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Robot-assisted kidney transplantation:Is it getting ready for prime time?

World Journal of Transplantation 2022年第7期12卷 163-174页

作者： Vincenzo Li Marzi Alessio Pecoraro Maria Lucia Gallo Leonardo Caroti Adriano Peris graziano Vignolini Sergio Serni Riccardo Campi Department of Minimally Invasive and Robotic Urologic Surgery Careggi University HospitalUniversity of FlorenceFlorence 50134Italy Nephrology Unit Careggi HospitalFlorence 50134Italy Intensive Care Unit and Regional ECMO Referral Centre Careggi HospitalFlorence 50134Italy Department of Minimally Invasive and Robotic Urologic Surgery University of FlorenceFlorence 50134Italy Department of Experimental and Clinical Medicine University of FlorenceFlorence 50134Italy

Kidney transplantation(KT)is the treatment of choice for patients with end-stage renal disease,providing a better survival rate and quality of life compared to *** the progress in the medical management of KT patients,from a purely surgical standpoint,KT has resisted innovations during the last 50 ***,robot-assisted KT(RAKT)has been proposed as an alternative approach to open surgery,especially due to its potential benefits for fragile and immunocompromised *** was not until 2014 that the role of RAKT has found value thanks to the pioneering Vattikuti Urology Institute-Medanta collaboration that conceptualized and developed a new surgical technique for RAKT following the Idea,Development,Exploration,Assessment,Long-term follow-up recommendations for introducing surgical innovations into real-life *** the last years,mirroring the Vattikuti-Medanta technique,several centers developed RAKT program worldwide,providing strong evidence about the safety and the feasibility of this ***,the majority of RAKT are still performed in the living donor setting,as an“eligible”procedure,while only a few centers have realized KT through a robotic approach in the challenging scenario of cadaver *** addition,despite the spread of minimally-invasive(predominantly robotic)surgery worldwide,many KTs are still performed in an open *** of the type of incision employed by surgeons,open KT may lead to nonnegligible risks of wound complications,especially among obese ***,the assessment for KT should consider not only the added surgical technical challenges but also the higher risk of postoperative *** this context,robotic surgery could offer several benefits,including providing a better exposure of the surgical field and better instrument maneuverability,as well as the possibility to integrate other technological nuances,such as the use of intraoperative fluorescence vascular imagi

关键词： Deceased donors Living donors Kidney transplantation Minimally invasive surgery Robotics

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意大利***地区白垩纪早阿普第期浅水碳酸盐岩沉积微相及其环境演化

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沉积学报 2019年第4期37卷 723-734页

作者：孙青青樊太亮 Roberto graziano 吴俊中国地质大学(北京)能源学院北京100083 中国地质大学(北京)海相储层演化与油气富集机理教育部重点实验室北京100083 意大利那不勒斯费德里克二世大学地球环境与资源科学系那不勒斯80138

通过对白垩纪早阿普第期***野外露头剖面宏观特征描述及室内岩石薄片分析,根据岩性及沉积特征变化,将其划分为A、B、C三个地层单元:A以潮下带粒泥灰岩为主,时有生物碎屑粒泥灰岩-泥粒灰岩夹层沉积;B以潮下带双壳类漂浮岩沉积为主,基质... 详细信息

通过对白垩纪早阿普第期***野外露头剖面宏观特征描述及室内岩石薄片分析,根据岩性及沉积特征变化,将其划分为A、B、C三个地层单元:A以潮下带粒泥灰岩为主,时有生物碎屑粒泥灰岩-泥粒灰岩夹层沉积;B以潮下带双壳类漂浮岩沉积为主,基质多为生屑泥粒灰岩;C与下伏地层呈不整合接触,该单元岩性变化复杂,整体以潮下带-潮上带沉积环境为主,偶尔发育潟湖沉积。根据三个地层单元所发育的骨架生物颗粒类型,可将地层A、B和C划分为"Chlorozoan"、"Chlorozoan&Foramol"、"Foramol&Microbial"三种不同组合的生物颗粒沉积。其沉积环境演变如下:A为暖水贫营养的水体环境,B为暖水富营养环境,而C则主要为温水富营养环境。基于***剖面的生物沉积特征及碳同位素数据可知,由温度、CO2及水体营养物质增加所引起的早白垩世生物沉积及其环境演化具全球性。

关键词：早阿普第期亚平宁碳酸盐岩台地碳酸盐岩沉积微相环境演化

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The Stava Valley Tailings Dams Disaster:A Reference Point for the Prevention of Severe Mine Incidents

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Journal of Environmental Science and Engineering(B) 2018年第6期7卷 234-241页

作者： Maurizio Boaretto graziano Lucchi Giovanni Tosatti Luca Zorzi Owner of B.C.Ingegneria Co.Tec.Design Firm Researcher in Mine EngineeringVia Satta 104Cagliari 09128Italy Chairman of the Stava 1985 Foundation(Charity) LocalitàStava 17Tesero 38038Italy Professor of Engineering and Environmental Geology Department of Chemical and Geological SciencesUniversity of Modena and Reggio EmiliaVia Nervi 78Modena 41125Italy Researcher in Geotechnical Engineering SRK Consulting Inc.1066 W Hastings StVancouver BC V6E 3X2Canada

On July 19,1985,at Stava near Tesero(Italian Alps),two reservoirs collapsed,causing the death of 268 people and the destruction of many *** two adjacent basins were constructed for the decantation and storage of fine-grained waste material,which was pumped from a nearby fluorite *** consequence of the failure was a vast flowslide that found its way downstream along the Stava valley destroying many houses in the village of Stava,eventually reaching Tesero,where more property was wrecked or severely *** Stava valley disaster was one of the most tragic of its *** paper aims to give a contribution on the technical aspects related to the causes of this catastrophic *** also describes alternative technical solutions for the proper management of mining waste disposal and environmental protection proposed by the Stava 1985 Foundation for disseminating knowledge and awareness on how to make these geotechnical structures safer and more profitable and avoid other similar disasters that still keep occurring every year around the world.

关键词： Stava disaster tailings dam failure safety measures and incident prevention

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Diazoxide toxicity in congenital hyperinsulinism:A case report

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World Journal of Clinical Pediatrics 2024年第4期13卷 102-108页

作者： Roberta Pajno Camilla Visconti Carmen Bucolo Maria Pia Guarneri Paolo Del Barba Paolo Silvani Marco Gregnanin graziano Barera Department of Pediatrics Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele InstituteMilan 20132LombardyItaly UniversitàVita-Salute San Raffaele Facoltàdi Medicina e ChirurgiaMilan 20132LombardyItaly Department of Anesthesia and Intensive Care Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific InstituteMilan 20132LombardyItaly Department of Neonatology Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele InstituteMilan 20132LombardyItaly

BACKGROUND Diazoxide is the sole approved drug for congenital hyperinsulinism;however,diuretic administration and vigilant monitoring are crucial to prevent and promptly identify potentially life-threatening adverse *** report aims to highlight a seldom-considered rare side effect of *** believe that this brief report is of general interest to World Journal of Clinical Pediatric readership and increase the physicians’awareness of the guideline ***,it underlines the importance of stopping immediately the drug if suspected side *** SUMMARY The manuscript describes a patient diagnosed with congenital hyperinsulinism(CHI)treated with diazoxide not overlapping with *** resulted in sudden respiratory distress and therefore was transferred to the Neonatal Intensive Care *** cardiological evaluation showed pericardial effusion and left ventricular myocardial hypertrophy,absent *** suspicion of an iatrogenic effect of diazoxide it was progressively reduced until stop while introducing diuretic treatment,with resolution of *** clinically stabilized,an 18 fluoro-diydroxy-phenylalanine positron emission tomography/computed tomography(PET/CT)was performed to differentiate between a focal or diffuse form of *** PET/CT highlighted the presence of a single focal accumulation of the tracer located in the pancreatic tail,consistent with a focal form of *** the age of four months,the patient underwent a distal pancreatectomy with histological confirmation of a focal form of nesidioblastosis,resulting in a curative *** Diuretic administration and vigilant monitoring of diazoxide therapy are crucial to prevent and promptly identify potentially life-threatening adverse effects.

关键词： Diazoxide Hypoglycemia Congenital hyperinsulinism Side effect Case report

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Upstream Operations in the Oil Industry： Rigorous Modeling ofan Electrostatic Coalescer

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Engineering 2017年第2期3卷 220-231页

作者： Francesco Rossi Simone colombo Sauro Pierucci Eliseo Ranzi Flavio Manenti Department of Chemistry Materials and Chemical Engineering "Giulio Natta" Polytechnic University of Milan Milan 20133 Italy Davidson School of Chemical Engineering Purdue University West Lafayette IN 47907-2100 USA

This paper deals with a first-principle mathematical model that describes the electrostatic coalescer unitsdevoted to the separation of water from oil in water-in-oil emulsions, which are typical of the upstreamoperations in oil fields. The main phenomena governing the behavior of the electrostatic coalescer are denscribed, starting from fundamental laws. In addition, the gradual coalescence of the emulsion droplets isconsidered in the mathematical modeling in a dynamic fashion, as the phenomenon is identified as a keystep in the overall yield of the unit operation. The resulting differential system with boundary conditionsis then integrated via performing numerical libraries, and the simulation results confirm the available lit-erature and the industrial data. A sensitivity analysis is provided with respect to the main parameters. Themathematical model results in a flexible tool that is useful for the purposes of design, unit behavior predic-tion. performance rnoniroring, and ontimization.

关键词： Upstream operations Electrostatic coalescer Desalter Rigorous modeling Water-oil emulsion

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Characterization and Enhancement of Microbial Biodiversity in Digestate in the Agronomic Field

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Journal of Life Sciences 2015年第4期9卷 139-151页

作者： Giuliana Conversano graziano Pizzolante Pietro Alifano Luigi De Bellis Dipartimento di Scienze e Tecnologie Biologiche e Ambientali Universith del Salento Via Prov.le Lecce-Monteroni Lecce 73100Italy

The possibility of producing biogas and methane from two phases olive pomace was considered using anaerobic digestion and the microbial characteristic of digestate for the agrarian use was analyzed. In the work, the main aim was to obtain biogas, made from at least 50% methane, and a digestate that can be used in the field of agronomy, from the anaerobic digestion of the substrates. The tests were carried out by digesting different mixtures of the two-phase pomace, mulberry leaves and mud civil wastewater （pre-digested） in a batch system and in anaerobic mesophilic conditions （35 ~C）. The substrates were properly homogenized in order to obtain mixtures of known and uniform composition. The initial and final STi （Total Solids） and initial SVi （Volatile Solids）, the concentration of chemical oxygen demand and total phenols were measured and the process yield （m3/t SV） was quantified with standard procedure. The objectives of the study were the analysis of microbial biodiversity developed during fermentation of mixtures based products and the microbial communities corresponding to Eubacteria, Archaea and Fungiwas analyzed. The suitability of the digestate for agronomical use was evaluated by estimating pathogens bacteria that may be present and by index of inhibition of plant organisms model.

关键词： Olive pomace anaerobic digestion Methane digestate microbial community.

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Cyclosporine-Associated Nephrotoxicity

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Open Journal of Nephrology 2013年第3期3卷 168-180页

作者： Maria Delia colombo Renata Perego Gilberto Bellia Department of Dermatology Marchesi Hospital Inzago (MI) Italy Novartis Farma S.p.A. Origgio (VA) Italy

Cyclosporine (CsA) has revolutionized transplant medicine and is currently one of the most important immunosuppressive agents for a wide range of organ transplantations and of autoimmune and inflammatory diseases, such as rheumatoid arthritis, uveitis, psoriasis, and atopic dermatitis. Renal impairment represents the main limitation to CsA long-term continuous therapy. However, it has been shown that nephrotoxicity is associated with longer treatment duration, larger cumulative doses and higher daily dose of CsA. With low dose regimens (<5 mg/kg/day), stable serum creatinine levels have been observed up to 15-20 years after kidney transplantation. Intermittent therapy may offer a good therapeutic strategy to limit long-term renal dysfunction, given the fact that renal structural changes are dose- and time-dependent. The best predictor of permanent renal damage is a persistent increase in serum creatinine level one month after treatment withdrawal. In patients with autoimmune diseases, the percentage increase in serum creatinine above baseline value during CsA therapy has been shown to predict CsA-induced nephropathy. Before CsA therapy initiation, patients should undergo a thorough baseline evaluation including laboratory assessments, in particular electrolytes, serum creatinine, and urea levels. Furthermore, patients should be evaluated for factors that might increase the risk of nephrotoxicity, such as obesity, older age, hypertension, concomitant use of nephrotoxic drugs, and pre-existing renal conditions. In the present paper, CsA-induced nephropathy will be reviewed in terms of pathophysiology, pathologic and clinical findings, and strategies for prevention and management.

关键词： Cyclosporine Nephrotoxicity Immunosuppression Transplant Creatinine

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Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: A case report

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World Journal of Gastroenterology 2005年第33期11卷 5226-5228页

作者： Piergiuseppe colombo Daoud Rahal Fabio Grizzi Vittorio Quagliuolo Massimo Roncalli Department of Pathology Istituto Clinico Humanitas Rozzano Milan Italy Scientific Direction Istituto Clinico Humanitas RozzanoMilanItaly Department of General Surgery Istituto Clinico Humanitas RozzanoMilanItaly Department of Pathology Istituto Clinico Humanitas RozzanoMilan Italy University of Milan School of Medicine MilanItaly

Intra-abdominal fibromatosis （IAF） is a benign mesenchymal lesion that can occur throughout the gastrointestinal tract. Although rare, it is the most common primary tumor of the mesentery and can develop at any age. We describe a rare case of primary IAF involving the mesentery and small bowel which clinically, macroscopically and histologically mimicked malignant gastrointestinal stromal tumor （GIST）. This report highlights the fact that benign IAF can be misdiagnosed as a malignant GIST localized in the mesentery or arising from the intestinal wall. Their diagnostic discrimination is essential because of their very different biological behaviors and the fact that the introduction of effective therapies involving tyrosine kinase inhibitor ST1571 （imatinib mesylate） has greatly changed the clinical approach to intra-abdominal stromal spindle cell tumors.

关键词： Intra-abdominal fibromatosis Gastrointestinaltract Gastrointestinal stromal tumor

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Management of adults with coarctation of aorta

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World Journal of Cardiology 2020年第5期12卷 167-191页

作者： Pradyumna Agasthi Sai Harika Pujari Andrew Tseng Joseph N graziano Francois Marcotte David Majdalany Farouk Mookadam Donald J Hagler Reza Arsanjani Department of Cardiovascular Diseases Mayo ClinicScottsdaleAZ 85259United States Department of Cardiovascular Diseases Mayo ClinicRochesterMN 55905United States Division of Cardiology Phoenix Children's HospitalChildren's Heart CenterPhoenixAZ 85016United States

Coarctation of the aorta(CoA)is a relatively common congenital cardiac defect often causing few symptoms and therefore can be challenging to *** hallmark finding on physical examination is upper extremity hypertension,and for this reason,CoA should be considered in any young hypertensive patient,justifying measurement of lower extremity blood pressure at least once in these *** presence of a significant pressure gradient between the arms and legs is highly suggestive of the *** diagnosis and treatment are important as long-term data consistently demonstrate that patients with CoA have a reduced life expectancy and increased risk of cardiovascular *** repair has traditionally been the mainstay of therapy for correction,although advances in endovascular technology with covered stents or stent grafts permit nonsurgical approaches for the management of older children and adults with native CoA and *** hypertension and vascular dysfunction can lead to an increased risk of coronary disease,which,remains the greatest cause of long-term ***,blood pressure control and periodic reassessment with transthoracic echocardiography and threedimensional imaging(computed tomography or cardiac magnetic resonance)for should be performed regularly as cardiovascular complications may occur decades after the intervention.

关键词： Coarctation of aorta Cardiac surgery Cardiac catheterization Balloon angioplasty Stents

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Adipose Derived Stem Cells and Growth Factors Applied on Hair Transplantation. Follow-Up of Clinical Outcome

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Journal of Cosmetics, Dermatological Sciences and Applications 2014年第4期4卷 268-274页

作者： Federica Zanzottera Emilio Lavezzari Letizia Trovato Alessandro Icardi Antonio graziano Hair Transplantation Surgery Studio Dr. Lavezzari Como Italy HBW Srl Torino Italy

Different studies show the need of immature adipose cell to induce the proliferation of bulge stem cells in order to kick off the anagen phase of hair cycle. Furthermore, the adipose derived stem cell, adipose progenitors, and growth factors secreted by mature adipocytes can help the wound healing and the vascular neogenesis. Nowadays, it is not known any protocol of tissue regeneration applied to hair transplantation, especially if aimed to the reconstruction of the main vascular network for the engraftment of transplanted hair and the healing process. The aim of the work is to investigate how the application of autologous cellular suspension obtained by Rigenera system, mechanical fragmentation procedure which allows to obtain a physiological saline solution consisting of a heterogeneous pool of cells rich in adipose derived mesenchymalstem cells and growth factors, helps the wound healing and engraftment of the transplanted hair. During hair restoration surgery, the adipose tissue recovered from the discard of follicular slicing, was processed using the Rigenera system. The obtained cell suspension was applied in the area of hair transplantation, increasing the natural background of adipocyte lineage and raising the amount of growth factors. In addition, the cellular suspension was applied to the suture on the occipital region. The cell population was characterized by FACS. The monthly evaluation of hair transplantation follow-up with photos and the patient’s impressions demonstrates that there is a faster healing of the micro-wound and a continuous growth of the transplanted hair even two months after the procedure, with a shortening of the dormant phase. In conclusion, this new approach aims to integrate regenerative medicine and hair restoration surgery in order to improve the outcome for the patient. It would be wonderful to continue this research to elaborate on the molecular cause behind this satisfying clinical.

关键词： Stem Cell ADSC Hair Transplantations Regenerative Medicine Hypoderm Hair Transplantations

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