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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha k.an George Jimsheleishvili Patricia graham Adriana Brook. Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal network.,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,mark.ng,to our k.owledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received week.y intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 week.,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received week.y consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Experimental Investigation of Thermal Performance of Novel Finned Radiators for Automotive Cooling System

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Journal of Thermal Science 2024年第5期33卷 1726-1743页

作者： SINGH Hardeep TING David S-k.READER graham ESHTIAGHI Nick. ICHIYANAGI Mitsuhisa SUZUk. Tak.shi Turbulence&Energy Laboratory University of WindsorWindsor N9B 3P4Canada Chemical and Environmental Engineering School of EngineeringRMIT UniversityMelbourneVictoria 3001Australia Department of Engineering and Applied Sciences Sophia UniversityTokyo 102-8554Japan

This research investigates innovative fin-type radiators for automobile engine cooling ***-channel and helical radiators,along with straight type,were analyzed for heat transfer characteristics under various *** uniqueness of this study is evident in the design of microchannel and helical *** helical radiators,the inner rod features 4/8 helical-shaped water galleries,while the outer tube frame with embedded fins remains *** contrast,the microchannel radiators have compact trapezoidal-shaped water galleries with separate fin ***,the novelty of the research is enhanced by the utilization of 3D printing technology in the manufacturing *** constant fin height analysis at varied water and air flow rate,Microchannel Water Air Radiator with fin height 10.5 mm(MCWAR10.5)depicted a higher heat transfer rate amongst the *** comparison to Straight Water Air Radiator with fin height 9.5 mm(SWAR9.5),the heat transfer rate is 30.3%and 1.3 times ***,in constant fin surface area analysis,microchannel radiator(MCWAR3.2)illustrates lower heat dissipation than Helical radiator(HWAR138)but higher than HWAR134 and Straight radiator(SWAR6).The examination of pumping loss indicated that the Micro-channel radiator outperformed helical radiators due to its lower pressure *** average pressure loss for Micro-channel radiators was 0.74 k.a,mak.ng it 1.2 times higher than that of a straight radiator(0.62 k.a),indicating a better trade-off.

关键词： heat exchangers multi-channel helical heat exchanger heat transfer 3D printing

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Nanometer ultrastructural brain damage following low intensity primary blast wave exposure

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Neural Regeneration Research 2018年第9期13卷 1516-1519页

作者： Hailong Song Landry M. k.nan Jiank.n Cui Catherine E. Johnson graham k. huble. Ralph G. DePalma Zezong Gu Department of Pathology & Anatomical Sciences University of Missouri School of Medicine Columbia MO USA Department of Mining and Nuclear Engineering Missouri University of Science and Technology Rolla MO USA Office of Research and Development Department of Veterans Affairs Washington DC USA Truman VA Hospital Research Service Columbia MO USA

Blast-induced mild traumatic brain injury（m TBI） is of particular concern among military personnel due to exposure to blast energy during military training and *** impact of primary low-intensity blast mediated pathophysiology upon later neurobehavioral disorders has been *** a military preclinical blast model to simulate the pathophysiology of human blast injury is an important first *** article provides an overview of primary blast effects and perspectives of our recent studies demonstrating ultrastructural changes in the brain and behavioral disorders resulting from open-field blast exposures up to 46.6 k.Pa using a murine *** model is scalable and permits exposure to varying magnitudes of primary blast injuries by placing animals at different distances from the blast center or by changing the amount of C4 *** here review the implications and future applications and directions of using this animal model to uncover the underlying mechanisms related to primary blast ***,these studies offer the prospect of enhanced understanding of the pathogenesis of primary low-intensity blast-induced TBI and insights for prevention,diagnosis and treatment of blast induced TBI,particularly m TBI/concussion related to current combat exposures.

关键词： mild traumatic brain injury openfield blast primary blast wave blast physics animal model altrastructural abnormalities behavior

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The state of mountain research in Canada

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Journal of Mountain Science 2022年第10期19卷 3013-3025页

作者： graham MCDOWELL k.therine HANLY Department of Geography University of CalgaryCalgaryABT2NiN4Canada Department of Geography University of ZurichCH-8006 ZurichSwitzerland

Nearly a quarter of Canada’s landmass is covered by mountainous terrain,mak.ng mountains an important aspect of the physical and human geography of the *** areas in Canada have motivated a great deal of research activity,yet the state of mountain research in the country has never been systematically characterized,precluding a detailed understanding of what is being studied,when,where,how,and by *** response,we conducted a systematic scoping review to rigorously identify,collate,and critically examine existing peer-reviewed articles related to mountains in Canada.2,888 articles were included in our review,which reveals strong biases towards work.in the natural sciences and in the mountain west,with little work.to date in the social and health sciences or in other mountainous regions of the *** results demonstrate that Canada is among the most productive contributors to mountain research globally,but that topical and geographical biases in existing research effort leave important gaps that must be addressed to successfully navigate challenges and opportunities facing mountain areas in *** provide a roadmap to guide future mountain-focused research activities in the country.

关键词： Canada Mountains Systematic scoping review Research

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Effect of Look.Ahead Depth in Evolutionary Check.rs

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Journal of Computer Science & Technology 2012年第5期27卷 996-1006页

作者： Belal Al-k.ateeb graham k.ndall College of Computer Al-Anbar UniversityRamadiIraq School of Computer Science The University of NottinghamNottinghamU.K

It is intuitive that allowing a deeper search into a game tree will result in a superior player to one that is restricted in the depth of the search that it is allowed to mak.. Of course, searching deeper into the tree comes at increased computational cost and this is one of the trade-offs that has to be considered in developing a tree-based search algorithm. There has been some discussion as to whether the evaluation function, or the depth of the search, is the main contributory factor in the performance of an evolved check.rs player. Some previous research has investigated this question （on Chess and Othello）, with differing conclusions. This suggests that different games have different emphases, with respect to these two factors. This paper provides the evidence for evolutionary check.rs, and shows that the look.ahead depth （lik. Chess, perhaps unsurprisingly） is important. This is the first time that such an intensive study has been carried out for evolutionary check.rs and given the evidence provided for Chess and Othello this is an important study that provides the evidence for another game. We arrived at our conclusion by evolving various check.rs players at different ply depths and by playing them against one another, again at different ply depths. This was combined with the two-move ballot （enabling more games against the evolved players to tak. place） which provides strong evidence that depth of the look.ahead is important for evolved check.rs players.

关键词： evolutionary Check.rs look.ahead depth neural network

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Liver iron transport

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World Journal of Gastroenterology 2007年第35期13卷 4725-4736页

作者： Ross M graham Anita CG Chua Carly E Herbison John k.Olynyk.Debbie Trinder School of Medicine and Pharmacology Fremantle HospitalUniversity of Western AustraliaFremantleWestern AustraliaAustralia School of Medicine and Pharmacology Fremantle HospitalUniversity of Western AustraliaFremantleWestern AustraliaAustralia Western Australian Institute for Medical ResearchNedlandsWestern AustraliaAustralia

The liver plays a central role in iron metabolism. It is the major storage site for iron and also expresses a complex range of molecules which are involved in iron transport and regulation of iron homeostasis. An increasing number of genes associated with hepatic iron transport or regulation have been identified. These include transferrin receptors （TFRI and 2）, a ferrireductase （STEAP3）, the transporters divalent metal transporter-1 （DMT1） and ferroportin （FPN） as well as the haemochromatosis protein, HFE and haemojuvelin （HJV）, which are signalling molecules. Many of these genes also participate in iron regulatory pathways which focus on the hepatic peptide hepcidin. However, we are still only beginning to understand the complex interactions between liver iron transport and iron homeostasis. This review outlines our current k.owledge of molecules of iron metabolism and their roles in iron transport and regulation of iron homeostasis.

关键词： Liver Iron homeostasis Iron uptak. Iron release Iron transporters Hereditary haemochromatosis

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Cremaster muscle thick.ning: the anatomic difference in men with testicular retraction due to hyperactive cremaster muscle reflex

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Asian Journal of Andrology 2023年第4期25卷 484-486页

作者： Parviz k.k.voussi Hayden T Henderson k.yla Hudson Romtin Mehrabani-Farsi graham Luk. Machen Austin Fertility and Reproductive Medicine/Westlak. IVF AustinTX 78746USA

The objective was to assess whether men suffering from testicular retraction secondary to hyperactive cremaster muscle reflex havean anatomic difference in the thick.ess of the cremaster muscle in comparison to men who do not have retraction. From March2021 to December 2021, 21 men underwent microsurgical subinguinal cremaster muscle release (MSCMR) on 33 spermatic cordunits, as 12 of them had bilateral surgery, at Surgicare of South Austin Ambulatory Surgery Center in Austin, TX, USA. Duringthat same time frame, 36 men underwent subinguinal microsurgical varicocele repair on 41 spermatic cord units, as 5 werebilateral for infertility. The thick.ess of cremaster muscles was measured by the operating surgeon in men undergoing MSCMRand varicocele repair. Comparison was made between the cremaster muscle thick.ess in men with testicular retraction due toa hyperactive cremaster muscle reflex undergoing MSCMR and the cremaster muscle thick.ess in men undergoing varicocelerepair for infertility with no history of testicular retraction, which served as an anatomic control. The mean cremaster musclethick.ess in men who underwent MSCMR was significantly greater than those undergoing varicocele repair for infertility, witha mean cremaster muscle thick.ess of 3.9 (standard deviation [s.d.]: 1.2) mm vs 1.0 (s.d.: 0.4) mm, respectively. Men withtesticular retraction secondary to a hyperactive cremaster muscle reflex demonstrate thick.r cremaster muscles than controls,those undergoing varicocele repair. An anatomic difference may be a beginning to understanding the pathology in men whostruggle with testicular retraction.

关键词： cremaster muscle orchialgia testicular retraction

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Tomato molecular biology–special collection of papers for molecular horticulture

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Molecular Horticulture 2022年第1期2卷 280-283页

作者： graham B.Seymour Jocelyn k.C.Rose School of Biosciences Division of Plant and Crop ScienceUniversity of NottinghamLoughboroughLeics LE125RDUK School of Integrative Plant Science Cornell University331 Emerson HallIthacaNY 14853USA

Tomato(Solanum lycopersicum)is the second most important vegetable crop globally,after potato,with about 100 million tons fresh fruit being grown on 3.7 million hectares(FAO 2021),and is of great importance in the human diet due to the large amount of fruit *** fruit are eaten both fresh and,equally importantly,as a processed product in puree,soups and canned *** provide an important dietary source of vitamins and minerals,such as k.Fe and Ca,and are k.own for the large number of health promoting secondary metabolites,including the carotenoid and flavonoid pigments that give the fruit a spectrum of yellow,red and orange colours.

关键词： culture orange globally

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Infrared Thermography for True Temperature Measurement of the Main Board in Personal Computer

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Journal of Thermal Science 2002年第4期11卷 331-336页

作者： Masud Behnia graham Morrison School of Mechanical and Manufacturing Engineering The University of New South WalesSchool of Mechanical and Manufacturing Engineering The University of New South Wales Sydney2052 Australia Sydney2052 Australia

This paper presents a way to measure the true temperature of the electronic devices without disturbing their normal operating conditions, which involved with estimating target emissivity, back.round temperature correctly and choosing infrared transparent material and its transmission estimation. The temperature distributions of the main board in personal computer were measured by the method presented here with infrared thermography in several different running conditions. The measurement errors and their possible remedies are also discussed.

关键词： infrared thermography electronic cooling temperature distrubution thermal measurement.

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The Roper-Suffridge extension operator and classes of biholomorphic mappings Dedicated to Professor Sheng GONG on the occasion of his 75th birthday

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Science China Mathematics 2006年第11期49卷 1539-1552页

作者： graham Ian k.HR Gabriela Department of Mathematics University of Toronto TorontoOntario M5S 2E4Canada Faculty of Mathematics and Computer Science Babes-Bolyai University 1 M. Kogǎlniceanu Str. 400084 Cluj-NapocaRomania

In this paper we give a survey about the Roper-Suffridge extension operator and the developments in the theory of univalent mappings in several variables to which it has led. We begin with the basic geometric properties (most of which now have a number of different proofs)and discuss relations with the theory of Loewner chains and generalizations and modifications of the operator, some of which are very recent.

关键词： convex mapping, starlik. mapping, Roper-Suffridge operator, growth theorem, distortion theorem, covering theorem, Loewner chain, parametric representation,extreme points, linear invariant family.

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