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硅烷偶联剂对玻璃及铝胶接耐久性的影响

粘接 2000年第1期21卷 9-11页

作者： W Brockmann S Emrich m graf 曲军德国Kaiserslautern大学

硅烷偶联剂被广泛用于胶粘剂与被粘物界面以提高其耐久性。用APES及GPmS硅烷偶联剂 ,采用了诸如混合法、浸入法等方法 ,并对玻璃 -玻璃 ,铝 -铝胶接接头的耐久性进行了研究。结果表明 :偶联剂可以显著提高胶接接头的耐久性。

关键词：硅烷偶联剂粘接耐久性玻璃铝胶粘剂

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卵巢机能障碍的发病机理

德国医学 1997年第4期14卷 227-230页

作者： m.graf W.Distler 闻良珍 Institut für Hormon-und Fortpflanzungsforschung Grandweg 64D-22529 HamburgGermany 同济医科大学附属同济医院

卵巢机能障碍关系到黄体机能不全、无排卵性月经或闭经,月经过多或过少常是黄体机能不全或无排卵性月经的主要症状。闭经分为原发性闭经(即满16岁而从无月经来潮)和继发性闭经(周期性月经停止3个月以上)。卵巢机能障碍可来源于下丘脑、... 详细信息

卵巢机能障碍关系到黄体机能不全、无排卵性月经或闭经,月经过多或过少常是黄体机能不全或无排卵性月经的主要症状。闭经分为原发性闭经(即满16岁而从无月经来潮)和继发性闭经(周期性月经停止3个月以上)。卵巢机能障碍可来源于下丘脑、垂体和卵巢平面,Plotz将卵巢机能障碍分为4类:即下丘脑-垂体性、高催乳素血症性。

关键词：卵巢机能障碍病理

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表面处理对粘接接头耐久性的影响

表面处理对粘接接头耐久性的影响

北京粘接学会第七届学术年会-中国粘接技术回顾与展望研讨会

作者： Brockmann W Emrich S graf m 曲军德国Kaiserslautern大学

选用APES及GPmS硅烷偶联剂,采用诸如混合法、浸入法,并结合机械表面处理方法对玻璃-玻璃、铝-铝粘接接头的耐久性的改善进行了研究。

关键词：表面处理粘接接头偶联剂耐久性

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眼神经性肌强直

世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 45-46页

作者： Koop G. graf m. 赵军(译） Zentrum für Augenheilkunde Justus-Liebig-Universitat GieβenFriedrichstra?e 1835385 GieβenGermany 不详

Background:Ocular neuromyotonia is a rare ocular motility disorder characterized by involuntary contractions of one or several ocular motor *** this report a typical case is *** and methods:A 61-year-old female patient was referred with persistent diplopia despite previous surgical treatment for right 6th nerve *** palsy was caused by a meningeoma of the petrous bone,which had been incompletely ***,the patient had received radiation *** and neuroophthalmological examinations were *** results coincide with data collected in our department from three other patients with ocular neuromyotonia(2 cranial nerveVI,1 cranial nerve IV),over the past three ***:The patient showed orthophoria at distance(5 m)and an exophoria of 6° at near *** abduction and adduction of the right eye were restricted to 40° and 35°,*** several seconds of eccentric gaze to the right,the right eye remained in an abducted position of approximately 25°.The gaze to the left led to a retraction instead of an adduction of the right *** spasm of the lateral rectus muscle resolved after some seconds,returning to the aforementioned right eye *** oral treatment with carbamazepine,initially 200 mg,later increasing to 400 mg per day,the symptoms improved significantly,did not resolve entirely,***:These typical findings permit the diagnosis of ocular *** characteristic symptoms of ocular neuromyotonia and the typical history of a previous intracranial tumor,treated neurosurgically with adjuvant radiotherapy,lead to the hypothesis that ephaptic transmission in the cranial nerve is the underlying pathophysiological mechanism in the development of ocular ***,efferent impulses from non-twitch motoneurons could activate neighbouring axons,and spread both peripherally and *** other mechanisms discussed,an involvement of proprioceptive el

关键词：神经性肌强直外展神经麻痹病理生理学机制肌强直症状运动神经元眼球运动异常放射治疗手术矫正

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河川水力学

The Influence of High Temperature Exposure on the Wear Performance of a Ni Based Alloy PTA Coating

1997年

作者：（瑞士）格拉夫（Walter Hans graf）（瑞士）m.S.阿廷拉卡（m.S.Altinakar）赵文谦万兆惠译

来源：汇雅图书（南通市图书馆... 评论

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材料热处理学报 2004年第5期25卷 152-156页

作者： Karin graf Ana Sofia C.m. d'OIiveira mechanical Department of Universidade Federal do Parana Curitiba BrazilMechanical Department of Universidade Federal do Parana Curitiba Brazil

Degradation phenomena like wear and corrosion, may have their effects accelerated as components operate at high temperature. The aim of this work is to make an indirect evaluation of the influence of high temperature exposure on wear behavior of Ni coatings. A Ni-Cr-mo-W alloy, was deposited with Plasma Transferred Arc (PTA) process. An indirect approach based on the Ahrrenius relationship was used to evaluated long time exposures at high temperatures. To simulate longer exposures at lower temperatures, coatings were exposed to higher temperatures for the same time interval. So coatings were soaked in an air furnace at 650°C, 1000°C and 1200°C. metal/metal wear behavior was evaluated by pin-on-disc tests. Pins were removed from the coatings by eletrodischarge machining and rubbed against a VC31 quenched and tempered tool steel. Two sets of wear tests were run at 2m/s, for different loads (0.5, 1.0, 2.0 and 3.0Kg) and for different sliding distances (120, 720, 1080, 1440 and 1800m).Coatings characterization was done by scanning electronic microscopy and Vickers microhardness. Results showed as temperature is increased, coatings wear performance is altered, and this is associated with microstructural changes.

关键词：磨损 Ni合金 PTA 高温曝露

脂肪乳剂可改善布比卡因而不是罗哌卡因或甲哌卡因诱发的心跳骤停复苏

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麻醉与镇痛 2011年第5期7卷 15-19页

作者： York A. Zausig, mD, DEAA Wolfgang Zink, mD, DEAA meike Keil, mS Barbara Sinner, mD, DEAA Juergen Barwing, mD, DEAA Christoph H. R. Wiese, mD Bernhard m. graf, mD, mSc 周全红（译） Department of Anaesthesiology University of Regensburg Regensburg Department of Anaesthesiology Emergency and Intensive Care Medicine University of Goettingen Goettingen Germany 不详

背景局麻药（10calanesthetics，LAs）的心肌毒性与其亲脂性有显著的相关性。近来的临床报道发现输注脂肪乳剂是治疗局麻药引起的心跳骤停的一种好方法。人们假设其作用机制是“脂肪库”（1ipidsink）效应，该效应的强度可能取决于局麻... 详细信息

背景局麻药（10calanesthetics，LAs）的心肌毒性与其亲脂性有显著的相关性。近来的临床报道发现输注脂肪乳剂是治疗局麻药引起的心跳骤停的一种好方法。人们假设其作用机制是“脂肪库”（1ipidsink）效应，该效应的强度可能取决于局麻药的亲脂性。本研究探讨是否脂肪效应与所使用的局麻药有关。方法用等效剂量的布比卡因、罗哌卡因和甲哌卡因使离体鼠心脏骤停，之后给予或不给予心脏灌注脂肪乳剂（0．25ml·k^-1·min^-1）进行复苏。监测指标包括从开始输注脂肪乳剂到心肌活动出现的时间、心率恢复的时间和心率一压力乘积恢复到基础值90％的时间。结果输注脂肪乳剂对各组的心肌活动恢复时间均没有作用。但是，输注脂肪乳剂可以显著缩短布比卡因组中心率恢复时间和心率-压力乘积恢复到基础值90％的时间，而在罗哌卡因和甲哌卡因组中却没有这个结果。结论以上的数据表明脂肪乳剂解救局麻药引起的心跳骤停的效果取决于不同的局麻药。我们认为局麻药的亲脂性对使用脂肪乳剂治疗因局麻药引起的心跳骤停的效果有显著影响。

关键词：脂肪乳剂心跳骤停甲哌卡因罗哌卡因布比卡因复苏心率恢复诱发

Reduced expression ofβ-catenin inhibitor Chibby in colon carcinoma cell lines

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World Journal of Gastroenterology 2006年第10期12卷 1529-1535页

作者： marion m Schuierer Elisabeth graf Ken-Ichi Takemaru Wolfgang Dietmaier Anja-Katrin Bosserhoff Institute of Pathology University of Regensburg Franz-Josef-Strauss-Alice 1193053 RegensburgGermany Department of Pharmacology BST 7-168 Stony BrookNY 11794-8651United States Institute of Pathology University of Regensburg Franz-Josef-Strauss-Allee 1193053 RegensburgGermany

AIm： To analyse the Chibby expression and its function in colon carcinoma cell lines and colorectal carcinoma （CRC）. mETHODS： Chibby expression levels were investigated by quantitative RT-PCR in a panel of seven different colon carcinoma cell lines. By sequencing, we analysed mutational status of Chibby. To test whether Chibby exhibited effects on β-catenin signalling in colon carcinoma cells, we transfected SW480 cells with Chibby expression plasmid and, subsequently, analysed activity of β-catenin and tested for alterations in cellular phenotype. In addition, we examined Chibby mRNA levels in samples of colorectal carcinomas and adjacent normal tissues by using quantitative RT-PCR and hybridised gene chips with samples from CRC and normal tissues. RESULTS： Chibby mRNA expression was strongly downregulated in colon carcinoma cell lines in comparison to normal colon epithelial cells and no mutation in any of the examined colon carcinoma cell lines was found. Further, we could show that Chibby inhibited β-catenin activity in TOPflash assays when over-expressed in SW480 cells. Proliferation and invasion assays with Chibby transfected SW480 cells did not reveal profound differences compared to control cells. In contrast to these in vitro data, quantitative RT-PCR analyses of Chibby mRNA levels in CRC tumor samples did not show significant differences to specimens in adjacent non-cancerous tissue. Consistent with these findings, gene chips analysing tissue samples of tumors and corresponding normal tissue did not show altered Chibby expressionCONCLUSION： Altered Chibby expression might be observed in vitro in different colon carcinoma cell lines. However, this finding could not be confirmed in vitro in CRC tumors, indicating that Chibby is not likely to promote CRC tumor development or progression. As Chibby is an important inhibitor of β-catenin signalling, our data implicate that the usability of colon carcinoma cell lines for in vitro studies analysing the Wnt/β-ca

关键词： Chibby Wnt β-catenin Colorectal carcinoma Colon carcinoma cell lines

Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis

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World Journal of Gastroenterology 2022年第10期28卷 1024-1054页

作者： Cristina m Hagen Eva Roth Theresia Reding graf François Verrey Rolf graf Anurag Gupta Giovanni Pellegrini Nadège Poncet Simone mafalda Rodrigues Camargo Institute of Physiology University of ZurichZurich 8057ZHSwitzerland Swiss Hepato-Pancreato-Biliary Center Department of Visceral and Transplantation SurgeryZurich University HospitalZurich 8091ZHSwitzerland Institute of Veterinary Pathology University of ZurichZurich 8057ZHSwitzerland

BACKGROUND The expression of amino acid transporters is known to vary during acute pancreatitis(AP)except for LAT1(slc7a5),the expression of which remains ***1 supports cell growth by importing leucine and thereby stimulates mammalian target of rapamycin(mTOR)activity,a phenomenon often observed in cancer *** mechanisms by which LAT1 influences physiological and pathophysiological processes and affects disease progression in the pancreas are not yet *** To evaluate the role of LAT1 in the development of and recovery from *** AP was induced with caerulein(cae)injections in female and male mice expressing LAT1 or after its knockout(LAT1 Cre/LoxP).The development of the initial AP injury and its recovery were followed for seven days after cae injections by daily measuring body weight,assessing microscopical tissue architecture,mRNA and protein expression,protein synthesis,and enzyme activity levels,as well as by testing the recruitment of immune cells by FACS and *** The initial injury,evaluated by measurements of plasma amylase,lipase,and trypsin activity,as well as the gene expression of dedifferentiation markers,did not differ between the ***,early metabolic adaptations that support regeneration at later stages were blunted in LAT1 knockout *** in females,we observed less mTOR reactivation and dysfunctional *** later regeneration phase was clearly delayed in female LAT1 knockout mice,which did not regain normal expression of the pancreas-specific differentiation markers recombining binding protein suppressor of hairless-like protein(rbpjl)and basic helixloop-helix family member A15(mist1).Amylase mRNA and protein levels remained lower,and,strikingly,female LAT1 knockout mice presented signs of fibrosis lasting until day *** contrast,pancreas morphology had returned to normal in wild-type *** LAT1 supports the regeneration of acinar cells after *** mice lacking LAT1 exh

关键词： Acute pancreatitis Amino acid transporter LAT1 metabolism Regeneration Fibrosis