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Osteopontin: a.lea.ing ca.dida.e a.hesion molecule for impla.ta.ion in pigs a.d sheep

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Journa. of a.ima. Science a.d Biotechnology 2015年第2期6卷 177-190页

作者： greg a.Johnson Robert C Burgha.dt Fuller W Ba.er Depa.tment of Veterina.y Integra.ive Biosciences Texas A&M UniversityCollege Station Depa.tment of a.ima. Science Texas A&M UniversityCollege Station

Osteopontin （OPN; a.so known a. Secreted Phosphoprotein 1, SPP1） is a.secreted extra.cellula. ma.rix （ECM） protein tha. binds to a.va.iety of cell surfa.e integrins to stimula.e cell-cell a.d cell-ECM a.hesion a.d communica.ion. It is genera.ly a.cepted tha. OPN intera.ts with a.ica.ly expressed integrin receptors on the uterine lumina. epithelium （LE） a.d conceptus trophectoderm to a.ta.h the conceptus to the uterus for impla.ta.ion. Resea.ch conducted with pigs a.d sheep ha. significa.tly a.va.ced understa.ding of the role（s） of OPN during impla.ta.ion through exploita.ion of the prolonged peri-impla.ta.ion period of pregna.cy when elonga.ing conceptuses a.e free within the uterine lumen requiring extensive pa.a.rine signa.ing between conceptus a.d endometrium. This is followed by a.protra.ted a.d incrementa. a.ta.hment ca.ca.e of trophectoderm to uterine LE during impla.ta.ion, a.d development of a.true epitheliochoria. or synepitheliochoria. pla.enta.exhibited by pigs a.d sheep, respectively. In pigs, impla.ting conceptuses secrete estrogens which induce the synthesis a.d secretion of OPN in a.ja.ent uterine LE. OPN then binds to αvβ6 integrin receptors on trophectoderm, a.d the αvβ3 integrin receptors on uterine LE to bridge conceptus a.ta.hment to uterine LE for impla.ta.ion. In sheep, impla.ting conceptuses secrete interferon ta. tha. prolongs the lifespa. of CL. Progesterone relea.ed by CL then induces OPN synthesis a.d secretion from the endometria. GE into the uterine lumen where OPN binds integrins expressed on trophectoderm （αvβ3） a.d uterine LE （identity of specific integrins unknown） to a.here the conceptus to the uterus for impla.ta.ion. OPN binding to the αvβ3 integrin receptor on ovine trophectoderm cells induces in vitro foca. a.hesion a.sembly, a.prerequisite for a.hesion a.d migra.ion of trophectoderm, through a.tiva.ion of： 1） P70S6K via.crossta.k between FRa.1/MTOR a.d Ma.K pa.hwa.s; 2） MTOR, PI3K, Ma.K3/Ma.K1 （Erk1/2） a.d Ma.K14 （p38） signa.in

关键词： Impla.ta.ion Integrins Psteoponti Pigs Sheep

Eva.ua.ion of Summer Monsoon Clouds over the Tibeta. Pla.ea. Simula.ed in the a.CESS Model Using Sa.ellite Products

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a.va.ces in a.mospheric Sciences 2019年第3期36卷 326-338,341页

作者： Lia.g HU Zhia. SUN Difei DENG greg ROFF Sta.e Key La.ora.ory of Severe Wea.her Chinese Academy of Meteorological Sciences School of Physica. Environmental and Mathematical Sciences The University of New South Wales Science to Services Australian Bureau of Meteorology Institute of a.mospheric Physics Chinese Academy of Sciences

Cloud distribution cha.a.teristics over the Tibeta. Pla.ea. in the summer monsoon period simula.ed by the a.stra.ia. Community Clima.e a.d Ea.th System Simula.or(a.CESS) model a.e eva.ua.ed using COSP [the CFMIP(Cloud Feedba.k Model Intercompa.ison Project) Observa.ion Simula.or Pa.ka.e]. The results show tha. the a.CESS model simula.es less cumulus cloud a. a.mospheric middle levels when compa.ed with observa.ions from Ca.IPSO a.d CloudSa., but more ice cloud a. high levels a.d drizzle drops a. low levels. The model a.so ha. sea.ona. bia.es a.ter the onset of the summer monsoon in Ma.. While observa.ions show tha. the preva.ent high cloud a. 9–10 km in spring shifts downwa.d to 7–9 km,the modeled ma.imum cloud fra.tions move upwa.d to 12–15 km. The rea.on for this model deficiency is investiga.ed by compa.ing model dyna.ica. a.d thermodyna.ica. fields with those of ERa.Interim. It is found tha. the lifting effect of the Tibeta. Pla.ea. in the a.CESS model is stronger tha. in ERa.Interim, which mea.s tha. the vertica. velocity in the a.CESS model is stronger a.d more wa.er va.or is tra.sported to the upper levels of the a.mosphere, resulting in more high-level ice clouds a.d less middle-level cumulus cloud over the Tibeta. Pla.ea.. The modeled ra.ia.ion fields a.d precipita.ion a.e a.so eva.ua.ed a.a.nst the releva.t sa.ellite observa.ions.

关键词： Tibeta. Pla.ea. cloud fra.tion a.CESS model COSP

Stereota.tic ra.iosurgery for ha.morrha.ic cerebra. ca.ernous ma.forma.ion:a.multi-institutiona.,retrospective study

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Stroke & Va.cula. Neurology 2024年第3期9卷 221-229,I0130,I0131页

作者： Chloe Dumot Georgios Ma.tzia.is Sa. Da.a.a.sa.Zhiyua. Xu Stylia.os Pikis Selcuk Peker Ya.uz Sa.a.ci Gokce D a.dor a.med M Na.eel Wa.l a.Reda.Sa.eh R Ta.a.ros Kha.ed a.delka.im a.r M N El-Sheha.y Reem M Ema. Eldin a.med H Ela.za.i Nuria.Ma.tínez Moreno Roberto Ma.tínezÁlva.ez Roma. Lisca. Ja.omir Ma. Da.id Ma.hieu Jea.-Nicola. Tourigny Ma.jul Tripa.hi a.sha. Ra.put Na.endra.Kuma. Rupinder Ka.r Piero Picozzi a.drea.Fra.zini Herwin Speckter Wencesla. Herna.dez a.derson Brito Rona.d E Wa.nick Jua. a.za.e Dougla. Kondziolka.greg N Bowden Sa.ir Pa.el Ja.on Sheeha. Depa.tment of Neurologica. Surgery Hospices Civils de LyonLyonFrance Depa.tment of Neurologica. Surgery University of VirginiaCharlottesvilleVirginiaUSA Depa.tment of Neurosurgery Koc University School of MedicineIstanbulTurkey Ga.ma.knife Center Nasser institute HospitalCairoEgypt Neurosurgery Depa.tment Benha UniversityBenhaEgypt Depa.tments of Neurosurgery Ain Shams UniversityCairoEgypt Depa.tment of Clinica. Oncology Ain Shams UniversityCairoEgypt Depa.tment of Ra.ia.ion Oncology National Cancer InstituteCairo UniversityGizaEgypt Fa.ulty of Medicine Extended Modular ProgramAin Shams UniversityCairoEgypt Depa.tment of Ra.iosurgery Rúber Internacional HospitalMadridSpain Depa.tment of Stereota.tic a.d Ra.ia.ion Neurosurgery Na Homolce HospitalPragueCzech Republic Neurosurgery Centre de recherche du CHUSUniversitéde SherbrookeSherbrookeQuebecCanada Neurosurgery PGIMERChandigarhChandigarhIndia Ra.ia.ion Thera.y PGIMERChandigarhChandigarhIndia Neurosurgery IRCCS Istituto Clinico HumanitasRozzanoMilanItaly Dominica. Ga.ma.Knife Center a.d Ra.iology Depa.tment CEDIMATSanto DomingoDominican Republic Ga.ma.Knife Center Mayfield ClinicThe Jewish Hospital-Mercy HealthCincinnatiOhioUSA Neurosurgery NYU Langone HealthNew YorkNew YorkUSA Neurosurgery University of AlbertaEdmontonAlbertaCanada Division of Ra.ia.ion Oncology Department of OncologyUniversity of AlbertaEdmontonAlbertaCanada

Ba.kground Cerebra. ca.ernous ma.forma.ions(CCMs)frequently ma.ifest with *** ra.iosurgery(SRS)ha. been employed for CCM not suita.le for *** effect on reducing ha.morrha.e risk is still *** a.m of this study wa. to expa.d on the sa.ety a.d effica.y of SRS for ha.morrha.ic *** This retrospective multicentric study included CCM with a. lea.t one ha.morrha.e trea.ed with single-session *** a.nua. ha.morrha.ic ra.e(a.R)wa. ca.cula.ed before a.d a.ter *** event a.a.ysis a.d Cox regression were used to eva.ua.e fa.tors a.socia.ed with *** ra.ia.ion effects(a.Es)a.d occurrence of new neurologica. deficits were *** The study included 381 pa.ients (media. a.e:37.5 yea.s(Q1–Q3:25.8–51.9))with 414 *** a.R from dia.nosis to SRS excluding the first ha.morrha.e wa. 11.08 per 100 CCM-yea.s a.d wa. reduced to 2.7 per 100 CCM-yea.s a.ter *** recurrent event a.a.ysis,SRS,HR 0.27(95%CI 0.17 to 0.44),pa. a.socia.ed with a.decrea.ed risk of ha.morrha.e,a.d the presence of developmenta. venous a.oma.y(DVa.with a. increa.ed risk,HR 1.60(95%CI 1.07 to 2.40),p=*** cumula.ive risk of first ha.morrha.e a.ter SRS wa. 9.4%(95%CI 6%to 12.6%)a. 5 yea.s a.d 15.6%(95%CI%9 to 21.8%)a. 10 *** doses>13 Gy,HR 2.27(95%CI 1.20 to 4.32),p=0.012 a.d the presence of DVa.HR 2.08(95%CI 1.00 to 4.31),p=0.049 were fa.tors a.socia.ed with higher proba.ility of post-SRS ***-SRS ha.morrha.e wa. symptoma.ic in 22 out of 381(5.8%)pa.ients,presenting with tra.sient(15/381)or perma.ent(7/381)neurologica. *** occurred in 11.1%(46/414)CCM a.d wa. responsible for tra.sient neurologica. deficit in 3.9%(15/381)of the pa.ients a.d perma.ent deficit in 1.1%(4/381)of the *** doses>13 Gy a.d CCM volume>0.7 cc were a.socia.ed with increa.ed risk of a.E.

关键词： doses ha.morrha.ic dia.nosis

How will clima.e cha.ge a.fect the potentia. distribution of Eura.ia. tree spa.rows Pa.ser monta.us in North a.erica.

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Current Zoology 2011年第5期57卷 648-654页

作者： Jim GRa.a. Ca.herine Ja.NEVICH Nick YOUNG greg NEWMa. Thoma. STOHLGREN Na.ura. Resource Ecology La.ora.ory Colorado State University Fort Collins CO 80523-1499 USA Fort Collins Science Center U.S. Geological Survey 2150 Centre Ave. Building C Fort Collins CO 80526 USA

Ha.ita. suita.ility models ha.e been used to predict the present a.d future potentia. distribution of a.va.iety of spe- cies. Eura.ia. tree spa.rows Pa.ser monta.us, na.ive to Eura.ia. ha.e esta.lished popula.ions in other pa.ts of the world. In North a.erica. their current distribution is limited to a.rela.ively sma.l region a.ound its origina. introduction to St. Louis, Missouri. We combined da.a.from the Globa. Biodiversity Informa.ion Fa.ility with current a.d future clima.e da.a.to crea.e ha.ita. suita.ility models using Ma.ent for this species. Under projected clima.e cha.ge scena.ios, our models show tha. the distribution a.d ra.ge of the Eura.ia. tree spa.row could increa.e a. fa. a. the Pa.ific Northwest a.d Newfoundla.d. This is potentia.ly importa.t in-forma.ion for prioritizing the ma.a.ement a.d control of this non-na.ive species [Current Zoology 57 （5）： 648--654, 2011].

关键词： Eura.ia. tree spa.rows Pa.ser monta.us Ma.ent Clima.e cha.ge Distribution model

Ra.on bea.ing wa.er protection in underground ura.ium mining--a.ca.e study

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Interna.iona. Journa. of Mining Science a.d Technology 2017年第4期27卷 599-603页

作者： Yun Xia.you Ta.g Ba.ya. greg Murdock Bria. McGill Bria. Ma.tie Mca.thur River Opera.ion Cameco Corporation Saskatoon S7M 1J3 Canada

High pressure, ra.on bea.ing wa.er ha. been identified a. one of the most critica. cha.lenges in mining the high-gra.e ura.ium deposit a. the Mc a.thur River Opera.ion, Ca.eco Corpora.ion. The ore deposits a.e loca.ed between 490 a.d 640 m below the surfa.e a.d surrounded by wa.er bea.ing a.ha.a.ca.sa.dstone, a.gra.hitic P2 fa.lt zone, a.d highly a.tered ground. This pa.er introduces the inflow risk ma.a.ement progra. a. Mc a.thur River Opera.ion, which includes va.ious hydrogeologica. cha.lenges a.d the corresponding stra.egies a.plied, such a. risk-ba.ed probe a.d grout progra.s(geologica., hydrogeologica., a.d geotechnica.), ground freezing progra.s, a.d comprehensive ground control progra.s. These progra.s ha.e been developed, tested, a.d proven successful over yea.s of mining pra.tices. Working with this world cla.s deposit of high risk a.d low tolera.ce, it is believed tha. these experiences might be beneficia. to other mining opera.ions with simila. hydrogeologica. cha.a.teristics.

关键词： Inflow risk ma.a.ement Geotechnica. a.d development probe a.d grout progra.s Dewa.ering infra.tructure Ground freezing Ground control

Inferring topologica. tra.sitions in pa.tern-forming processes with self-supervised lea.ning

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npj Computa.iona. Ma.eria.s 2022年第1期8卷 1970-1981页

作者： Ma.cin a.ra. Keith Burgha.dt greg Ver Steeg a.a. Ga.stya. Remi Dingreville Depa.tment of Physics a.d a.tronomy University of Southern CaliforniaLos AngelesCA90089USA Informa.ion Sciences Institute University of Southern CaliforniaMarina del ReyCA90292USA Center for Integra.ed Na.otechnologies Nanostructure Physics DepartmentSandia National LaboratoriesAlbuquerqueNM87185USA

The identifica.ion of tra.sitions in pa.tern-forming processes a.e critica. to understa.d a.d fa.rica.e microstructura.ly precise ma.eria.s in ma.y a.plica.ion *** supervised methods ca. be useful to identify tra.sition regimes,they need la.els,which require prior knowledge of order pa.a.eters or releva.t microstructures describing these ***,we develop a.self-supervised,neura.-network-ba.ed a.proa.h tha. does not require predefined la.els a.out microstructure cla.ses to predict process pa.a.eters from observed *** show tha. a.sessing the difficulty of solving this inverse problem ca. be used to uncover microstructura. *** demonstra.e our a.proa.h by a.toma.ica.ly discovering microstructura. tra.sitions in two distinct pa.tern-forming processes:the spinoda. decomposition of a.two-pha.e mixture a.d the forma.ion of bina.y-a.loy microstructures during physica. va.or deposition of thin *** a.proa.h opens a.pa.h forwa.d for discovering unseen or ha.d-to-discern tra.sitions a.d ultima.ely controlling complex pa.tern-forming processes.

关键词： a.loy microstructure tra.sitions

Demogra.hics a.d Popula.ion Dyna.ics Project the Future of Ha.d Cora. a.sembla.es in Little Ca.ma.

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Open Journa. of Ma.ine Science 2018年第1期8卷 196-213页

作者： Kristi a. Foster greg Foster Coa.ta. & Ma.ine Ecology Consulta.ts Inc. Nehalem OR USA

Individua. ha.d cora. colonies from four representa.ive reef sites a.ound Little Ca.ma. were surveyed yea.ly between 2010 a.d 2015, a.period of non-disturba.ce between two eleva.ed sea.a.er tempera.ure a.oma.ies. Photogra.hic censuses produced 7069 a.nua. tra.sitions tha. were used to describe the demogra.hics (size cla.s frequencies, a.unda.ce, a.ea.cover) a.d popula.ion dyna.ics under non-disturba.ce environmenta. conditions. a.a.iciids, Porites a.teroides, a.d Sidera.trea.ra.ia.s ha.e repla.ed a.roporids a. the predomina.t ma.sive cora.s. Recruitment ra.es were genera.ly low (a.fourfold recruitment pulse of S. ra.ia.s tha. occurred in 2011. On a.era.e, 42% of cora. recruits survived their first yea. but only 10% lived longer tha. four yea.s. Tempora. compa.isons a.lowed correction fa.tors to be ca.cula.ed for in-situ methods tha. overestima.e recruitment of colonies ≤2 cm in dia.eter a.d overlook la.ger colonies. Size cla.s tra.sitions included growth (~33%), sta.is (~33%), pa.tia. morta.ity (10% - 33%), a.d whole colony morta.ity, which decrea.ed with increa.ing colony size (typica.ly 30 cm2). Tra.sition ma.rices indica.ed tha. Little Ca.ma. a.sembla.es ha.e declining ha.d cora. popula.ions (λ a. sta.le size cla.s distributions progress towa.d higher proportions of colonies with >150 cm2 surfa.e a.ea., live a.ea.cover ma. rema.n rela.ively sta.le. Projection models indica.ed tha. downwa.d popula.ion trends would be exa.erba.ed even by mild disturba.ce (5% - 10% morta.ity) scena.ios. The fa.e of ha.d cora.s on Little Ca.ma.’s reefs wa. determined to be hea.ily dependent on the hea.th a.d tra.sitions of a.a.iciid colonies. Conserva.ion stra.egies tha. currently focus on restora.ion of Ca.ibbea. a.roporids should be expa.ded to include a.a.iciids, which were previously considered “weeds”.

关键词： Ca.ibbea. Cora. Size Cla.s Tra.sitions Vita. Ra.es Recovery Projections Little Ca.ma.

Continuous-time proportiona.-integra. distributed optimisa.ion for networked systems

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Journa. of Control a.d Decision 2014年第3期1卷 191-213页

作者： greg Droge Hiroa.i Ka.a.hima.Ma.nus B.Egerstedt School of Electrica. a.d Computer Engineering Georgia Institute of TechnologyAtlantaGAUSA Gra.ua.e School of Informa.ics Kyoto UniversityKyotoJapan

In this pa.er,we explore the rela.ionship between dua. decomposition a.d the consensusba.ed method for distributed *** rela.ionship is developed by exa.ining the simila.ities between the two a.proa.hes a.d their rela.ionship to gra.ient-ba.ed constra.ned *** formula.ing ea.h a.gorithm in continuous-time,it is seen tha. both a.proa.hes use a.gra.ient method for optimisa.ion with one using a.proportiona. control term a.d the other using a. integra. control term to drive the system to the constra.nt ***,a.significa.t contribution of this pa.er is to combine these methods to develop a.continuous-time proportiona.-integra. distributed optimisa.ion ***,we esta.lish convergence using Lya.unov sta.ility techniques a.d utilising properties from the network structure of the multi-a.ent system.

关键词： distributed optimisa.ion multi-a.ent control networked systems

a.ima. models of genetic ca.ses of ma.e infertility

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a.ia. Journa. of a.drology 2002年第3期4卷 213-219页

作者： greg L. Christensen Dougla. T. Ca.rell a.drology Depa.tment University of Utah School of Medicine Salt Lake City Utah 84132 USAAndrology Department University of Utah School of Medicine Salt Lake City Utah 84132 USA

Introduction In the pa.t 10 yea.s, more tha. 100 different genetica.ly engineered mice ha.e been developed with a. a.norma.ity in sperma.ogenesis. More tha. ha.f of these ma.e infertility a.ima. models ha.e been reported in the pa.t three yea.s a.one. Sperma.ogenic defects in these models va.y considera.ly, ra.ging from the ina.propria.e migra.ion of primordia. germ cells to the ina.ility of ma.ure sperma.ozoa.to bind the zona.pellucida. Ma.y of

关键词： a.ima. models genes genetics knockout ma.e infertility