrogen levels for corn *** different nitrogen treatments of 0%,80%,100%and 120%BMP(best management practice)were *** component analysis-loading(PCA-loading)was used to identify the effective *** least squares(PLS)and multiple linear regression(MLR)models were built to predict different nitrogen *** indices(VIs)were calculated and then used to build more prediction *** full and selected wavelengths-based models showed similar prediction *** overall PLS model obtained the coefficient of determination(R^(2))of 0.6535 with a root mean square error(RMSE)of 0.2681 in the prediction *** selected wavelengths for overall MLR model obtained the R^(2) of 0.6735 and RMSE of 0.3457 in the prediction *** results showed that the wavelengths in visible and near infrared region(350-1000 nm)performed better than the two either spectral regions(1001-1350/1425-1800 nm and 2000-2400 nm).For each data set,the wavelengths around 555 nm and 730 nm were identified to be the most important to predict nitrogen *** vogelmann red edge index 2(VOG 2)performed the best among all *** demonstrated that spectral reflectance has the potential to be used for analyzing nitrogen response in corn.

关键词： spectrum effective wavelengths principal component analysis-loading(PCA-loading) prediction vegetation indices(VIs) corn

Application of anti-CD103 immunotoxin for saving islet allograft in context of transplantation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2010年第24期123卷 3644-3651页

作者： ZHANG Lei gregg A. Hadley Department of General Surgery the Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150086 China Division of transplantation Department of Surgery the Ohio State University Medical Center Columbus OH 43210 USA

Background Previous studies using knockout mice document a key role for the integrin CD103 in promoting organ allograft rejection and graft-versus-host disease. However, a determination of whether blockade of the CD103 pathway represents a viable therapeutic strategy for intervention in these processes has proven problematic due to the lack of reagents that efficiently deplete CD103＋ cells from wild type hosts. to circumvent this problem, in the present study, we invented an anti-CD103 immunotoxin （M290-SAP）. We investigated whether M290-SAP has capacity to eliminate CD103-expressing cells in vivo and protect transplanted islets from destroying by host immune *** Flow cytometry was used to analyze the efficacy of M290-SAP in depleting CD103-expressing cells in *** using allogenic islet transplantation models as well as NOD mice with recent onset type 1 diabetes, the therapeutic efficacy of CD103-expressing cell depletion was *** M290-SAP dramatically reduces the frequency and absolute numbers of CD103-expressing leukocytes in peripheral lymphatic tissues of treated mice. Balb/c islets transplanted into streptozotocin-induced diabetic C57BL/6 mice under single M290-SAP treatment showed an indefinite survival time compared with untreated mice, M290-treated mice and IgG-SAP treated mice （mean survival time, ＞100 days vs. ＜20 days）. C57BL/6 islets transplanted into hyperglycemic NOD mice under single M290-SAP treatment showed a pronounced delay in allograft rejection compared with untreated mice （mean survival time 12-13 days vs. ＜7 days）. Immunological analysis of mice with long-term islet allograft survival revealed an obvious atrophy thymus and severe downregulation of alloimmunity of CD8 subpopulation response to allogenic *** Regardless of the underlying mechanisms, these data document that depletion of CD103-expressing cells represents a viable strategy for therapeutic intervention in islet allograft rejection.

关键词： immunotoxin saporin CD8 t lymphocytes pancreatic islets transplantation thymus

Management of subretinal hemorrhage

在线全文

学校读者我要写书评

暂无评论

Eye Science 2017年第1期32卷 22-24页

作者： gregg t.Kokame Department of Surgery University of Hawaii John A Burns School of MedicineHonoluluHI 96813USA Hawaii Macula and Retina Institute Hawan 96701USA Retina Consultants of Hawau HonoluluHI 96813USA

Subretinal hemorrhage is a vision threatening complication of exudative age related macular degeneration(AMD) and polypoidal choroidal vasculopathy(PCV). timely removal or displacement of subretinal hemorrhage from the central macula, ideally within 7 to 10 days after onset, is critical to allowing potential recovery of vision. Surgical techniques with the use of a bubble to displace the subretinal hemorrhage can now be performed with tissue plasminogen activator to lyze the blood and with or without vitrectomy.

关键词： Subretinal hemorrhage age related macular degeneration(AMD) polypoidal choroidal vasculopathy(PCV) vitrectomy tissue plasminogen activator intraocular gas bubble

Protective effect of hydroxychloroquine on rheumatoid arthritis-associated atherosclerosis

在线全文

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2019年第2期2卷 98-106页

作者： Na Shi Shuangyue Zhang gregg Silverman Mengtao Li Jun Cai Haitao Niu NHC Key Laboratory of Human Disease Comparative Medicine (the Institute of Laboratory Animal Sciences CAMS&PUMC) Key Laboratory of Human Diseases Animal Model State Administration of Traditional Chinese Medicine Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing China Department of Rheumatology Langone Medical Center New York University New York City New York Peking Union Medical College Hospital Beijing China Fuwai Hospital Chinese Academy of Medical Sciences Beijing China

Background: Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease. We examined the effect of gut microbiota in a mouse model of RA that develops atherosclerosis. Methods: We created three groups of K/BxN female mice that were positive for the anti‐glucose‐6‐phosphate isomerase (GPI) antibody: control diet (CD), high fat diet (HFD), and HFD with hydroxychloroquine (HFD + HCQ). Serological tests were used to detect the serum levels of total cholesterol (tCHO), low‐density lipoprotein cholesterol (LDL‐C), triglyceride (tG), high‐density lipoprotein cholesterol (HDL‐C), anti‐ GPI antibody titers, and serum cytokines. Atherosclerotic plaque was determined by histological analysis, and gut microbiota were determined by 16sV4 sequencing. Results: Relative to mice given the CD, those receiving the HFD had increased serum levels of LDL‐C, tCHO, and tG, decreased serum levels of HDL‐C, increased atherosclerotic lesions in the aortic root, and altered gut microbiota. Addition of HCQ to HFD decreased the serum levels of LDL‐C, tCHO, and tG, increased serum levels of HDL‐C, and decreased the atherosclerotic lesions in the aortic root. Mice receiving HFD + HCQ also had the greatest bacterial diversity among the three experimental groups. Moreover, HCQ treatment significantly increased the abundance of Akkermansia and Parabacteroides, and decreased the abundance of Clostridium sensu stricto cluster 1, and therefore may be responsible for the reduced RA‐associated atherosclerosis and dyslipidemia. Conclusion: Our mouse model of RA indicated that HFD increased ankle width and aggravated a therosclerosis a nd d yslipidemia, a nd t hat H CQ a lleviated t he d yslipidemia and atherosclerosis, but had no effect on ankle width.

关键词： atherosclerosis autoimmunity hydroxychloroquine intestinal microbiota rheumatoid arthritis

在线全文

学校读者我要写书评

暂无评论

CD103免疫毒素在同种胰岛移植中的应用

中华实验外科杂志 2011年第2期28卷 194-196页

作者：张雷 gregg Hadley 哈尔滨医科大学附属第二医院普通外科 150086 美国俄亥俄州立大学移植外科

目的制备能体内杀伤CD103表达细胞的免疫毒素,观察其对同种胰岛移植排斥反应的影响.方法将CD103抗体与植物毒素saporin耦联产生M290-SAP,以2 mg/kg剂量注入小鼠腹腔,实验分为磷酸盐缓冲液（PBS）、IgG-SAP、M290和M290-SAP组,用流式... 详细信息

目的制备能体内杀伤CD103表达细胞的免疫毒素,观察其对同种胰岛移植排斥反应的影响.方法将CD103抗体与植物毒素saporin耦联产生M290-SAP,以2 mg/kg剂量注入小鼠腹腔,实验分为磷酸盐缓冲液（PBS）、IgG-SAP、M290和M290-SAP组,用流式细胞术检测CD103阳性细胞的肖减,之后将M290-SAP应用于化学性糖尿病小鼠胰岛移植模型,观察胰岛有功能存活情况.结果 PBS、IgG-SAP和M290组,肠上皮内CD103＋CD8＋淋巴细胞占CD3＋淋巴细胞的百分比分别为70.9%、68.4%和79.5%,而M290-SAP组几乎降至0;M290-SAP也杀灭了CD103＋的胸腺细胞.M290-SAP组胰岛移植物存活时间（＞100 d,n=9）,明显优于未处理组、IgG-SAP和M290组（均在20d内排斥）（P＜0.01）.结论 M290-SAP消除CD103表达细胞能促进同种胰岛移植物长期存活.

关键词：胰岛移植胸腺免疫毒素抗-CD103 CD8t淋巴细胞

CD103分子介导CD8^＋t淋巴细胞对同种胰岛移植物的损伤

在线全文

学校读者我要写书评

暂无评论

中华器官移植杂志 2011年第2期32卷 91-94页

作者：张雷 gregg Hadley 哈尔滨医科大学附属第二医院普外一科 150086 the Ohio State University

目的检验CD103分子是否介导了CD8^＋t淋巴细胞对同种移植胰岛的免疫损伤。方法用流式细胞仪检测野生型C57BL／6小鼠外周血CD8^＋t淋巴细胞表达CDl03的情况。以Balb／c小鼠为供者，C57BL／6小鼠为受者，制作同种胰岛移植模型。受者分为3... 详细信息

目的检验CD103分子是否介导了CD8^＋t淋巴细胞对同种移植胰岛的免疫损伤。方法用流式细胞仪检测野生型C57BL／6小鼠外周血CD8^＋t淋巴细胞表达CDl03的情况。以Balb／c小鼠为供者，C57BL／6小鼠为受者，制作同种胰岛移植模型。受者分为3组：M290-SAP组小鼠注射CDl03免疫毒素M290-SAP；M290组小鼠注射抗CDl03单克隆抗体M290；另以仅接受胰岛移植、不注射任何药物的小鼠为未处理组。检测移植胰岛CD3、CD8、CD44和CDl03阳性细胞的表达，检测肠系膜淋巴结中CD3、CD8和CD103阳性细胞的表达。移植物功能丧失或观察期结束时获取移植胰岛，行HE染色和免疫组织化学染色。结果野生型C57BL／6小鼠外周血的CD8^＋t淋巴细胞中有44．06％表达CDl03。未处理组移植胰岛浸润的细胞成分中有29％的CD8^＋t淋巴细胞表达CDl03。M290-SAP组小鼠淋巴细胞不仅丧失了CDl03的表达，而且CD8^＋t淋巴细胞的绝对数量也减少，该组小鼠血糖稳定时间超过100d（未处理组为13d，P〈C0．05），移植胰岛组织学形态良好。结论CD8^＋t淋巴细胞免疫损伤同种移植胰岛必须表达CDl03，CDl03有可能成为胰岛移植抗排斥反应治疗的新靶点。

关键词：胰岛移植 CD103 CD8 免疫毒素类

New Developments in Water Efficiency

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2006年第4期5卷 375-380页

作者： tony t. gregg Amanda Deweesn Drema Grossn Bill Hoffmann Dan Strubn Matt Watson Water Conservation Division Austin Water Utility Austin TX 78 767USA

An overview of significant new developments in water efficiency is presented in this paper. the areas covered will be legislative, regulatory, new programs or program wrinkles, new products, and new studies on the effectiveness of conservation programs. Examples include state and local level efficiency regulations in texas; the final results of the national submetering study for apartments in the US; the US effort to adopt the IWA protocols for leak detection; new water efficient commercial products such as Et irrigation controllers, new models of efficient clothes washers, and innovative toilet designs.

关键词：节水经济奖励用水调节用水立法用水效率

targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第8期26卷 52-63页

作者： Nisakorn Yodsanit takuro Shirasu Yitao Huang Li Yin Zain Husain Islam Alexander Christopher gregg Alessandra Marie Riccio Runze tang Eric William Kent Yuyuan Wang Ruosen Xie Yi Zhao Mingzhou Ye Jingcheng Zhu Yi Huang Nicholas Hoyt Mengxue Zhang John A.Hossack Morgan Salmon K.Craig Kent Lian-Wang Guo Shaoqin Gong Bowen Wang Department of Biomedical Engineering Wisconsin Institute for DiscoveryUniversity of Wisconsin-MadisonMadisonWI53715USA Department of Ophthalmology and Visual Sciences University of Wisconsin-MadisonMadisonWI53715USA Department of Surgery School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA the Biomedical Sciences Graduate Program(BIMS) School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA Department of Biomedical Engineering School of EngineeringUniversity of VirginiaCharlottesvilleVA22908USA School of Medicine and Health Sciences George Washington UniversityWashingtonDC20052USA Department of Cardiac Surgery Michigan MedicineUniversity of MichiganAnn ArborMI48109USA

Abdominal aortic aneurysm(AAA)is a progressive aortic dilatation,causing~80%mortality upon ***,there is no approved drug therapy for *** repairs are invasive and risky and thus not recommended to patients with small AAAs which,however,account for~90%of the newly diagnosed *** is therefore a compelling unmet clinical need to discover effective non-invasive strategies to prevent or slow down AAA *** contend that the first AAA drug therapy will only arise through discoveries of both effective drug targets and innovative delivery *** is substantial evidence that degenerative smooth muscle cells(SMCs)orchestrate AAA pathogenesis and *** this study,we made an exciting finding that PERK,the endoplasmic reticulum(ER)stress Protein Kinase R-like ER Kinase,is a potent driver of SMC degeneration and hence a potential therapeutic ***,local knockdown of PERK in elastase-challenged aorta significantly attenuated AAA lesions in *** parallel,we also conceived a biomimetic nanocluster(NC)design uniquely tailored to AAA-targeting drug *** NC demonstrated excellent AAA homing via a platelet-derived biomembrane coating;and when loaded with a selective PERK inhibitor(PERKi,GSK2656157),the NC therapy conferred remarkable benefits in both preventing aneurysm development and halting the progression of pre-existing aneurysmal lesions in two distinct rodent models of *** summary,our current study not only establishes a new intervention target for mitigating SMC degeneration and aneurysmal pathogenesis,but also provides a powerful tool to facilitate the development of effective drug therapy of AAA.

关键词： Abdominal aortic aneurysm ER stress PERK Biomimetic nanomedicine targeted delivery

temporal trends and rural-urban disparities in cerebrovascular risk factors,in-hospital management and outcomes in ischaemic strokes in China from 2005 to 2015:a nationwide serial cross-sectional survey

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2023年第1期8卷 34-50页

作者： Chun-Juan Wang Hong-Qiu Gu Xin-Miao Zhang Yong Jiang Hao Li Janet Prvu Bettger Xia Meng Ke-Hui Dong Run-Qi Wangqin Xin Yang Meng Wang Chelsea Liu Li-Ping Liu Bei-Sha tang Guo-Zhong Li Yu-Ming Xu Zhi-Yi He Yi Yang Winnie Yip gregg C Fonarow Lee H Schwamm Ying Xian Xing-Quan Zhao Yi-Long Wang Yongjun Wang Zixiao Li China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeiingChina Center of Stroke Beijing Institute for Brain DisordersBeijngChina Beijing Key Laboratory of translational Medicine for Cerebrovascular Disease BeijingChina Duke Clinical Research Institute Duke UniversityDurhamNorth CarolinaUSA Department of Neurology Duke Univeristy Medical CenterDurhamNorth CarolinaUSA Department of Epidemiology Harvard T H Chan School of Public HealthBostonMassachusettsUSA Neuro-intensive Care Unit Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Neurology The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Key Laboratory of Cerebrovascular Disease Prevention and treatment National Health Commission(Province and Ministry Co-constructed)ZhengzhouHenanChina Department of Neurology The First Affiliated Hospital of China Medical UniversityShenyangLiaoningChina Department of Neurology The First Hospital of Jilin UniversityChangchunJilinChina Department of Global Health and Population Harvard T.H.Chan School of Public HealthBostonMAUSA Ahmanson-UCLA Cardiomyopathy Center Ronald Reagan-UCLA Medical CenterLos AngelesCAUSA Department of Neurology Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Neurology The University of Texas Southwestern Medical CenterDallasTexasUSA Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Chinese Inst

Background Stroke is the leading cause of mortality in China,with limited evidence of in-hospital burden obtained from nationwide *** aimed to monitor and track the temporal trends and rural-urban disparities in cerebrovascular risk factors,management and outcomes from 2005 to *** We used a two-stage random sampling survey to create a nationally representative sample of patients admitted for ischaemic stroke in 2005,2010 and *** sampled participating hospitals with an economic-geographical region-stratified random-sampling approach first and then obtained patients with a systematic sampling *** weighed our survey data to estimate the national-level results and assess changes from 2005 to *** We analysed 28277 ischaemic stroke admissions from 189 participating *** 2005 to 2015,the estimated national hospital admission rate for ischaemic stroke per 100000 people increased(from 75.9 to 402.7,Ptrendthe prevalence of risk factors,including hypertension,diabetes,dyslipidaemia and current smoking,*** composite score of diagnostic tests for stroke aetiology assessment(from 0.22 to 0.36,Ptrendtion treatments(from 0.46 to 0.70,Ptrendtemporal decrease was found in discharge against medical advice(DAMA)(from 15.2%(95%CI 13.7%to 16.7%)to 8.6%(8.1%to 9.0%);adjusted Ptrend=0.046),and decreases in in-hospital mortality(0.7%in 2015 vs 1.8%in 2005;adjusted OR(aOR)0.52;95%CI 0.32 to 0.85)and the composite outcome of in-hospital mortality or DAMA(8.4%in 2015 vs 13.9%in 2005;aOR 0.65;95%CI 0.47 to 0.89)were *** between rural and urban hospitals narrowed;however,disparities persisted in in-hospital management(brain MRI:rural-urban difference from−14.4%to−11.2%;cerebrovascular assessment:from−20.3%to−16.7%;clopidogrel:from−2.1%to−10.3%;anticoagulant for atrial fibrillation:from−10.9%to−8.2%)and in-hospital outcomes(DAMA:from 2.7%to 5.0%;composite outcome

关键词： admitted nationwide survey