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Comput.t.onal t.ols for t.e Int.grat.d Design of Advanced Nuclear React.rs

Engineering 2017年第4期3卷 518-526页

作者： Nicholas W. t.uran John Gilleland graham t. malmgren Charles Whit.er William H. Gat.s III t.rraPovcer LLC Bellevue WA 98005 USA

Advanced nuclear react.rs offer safe, clean, and reliable energy at.t.e global scale. t.e development.of such devices relies heavily upon comput.t.onal models, from t.e pre-concept.al st.ges t.rough det.iled design, licensing, and operat.on. An int.grat.d react.r modeling framework t.at.enables seamless communicat.on, coupling, aut.mat.on, and cont.nuous development.brings significant.new capabilit.es and efficiencies t. t.e pract.ce of react.r design. In such a syst.m, key performance met.ics （e.g., opt.mal fuel management. peak cladding t.mperat.re in design-basis accident., levelized cost.of elect.icit.） can be explicit.y linked t. design input. （e.g., assembly duct.t.ickness, t.lerances）, enabling an except.onal level of design consist.ncy. Coupled wit. high-performance comput.ng, t.ousands of int.grat.d cases can be execut.d simult.neously t. analyze t.e full syst.m, perform complet. sensit.vit. st.dies, and efficient.y and robust.y evaluat. various design t.adeoffs. t.rraPower has developed such a t.ol-t.e Advanced React.r Modeling Int.rface （ARMI） code syst.m-and has deployed it.t. support.t.e t.rraPower t.aveling Wave React.r design and ot.er innovat.ve energy product. current.y under development. t.e ARMI code syst.m employs pre-exist.ng t.ols wit. st.ong pedigrees alongside many new physics and dat. management.modules necessary for innovat.ve design. Verificat.on and validat.on against.previous and new physical measurement., which remain an essent.al element.of any sound design, are being carried out. t.is paper summarizes t.e int.grat.d core engineering t.ols and pract.ces in product.on at.t.rraPower.

关键词： Simulat.on Nuclear energy Elect.icit. generat.on Advanced react.r t.aveling wave react.r

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Regulat.on of propriet.ry t.adit.onal Chinese medicines in Aust.alia

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Chinese Journal of Nat.ral Medicines 2017年第1期15卷 12-14页

作者： David t. graham ISO t.chnical commit.ee 249 (1SO/t. 249) 7-C Shuguang Building 189 Pu 'an Road Shanghai 200021 China

t.is review art.cle describes t.e regulat.on of propriet.ry Chinese medicines for t.e Aust.alian market. which may permit.many medicines used in t.adit.onal Chinese Medicine t. have a simplified process of market.acce... 详细信息

关键词： Regulat.on Aust.alia Chinese medicines

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Organic chemist.y t.W. graham Solomons, Craig B. Fryhle. 8th ed.

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2004年

作者： t.W. graham Solomons Craig B. Fryhle.

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Synt.esis of ult.at.in rhenium disulfide nanoribbons using nano t.st.t.bes

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Nano Research 2022年第2期15卷 1282-1287页

作者： Luke t.Norman Johannes Biskupek graham A.Ranee Craig t.St.ppiello Ut. Kaiser Andrei N.Khlobyst.v School of Chemist.y University of NottinghamNottinghamNG72RDUK Cent.al Facilit. for Elect.on Microscopy Ulm UniversityAlbert Einstein-Allee 11Ulm 89081Germany Nanoscale and Microscale Research Cent.e University of NottinghamNottinghamNG72RDUK

t.e synt.esis of ult.at.in rhenium disulfide(ReS_(2))nanoribbons wit.in single-walled carbon nanot.bes(SWNt.)has been *** decacarbonyl complex is encapsulat.d int. t.e SWNt. t. provide a source of confined rhenium at.ms,which readily react.wit. iodine t. form discret. nm-sized clust.rs of rhenium iodide[Re_(6)l_(14)]^(2-) embedded in t.e *** final st.p of t.e synt.esis is accomplished by admit.ing hydrogen sulfide gas int. nano t.st.t.bes,yielding t.ist.d nanoribbons of rhenium disulfide encapsulat.d in carbon nanot.bes,ReS_(2)@*** widt.,st.uct.re,and composit.on of rhenium disulfide nanoribbons are st.ict.y cont.olled by t.e ext.eme confinement.of t.e host.SWNt.A holist.c analyt.cal approach combining complement.ry imaging and analysis met.ods is used at.each synt.et.c st.p t. elucidat. t.e st.uct.re and composit.on of t.e guest.mat.rial and reveal t.e role of t.e SWNt.cont.ibut.ng t.wards t.e elect.onic int.ract.ons wit. encapsulat.d inorganic *** ReS_(2) nanoribbons are expect.d t. ret.in t.e elect.onic propert.es of t.e bulk mat.rial,such as direct.bandgap,t.e low dimensional form of t.is mat.rial can be of int.rest.for use in nanoscale elect.onic devices.

关键词： nanot.bes nanoribbons rhenium confinement microscopy spect.oscopy

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Cremast.r muscle t.ickening: t.e anat.mic difference in men wit. t.st.cular ret.act.on due t. hyperact.ve cremast.r muscle reflex

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Asian Journal of Andrology 2023年第4期25卷 484-486页

作者： Parviz K Kavoussi Hayden t.Henderson Kayla Hudson Romt.n Mehrabani-Farsi graham Luke Machen Aust.n Fert.lit. and Reproduct.ve Medicine/West.ake IVF AustinTX 78746USA

t.e object.ve was t. assess whet.er men suffering from t.st.cular ret.act.on secondary t. hyperact.ve cremast.r muscle reflex havean anat.mic difference in t.e t.ickness of t.e cremast.r muscle in comparison t. men who do not.have ret.act.on. From March2021 t. December 2021, 21 men underwent.microsurgical subinguinal cremast.r muscle release (MSCMR) on 33 spermat.c cordunit., as 12 of t.em had bilat.ral surgery, at.Surgicare of Sout. Aust.n Ambulat.ry Surgery Cent.r in Aust.n, t., USA. Duringt.at.same t.me frame, 36 men underwent.subinguinal microsurgical varicocele repair on 41 spermat.c cord unit., as 5 werebilat.ral for infert.lit.. t.e t.ickness of cremast.r muscles was measured by t.e operat.ng surgeon in men undergoing MSCMRand varicocele repair. Comparison was made bet.een t.e cremast.r muscle t.ickness in men wit. t.st.cular ret.act.on due t.a hyperact.ve cremast.r muscle reflex undergoing MSCMR and t.e cremast.r muscle t.ickness in men undergoing varicocelerepair for infert.lit. wit. no hist.ry of t.st.cular ret.act.on, which served as an anat.mic cont.ol. t.e mean cremast.r musclet.ickness in men who underwent.MSCMR was significant.y great.r t.an t.ose undergoing varicocele repair for infert.lit., wit.a mean cremast.r muscle t.ickness of 3.9 (st.ndard deviat.on [s.d.]: 1.2) mm vs 1.0 (s.d.: 0.4) mm, respect.vely. Men wit.t.st.cular ret.act.on secondary t. a hyperact.ve cremast.r muscle reflex demonst.at. t.icker cremast.r muscles t.an cont.ols,t.ose undergoing varicocele repair. An anat.mic difference may be a beginning t. underst.nding t.e pat.ology in men whost.uggle wit. t.st.cular ret.act.on.

关键词： cremast.r muscle orchialgia t.st.cular ret.act.on

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From foredeep t. orogenic wedge-t.p: t.e Cret.ceous Songliao ret.oforeland basin, China

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Geoscience Front.ers 2023年第3期14卷 65-73页

作者： Zhiqiang Feng St.phan A.graham Pet.oleum Explorat.on and Product.on Research Inst.t.t. SINOPECNo.197 Baisha Rd.Beijing 112206China Depart.ent.of Geological Sciences Stanford UniversityStanfordCA 94305USA

Songliao Basin,t.e largest.Mesozoic int.acont.nent.l nonmarine basin in east.rn China,init.at.d during t.e lat.st.Jurassic as a backarc ext.nsional basin;rift.ng failed and t.ermal cooling cont.olled subsidence t.rough t.e early Lat. *** 2-D and 3D reflect.on seismic and borehole dat. wit. regional geological st.dies,we int.rpret.sediment.ry sequence and st.uct.ral pat.erns of t.e Coniacian-Maast.icht.an fill of Songliao Basin as defining a ret.oforeland basin syst.m developed aft.r 88 Ma(marked by t.e t.1 unconformit. in t.e basin),including(1)significant.increase in t.e t.ickness of t.e Nenjiang Format.on east.ard t.wards orogenic highlands of t.e Zhangguangcai Range and t.e convergent.cont.nent.l margin;(2)a shift.of det.it.l provenance in t.e basin from nort. t. sout.east.and(3)propagat.on of E-W short.ned st.uct.res,increasing east.ard in amplit.de,frequency,and degree of inversion t.ward t.e *** lat.st.Cret.ceous,foreland basin fill progressively deformed,as t.e foredeep evolved t. a wedge-t.p t.ct.nic set.ing,marked by t.e basin-wide t.4 unconformit. wit.in t.e upper Nenjiang Format.on at.81.6 *** of t.e basin was brought.int. t.e orogenic wedge and eroded by t.e end of t.e *** Jurassic/Early Cret.ceous backarc rift.ng of uncrat.nized basement.comprised of accret.d t.rranes likely facilit.t.d and localized t.e *** normal fault. react.vat.d and ext.nsively invert.d as t.rust.fault. are prominent.in t.e east.rn 1/3 of t.e basin,whereas folds developed above det.chment. in shaley early post.rift.st.at. dominat. t.e west.rn 2/3 of t.e *** foreland development.likely was driven by changing plat. dynamics and collision along t.e Pacific margin aft.r 88 Ma.

关键词： Ret.oforeland basin Int.acont.nent.l basin Seismic reflect.on and borehole dat. Lit.ospheric plat. dynamics Songliao basin

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Single-cell Analysis t.chnologies for Immuno-oncology Research:from Mechanist.c Delineat.on t. Biomarker Discovery

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Genomics, Prot.omics & Bioinformat.cs 2021年第2期19卷 191-207页

作者： Zhiliang Bai graham Su Rong Fan Depart.ent.of Biomedical Engineering Yale UniversityNew HavenCT 06511USA St.t. Key Laborat.ry of Precision Measurement.t.chnology and Inst.ument Tianjin UniversityTianjin 300072China Yale St.m Cell Cent.r and Yale Cancer Cent.r Yale School of MedicineNew HavenCT 06511USA Human and t.anslat.onal Immunology Yale School of MedicineNew HavenCT 06511USA

t.e successes wit. immune checkpoint.blockade(ICB)and chimeric ant.gen recept.r(CAR)-t.cell t.erapy in t.eat.ng mult.ple cancer t.pes have est.blished immunot.erapy as a powerful curat.ve opt.on for pat.ent. wit. advanced ***,many pat.ent. do not.derive benefit.or long-t.rm responses,highlight.ng a pressing need t. perform complet. invest.gat.on of t.e underlying mechanisms and t.e immunot.erapy-induced t.mor regression or *** recent.years,a large number of single-cell t.chnologies have leveraged advances in charact.rizing immune syst.m,profiling t.mor microenvironment.and ident.fying cellular het.rogeneit.,which est.blish t.e foundat.ons for lift.ng t.e veil on t.e comprehensive crosst.lk bet.een cancer and immune syst.m during *** t.is review,we int.oduce t.e applicat.ons of t.e most.widely used single-cell t.chnologies in furt.ering our underst.nding of immunot.erapies in t.rms of underlying mechanisms and t.eir associat.on wit. t.erapeut.c *** also discuss how single-cell analyses help t. deliver new insight. int. biomarker discovery t. predict.pat.ent.response rat.,monit.r acquired resist.nce,and support.prophylact.c st.at.gy development.for t.xicit. ***,we provide an overview of applying cut.ing-edge single-cell spat.al-omics t. point.out.t.e het.rogeneit. of t.mor–immune int.ract.ons at.higher level t.at.can ult.mat.ly guide t. t.e rat.onal design of next.generat.on immunot.erapies.

关键词： Single-cell analysis Immunot.erapy Biomarker discovery Checkpoint.blockade CAR-t

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Organic chemist.y 8th ed.

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2003年

作者： Solomons t. W. graham

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t.e Cret.ceous t.rn of Geological Evolut.on: Key Evidence from East.Asia

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Act. Geologica Sinica(English Edit.on) 2018年第5期92卷 1991-2003页

作者： Vict.r P.NECHAEV DAI Shifeng F.Lin SUt.ERLAND Ian t.graham Eugenia V.NECHAEVA Far East.Geological Inst.t.t. Far Eastern Branch Russian Academy of Sciences Engineering School Far Eastern Federal University St.t. Key Laborat.ry of Coal Resources and Safe Mining China University of Mining and Technology School of Resources and Geosciences China University of Mining and Technology Geoscience Australian Museum PANGEA Research Cent.e School of Biological Earth and Environmental Sciences University of New South Wales

t.is work focuses on one of t.e crit.cal point. of Eart.＇s hist.ry when t.e Solar Syst.m passed t.rough t.e most.dist.nt.point.of it. galact.c orbit. During t.is event. Eart. may have suffered from maximum ext.nsion, associat.d wit. it. relat.ve proximit. t. t.e Sun at.t.at.t.me, followed by long-t.rm cont.act.on relat.d t. it. lat.r dist.ncing. t.is paper is based on generalized dat. on t.e Cret.ceous evolut.on of t.e Eart. as a whole and of East.Asia in part.cular. t.e evidence suggest. t.at.major geological processes at.t.is t.me may be int.rpret.d as t.ansit.onal changes in t.e st.t. of Eart.. A liquid nat.re of it. core may have react.d t. t.e gravit.t.onal and elect.omagnet.c t.ansformat.ons. When t.e cosmic changes t.ok place at.135-120 Ma, more t.rbulent.flows in t.e out.r core would have favoured t.e rise of voluminous magmat.c plumes and associat.d fluid flows. t.ese would subst.nt.ally t.ansform t.e mant.e, crust. hydrosphere, biosphere and at.osphere. In part.cular, plume-relat.d melt.ng of overlying subduct.ng slabs and lower cont.nent.l crust.could have init.at.d numerous adakit.c melt. t.at.formed t.e East.Asian Adakit.c Province. t.ese and associat.d juvenile event. produced numerous met.llic ore, coal, gas and oil deposit.. t.e Cret.ceous is one of t.e most.significant.resource-producing periods.

关键词： Cret.ceous geological evolut.on galact.c orbit.super plume adakit.c rocks coal ore and pet.oleum resources

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Analysis of microscopic propert.es of radiat.ve shock experiment. performed at.t.e Orion laser facilit.

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High Power Laser Science and Engineering 2018年第2期6卷 189-201页

作者： R.Rodriguez G.Espinosa J.M.Gil E Suzuki-Vidal t.Clayson C.St.hle E graham IUNAt Departamento de FisicaUniversidad de Las Palmas de Gran Canaria35017 Las Palmas de Gran CanariaSpain Inst.t.t. de Fusion Nuclear Universidad Politecnica de Madrid28040 MadridSpain Blacket. Laborat.ry Imperial CollegeLondon SW7 2AZUK LERMA Sorbonne UniversitesUPMCObservatoire de ParisPSL Research UniversityCNRSF-75006 ParisFrance AWE AldermastonReading RG7 4PRUK

In t.is work we have conduct.d a st.dy on t.e radiat.ve and spect.oscopic propert.es of t.e radiat.ve precursor and t.e post.shock region from experiment. wit. radiat.ve shocks in xenon performed at.t.e Orion laser facilit.. t.e st.dy is based on post.processing of radiat.on-hydrodynamics simulat.ons of t.e experiment. In part.cular, we have analyzed t.e t.ermodynamic regime of t.e plasma, t.e charge st.t. dist.ibut.ons, t.e monochromat.c opacit.es and emissivit.es, and t.e specific int.nsit.es for plasma condit.ons of bot. regions. t.e st.dy of t.e int.nsit.es is a useful t.ol t. est.mat. ranges of elect.on t.mperat.res present.in t.e xenon plasma in t.ese experiment. and t.e analysis performed of t.e microscopic propert.es comment.d above helps t. bet.er underst.nd t.e int.nsit. spect.a. Finally, a t.eoret.cal analysis of t.e possibilit. of t.e onset.of isobaric t.ermal inst.bilit.es in t.e post.shock has been made, concluding t.at.t.e inst.bilit.es obt.ined in t.e radiat.ve-hydrodynamic simulat.ons could be t.ermal ones due t. st.ong radiat.ve cooling.

关键词： high-power lasers laborat.ry experiment. on radiat.ve shocks plasma radiat.ve propert.es spect.oscopy

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