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Culturomics and metagenomics: In understanding of environmental resistome

Frontiers of Environmental Science & Engineering 2019年第3期13卷 29-40页

作者： Monika Nowrotek Lukasz Jalowiecki Monika Harnisz grazyna anna plaza Microbiology Unit Institute for Ecology of Industrial Areas Kossutha 6 Str. 40-844 Katowice Poland Department of Environmental Microbiology Faculty of Environmental Sciences University of Warmia and Mazuiy Prawochenskiego 1 Str. 10-720 Olsztyn Poland Silesian University of Technology Faculty of Organization and Management Institute of Engineering Production Roosevelta 26 Str. 41-800 Zabrze Poland

Pharmaceutical residues, mainly antibiotics, have been called "emerging contaminants" in the environment because of their increasing frequency of detection in aquatic and terrestrial systems and their sublethal ecological effects. Most of them are undiscovered. Both human and veterinary pharmaceuticals, including antibiotics, are introduced into the environment via many different routes, including discharges from municipal wastewater treatment plants and land application of animal manure and biosolids to fertilize croplands. To gain a comprehensive understanding of the widespread problem of antibiotic resistance, modem and scientific approaches have been developed to gain knowledge of the entire antibiotic-resistant microbiota of various ecosystems, which is called the resistome. In this review, two omics methods, i.e. culturomics, a new approach, and metagenomics, used to study antibiotic resistance in environmental samples, are described. Moreover, we discuss how both omics methods have become core scientific tools to characterize microbiomes or resistomes, study natural communities and discover new microbes and new antibiotic resistance genes from environments. The combination of the method for get better outcome of both culturomics and metagenomics will significantly advance our understanding of the role of microbes and their specific properties in the environment.

关键词： Culturomics Metagenomics Antibiotic resistance Resistome

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Microstructure and electrical resistivity in the GdNi_(5–x)Cu_x intermetallic series

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Journal of Rare Earths 2017年第1期35卷 71-78页

作者： anna Bajorek grazyna Chelkowska A. Chelkowski Institute of Physics University of Silesia Katowice Poland Silesian Center for Education and Interdisciplinary Research University of Silesia Chorzow Poland

The effect of the Ni/Cu substitution on the electrical resistivity and microstructure of the polycrystalline GdNi5-xCux series was studied. The value of temperature of phase transition（T_（ph）） estimated from temperature dependence of electrical resistance varied non-linearly across copper doping from 32.5 K（x=0.0） to 29.1 K（x=5.0）. The value of residual resistivity（ρo） estimated at low temperature range decreased from 27.28 μΩcm（x=0.0） to 9.44 μΩcm（x=5.0）, which was discussed as the influence of microstructure. In order to describe the temperature dependence of resistivity ρ（T） a variety of approaches were applied due to different scattering mechanisms occurring at high and low temperature ranges. The change within ρ（T） curvature was evidenced at low temperature range across copper doping. The temperature variation of the resistivity was quite peculiar for Cu-rich compounds（x=4.8, x=5.0）, which might be correlated with the incommensurate magnetic structure derived from the weakly negative interaction between the nearest neighbours of Gd. The correlation between microstructure and resistivity was observed.

关键词： intermetallics rare earth alloys and compounds crystal structure electrical resistivity scanning electron microscopy

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TT virus infection and pancreatic cancer: Relationship or accidental coexistence

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World Journal of Gastroenterology 2005年第18期11卷 2847-2849页

作者： Krzysztof Tomasiewicz Roma Modrzewska anna Lyczak grazyna Krawczuk Department of Infectious Diseases Medical University of Lublin Biernackiego 9 20-089 Lublin Poland

TT virus (TTV) was first isolated in 1997 from the patient with acute post-transfusion hepatitis. This fact led to the conclusion that the virus was hepatotropic and could be one of the causative agents of acute hepatitis. Afterwards, however, the virus was found in other human tissues and serological studies revealed that it was widespread. Multiple tropisms of TTV and the fact of its high incidence in general population are considered to indicate no medical significance of TTV in human pathology. Here we present a report of two cases of TTV infection in patients who developed pancreas cancer. The patients were hospitalized at the Department of Infectious Diseases due to hepatitis of unknown origin. Since serological and virological markers of common primary and secondary hepatotropic viruses were negative, TTV-DNA was found in serum and was believed to be the only causative agent with probable hepatotropic action. The patients later developed pancreas cancer and they underwent operation. The relationship is difficult to confirm, however the cases we present should be treated as a preliminary report and a comment on the real role of TTV in human pathology.

关键词： TT病毒病毒传染胰腺癌病理机制

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HIV/HCV Co-Infection—A Dual Neurocognitive Problem

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World Journal of AIDS 2012年第1期2卷 33-41页

作者： Kalwa Agnieszka Szymanska Bogna Cholewinska grazyna Siwy-Hudowska anna Institute of Psychiatry and Neurology Addiction Prevention and Treatment Unit Warsaw Poland Warsaw Hospital for Infectious Diseases Warsaw Poland Warsaw School of Social Sciences and Humanities Warsaw Poland

Presence of the hepatitis C virus in HIV infected patients has an additional neurotoxic influence on the Central Nervous System. It has been described that HCV co-infection leads to neuropsychological impairment whose severity is greater than in mono-HIV infected subjects. In the present study we assessed the neuropsychological status of 46 human immunodeficiency virus (HIV)-infected individuals from the Warsaw Hospital for Infectious Diseases. For the purpose of cognitive assessment, neuropsychological tests measuring global cognitive functions, attention and perception, verbal memory, as well as non-verbal aspects of executive functions, e.g. visual monitoring and planning, were assessed. In 60% of the investigated patients, who were co-infected with the hepatitis C virus, the overall cognitive outcome observed was worse than in mono-HIV infected subjects. The following factors were taken into account: ART therapy’s influence on cognitive functions using the CPE rank (CNS Penetration Efficacy, 2010), route of HIV transmission, conditions of human existence and age of investigated patients. The present work should be treated as a preliminary research and interpreted in the context of several limitations described in the text.

关键词： HIV HCV Cognitive Functions Co-Infection

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下肢慢性缺血患者的超重和肥胖对血浆中VEGF-A、VEGFR-1和VEGFR-2浓度的影响（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第11期17卷 842-849页

作者： Radoslaw WIECZóR anna Maria WIECZóR grazyna GADOMSKA Katarzyna STANKOWSKA Jacek FABISIAK Karol SUPPAN Grzegorz PULKOWSKI Jacek BUDZYNSKI Danuta ROSC Department of Pathophysiology Faculty of PharmacyNicolaus Copernicus University in ToruhLudwik Rydygier Collegium Medicum in BydgoszczBydgoszcz PL 85-094Poland Clinic of Vascular and Internal Medicine Dr.Jan Biziel University Hospital No.2 in BydgoszezBydgoszcz PL 85-168Poland Department of Vascular and Internal Medicine Faculty of Health SciencesNicolaus Copernicus University in ToruhLudwik Rydygier Collegium Medicum in BydgoszezBydgoszcz PL 85-168Poland

目的:研究外周动脉疾病(PAD)患者血浆中血管内皮生长因子A(VEGF-A)和它的可溶性1型和2型受体(sV EGFR-1和sV EGFR-2)的浓度与营养水平的关系,同时根据身体质量指数(BMI)来评估营养水平。创新点:将血管生成与超重和肥胖及下肢局部缺血联... 详细信息

目的:研究外周动脉疾病(PAD)患者血浆中血管内皮生长因子A(VEGF-A)和它的可溶性1型和2型受体(sV EGFR-1和sV EGFR-2)的浓度与营养水平的关系,同时根据身体质量指数(BMI)来评估营养水平。创新点:将血管生成与超重和肥胖及下肢局部缺血联系起来,并根据BMI评估了它们之间的关系。方法:研究组包括46名Fontaine等级IIa至IV且没有任何肿瘤疾病史的PAD症状患者,其中15名BMI正常,21名超重,10名肥胖。对照组由30名不超重且不肥胖的健康非吸烟志愿者组成。试验在上午休息时间采集两组静脉血的血浆标本,用酶联免疫吸附(ELISA)方法确定血浆中的VEGF-A、s VEGFR-1和s VEGFR-2浓度。结论:如果PAD患者同时伴随着超重或者肥胖,会影响血管再生的过程。sV EGFR-2水平和BMI值之间有正相关关系,这说明代谢紊乱患者中的一些抗血管生成因子患病率的线性增长的原因,同时这可能是导致PAD患者侧支循环发展效率不完全的众多因素之一。

关键词：超重肥胖血管生成血管内皮生长因子可溶性1型和2型受体外周动脉疾病

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