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Tomato Flavor： Lost and Found？

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Molecular Plant 2017年第6期10卷 782-784页

作者： Duoduo Wang graham b. Seymour University of Nottingham School of Biosciences Division of Plant and Crop Science Sutton Bonington Lough Leics LE12 5RD UK

Tomato is the highest value fruit crop in the world （Tieman et al., 2017） and a major component of healthy diets as it provides ready sources of vitamins A, C, E, and K, minerals including K and Fe, and lycopene as an antioxidant. However, modern varieties are often described as having little flavor, especially in comparison with traditional or heirloom types.

关键词： Tomato Flavor Lost and Found volatile compounds

Tomato molecular biology–special collection of papers for molecular horticulture

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Molecular Horticulture 2022年第1期2卷 280-283页

作者： graham b.Seymour Jocelyn K.C.Rose School of biosciences Division of Plant and Crop ScienceUniversity of NottinghamLoughboroughLeics LE125RDUK School of Integrative Plant Science Cornell University331 Emerson HallIthacaNY 14853USA

Tomato(Solanum lycopersicum)is the second most important vegetable crop globally,after potato,with about 100 million tons fresh fruit being grown on 3.7 million hectares(FAO 2021),and is of great importance in the human diet due to the large amount of fruit consumed.The fruit are eaten both fresh and,equally importantly,as a processed product in puree,soups and canned products.They provide an important dietary source of vitamins and minerals,such as K,Fe and Ca,and are known for the large number of health promoting secondary metabolites,including the carotenoid and flavonoid pigments that give the fruit a spectrum of yellow,red and orange colours.

关键词： culture orange globally

2016 AAOS临床实践循证指南:腕管综合征管理

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中国骨科临床与基础研究杂志 2017年第4期9卷 247-250页

作者： graham b Peljovich AE Afra R 白朝晖夏远军

前言美国骨科医师学会（American Academy of Orthopaedic Surgeons，AAOS）腕管综合征（carpal tunnel syndrome，CTS）管理循证指南包括诊断和治疗两方面。这一指南目前已得到美国手外科学会（American Society for Surgery of the H... 详细信息

前言美国骨科医师学会（American Academy of Orthopaedic Surgeons，AAOS）腕管综合征（carpal tunnel syndrome，CTS）管理循证指南包括诊断和治疗两方面。这一指南目前已得到美国手外科学会（American Society for Surgery of the Hand，ASSH）、美国放射学会（American College of Radiology，ACR）、美国外科医师学会（American College of Surgeons，ACS）和美国整形医师学会（American Society of Plastic Surgeons，ASPS）的认可。以下为AAOS临床实践指南的简短摘要，逐条列出推荐意见及其推荐级别，如需了解每条推荐意见形成的过程及其完整的证据报告，可查阅***/guidelines上发布的完整指南。

关键词：临床实践指南腕管综合征循证指南美国骨科医师学会管理 Surgery 美国放射学会 AAOS

Efficiency of a Modular Cleanroom for Space Applications

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Fluid Dynamics & Materials Processing 2024年第3期20卷 547-562页

作者： Matthew R.Coburn Charlie Young Chris Smith graham Schultz Miguel Robayo Zheng-Tong Xie Faculty of Engineering and Physical Sciences University of SouthamptonSouthamptonSO171BJUK Plastron UK Ltd. Westcott Venture ParkWestcottHP180XBUK Renewable Energy Group University of ExeterExeterTR109FEUK

A prototype cleanroom for hazardous testing and handling of satellites prior to launcher encapsulation,satisfying the ISO8 standard has been designed and analyzed in terms of performances.Unsteady Reynolds Averaged Navier-Stokes(URANS)models have been used to study the related flow field and particulate matter(PM)dispersion.The outcomes of the URANS models have been validated through comparison with equivalent large-eddy simulations.Special attention has been paid to the location and shape of the air intakes and their orientation in space,in order to balance the PM convection and diffusion inside the cleanroom.Forming a cyclone-type flow pattern inside the cleanroom is a key to maintaining a high ventilation efficiency.

关键词： Diffuser LES PM RANS unsteady flow exponential decay

Organic chemistry T.W. graham Solomons, Craig b. Fryhle. 8th ed.

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Universal silicon ring resonator for error-free transmission links

2004年

作者： T.W. graham Solomons Craig b. Fryhle.

来源：畅想之星图书光盘版（南... 评论

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Photonics Research 2024年第4期12卷 701-711页

作者： JUNbO ZHU WEIWEI ZHANG KE LI bHARAT PANT MARTIN EbERT XINGZHAO YAN MEHDI bANAKAR DEHN T.TRAN CALLUM G.LITTLEJOHNS FUWAN GAN graham REED DAVID J.THOMSON Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China Peng Cheng Laboratory ShenzhenChina

We report the design, fabrication, and characterization of a universal silicon PN junction ring resonator for C band error-free communication links operated up to 50 Gb/s with co-designed optical modulation and detection performance. The universal p-n junction ring device shows co-designed detection responsivity up to 0.84 A/W, in conjunction with a modulation efficiency of -4 V·mm and>8 d b optical modulation extinction ratio, enabling C band 50 Gb/s NRZ communication link with a bit error rate≤3×10^(-12).

关键词： Gb/s resonator communication

Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension

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Cellular & Molecular Immunology 2021年第2期18卷 374-384页

作者： Jonathan Florentin Jingsi Zhao Yi-Yin Tai Sathish babu Vasamsetti Scott P.O’Neil Rahul Kumar Anagha Arunkumar Annie Watson John Sembrat Grant C.bullock Linda Sanders biruk Kassa Mauricio Rojas brian b.graham Stephen Y.Chan Partha Dutta Center for Pulmonary Vascular biology and Medicine Pittsburgh HeartLungBloodand Vascular Medicine InstituteDivision of CardiologyDepartment of MedicineUniversity of Pittsburgh School of MedicineUniversity of Pittsburgh Medical CenterPittsburghPA15213USA Division of Pulmonary and Critical Care Medicine Zuckerberg San Francisco General Hospital and Trauma CenterUniversity of California San FranciscoBuilding 1002nd floor1001 Potrero AveSan FranciscoCAUSA Division of Pulmonary Allergy and Critical Care MedicineUniversity of PittsburghPittsburghPA15261USA Division of Hematopathology Pittsburgh HeartLungBloodand Vascular Medicine Institute University of Pittsburgh School of MedicineUniversity of Pittsburgh Medical CenterPittsburghPA15213USA Department of Medicine Anschutz Medical CampusBuilding RC29th floor12700 E 19th AveAuroraCO80045USA Department of Immunology University of Pittsburgh School of MedicinePittsburghPA15213USA

Myeloid cells,such as neutrophils,are produced in the bone marrow in high quantities and are important in the pathogenesis of vascular diseases such as pulmonary hypertension(PH).Although neutrophil recruitment into sites of inflammation has been well studied,the mechanisms of neutrophil egress from the bone marrow are not well understood.Using computational flow cytometry,we observed increased neutrophils in the lungs of patients and mice with PH.Moreover,we found elevated levels of IL-6 in the blood and lungs of patients and mice with PH.We observed that transgenic mice overexpressing Il-6 in the lungs displayed elevated neutrophil egress from the bone marrow and exaggerated neutrophil recruitment to the lungs,resulting in exacerbated pulmonary vascular remodeling,and dysfunctional hemodynamics.Mechanistically,we found that IL-6-induced neutrophil egress from the bone marrow was dependent on interferon regulatory factor 4(IRF-4)-mediated CX3CR1 expression in neutrophils.Consequently,Cx3cr1 genetic deficiency in hematopoietic cells in Il-6-transgenic mice significantly reduced neutrophil egress from bone marrow and decreased neutrophil counts in the lungs,thus ameliorating pulmonary remodeling and hemodynamics.In summary,these findings define a novel mechanism of IL-6-induced neutrophil egress from the bone marrow and reveal a new therapeutic target to curtail neutrophil-mediated inflammation in pulmonary vascular disease.

关键词： neutrophil IL-6 pulmonary hypertension CX3CR1 inflammation

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肺动脉高压的发病机制

中华医学杂志 2009年第30期89卷 2091-2093页

作者： brian b. graham Rubin M. Tuder 王丛(译) 王军(审校) Division oi Pulmonary Medicine and Critical Care Sciences University of Colorado at Denver and Health Sciences Center Denver CO USA 不详

肺动脉高压是严重影响人类健康的重大卫生保健问题，其基础和临床研究近年来备受关注，并取得了令人瞩目的进展。为了促进这个领域的学术交流，经中华医学会呼吸病学分会肺栓塞与肺血管病学组邀请，欧美肺血管病领域的知名专家围绕肺动... 详细信息

肺动脉高压是严重影响人类健康的重大卫生保健问题，其基础和临床研究近年来备受关注，并取得了令人瞩目的进展。为了促进这个领域的学术交流，经中华医学会呼吸病学分会肺栓塞与肺血管病学组邀请，欧美肺血管病领域的知名专家围绕肺动脉高压研究热点问题特为本刊撰写了一组论文。他们分别是来自美国Colorado大学的brian b．graham教授、Rubin M．Tuder教授和麻省总医院的Ioana R．Preston教授，来自英国帝国理工学院的Martin R Wilkins教授、LanZhao教授和剑桥大学的Nicholas W．Morrell教授。北京朝阳医院一北京呼吸疾病研究所的部分研究生承担了翻译工作，首都医科大学王军教授、杨媛华教授和翟振国博士等对译文进行了审校。论文的组织、翻译和审校工作得到首都医科大学附属北京朝阳医院王辰教授、中国医学科学院北京协和医院陆慰萱教授、国际肺血管病研究院（Pulmonary Vascular Research Institute）Ghazwan butrous教授的大力支持。

关键词：肺动脉高压首都医科大学附属北京朝阳医院发病机制中国医学科学院北京呼吸疾病研究所卫生保健问题肺血管病 graham

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运动员视觉保健(英文)

眼视光学杂志 2005年第2期7卷 73-75页

作者： grahamb.Erickson HaoChert binWang PacificUniversityCollegeofOptometry 2043CollegeWayForestGroveOR97116 EyeHospitalofWenzhouMedicalCollege WenzhouChina325027 SUNY／StateCollegeofOptometry

视觉作为在人类多种感观认识功能中占主导地位的感知方式,对体育竞技中的各类感觉运动性活动具有举足轻重的作用。运动视觉的医疗职能包括①预防和治疗体育和竞技运动中造成的眼部损伤。②评估和矫正某些影响协调性运动机能的视功能异... 详细信息

视觉作为在人类多种感观认识功能中占主导地位的感知方式,对体育竞技中的各类感觉运动性活动具有举足轻重的作用。运动视觉的医疗职能包括①预防和治疗体育和竞技运动中造成的眼部损伤。②评估和矫正某些影响协调性运动机能的视功能异常。③针对体育运动的环境性因素展开专业性的角膜接触镜业务,并对一些对眼动、视力和应急状态具有特殊要求的竞技项目提供帮助。④基于视觉和环境等因素的考虑,向专业运动员提供特制的眼部保护装置和助视仪器。⑤评估与某些竞技运动项目密切相关的视觉功能及技巧。⑥通过对运动员的视功能强化训练进而提高其运动成绩。⑦向运动员、教练员或整个团队提供有助于提高运动成绩的视觉功能及技巧的咨询。人们一直都很关注视觉功能与运动成绩之间的联系,许多专家与临床医生都试图寻求与特定的运动技能相关的特殊视觉技巧,进而建立精确的方法予以评估。运动员具有比非运动员更好的视觉功能,而与一般的运动员比较,顶尖水平的运动员往往从优异的视觉功能中获益更大。不同的视觉功能对于帮助运动员取得优秀成绩的作用在运动项目中是有所差异的。运动视觉专家必须区分出哪些视功能是与运动相关的关键性的视功能,并用最恰当的方法对其进行评估。不同的运动项目,对视觉功能的要求也常常不同。运动员的验光矫正包括运动或娱乐过程中配戴特制的框架眼镜及角膜接触镜。在决定最佳处方的同时,应考虑最适合的镜片种类、镜框设计、染色特征和应考虑的安全防护因素。基于运动和环境需要的角膜接触镜染色工艺是目前正在研究和发展中的高新技术,其产品即将面世,在运动或娱乐场所的不同光照环境下能够减少眩光,提高视觉舒适性,增强视功能。运动型太阳眼镜光学性能的改善和上述染色型角膜接触镜的发展,将为运动员们减少眩光提供了可能的解决方法。为运动员们提供视觉保健时,首先应予考虑的问题是减少在训练和比赛中的眼部损伤。通常在采用了这些眼保措施后,绝大多数损伤是可以避免的。运动员所接收的视觉信息的质量和各种感观接收器提供的大量反馈信息是影响其赛场表现的关键因素。技巧性动作的熟练程度和运动员以往的经验对于运动系统(肌肉)运行的有效性和效率的影响是不可估量的。有天赋的运动员能够稳定而持久地在赛场发挥出色,而且似乎一点都不费力。通过筛选出对运动影响显著的视功能并加以强化训练,进而提高运动员成绩已成为可能。专业人士已经设计出多种视功能训练方案以改善视觉技巧和与视觉相关的运动技巧,并提高视觉信息传递过程中的效率。眼科保健工作者可以采用很多方法来帮助运动员尽量发挥其潜能。通过分析与运动员从事的运动最相关的视功能,可以指导眼科保健工作者选择最适合的矫正模式,如最佳的配戴设计、染色、角膜接触镜参数以及保护方案等。当眼保健工作者选择视觉训练来矫正功能不足或强化与运动相关的视功能时,需要和运动员进行交流,使其积极配合。结果表明,不但是那些顶尖的运动员能从我们的医疗服务中获益,而且各种人群因为接受训练进而改善了视功能并提高了自身的生活质量。

关键词：视觉保健运动员视功能