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Neurodegenerative diseases are a function of matrix breakdown:how to rebuild extracellular matrix and intracellular matrix

2002年

作者： Norman Gaither greg Frazier.

来源：畅想之星图书光盘版（南... 评论

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Neural Regeneration Research 2018年第7期13卷 1185-1186页

作者： greg Maguire Bio Regenerative Sciences Inc.Neo GenesisInc.

Matrix within cells,the cytoskeleton,and that which surrounds cells,the extracellular matrix（ECM）,are connected to one another through a number of receptors including those in primary cilia,serving as an important chemical and physical signaling system：Mechanical forces generated through the matrix play a critical role in determining the form and function of tissues（Hughes et al.,2018）.

关键词： ECM Neurodegenerative diseases are a function of matrix breakdown:how to rebuild extracellular matrix and intracellular matrix

Introduction to non-Hermitian photonics in complex media:PT-symmetry and beyond

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Photonics Research 2018年第5期6卷 I0001-I0003页

作者： greg GBUR KONSTANTINOS MAKRIS University of North Carolina at Charlotte Department of Physics and Optical ScienceCharlotteNorth Carolina 28223USA University of Crete Physics Department71003 HeraklionGreece

This special issue is dedicated to the emerging field of non-Hermitian photonics of complex media, with emphasis on PT-symmetric optical structures. In particular, the papers highlight the variety of applications bein... 详细信息

关键词： PT

Optimization of the catch bench design using a genetic algorithm

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International Journal of Mining Science and Technology 2016年第6期26卷 1011-1016页

作者： Ruvin Wijesinghe Dakshith You greg Mining Engineering Program Faculty of Science and Technology Federation University Australia Ballarat 3350 Australia

Rockfalls are one of the hazards that may be associated with open pit mining. The majority of rockfalls occur due to the existing conditions of slopes, such as back break, fractures and joints. Constructing a berm on the catch bench is a popular method for the mitigation of rockfall hazards in open pit *** width of the catch bench and the height of the berm play a major role in the open pit bench ***, there is no systematic method currently available to optimize the size of these parameters. This study proposes a novel methodology which calculates the optimum catch bench width by integrating the rockfall simulation model and genetic algorithm into a Simulation-Optimization Model. The proposed methodology is useful when used to determine the minimum catch bench width, or the maximum overall slope angle, insuring that a sufficient factor of safety of the slope is included while maximizing the overall profitability of the open pit mine.

关键词：优化设计遗传算法捕集宽度计算露天开采仿真模型边坡角常用方法

Core Polarization and Tensor Coupling Effects on Magnetic Moments of Hypernuclei

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Chinese Physics Letters 2008年第5期25卷 1629-1632页

作者：尧江明吕洪风 Hillhouse greg 孟杰 School of Phyics and State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 College of Science Chinese Agriculture University Beijing 100083 Department of Physics University of Stellenbosch Stellenbosch South Africa Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100080 Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator Lanzhou 730000

Effects of core polarization and tensor coupling on the magnetic moments in A^13 C, A^17O, and A^41 Ca A-hypernuclei are studied by employing the Dirac equation with scalar, vector and tensor potentials. It is found that the effect of core polarization on the magnetic moments is suppressed by A tensor coupling. The A tensor potential reduces the spin-orbit splitting of pA states considerably. However, almost the same magnetic moments are obtained using the hyperon wavefunction obtained via the Dirac equation either with or without the A tensor potential in the electromagnetic current vertex. The deviations of magnetic moments for PA states from the Schmidt values are found to increase with nuclear mass number.

关键词： supernova explosion proto-neutron star shock wave

Quick Response Disaster Research:Opportunities and Challenges for a New Funding Program

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International Journal of Disaster Risk Science 2020年第5期11卷 568-577页

作者： greg Oulahen Brennan Vogel Chris Gouett-Hanna Department of Geography and Environmental Studies Ryerson UniversityToronto.ON M5B 2K3.Canada Centre for Environment and Sustainability Western UniversityLondonON N6A 3K7Canada

Quick response research conducted by social scientists in the aftermath of a disaster can reveal important findings about hazards and their impacts on *** to collect perishable data,or data that will change or be lost over time,immediately following disaster has been supported for decades by two programs in the United States,amassing a collection of quick response studies and an associated research *** culture is currently being challenged to better address power imbalances between researchers and disaster-affected *** recently,Canada has not had a quick response grant *** order to survey the state of knowledge and draw from it in helping to shape the new program in Canada,this article systematically analyzes the body of research created by the two US *** results reveal a wide-ranging literature:the studies are theoretically,conceptually,topically,and methodologically quite unique to one *** diversity might appropriately reflect the nature of disasters,but the finding that many studies are not building on previous quick response research and other in sights indicate opportunities for how a new grant program in Canada can contribute to growing a robust subdiscipline of disaster research.

关键词： Canada Disaster research Hazards Quick response Social science

Conceptus elongation in ruminants: roles of progesterone, prostaglandin, interferon tau and cortisol

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Journal of Animal Science and Biotechnology 2015年第2期6卷 151-162页

作者： Kelsey Brooks greg Burns Thomas E Spencer Department of Animal Science and Center for Reproductive Biology Washington State University

The majority of pregnancy loss in ruminants occurs during the first three weeks after conception, particularly during the period of conceptus elongation that occurs prior to pregnancy recognition and implantation. This review integrates established and new information on the biological role of ovarian progesterone （P4）, prostaglandins （PGs）, interferon tau （IFNT） and cortisol in endometrial function and conceptus elongation. Progesterone is secreted by the ovarian corpus luteum （CL） and is the unequivocal hormone of pregnancy. Prostaglandins （PGs） and cortisol are produced by both the epithelial cells of the endometrium and the trophectoderm of the elongating conceptus. In contrast, IFNT is produced solely by the conceptus trophectoderm and is the maternal recognition of pregnancy signa that inhibits production of luteolytic pulses of PGF2α by the endometrium to maintain the CL and thus production of P4. Available results in sheep support the idea that the individual, interactive, and coordinated actions of P4, PGs, IFNT and cortisol regulate conceptus elongation and implantation by controlling expression of genes in the endometrium and/or trophectoderm. An increased knowledge of conceptus-endometrial interactions during early pregnancy in ruminants is necessary to understand and elucidate the causes of infertility and recurrent early pregnancy loss and provide new strategies to improve fertility and thus reproductive efficiency.

关键词： Conceptus Cortisol Endometrium Interferon Prostaqlandin Ruminant

Time-series prediction of shellfish farm closure: A comparison of alternatives

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Information Processing in Agriculture 2014年第1期1卷 42-50页

作者： Ashfaqur Rahman Md Sumon Shahriar Claire D’Este greg Smith John McCulloch greg Timms Autonomous Systems Program CSIRO Computational InformaticsHobartTAS 7000Australia

Shellfish farms are closed for harvest when microbial pollutants are *** pollutants are typically present in rainfall runoff from various land uses in *** currently use a number of observable parameters(river flow,rainfall,salinity)as proxies to determine when to close *** have proposed using the short term historical rainfall data as a time-series prediction problem where we aim to predict the closure of shellfish farms based only on ***-series event prediction consists of two steps:(i)feature extraction,and(ii)prediction.A number of data mining challenges exist for these scenarios:(i)which feature extraction method best captures the rainfall pattern over successive days that leads to opening or closure of the farms?,(ii)The farm closure events occur infrequently and this leads to a class imbalance problem;the question is what is the best way to deal with this problem?In this paper we have analysed and compared different combinations of balancing methods(under-sampling and over-sampling),feature extraction methods(cluster profile,curve fitting,Fourier Transform,Piecewise Aggregate Approximation,and Wavelet Transform)and learning algorithms(neural network,support vector machine,k-nearest neighbour,decision tree,and Bayesian Network)to predict closure events accurately considering the above data mining *** have identified the best combination of techniques to accurately predict shellfish farm closure from rainfall,given the above data mining challenges.

关键词： Aquaculture Shellfish farm closure Data mining Time series data

A model-based approximate λ-policy iteration approach to online evasive path planning and the video game ***-Man

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控制理论与应用（英文版） 2011年第3期9卷 391-399页

作者： greg FODERARO Vikram RAJU Silvia FERRARI Department of Mechanical Engineering and Materials Science Duke University

This paper presents a model-based approximate λ-policy iteration approach using temporal differences for optimizing paths online for a pursuit-evasion problem,where an agent must visit several target positions within a region of interest while simultaneously avoiding one or more actively pursuing *** method is relevant to applications,such as robotic path planning,mobile-sensor applications,and path *** methodology described utilizes cell decomposition to construct a decision tree and implements a temporal difference-based approximate λ-policy iteration to combine online learning with prior knowledge through modeling to achieve the objectives of minimizing the risk of being caught by an adversary and maximizing a reward associated with visiting target *** learning and frequent decision tree updates allow the algorithm to quickly adapt to unexpected movements by the adversaries or dynamic *** approach is illustrated through a modified version of the video game ***-Man,which is shown to be a benchmark example of the pursuit-evasion *** results show that the approach presented in this paper outperforms several other methods as well as most human players.

关键词： Approximate dynamic programming Reinforcement learning Path planning Pursuit evasion games

Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep

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Journal of Animal Science and Biotechnology 2015年第2期6卷 177-190页

作者： greg A Johnson Robert C Burghardt Fuller W Bazer Department of Veterinary Integrative Biosciences Texas A&M UniversityCollege Station Department of Animal Science Texas A&M UniversityCollege Station

Osteopontin （OPN; also known as Secreted Phosphoprotein 1, SPP1） is a secreted extra-cellular matrix （ECM） protein that binds to a variety of cell surface integrins to stimulate cell-cell and cell-ECM adhesion and communication. It is generally accepted that OPN interacts with apically expressed integrin receptors on the uterine luminal epithelium （LE） and conceptus trophectoderm to attach the conceptus to the uterus for implantation. Research conducted with pigs and sheep has significantly advanced understanding of the role（s） of OPN during implantation through exploitation of the prolonged peri-implantation period of pregnancy when elongating conceptuses are free within the uterine lumen requiring extensive paracrine signaling between conceptus and endometrium. This is followed by a protracted and incremental attachment cascade of trophectoderm to uterine LE during implantation, and development of a true epitheliochorial or synepitheliochorial placenta exhibited by pigs and sheep, respectively. In pigs, implanting conceptuses secrete estrogens which induce the synthesis and secretion of OPN in adjacent uterine LE. OPN then binds to αvβ6 integrin receptors on trophectoderm, and the αvβ3 integrin receptors on uterine LE to bridge conceptus attachment to uterine LE for implantation. In sheep, implanting conceptuses secrete interferon tau that prolongs the lifespan of CL. Progesterone released by CL then induces OPN synthesis and secretion from the endometrial GE into the uterine lumen where OPN binds integrins expressed on trophectoderm （αvβ3） and uterine LE （identity of specific integrins unknown） to adhere the conceptus to the uterus for implantation. OPN binding to the αvβ3 integrin receptor on ovine trophectoderm cells induces in vitro focal adhesion assembly, a prerequisite for adhesion and migration of trophectoderm, through activation of： 1） P70S6K via crosstalk between FRAP1/MTOR and MAPK pathways; 2） MTOR, PI3K, MAPK3/MAPK1 （Erk1/2） and MAPK14 （p38） signalin

关键词： Implantation Integrins Psteoponti Pigs Sheep