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Case Study: The Determination of a Complex Multi-Systemic Medical Condition by a Cognitive, Virtual Scanning Technique

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Case Reports in Clinical Medicine 2015年第6期4卷 209-221页

作者： graham Wilfred ewing Mimex Montague Healthcare Limited Nottingham UK

The study of various medical conditions is limited by the current state of knowledge. New tech-nologies enable researchers to advance their understanding of various medical conditions and to advance their understanding of particular pathologies. Strannik Virtual Scanning (SVS) is such a technology. SVS is able to determine the genetic and non-genetic components of every pathology in each of the 30 main organs, and it is able to determine the onset of pathologies at a much earlier stage than any other technologies or techniques. This makes it an ideal tool to screen for the onset and progression of pathologies which are implicated in multi-systemic conditions and to determine the spectrum of pathologies i.e. comorbidities which are involved in diabetes, cardiovascular disease, migraine, chronic fatigue syndrome, fibromyalgia, depression, chronic kidney disease, etc. This case study illustrates how the technology can be usefully and cost-effectively deployed to determine the spectrum of pathologies which characterise Reynaud’s phenomenon. This includes pathologies in the liver and kidneys e.g. portal hypertension, renal insufficiency, nephritis, liver insufficiency, pre-symptomatic onset of heart attack, presymptomatic indications of dementia, pancreatic cancer, and ovarian cancer, which are difficult to diagnose and/or for which there is currently an unmet clinical need.

关键词： Raynaud Strannik Strannik Virtual Scanning Autonomic Dysfunction

The Successful Treatment of Dysarthria Using Strannik Light Therapy (Biofeedback): A Case Study

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Case Reports in Clinical Medicine 2015年第7期4卷 266-269页

作者： graham Wilfred ewing Montague Healthcare Nottingham UK

This article reports a case of dysarthria which was successfully treated by Strannik Light Therapy (SLT). It briefly discusses the known etiology for the condition and illustrates that dysarthria must be a problem of autonomic dysfunction in which pathological changes can influence the structure and/or subsequent function of the dynamic interplay between the brain and the organs involving the autonomic nervous system and physiological systems. The author reports a particular case in which a patient undertaking SLT fully recovered the ability to speak within 6 days.

关键词： Dysarthria Dysautonomia Autonomic Dysfunction Physiological Systems Strannik Virtual Scanning (SVS) Strannik Light Therapy (SLT)

A further review of the genetic and phenotypic nature of diabetes mellitus

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Case Reports in Clinical Medicine 2013年第9期2卷 538-553页

作者： graham Wilfred ewing Igor Gennadyevich Grakov MIMEX Inc Sochi Russia Montague Healthcare Mulberry House Nottingham England

Background: The organs in the body function in coherent organ networks. These organ networks are commonly known as physiological systems. Blood Glucose, Blood Pressure and pH exhibit the characteristics of neurally regulated Physiological Systems. Any medical condition, such as diabetes, has origins which are due to systemic dysfunction. This influences the genetic expression of proteins and the rate at which such expressed proteins subsequently react. Increased levels of acidity influence the levels of available minerals, protein conformation, and hence the rate at which expressed proteins such as insulin and leptin react or function. This is particularly significant in diabetes etiology where a deficiency of insulin and insulin-“resistance” are significant features of type 1 and type 2 diabetes. Proteins such as Insulin absorb and emit light. Moreover, the spectrum and intensity of the bioluminescence emitted from glycated proteins (which are more significantly bioluminescent) influence colour perception. Accordingly, changes to the diabetic’s colour perception can be used as the basis of a cognitive screening technique which is able to quantify the influence of genotype and phenotype. This may have significant advantages over current biomarker techniques which are not able to satisfactorily determine the earliest onset of?diabetes or distinguish between the symptomatic and presymptomatic onset of diabetes. Such methodology, based upon the properties of proteins, i.e. effectively, the rate at which proteins are expressed and the rate at which such expressed proteins subsequently react, allows the clinician to quantify genotype and phenotype and may contribute to a greater understanding of the processes responsible for what are commonly known as type 1 and type 2 diabetes. The aim of this article is to highlight the limitations of the current techniques used to diagnose diabetes and to highlight, at least from the theoretical perspective, the significance of the au

关键词： Autonomic Nervous System (ANS) Physiological Systems Mathematical Modelling Blood Glucose Diabetes Genotype Phenotype Sensory Input Visual Perception Colour Perception

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

The state of mountain research in Canada

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Journal of Mountain Science 2022年第10期19卷 3013-3025页

作者： graham MCDOWELL Katherine HANLY Department of Geography University of CalgaryCalgaryABT2NiN4Canada Department of Geography University of ZurichCH-8006 ZurichSwitzerland

Nearly a quarter of Canada’s landmass is covered by mountainous terrain,making mountains an important aspect of the physical and human geography of the *** areas in Canada have motivated a great deal of research activity,yet the state of mountain research in the country has never been systematically characterized,precluding a detailed understanding of what is being studied,when,where,how,and by *** response,we conducted a systematic scoping review to rigorously identify,collate,and critically examine existing peer-reviewed articles related to mountains in Canada.2,888 articles were included in our review,which reveals strong biases towards work in the natural sciences and in the mountain west,with little work to date in the social and health sciences or in other mountainous regions of the *** results demonstrate that Canada is among the most productive contributors to mountain research globally,but that topical and geographical biases in existing research effort leave important gaps that must be addressed to successfully navigate challenges and opportunities facing mountain areas in *** provide a roadmap to guide future mountain-focused research activities in the country.

关键词： Canada Mountains Systematic scoping review Research

Effect of Look-Ahead Depth in Evolutionary Checkers

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Journal of Computer Science & Technology 2012年第5期27卷 996-1006页

作者： Belal Al-Khateeb graham Kendall College of Computer Al-Anbar UniversityRamadiIraq School of Computer Science The University of NottinghamNottinghamU.K

It is intuitive that allowing a deeper search into a game tree will result in a superior player to one that is restricted in the depth of the search that it is allowed to make. Of course, searching deeper into the tree comes at increased computational cost and this is one of the trade-offs that has to be considered in developing a tree-based search algorithm. There has been some discussion as to whether the evaluation function, or the depth of the search, is the main contributory factor in the performance of an evolved checkers player. Some previous research has investigated this question （on Chess and Othello）, with differing conclusions. This suggests that different games have different emphases, with respect to these two factors. This paper provides the evidence for evolutionary checkers, and shows that the look-ahead depth （like Chess, perhaps unsurprisingly） is important. This is the first time that such an intensive study has been carried out for evolutionary checkers and given the evidence provided for Chess and Othello this is an important study that provides the evidence for another game. We arrived at our conclusion by evolving various checkers players at different ply depths and by playing them against one another, again at different ply depths. This was combined with the two-move ballot （enabling more games against the evolved players to take place） which provides strong evidence that depth of the look-ahead is important for evolved checkers players.

关键词： evolutionary Checkers look-ahead depth neural network

Infrared Thermography for True Temperature Measurement of the Main Board in Personal Computer

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Journal of Thermal Science 2002年第4期11卷 331-336页

作者： Masud Behnia graham Morrison School of Mechanical and Manufacturing Engineering The University of New South WalesSchool of Mechanical and Manufacturing Engineering The University of New South Wales Sydney2052 Australia Sydney2052 Australia

This paper presents a way to measure the true temperature of the electronic devices without disturbing their normal operating conditions, which involved with estimating target emissivity, background temperature correctly and choosing infrared transparent material and its transmission estimation. The temperature distributions of the main board in personal computer were measured by the method presented here with infrared thermography in several different running conditions. The measurement errors and their possible remedies are also discussed.

关键词： infrared thermography electronic cooling temperature distrubution thermal measurement.

The Roper-Suffridge extension operator and classes of biholomorphic mappings Dedicated to Professor Sheng GONG on the occasion of his 75th birthday

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Science China Mathematics 2006年第11期49卷 1539-1552页

作者： graham Ian KOHR Gabriela Department of Mathematics University of Toronto TorontoOntario M5S 2E4Canada Faculty of Mathematics and Computer Science Babes-Bolyai University 1 M. Kogǎlniceanu Str. 400084 Cluj-NapocaRomania

In this paper we give a survey about the Roper-Suffridge extension operator and the developments in the theory of univalent mappings in several variables to which it has led. We begin with the basic geometric properties (most of which now have a number of different proofs)and discuss relations with the theory of Loewner chains and generalizations and modifications of the operator, some of which are very recent.

关键词： convex mapping, starlike mapping, Roper-Suffridge operator, growth theorem, distortion theorem, covering theorem, Loewner chain, parametric representation,extreme points, linear invariant family.

Catch-as-catch-can:mRNA vaccination boosts immune responses to SARS-CoV-2 variants

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2255-2256页

作者： graham Pawelec Emilie Picard Department of Immunology University of TubingenTubingenGermany Health Sciences North Research Institute SudburyONCanada

In a recent article published in Science,Stamatatos et al.1 show that vaccination with mRNA vaccines containing the ancestral form of the SARS-CoV-2 virus boosts cross-variant neutralizing antibodies elicited by infec... 详细信息

关键词： vaccination boost