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Testing a hypothesis arising from the epidemiology of schizophrenia in New Zealand

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General Psychiatry 2019年第2期32卷 57-58页

作者： graham mellsop Rees lapsell David Benjamin Menkes Department of Psychological Medicine University of Auckland Waikato Clinical School Hamilton New Zealand

A 2011 publication in World Psychiatry thoughtfully, but somewhat pessimistically, addressed the question of how schizophrenia might be prevented.1 A review of causal evidence2 a decade later offers little further hope. We hypothesise that an emergent increase in syndromal schizophrenia in New Zealand, particularly in Maori (descendants of the indigenous Polynesian population), may present opportunities for prevention.

关键词： New Zealand schizophrenia epidemiology

Involuntary admission and treatment of patients with mental disorder

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Neuroscience Bulletin 2015年第1期31卷 99-112页

作者： Simei Zhang graham mellsop Johann Brink Xiaoping Wang Mental Health Institute of The Second Xiangya Hospital Hunan Province Technology Institute of PsychiatryKey Laboratory of Psychiatry and Mental Health of Hunan ProvinceCentral South University Waikato Clinical School University of Auckland University of British Columbia VancouverBritish ColumbiaCanada

Despite the efforts of the World Health Organization to internationally standardize strategies for mental-health care delivery,the rules and regulations for involuntary admission and treatment of patients with mental disorder still differ markedly across countries. This review was undertaken to describe the regulations and mental-health laws from diverse countries and districts of Europe（UK,Austria,Denmark,France,Germany,Italy,Ireland,and Norway）,the Americas（Canada,USA,and Brazil）,Australasia（Australia and New Zealand）,and Asia（Japan and China）. We outline the criteria and procedures for involuntary admission to psychiatric hospitals and to community services,illustrate the key features oflaws related to these issues,and discuss their implications for contemporary psychiatric practice. This review may help to standardize the introduction oflegislation that allows involuntary admission and treatment of patients with mental disorders in the mainland of China,and contribute to improved mental-health care. In this review,involuntary admission or treatment does not include the placement of mentally-ill offenders,or any other aspect of forensic psychiatry.

关键词： involuntary admission involuntary treatment mental-health legislation compulsory admission commitment criteria

Service availability, compulsion, and compulsory hospitalisation

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上海精神医学 2012年第1X期24卷 44-45页

作者： graham mellsop Kate DIESFELD Waikato Clinical School University of Auckland New Zealand Te Piringa-Faculty of Law University of Waikato Hamilton New Zealand

Legislation sometimes leads to social change, but more often it formalises evolutions in existing community views. China's draft Mental Health Act appears to have both elements. While the draft Act (the Act) has a significant emphasis on patients' rights, it also aims to improve and increase services for people who are mentally unwell in China.

关键词：服务可用性社会精神中国法案

中华人民共和国精神卫生法:邀请对话(英文)

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上海精神医学 2012年第6期24卷 360-361页

作者： Kate DIESFELD graham mellsop Auckland University of Technology Waikato Clinical School University of Auckland

The Shanghai Archives of Psychiatry is commended for publishing an English translation of China's first mental health *** illuminates how a society functions, the issues it faces and its collective *** to an extensively annotated English translation of Chinese legislation about mental health will stimulate reflection, comparison and constructive critique from both Chinese and international observers about the mental health laws in different countries,about different governments' priorities, and about the robustness of mental health services *** translation of the Mental Health Law of the People's Republic of China (the Act) will foster fruitful communication across borders and, thus, benefit the persons with mental disorders whom we all serve.

关键词：中国法律卫生法规中华人民共和国精神对话心理健康英文翻译社会功能

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强制性治疗的法律构架(及其他相关问题)

上海精神医学 2011年第1期23卷 53-55页

作者： graham mellsop Kate DIESFELD 新西兰奥克兰大学怀卡托临床医学院怀卡托大学法学院

Richardson 教授在分析了非自愿治疗相关法律的共同影响因素后发现：许多拥有较为完善的精神卫生服务体系的国家都已经建立了精神卫生服务的特有法律体系。

关键词：法律构架强制性治疗精神卫生服务卫生服务体系影响因素自愿治疗法律体系

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中国解决精神卫生老问题的新举措

上海精神医学 2011年第4期23卷 243-244页

作者： graham W.mellsop 新西兰奥克兰大学怀卡托医学院

由于疾病本身的影响，精神障碍患者主动寻求或接受治疗的意愿和能力受到损害。许多国家都在致力于提高此类患者的治疗率。其中，以下两个问题颇受争论。

关键词：精神卫生精神障碍患者中国治疗率

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

The state of mountain research in Canada

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Journal of Mountain Science 2022年第10期19卷 3013-3025页

作者： graham MCDOWELL Katherine HANLY Department of Geography University of CalgaryCalgaryABT2NiN4Canada Department of Geography University of ZurichCH-8006 ZurichSwitzerland

Nearly a quarter of Canada’s landmass is covered by mountainous terrain,making mountains an important aspect of the physical and human geography of the *** areas in Canada have motivated a great deal of research activity,yet the state of mountain research in the country has never been systematically characterized,precluding a detailed understanding of what is being studied,when,where,how,and by *** response,we conducted a systematic scoping review to rigorously identify,collate,and critically examine existing peer-reviewed articles related to mountains in Canada.2,888 articles were included in our review,which reveals strong biases towards work in the natural sciences and in the mountain west,with little work to date in the social and health sciences or in other mountainous regions of the *** results demonstrate that Canada is among the most productive contributors to mountain research globally,but that topical and geographical biases in existing research effort leave important gaps that must be addressed to successfully navigate challenges and opportunities facing mountain areas in *** provide a roadmap to guide future mountain-focused research activities in the country.

关键词： Canada Mountains Systematic scoping review Research

Effect of Look-Ahead Depth in Evolutionary Checkers

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Journal of Computer Science & Technology 2012年第5期27卷 996-1006页

作者： Belal Al-Khateeb graham Kendall College of Computer Al-Anbar UniversityRamadiIraq School of Computer Science The University of NottinghamNottinghamU.K

It is intuitive that allowing a deeper search into a game tree will result in a superior player to one that is restricted in the depth of the search that it is allowed to make. Of course, searching deeper into the tree comes at increased computational cost and this is one of the trade-offs that has to be considered in developing a tree-based search algorithm. There has been some discussion as to whether the evaluation function, or the depth of the search, is the main contributory factor in the performance of an evolved checkers player. Some previous research has investigated this question （on Chess and Othello）, with differing conclusions. This suggests that different games have different emphases, with respect to these two factors. This paper provides the evidence for evolutionary checkers, and shows that the look-ahead depth （like Chess, perhaps unsurprisingly） is important. This is the first time that such an intensive study has been carried out for evolutionary checkers and given the evidence provided for Chess and Othello this is an important study that provides the evidence for another game. We arrived at our conclusion by evolving various checkers players at different ply depths and by playing them against one another, again at different ply depths. This was combined with the two-move ballot （enabling more games against the evolved players to take place） which provides strong evidence that depth of the look-ahead is important for evolved checkers players.

关键词： evolutionary Checkers look-ahead depth neural network