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A further review of the genetic and phenotypic nature of diabetes mellitus

Case Reports in Clinical Medicine 2013年第9期2卷 538-553页

作者： graham Wilfred ewing Igor Gennadyevich Grakov MIMeX Inc Sochi Russia Montague Healthcare Mulberry House Nottingham England

Background: The organs in the body function in coherent organ networks. These organ networks are commonly known as physiological systems. Blood Glucose, Blood Pressure and pH exhibit the characteristics of neurally regulated Physiological Systems. Any medical condition, such as diabetes, has origins which are due to systemic dysfunction. This influences the genetic expression of proteins and the rate at which such expressed proteins subsequently react. Increased levels of acidity influence the levels of available minerals, protein conformation, and hence the rate at which expressed proteins such as insulin and leptin react or function. This is particularly significant in diabetes etiology where a deficiency of insulin and insulin-“resistance” are significant features of type 1 and type 2 diabetes. Proteins such as Insulin absorb and emit light. Moreover, the spectrum and intensity of the bioluminescence emitted from glycated proteins (which are more significantly bioluminescent) influence colour perception. Accordingly, changes to the diabetic’s colour perception can be used as the basis of a cognitive screening technique which is able to quantify the influence of genotype and phenotype. This may have significant advantages over current biomarker techniques which are not able to satisfactorily determine the earliest onset of?diabetes or distinguish between the symptomatic and presymptomatic onset of diabetes. Such methodology, based upon the properties of proteins, i.e. effectively, the rate at which proteins are expressed and the rate at which such expressed proteins subsequently react, allows the clinician to quantify genotype and phenotype and may contribute to a greater understanding of the processes responsible for what are commonly known as type 1 and type 2 diabetes. The aim of this article is to highlight the limitations of the current techniques used to diagnose diabetes and to highlight, at least from the theoretical perspective, the significance of the au

关键词： Autonomic Nervous System (ANS) Physiological Systems Mathematical Modelling Blood Glucose Diabetes Genotype Phenotype Sensory Input Visual Perception Colour Perception

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Machine learning for detecting mesial temporal lobe epilepsy by structural and functional neuroimaging

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Frontiers of Medicine 2020年第5期14卷 630-641页

作者： Baiwan Zhou Dongmei An Fenglai Xiao Running Niu Wenbin Li Wei Li Xin Tong graham J Kemp Dong Zhou Qiyong Gong Du Lei Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengdu 610041China Department of Neurology West China Hospital of Sichuan UniversityChengdu 610041China Department of Clinical and experimental epilepsy Institute of NeurologyUniversity College LondonLondon WC1E 6BTUK Institute of Ageing and Chronic Disease Faculty of Health and Life SciencesUniversity of LiverpoolLiverpool L97ALUK Department of Psychology School of Public AdministrationSichuan UniversityChengdu 610041China Department of Psychosis Studies Institute of PsychiatryPsychology and NeuroscienceKings College LondonLondon SE58AFUK Department of Psychiatry and Behavioral Neuroscience University of CincinnatiCincinnatiOH 45219USA

Mesial temporal lobe epilepsy(mTLe),the most common type of focal epilepsy,is associated with functional and structural brain *** learning(ML)techniques have been successfully used in discriminating mTLe from healthy ***,either functional or structural neuroimaging data are mostly used separately as input,and the opportunity to combine both has not been exploited *** conducted a multimodal ML study based on functional and structural neuroimaging *** enrolled 37 patients with left mTLe,37 patients with right mTLe,and 74 healthy controls and trained a support vector ML model to distinguish them by using each measure and the combinations of the *** each single measure,we obtained a mean accuracy of 74%and 69%for discriminating left mTLe and right mTLe from controls,respectively,and 64%when all patients were *** achieved an accuracy of 78%by integrating functional data and 79%by integrating structural data for left mTLe,and the highest accuracy of 84%was obtained when all functional and structural measures were *** findings suggest that combining multimodal measures within a single model is a promising direction for improving the classification of individual patients with mTLe.

关键词： mesial temporal lobe epilepsy functional magnetic resonance imaging structural magnetic resonance imaging machine learning support vector machine

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鱼类禽类哺乳类动物精子的冷冻保存和受精力(下)

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国外畜牧科技 1989年第3期16卷 15-19页

作者： e.F.graham 朱捷

公牛的精液稀释液和冷冻保护剂稀释液和冷冻保护液是冷冻保存技术的重要组成部分。Darii等(1979)进行了66种含单糖的稀释液与Laichiphos液(一种法国的商业稀释液)及乳糖-卵黄稀释液受胎率比较,在一次受胎率测定时,含有70％乳糖或蔗糖、2... 详细信息

公牛的精液稀释液和冷冻保护剂稀释液和冷冻保护液是冷冻保存技术的重要组成部分。Darii等(1979)进行了66种含单糖的稀释液与Laichiphos液(一种法国的商业稀释液)及乳糖-卵黄稀释液受胎率比较,在一次受胎率测定时,含有70％乳糖或蔗糖、20％果糖、10％蜜三糖、12mmMgSO_4加甘油和卵黄的冷冻稀释液受胎率达66.4％,而Lai-chiphos缓冲液的受胎率为(?)1.6％,Foulkes等(1980)给母鸡饲喂高浓度葵花油和牛、羊脂肪的仔鸡日粮,试图提高稀释液中卵黄的冷冻保护性能。

关键词：动物精子冷冻保存受精力

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鱼类禽类哺乳类动物精子的冷冻保存和受精力(上)

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国外畜牧科技 1989年第2期16卷 14-17页

作者： e.F.graham 朱捷

这篇综述是为了促进更广泛地推广人工授精技术。关于精子的代谢、生理以及形态学方面的文章已有大量发表,以下列出几篇有参考价值的文章:Foote(1982)综述人工授精过去、现在和将来的概况;graham等(1978)综述非驯化动物,特别是野生动物... 详细信息

这篇综述是为了促进更广泛地推广人工授精技术。关于精子的代谢、生理以及形态学方面的文章已有大量发表,以下列出几篇有参考价值的文章:Foote(1982)综述人工授精过去、现在和将来的概况;graham等(1978)综述非驯化动物,特别是野生动物的精液冷冻;Iri-tani(1980)和Watson(1979)综述几乎所有农畜、其它家养及实验动物精液冷冻的问题。Memon和Ott(1981)综述山羊和绵羊精液的冷冻问题,Scott和Baynes(1980)

关键词：鱼禽哺乳动物精子冷冻受精力

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Two decades of compositional and structural change in deciduous old-growth forests of Indiana,USA

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Journal of Plant ecology 2016年第3期9卷 256-271页

作者： Christy A.Lowney Bradley D.graham Martin A.Spetich Stephen R.Shifley Michael R.Saunders Michael A.Jenkins Department of Forestry and Natural Resources and Hardwood Tree Improvement and Regeneration Center Purdue University715 West State StreetWest Lafayette IN 47907USA Arkansas Forestry Sciences Laboratory USDA Forest ServiceSouthern Research StationP.O.Box 1270Hot SpringsAR 71902USA USDA Forest Service Northern Research Station202 ABNR BuildingColumbiaMO 65201USA

Aims Using a network of permanent plots,we determined how multiple old-growth forests changed over an 18-19-year period at a state-wide *** examination of change allowed us to assess how the compositional and structural stability of each forest varied with site characteristics(topography,physiography and productivity)and stochastic *** In 2011,we resampled 150 plots distributed across five old-growth hardwood forests in Indiana,USA that were originally sampled in *** each plot,we relocated and remeasured the diameter at breast height(dbh)of all trees(≥10.0 cm)present during the 1992-1993 sample,which allowed us to track their individual fates through time for growth and mortality *** that grew to≥10.0 cm dbh since plot establishment were designated as *** dbh and species of all saplings(stems≥2.0 cm butere also *** each forest,we calculated density(stems ha^(−1)),basal area(BABA;m^(2)ha^(−1))and importance value(relative density+relative BABA)/2 of trees by *** saplings,density per ha was calculated by species for each *** also calculated annual mortality rate(AMR)for three diameter classes(10-29.9,30-59.9 and≥60 cm)and species richness(S),evenness(e)and Shannon-Weiner diversity(H')for the tree and sapling *** between years were compared for each forest using paired t-tests and Wilcoxon signed rank *** FindingsAlthough we observed commonality in changes across some sites,our results suggest that these forests differ in their rates and trajectories of *** in total stand BABA and density varied across sites and were influenced by past disturbance and mortality *** observed a general increase in the overstory dominance of Acer saccharum coupled with a general decrease in the dominance of Quercus section Lobatae(red oak group)*** of overstory trees present in 1992-1993 ranged from 27%to 49%over the study period(mean AM

关键词： forest remnants forest structure long-term data mortality species diversity stand development.

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International marketing / 12th ed.

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丛书名： McGraw-Hill/Irwin series in marketing

2005年

作者： graham John L.

来源：畅想之星图书光盘版（南... 评论

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孤岛状态下含分布式电源的配电系统可靠性分析

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电网技术 2008年第23期32卷 77-81页

作者：孙瑜 Math Bollen graham Ault 华北电力科学研究院有限责任公司北京市西城区100045 瑞典输电研究院斯特拉斯克莱德大学电气工程系

分析了孤岛状态下含分布式电源的配电系统可靠性。针对配电网孤岛运行的特点,提出了可靠性分析的复合随机性负荷模型,提出了既能反映系统充裕度又体现动态特性的可靠性计算方法和衡量指标。计算结果表明,所提的模型、计算方法和衡量指... 详细信息

分析了孤岛状态下含分布式电源的配电系统可靠性。针对配电网孤岛运行的特点,提出了可靠性分析的复合随机性负荷模型,提出了既能反映系统充裕度又体现动态特性的可靠性计算方法和衡量指标。计算结果表明,所提的模型、计算方法和衡量指标能充分反映分布式电源在不同程度上提高配电系统的可靠性,为系统的规划设计提供了重要参考。

关键词：可靠性分布式电源配电网蒙特卡罗仿真

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Risk factors in cardiovascular patients:Challenges and opportunities to improve secondary prevention

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World Journal of Cardiology 2023年第7期15卷 342-353页

作者： Rahima Gabulova Anna Marzà-Florensa Uzeyir Rahimov Mahluga Isayeva Shahana Alasgarli Afag Musayeva Sona Gahramanova Firdovsi Ibrahimov Farid Aliyev Galib Imanov Rahmana Rasulova Ilonca Vaartjes Kerstin Klipstein-Grobusch Ian graham Diederick e Grobbee Teaching-Therapeutical Hospital Azerbaijan Medical UniversityBaku AZ1022Azerbaijan Julius Center for Health Sciences and Primary Care University Medical Center UtrechtUtrecht 3508 GANetherlands Department of Cardiology Baku Medical PlazaBaku AZ1014Azerbaijan Department of CHD and Arrhythmias Scientific-Research Institute of CardiologyBaku AZ1072Azerbaijan Department of Cardiology Central Clinic HospitalBaku AZ1006Azerbaijan Heart Center Baku Health CenterBaku AZ1072Azerbaijan Teaching-Surgical Hospital Azerbaijan Medical UniversityBaku AZ1022Azerbaijan Department of Public Health Azerbaijan Medical UniversityBaku AZ1022Azerbaijan Department of Cardiology Trinity College DublinDublin Dublin-2Ireland

BACKGROUND effective management of major cardiovascular risk factors is of great importance to reduce mortality from cardiovascular disease(CVD).The Survey of Risk Factors in Coronary Heart Disease(SURF CHD)II study is a clinical audit of the recording and management of CHD risk *** was developed in collaboration with the european Association of Preventive Cardiology and the european Society of Cardiology(eSC).Previous studies have shown that control of major cardiovascular risk factors in patients with established atherosclerotic CVD is generally *** is a country in the South Caucasus,a region at a very high risk for *** To assess adherence to eSC recommendations for secondary prevention of CVD based on the measurement of both modifiable major risk factors and their therapeutic management in patients with confirmed CHD at different hospitals in Baku(Azerbaijan).MeTHODS Six tertiary health care centers participated in the SURF CHD II study between 2019 and *** on demographics,risk factors,physical and laboratory data,and medications was collected using a standard questionnaire in consecutive patients aged≥18 years with established CHD during outpatient *** from 687 patients(mean age 59.6±9.58 years;24.9%female)were included in the *** Only 15.1%of participants were involved in cardiac rehabilitation *** rate of uncontrolled risk factors was high:Systolic blood pressure(BP)(SBP)(54.6%),low-density lipoprotein cholesterol(LDL-C)(86.8%),diabetes mellitus(DM)(60.6%),as well as overweight(66.6%)and obesity(25%).In addition,significant differences in the prevalence and control of some risk factors[smoking,body mass index(BMI),waist circumference,blood glucose(BG),and SBP]between female and male participants were *** cardiovascular health index score(CHIS)was calculated from the six risk factors:Non-or ex-smoker,BMIerate/vigorous physical activity,controlled BP(<140/90 mmHg;140/80 mmHg

关键词： Coronary heart disease Cardiovascular risk factors Secondary prevention Clinical practice guidelines Clinical audit Survey of risk factors

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Impact of age on host responses to diet-induced obesity:Development of joint damage and metabolic set points

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Journal of Sport and Health Science 2020年第2期9卷 132-139页

作者： Kelsey H.Collins graham Z.MacDonald David A.Hart Ruth A.Seerattan Jaqueline L.Rios Raylene A.Reimer Walter Herzog Human Performance Laboratory University of CalgaryCalgaryAB T2N IN 4Canada McCaig Institute for Bone and Joint Health University of CalgaryAB T2N1N4Canada Department of Orthopaedic Surgery Washington UniversitySt.LouisMO 63108USA Bone&Joint Health Strategic Clinical Network Alberta Health ServicesEdmontonAB T5E 4E3Canada Department of Biochemistry and Molecular Biology Cumming School of MedicineUniversity of CalgaryAB T2N IN4Canada

Background:Osteoarthritis is one of the leading causes of pain and disability worldwide,and a large percentage of patients with osteoarthritis are individuals who are also *** recent years,a series of animal models have demonstrated that obesity-inducing diets can result in synovial joint damage(both with and without the superimposition of trauma),which may be related to changes in percentage of body fat and a series of low-level systemic inflammatory *** note,there is a disparity between whether the dietary challenges commence at weaning,representing a weanling onset,or at skeletal maturity,representing an adult onset of *** wished to evaluate the effect ofthe dietary exposure time and the age at which animals are exposed to a high-fat and high-sucrose(HFS) diet to determine whether these factors may result in disparate outcomes,as there is evidence suggesting that these factors result in differential metabolic *** on dietary exposure time,we hypothesized that rats fed an HFS diet for 14 weeks from weaning(HFS Weanling) would demonstrate an increase in knee joint damage scores,whereas rats exposed to the HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult) and rats exposed to a standard chow diet(Chow)would not display an increase in knee joint damage ***:Male Sprague-Dawley rats were fed either an HFS diet for 14 weeks from weaning(HFS Weanling) or an HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult).At sacrifice,joints were scored using the modified Mankin Criteria,and serum was analyzed for a defined subset of inflammatory markers(Interleukin-6,leptin,monocyte chemoattractant protein-1,and tumor necrosis factorα).Results:When the HFS Weanling and HFS Adult groups were compared,both groups had a similar percent of body fat,although the HFS Weanling group had a significantly greater body mass than the HFS Adult *** HFS Weanling and HFS Adult animals had a significant increase in body mass and pe

关键词： Adult exposure High-fat high-sucrose diet Rat obesity model Serum biomarkers Weanling exposure

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临床全视野视网膜电图标准

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中华眼科杂志 2020年第9期56卷 662-669页

作者：无 McCulloch D.L. Marmor Michael F. Brigell Mitchell G. Hamilton Ruth Holder graham e. Tzekov Radouil Bach Michael 国际临床视觉电生理学会 School of Optometry and Vision Sciences University of WaterlooWaterlooCAN 不详

本标准由国际临床视觉电生理学会(ISCeV)制定并修订,旨在提出临床全视野视网膜电图(eRG)检测的ISCeV最新意见。本次修订的主要内容是修改了标准刺激闪光的参数,以适应各种不同光源(包括气体放电灯和发光二极管灯)的刺激器;规定了基于明... 详细信息

本标准由国际临床视觉电生理学会(ISCeV)制定并修订,旨在提出临床全视野视网膜电图(eRG)检测的ISCeV最新意见。本次修订的主要内容是修改了标准刺激闪光的参数,以适应各种不同光源(包括气体放电灯和发光二极管灯)的刺激器;规定了基于明适应和暗适应下不同刺激闪光强度引发的6种eRG反应(即6种检测方案),同时ISCeV也鼓励使用其他全视野eRG检测扩展方案。

关键词：气体放电灯发光二极管灯刺激器暗适应标准刺激闪光强度检测方案 eRG

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