检索结果-南通市图书馆

Morphological properties and residual strain along the small intestine in rats

World Journal of Gastroenterology 2002年第2期8卷 312-317页

作者： Hans gregersen Biomechanics Lab Centre for Sensory-Motor InteractionAalborg University and Department of surgery AAalborg HospitalDenmark

AIM: Residual stress and strain are important for gastrointestinal function and relate to the geometric configuration, the loading conditions and the zero-stress state of the gastrointestinal tract. The purpose of this project is to provide morphometric data and residual strains for the rat small intestine ( n =11). METHODS: To approach the no-load state, the intestine was surgically excised, transferred to an organ bath and cut transversely into short ring-shaped segments. Each ring was cut radially for obtaining the zero-stress state. The residual stress can be characterised by an opening angle. The strain difference between the zero-stress state and the no-load state is called residual strain. RESULTS: Large morphometric variations were found along the small intestine. The wall thickness was highest in the proximal duodenum and decreased in distal direction along the axis of the small intestine (Pntial length of the inner and outer surfaces decreased rapidly along the length of duodenum by 30-50% (Pnd lumen area showed a similar pattern (Pn zero-stress state the rings always opened up after making the cut. The experiments resulted in larger inner circumferential length and smaller outer circumferential length when compared to the no-load state. The wall thickness and wall area did not differ between the no-load and zero-stress state. The opening angle and tangent rotation angle increased along the length of the duodenum and had its highest value 30% down the intestine. Further down the intestine it decreased again (Pn was tensile with the highest value close to the ligament of Treitz (Pn was compressive in all segments of the small intestine with average values between -0.25 and -0.4 and with the lowest values close to the ligament of Treitz (PnCLUSIOn: Axial variation in morphometric properties and residual s

关键词： Animals In Vitro Intestine, Small histology Male Rats Rats, Sprague-Dawley Research Support, non-U.S. Gov't Stress, Mechanical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Do we really understand the role of the oesophagogastric junction in disease?

引用

World Journal of Gastroenterology 2009年第2期15卷 144-150页

作者： Barry P McMahon Blair A Jobe John E Pandolfino Hans gregersen Department of Medical Physics & Clinical Engineering Adelaide & Meath Hospital Tallaght Dublin 24 Ireland Associate Professor of Surgery Director of Esophageal Diagnostics & Therapeutic Endoscopy Heart Lung and Esophageal Surgery Institute University of Pittsburgh Medical Centre Shadyside Medical Building Suite 715 Pittsburgh PA 15232 United States Division of Gastroenterology Northwestern Memorial University Hospital 676 N. St. Clair St. Suite 1400 Chicago IL 60611 United States Professor of Biomechanics Director of Research Mech-Sense Aalborg Hospital Science and Innovation Centre Sφndre Skovvej 15 9000 Aalborg Denmark

The role of the oesophago-gastric junction (OGJ) in gastro-oesophageal reflux disease is still not completely understood, and there is no clinically used method to assess the OGJ function in patients. Only indirect methods such as pH studies are carried out. The OGJ acts a valve controlling the flow of solids, liquids and gases between the oesophagus and the stomach. Manometry can determine if a sphincter is toned or relaxed; but, it cannot confirm that the sphincter region is actually open. Distension is a new technique for measuring function in the OGJ. By measuring the cross-sectional area through the narrow region in the junction during distension of a catheter mounted bag, much more information on the opening and closing patterns of the junction can be determined. This technique has already been demonstrated to show changes in the OGJ after surgical treatments for reflux disease. new measurement ideas around the concept of distending the OGJ offer new hope that a clinically useable test for compliance at the junction can be developed and could potentially help in determining appropriate therapy.

关键词： Achalasia Distensibility Impedance Planimetry Intraluminal impedance manometry Oesophago-gastric junction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Kaiyu Qingwei Jianji on the morphometry and residual strain distribution of small intestine in experimental diabetic rats

引用

World Journal of Gastroenterology 2006年第44期12卷 7149-7154页

作者： Hong Sha Jing-Bo Zhao Zhi-Yuan Zhang Shui-Ping Zhou Xiao-Lin Tong Feng-Yuan Zhuang Hans gregersen China-Japan Friendship Hospital Beijing 100029 China Center of Excellence in Visceral Biomechanics and Pain Aalborg Hospital DK 9000 Aalborg Denmark Bioengineering Department Beijing University of Aeronautics and Astronautics 37 Xueyuan Rd. Beijing 100083 China

AIM： To investigate the effect of a Chinese medicine, Kaiyu Qingwei Jianji （KYQWJJ） used for diabetic treatment, on the morphometry and residual strain distribution of the small intestine in streptozotocin （STZ） -induced diabetic rats. Correlation analysis was also performed between the opening angle and residual strain with the blood glucose level. METHODS： Forty-two male Wistar rats weighing 220-240 g were included in this study. Thirty-two STZ- induced diabetic rats were subdivided into four groups （n = 8 in each group）, i.e. diabetic control group （DM）; high dose of KYQWJJ （T1, 36g/kg per day）; low dose of KYQWJJ （T2, 17 g/kg per day） and Gliclazide （T3, 50 mg/kg per day）. Another ten rats were used as nondiabetic control （COn）. The medicines were poured directly into stomach lumen by gastric lavage twice daily. The rats of COn and DM groups were only poured the physiological saline. Blood glucose and plasma insulin levels were measured. Experimental period was 35 d. At the end of experiment, three 5-cm long segments were harvested from the duodenum, jejunum and ileum. Three rings of 1-2 mm in length for no-load and zero-stress state tests were cut from the middle of different segments. The morphometric data, such as the circumferential length, the wall thickness and the opening angle were measured from the digitized images of intestinal segments in the no-load state and zerostress state. The residual strain was computed from the morphometry data. Furthermore, the linear regression analysis was performed between blood glucose level with morphometric and biomechanical data in the different intestinal segments. RESULTS： The blood glucose level of DM group was consistent 4-fold to 5-fold higher than those in COn group during the experiment （16.89 ± 1.11 vs 3.44 ± 0.15 mmol/L, P 〈 0.001）. The blood glucose level in the T1 （16.89 ± 1.11 vs 11.08 ± 2.67 mmol/L, P 〈 0.01） and T3 groups （16.89 ± 1.11 vs 13.54 ± 1.73 mmol/L, P 〈 0.05）, but not in T2 group （P 〉 0.05）

关键词： Diabetes Intestine Kaiyu Qingwei Jianji Residual strain Rat

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

磷酸二酯酶3A与动脉高血压

引用

中华高血压杂志 2020年第7期28卷 623-623页

作者：周卫(译) 叶鹏(摘/审校) Ercu M MarkóL Schachterle C Tsvetkov D Cui Y Maghsodi S Theda UP.Bartolomaeus Maass PG Zühlke K gregersen n Hübner n Hodge R Mühl A Pohl B Molé-Illas R Geelhaar A Walter S napieczynska H Schelenz S Taube M Heuser A Anistan YM Qadri F Todiras M Plehm R Popova E Langanki R Eichhorst J Lehmann M Wiesner B Russwurm M Forslund SK Kamer I Müller Dn Gollasch M Aydin A Bohring S Bader M Luft FC Klussmann E 不详

高血压是全球心血管病死亡的主要危险因素。高血压伴短指(趾)畸形综合征在临床上类似于耐盐性原发性高血压,常导致患者在50岁之前因脑卒中而死亡。然而,最近研究者应用磷酸二酯酶3A(phosphodiesterase 3A,PDE3A)编码基因技术进行体内遗... 详细信息

高血压是全球心血管病死亡的主要危险因素。高血压伴短指(趾)畸形综合征在临床上类似于耐盐性原发性高血压,常导致患者在50岁之前因脑卒中而死亡。然而,最近研究者应用磷酸二酯酶3A(phosphodiesterase 3A,PDE3A)编码基因技术进行体内遗传缺陷模型研究,显示突变体PDE3A并未参与其中作用。方法:通过遗传图谱,测序,转基因技术.

关键词：动脉高血压遗传缺陷心血管病原发性高血压主要危险因素脑卒中转基因技术遗传图谱

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Tangweian Jianji on upper gastrointestinal remodeling in streptozotocin-induced diabetic rats

引用

World Journal of Gastroenterology 2012年第35期18卷 4875-4884页

作者： Gui-Fang Liu Jing-Bo Zhao Zhong Zhen Hong Sha Peng-Min Chen Min Li Jia-Cheng Zhang Ming-Ze Yuan Wen Gao Hans gregersen Xiao-Lin Tong Guang'anmen Hospital China Acad-emy of Chinese Medical Sciences Beijing 100053 China DK 9000 Aalborg and Instituteof Clinical Medicine Aarhus University DK8200 Aarhus NDenmark

AIM： To investigate the effect of Tangweian Jianji （TWAJJ） on the biomechanical and morphometrical remodeling of the upper gastrointestinal tract in diabetic rats. METHODS： Diabetes was induced in 27 rats by in- jecting streptozotocin （40 mg/kg body weight）, the animals were then divided into three groups （n = 9 in each group）, i.e., diabetic control （DM）; high dose （10 g/kg, T1） and low dose （5 g/kg, T2）. Another 10 rats acted as normal controls （Control）. TWAJJ was admin- istered by gavage once daily. Blood glucose and serum insulin levels were measured. Circumferential length, wall thickness and opening angle were measured from esophageal, duodenal, jejunal and ileal ring segments. The residual strain was calculated from the morpho- metric data. Step-wise distension was carried out on esophageal and jejunal segments. The obtained data on the length, diameter and pressure changes were then used to calculate the circumferential and longitu- dinal stresses and strains. Real-time reverse transcrip- tion polymerase chain reaction was used to detect the receptor of advanced glycation end-products （RAGE） mRnA level in jejunal tissues. RESULTS： At the end of the experiment, the blood glucose level was significantly higher and the serum insulin level was significantly lower in DM, T1 and T2 groups than in the control group （Glucose： 30.23 ± 0.41 mmol/L, 27.48 ± 0.27 mmol/L and 27.84 ± 0.29 mmol/ L vs 5.05 ± 0.04 mmol/L, P = 1.65 x 10-16, P = 5.89 x 1019 and P = 1.63 x 10-Is, respectively; Insulin： 1.47 ± 0.32 °tg/L, 2.66 ± 0.44 pg/L, 2.03 ± 0.29 pg/L and 4.17 ± 0.54 pg/L, P = 0.0001, P = 0.029 and P = 0.025, re- spectively）. However, these levels did not differ among the DM, T1 and T2 groups. The wet weight per unit length, wall thickness and opening angle of esophageal and intestinal segments in the DM group were signifi- cantly higher than those in the control group （from P = 0.009 to P = 0.004）. These parameters in the T1 group were significantly lower than those in th

关键词： Biomechanics and morphometric remodel-ing Diabetes rats Gastrointestinal tract Mechanism Tangweian .]ianji

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

糖基化终末产物及其受体在胃肠道中的分布

引用

世界华人消化杂志 2012年第36期20卷 3638-3643页

作者：陈朋民赵静波 Hans gregersen Mech-Sense Aalborg Hospital 中日友好医院临床医学研究所生化与分子生物学研究室北京市100029 Sino-Danish Centre for Education and Research

目的:研究糖基化终末产物(advanced glycation end products,AGE)及其受体(receptor for advanced glycation end products,RAGE)在胃肠道中的分布,为进一步探索其在慢性糖尿病胃肠功能紊乱中的作用奠定基础.方法:分别对成年Wistar大鼠... 详细信息

目的:研究糖基化终末产物(advanced glycation end products,AGE)及其受体(receptor for advanced glycation end products,RAGE)在胃肠道中的分布,为进一步探索其在慢性糖尿病胃肠功能紊乱中的作用奠定基础.方法:分别对成年Wistar大鼠食管、胃、十二指肠、空肠、回肠、结肠及直肠组织进行AGE及RAGE免疫组织化学染色.结果:(1)食管:AGE及RAGE主要分布在横纹肌的肌细胞及黏膜的鳞状上皮细胞;(2)胃:AGE在壁细胞为强阳性.RAGE在主细胞、肥大细胞、神经细胞为强阳性,在壁细胞为中等强度阳性,在表面黏液细胞为弱阳性;(3)小肠:AGE及RAGE在绒毛及固有层上皮细胞为阳性或强阳性.RAGE在肠道的神经细胞亦为强阳性;(4)结肠及直肠:AGE及RAGE在黏膜上皮细胞为弱阳性,RAGE在神经细胞为强阳性.结论:AGE及RAGE广泛分布于肠道上皮细胞及食管的横纹肌细胞,AGE亦分布于胃的壁细胞,RAGE亦分布于胃的壁细胞、主细胞、表面黏液细胞、肥大细胞及胃肠道的神经细胞.

关键词：糖尿病胃肠道合并症糖基化终末产物糖基化终末产物受体

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

表皮生长因子影响鼠小肠增量杨氏模量的研究

引用

力学学报 2004年第2期36卷 171-176页

作者：廖东华高松曾衍钧刘有军杨坚赵静波 L.Vinter-Jensen H.gregersen 北京工业大学生物力学与医学信息研究所北京100022 北京工业大学生物力学丹麦Aalborg大学生物力学实验室丹麦Aarhus大学医院临床实验研究所

研究表皮生长因子(EGF)2,4,7,14d处理后鼠小肠所发生的生物力学重建。通过双轴试验(膨胀与轴向拉伸组合),用最小二乘法计算了近于在体状态下环向、纵向及交叉向增量杨氏模量。各组环向和纵向模量均不相等,即正常状态和EGF处理后的小肠... 详细信息

研究表皮生长因子(EGF)2,4,7,14d处理后鼠小肠所发生的生物力学重建。通过双轴试验(膨胀与轴向拉伸组合),用最小二乘法计算了近于在体状态下环向、纵向及交叉向增量杨氏模量。各组环向和纵向模量均不相等,即正常状态和EGF处理后的小肠是各向异性的。在EGF处理期间,各向的杨氏模量随时间变化(P<0.05)。在EGF处理的最初7d中,环向模量减小,在处理14d后,又恢复到对照组的水平。增量模量介于17.4kPa与24.2kPa之间。纵向模量的值介于22.9kPa与32.4kPa之间,在处理4d后,比对照值显著增大(P<0.02)。交叉模量的值介于4.7kPa与6.6kPa之间,在最初EGF处理的4d中降低,此后增加并于第7d达到最大值。可以得出结论,肠壁的力学性质呈各向异性且在EGF处理期间会发生重建。

关键词：表皮生长因子鼠小肠杨氏模量各向异性生物物理学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

糖胃安煎剂改善糖尿病大鼠空肠生物力学重构的机制研究

引用

中日友好医院学报 2018年第4期32卷 220-224,F0002页

作者：沙洪赵东廖东华仝小林 Hans gregersen 赵静波中日友好临床医学研究所临床医学数据与项目管理平台北京100029 Department of Clinical Medicine Aarhus University8200 Aarhus NDenmark 重庆大学生物工程学院重庆400044 中国中医科学院广安门医院北京100053

目的:通过检测糖尿病大鼠脑源性神经营养因子(BDnF)及Trk受体Trk A、Trk B的表达变化与生物力学重构相关性,结合BDnF引起肠壁平滑肌形态及功能重构;肠壁平滑肌收缩张力改变影响生物力学重构的前期研究,探讨糖胃安的作用机制。方法:SD雄... 详细信息

目的:通过检测糖尿病大鼠脑源性神经营养因子(BDnF)及Trk受体Trk A、Trk B的表达变化与生物力学重构相关性,结合BDnF引起肠壁平滑肌形态及功能重构;肠壁平滑肌收缩张力改变影响生物力学重构的前期研究,探讨糖胃安的作用机制。方法:SD雄性大鼠30只,分为对照组、糖尿病模型组(链脲佐菌素40mg/kg)和糖胃安治疗组(链脲佐菌素40mg/kg造模+糖复安10g/kg灌胃60d)。免疫组化染色检测BDnF、Trk A和Trk B在空肠各层表达,通过图像、线性回归分析上述指标与生物力学重构的相关性。结果:糖尿病组与对照组比较,BDnF、Trk A和Trk B表达均显著降低(PnF、Trk A和Trk B表达,影响生物力学重构改善。

关键词：糖尿病小肠生物力学重构糖胃安煎剂脑源性神经营养因子及受体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advanced glycation end-product expression is upregulated in the gastrointestinal tract of type 2 diabetic rats

引用

World Journal of Diabetes 2015年第4期6卷 662-672页

作者： Peng-Min Chen Hans gregersen Jing-Bo Zhao Department of Molecular Biology Institute of Clinical MedicineChina-Japan Friendship Hospital GIOME Center College of BioengineeringChongqing University Institute of Clinical Medicine Aarhus University

AIM:To investigate changes in advanced glycation end products(AGEs) and their receptor(RAGE) expression in the gastrointestinal(GI) tract in type 2 diabetic ***:Eight inherited type 2 diabetic rats GotoKakizak(GK) and ten age-matched normal rats were used in the *** 18 wk of age,the body weight and blood glucose were measured every week and 2 wk *** the rats reached 32 wk,twocentimeter segments of esophagus,duodenum,jejunum,ileum,and colon were excised and the wet weight was *** segments were fixed in 10% formalin,embedded in paraffin and five micron sections were *** layer thickness was measured in Hematoxylin and Eosin-stained *** [n epsilon-(carboxymethyl) lysine and n epsilon-(carboxyethyl)lysine] and RAGE were detected by immunohistochemistry staining and image analysis was done using Sigmascan Pro 4.0 image analysis ***:The blood glucose concentration(mmol/L) at 18 wk age was highest in the GK group(8.88 ± 1.87 vs 6.90 ± 0.43,P nce that continued to exist until the end of the *** wet weight per unit length(mg/cm) increased in esophagus,jejunum and colon from the normal to the GK group(60.64 ± 9.96 vs 68.56 ± 11.69,P num; 91.37 ± 7.25 vs 97.28 ± 10.90,P n).Histologically,the layer thickness of the GItract was higher for esophagus,jejunum and colon in the GK group [full thickness(μm):575.37 ± 69.22 vs 753.20 ± 150.41,P num; 467.12 ± 65.92 vs 572.26 ± 93.60,P n].In esophagus,the AGE and RAGE mainly distributed in striated muscle cells and squamous epithelial *** AGE distribution was much stronger in the GK group compared to the normal group both in the striated muscle layer and mucosa layer(immuno-positive area/ total measuring area %:4.52 ± 0.89 vs 10.96 ± 1.34,P < 0.01 for muscle; 8.90 ± 2.62 vs

关键词： Diabetes mellitus Gastrointestinal complications Advanced glycation end products Receptor ofadvanced glycation end products

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：