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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.goldschmidt-Clermont Aisha Khan george Jimsheleishvili Patricia graham Adriana Brooks Risset Silvera Alexander J.P.goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

From thermal conductive to thermal insulating:Effect of carbon vacancy content on lattice thermal conductivity of ZrC_(x)

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Journal of Materials Science & Technology 2021年第23期82卷 105-113页

作者： Yue Zhou William g.Fahrenholtz Joseph graham gregory E.Hilmas Department of Materials Science and Engineering Missouri University of Science and TechnologyRollaMO 65409USA

Lattice thermal conductivities of zirconium carbide(ZrC_(x),x=1,0.75 and 0.5)ceramics with different carbon vacancy concentrations were calculated using a combination of first-principles calculations and the Debye-Callaway *** gruneisen parameters,Debye temperatures,and phonon group velocities were deduced from phonon dispersions of ZrC_(x) determined using first-principles *** addition,the effects of average atomic mass,grain size,average atomic volume and Zr isotopes on the lattice thermal conductivities of ZrC_(x) were analyzed using phonon scattering *** lattice thermal conductivity decreased as temperature increased for ZrC,ZrC_(0.75) and ZrC_(0.5)(Zr2 C),and decreased as carbon vacancy concentration ***,ZrC_(x) can be tailored from a thermal conducting material for ZrC with high lattice thermal conductivity to a thermal insulating material for ZrC_(0.5) with low lattice thermal ***,it opens a window to tune the thermal properties of ZrC_(x) by controlling the carbon vacancy content.

关键词： Zirconium carbide Lattice thermal conductivity Theoretical study First-principle calculations

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渗透压和乙醇对酵母活力和形态的影响

啤酒科技 2004年第9期 61-65页

作者： Patricia L.Pratt James H.Bryce graham g.stewart 林文北京燕京啤酒集团公司科研技术中心 101300

酵母菌会影响发酵速度和发酵度,还会影响成品酒的风味、质量和稳定性.由于高浓度的麦汁会对酵母菌的发酵性能产生有害影响,因此必须筛选能适应这种恶劣环境的酵母菌,能经受高渗透压和不断上升的乙醇水平.在体外渗透压和乙醇形成的压力... 详细信息

酵母菌会影响发酵速度和发酵度,还会影响成品酒的风味、质量和稳定性.由于高浓度的麦汁会对酵母菌的发酵性能产生有害影响,因此必须筛选能适应这种恶劣环境的酵母菌,能经受高渗透压和不断上升的乙醇水平.在体外渗透压和乙醇形成的压力作用下,Lager和Ale啤酒酵母菌的平均细胞体积会减少.研究发现,在相同条件下Lager啤酒酵母的存活力下降得非常明显,而Ale啤酒酵母菌的存活力则基本不受影响.对细胞表面的研究揭示,在上述两种压力作用下,酵母细胞发生收缩,细胞壁呈圆锯齿状.乙醇对酵母细胞表面的影响比由山梨醇产生的渗透压影响更加显著.

关键词：渗透压乙醇酵母活力啤酒细胞体积发酵性能

The state of mountain research in Canada

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Journal of Mountain Science 2022年第10期19卷 3013-3025页

作者： graham MCDOWELL Katherine HANLY Department of geography University of CalgaryCalgaryABT2NiN4Canada Department of geography University of ZurichCH-8006 ZurichSwitzerland

Nearly a quarter of Canada’s landmass is covered by mountainous terrain,making mountains an important aspect of the physical and human geography of the *** areas in Canada have motivated a great deal of research activity,yet the state of mountain research in the country has never been systematically characterized,precluding a detailed understanding of what is being studied,when,where,how,and by *** response,we conducted a systematic scoping review to rigorously identify,collate,and critically examine existing peer-reviewed articles related to mountains in Canada.2,888 articles were included in our review,which reveals strong biases towards work in the natural sciences and in the mountain west,with little work to date in the social and health sciences or in other mountainous regions of the *** results demonstrate that Canada is among the most productive contributors to mountain research globally,but that topical and geographical biases in existing research effort leave important gaps that must be addressed to successfully navigate challenges and opportunities facing mountain areas in *** provide a roadmap to guide future mountain-focused research activities in the country.

关键词： Canada Mountains Systematic scoping review Research

Effect of Look-Ahead Depth in Evolutionary Checkers

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Journal of Computer Science & Technology 2012年第5期27卷 996-1006页

作者： Belal Al-Khateeb graham Kendall College of Computer Al-Anbar UniversityRamadiIraq School of Computer Science The University of NottinghamNottinghamU.K

It is intuitive that allowing a deeper search into a game tree will result in a superior player to one that is restricted in the depth of the search that it is allowed to make. Of course, searching deeper into the tree comes at increased computational cost and this is one of the trade-offs that has to be considered in developing a tree-based search algorithm. There has been some discussion as to whether the evaluation function, or the depth of the search, is the main contributory factor in the performance of an evolved checkers player. Some previous research has investigated this question （on Chess and Othello）, with differing conclusions. This suggests that different games have different emphases, with respect to these two factors. This paper provides the evidence for evolutionary checkers, and shows that the look-ahead depth （like Chess, perhaps unsurprisingly） is important. This is the first time that such an intensive study has been carried out for evolutionary checkers and given the evidence provided for Chess and Othello this is an important study that provides the evidence for another game. We arrived at our conclusion by evolving various checkers players at different ply depths and by playing them against one another, again at different ply depths. This was combined with the two-move ballot （enabling more games against the evolved players to take place） which provides strong evidence that depth of the look-ahead is important for evolved checkers players.

关键词： evolutionary Checkers look-ahead depth neural network

Infrared Thermography for True Temperature Measurement of the Main Board in Personal Computer

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Journal of Thermal Science 2002年第4期11卷 331-336页

作者： Masud Behnia graham Morrison School of Mechanical and Manufacturing Engineering The University of New South WalesSchool of Mechanical and Manufacturing Engineering The University of New South Wales Sydney2052 Australia Sydney2052 Australia

This paper presents a way to measure the true temperature of the electronic devices without disturbing their normal operating conditions, which involved with estimating target emissivity, background temperature correctly and choosing infrared transparent material and its transmission estimation. The temperature distributions of the main board in personal computer were measured by the method presented here with infrared thermography in several different running conditions. The measurement errors and their possible remedies are also discussed.

关键词： infrared thermography electronic cooling temperature distrubution thermal measurement.

The Roper-Suffridge extension operator and classes of biholomorphic mappings Dedicated to Professor Sheng gONg on the occasion of his 75th birthday

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Science China Mathematics 2006年第11期49卷 1539-1552页

作者： graham Ian KOHR gabriela Department of Mathematics University of Toronto TorontoOntario M5S 2E4Canada Faculty of Mathematics and Computer Science Babes-Bolyai University 1 M. Kogǎlniceanu Str. 400084 Cluj-NapocaRomania

In this paper we give a survey about the Roper-Suffridge extension operator and the developments in the theory of univalent mappings in several variables to which it has led. We begin with the basic geometric properties (most of which now have a number of different proofs)and discuss relations with the theory of Loewner chains and generalizations and modifications of the operator, some of which are very recent.

关键词： convex mapping, starlike mapping, Roper-Suffridge operator, growth theorem, distortion theorem, covering theorem, Loewner chain, parametric representation,extreme points, linear invariant family.

Catch-as-catch-can:mRNA vaccination boosts immune responses to SARS-CoV-2 variants

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2255-2256页

作者： graham Pawelec Emilie Picard Department of Immunology University of TubingenTubingenGermany Health Sciences North Research Institute SudburyONCanada

In a recent article published in Science,Stamatatos et al.1 show that vaccination with mRNA vaccines containing the ancestral form of the SARS-CoV-2 virus boosts cross-variant neutralizing antibodies elicited by infec... 详细信息

关键词： vaccination boost

Regulation of proprietary traditional Chinese medicines in Australia

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Chinese Journal of Natural Medicines 2017年第1期15卷 12-14页

作者： David T. graham ISO technical committee 249 (1SO/TC 249) 7-C Shuguang Building 189 Pu 'an Road Shanghai 200021 China

This review article describes the regulation of proprietary Chinese medicines for the Australian market, which may permit many medicines used in Traditional Chinese Medicine to have a simplified process of market acce... 详细信息

关键词： Regulation Australia Chinese medicines