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Surface-bound myeloperoxidase is a ligand for recognition of late apoptotic neutrophils by human lung surfactant proteins A and D

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Protein & Cell 2010年第6期1卷 563-572页

作者： Anne Jäkel Howard clark Kenneth B.m.Reid Robert B.Sim Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK University of Southampton School of MedicineDivision of Infection Inflammation&ImmunitySouthampton General HospitalSouthampton SO166YDUK mRC Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUK

Surfactant proteins A(SP-A)and D(SP-D),both members of the collectin family,play a well established role in apoptotic cell recognition and *** in vitro data show that SP-A and SP-D interact with apoptotic neutrophils in a distinct ***-A and SP-D bind in a Ca^(2+)-dependent manner to viable and early apoptotic neutrophils whereas the much greater interaction with late apoptotic neutrophils is Ca^(2+)-*** surface molecules on the apoptotic target cells responsible for these interactions had not been identified and this study was done to find candidate target ***(mPO),a specific intracellular defense molecule of neutrophils that becomes exposed on the outside of the cell upon apoptosis,was identified by affinity purification,mass-spectrometry and western blotting as a novel binding molecule for SP-A and *** confirm its role in recognition,it was shown that purified immobilised mPO binds SP-A and SP-D,and that mPO is surface-exposed on late apoptotic ***-A and SP-D inhibit binding of an anti-mPO monoclonal Ab to late apoptotic *** microscopy confirmed that anti-mPO mAb and SP-A/SP-D colocalise on late apoptotic *** was identified as a further potential ligand for SP-A,and neutrophil defensin as a target for both proteins.

关键词： SP-A SP-D myeloperoxidase neutrophils flow cytometry mass spectrometry

Developing an interatomic potential for martensitic phase transformations in zirconium by machine learning

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npj Computational materials 2018年第1期4卷 254-261页

作者： Hongxiang Zong Ghanshyam Pilania Xiangdong Ding graeme J.Ackland Turab Lookman State Key Laboratory for mechanical Behavior of materials Xi’an Jiaotong UniversityXi’an 710049China Theoretical Division&materials Science and Technology Division Los Alamos National LaboratoryLos AlamosNM 87545USA Centre for Science at Extreme Conditions(CSEC) School of Physics and AstronomyUniversity of EdinburghEdinburgh EH93FDUK

Atomic simulations provide an effective means to understand the underlying physics of structural phase ***,this remains a challenge for certain allotropic metals due to the failure of classical interatomic potentials to represent the multitude of *** on machine-learning(mL)techniques,we develop a hybrid method in which interatomic potentials describing martensitic transformations can be learned with a high degree of fidelity from ab initio molecular dynamics simulations(AImD).Using zirconium as a model system,for which an adequate semiempirical potential describing the phase transformation process is lacking,we demonstrate the feasibility and effectiveness of our ***,the mL-AImD interatomic potential correctly captures the energetics and structural transformation properties of zirconium as compared to experimental and density-functional data for phonons,elastic constants,as well as stacking fault *** dynamics simulations successfully reproduce the transformation mechanisms and reasonably map out the pressure–temperature phase diagram of zirconium.

关键词： martensitic transformation zirconium

Prograde and retrograde growth of monazite in migmatites:An example from the Nagercoil Block,southern India

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Geoscience Frontiers 2015年第3期6卷 373-387页

作者： Tim E.Johnson Chris clark Richard J.m.Taylor m.Santosh Alan S.Collins Department of Applied Geology The Institute for Geoscience Research(TIGeR)Curtin University School of the Earth Sciences and Resources China University of Geosciences(Beijing) Tectonics Resources and Exploration(TRaX)Department of Earth SciencesUniversity of Adelaide

Data from a migmatised metapelite raft enclosed within charnockite provide quantitative constraints on the pressure-temperature-time （P-T-t） evolution of the Nagercoil Block at the southernmost tip of peninsular India. An inferred peak metamorphic assemblage of garnet, K-feldspar, sillimanite, plagioclase, magnetite, ilmenite, spinel and melt is consistent with peak metamorphic pressures of 6-8 kbar and temperatures in excess of 900 ℃. Subsequent growth of cordierite and biotite record high-temperature retrograde decompression to around 5 kbar and 800 ℃. SHRImP U-Pb dating of magmatic zircon cores suggests that the sedimentary protoliths were in part derived from felsic igneous rocks with Palae- oproterozoic crystallisation ages. New growth of metamorphic zircon on the rims of detrital grains constrains the onset of melt crystallisation, and the minimum age of the metamorphic peak, to around 560 ma. The data suggest two stages of monazite growth. The first generation of REE-enriched monazite grew during partial melting along the prograde path at around 570 ma via the incongruent breakdown of apatite. Relatively REE-depleted rims, which have a pronounced negative europium anomaly, grew during melt crystallisation along the retrograde path at around 535 ma. Our data show the rocks remained at suprasolidus temperatures for at least 35 million years and probably much longer, supporting a long-lived high-grade metamorphic history. The metamorphic conditions, timing and duration of the implied clockwise P-T-t path are similar to that previously established for other regions in peninsular India during the Ediacaran to Cambrian assembly of that part of the Gondwanan supercontinent.

关键词： monazire migmatite Zircon Geochronology Phase equilibria modelling Gondwana

美国青少年体育发展现状给我国学校体育带来的启示

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沈阳体育学院学报 2006年第3期25卷 41-42页

作者：门丽 HUI m.clark 吴加利沈阳体育学院竞技体校辽宁沈阳110032 Alliant International University San Diego California USA 沈阳体育学院辽宁沈阳110032

青少年体育活动作为现代化生活方式之一,已经渗透到美国家庭的日常生活中,并成功地改变了人们培养青少年的价值观念。美国的教育把初、高中学生体育运动的参与程度作为对学生最重要的择优标准之一。这样的教育在积极鼓励并引导学生在走... 详细信息

青少年体育活动作为现代化生活方式之一,已经渗透到美国家庭的日常生活中,并成功地改变了人们培养青少年的价值观念。美国的教育把初、高中学生体育运动的参与程度作为对学生最重要的择优标准之一。这样的教育在积极鼓励并引导学生在走向光明未来的同时,保证其有健康的体魄和坚毅自信的性格。美国青少年体育的发展受到家庭、学校、社会的高度重视。中国正在进行基础教育改革,学校体育也被愈来愈多的人所重视。把握契机,借鉴美国青少年体育运动成功的经验,有利于完善我们的教育体制,使我们的青少年成为最终的受益者。

关键词：美国青少年体育现状我国学校体育借鉴与启示

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新疆东北部晚侏罗世一新的柱齿兽

古脊椎动物学报 2007年第3期45卷 173-194页

作者：胡耀明孟津詹姆斯 m.克拉克中国科学院古脊椎动物与古人类研究所北京100044 美国乔治华盛顿大学生物科学系华盛顿dc20052

描述了哺乳纲柱齿兽目柱齿兽科(Docodontidae,Docodonta,mammalia)一新属种——孙氏尖钝齿兽(Acuodulodon sunae *** ***.)。标本产于新疆东北部准噶尔盆地五彩湾地区上侏罗统牛津阶石树沟组上部(159～161 ma),为一不完整左下颌骨及齿... 详细信息

描述了哺乳纲柱齿兽目柱齿兽科(Docodontidae,Docodonta,mammalia)一新属种——孙氏尖钝齿兽(Acuodulodon sunae *** ***.)。标本产于新疆东北部准噶尔盆地五彩湾地区上侏罗统牛津阶石树沟组上部(159～161 ma),为一不完整左下颌骨及齿列。新属下臼齿具柱齿兽类典型特征:齿尖b位于齿尖a前方;齿尖c位于齿尖a后舌侧;齿尖a前舌侧发育有齿尖g。不同于其他柱齿兽,新属下臼齿无齿尖e和齿脊b-e。齿尖g和齿脊b-g很快被磨蚀掉而齿尖a和c却能保持尖锐状态,表明该动物的臼齿在生活中具备并保持切割和碾压双重功能。基于下臼齿性状特征的系统发育分析表明,柱齿兽目作为一单系类群具有显著的鉴定特征。其中尖钝齿兽和Itatodon+(Simpsonodon,Castorocauda+(Tegotherium+Sibirotherium))形成一单系子类群;但tegotheriids各分子未形成独立于柱齿兽科的单系类群。尖钝齿兽的下颌齿骨亦为典型的柱齿兽类型。齿骨内侧下部近腹缘有浅的齿后骨槽和宽大的内侧脊,但两者未延伸到下颌关节髁的基柄部。这表明尖钝齿兽的齿后骨与齿骨的连接比摩根齿兽类更为松散,其中耳在进化上更接近真正意义上的哺乳动物中耳。

关键词：新疆晚侏罗世柱齿兽目尖钝齿兽系统发育

mapping groundwater dependent ecosystem potential in a semi-arid environment using aremote sensing-based multiple-lines-of-evidence approach

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International Journal of Digital Earth 2023年第1期16卷 375-406页

作者： Stephen G.Fildes Tanya m.Doody David Bruce Ian F.clark Okke Batelaan UniSA STEm University of South AustraliaAdelaideAustralia CSIRO Land and WaterAdelaideAustralia National Centre for Groundwater Research and Training(NCGRT) College of Science and EngineeringFlinders UniversityBedford ParkAustralia

Groundwater dependent ecosystems(GDEs)are vulnerable to groundwater regime ***,their protection is often hampered by challenges in their *** is presented a remote sensing-based GDE potential mapping approach based on the persistency of relevant vegetation parameters during prolonged dry periods as an indicator of potential‘consistency’of water supply(***).The study uses a novel approach to characterising persistency for selected vegetation parameters based on a normalised difference measure and an adaptation of the coefficient of variation *** of parameters was facilitated through the analytic hierarchy process providing a structured weighting approach to minimise parameter *** approach is demonstrated in the semi-arid Flinders Ranges of South Australia where new groundwater resources are being sought to support local domestic and industry *** in GDE potential were mapped to better target areas where exploration of groundwater should be *** results indicated a high-level of agreement of 77%with an independent springs dataset,along with an 87%agreement with areas coinciding with known phreatophyte species and depths to *** index-based mapping approach has potential applicability across landscapes,as it normalises for variations in vegetation cover,minimises technical overheads,and employs continental-wide remote sensing data-products.

关键词： coefficient of variation NDVI coefficient of variation fractional cover barest Earth wetness percentiles actual evapotranspiration analytic hierarchy process groundwater potential

Unique,Persistent,Resolvable:Identifiers as the Foundation of FAIR

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Data Intelligence 2020年第1期2卷 30-39,302页

作者： Nick Juty Sarala m.Wimalaratne Stian Soiland-Reyes John Kunze Carole A.Goble Tim.clark Department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK European Bioinformatics Institute(EmBL-EBI) HinxtonCambridgeCB101SDUK California Digital Library OaklandCalifornia 94612-2901USA Data Science Institute University of VirginiaCharlottesvilleVA 22903-1738USA

The FAIR principles describe characteristics intended to support access to and reuse of digital artifacts in the scientific research ***,globally unique identifiers,resolvable on the Web,and associated with a set of additional descriptive metadata,are foundational to FAIR *** we describe some basic principles and exemplars for their design,use and orchestration with other system elements to achieve FAIRness for digital research objects.

关键词： Identifiers metadata findability FAIR data data infrastructures

Staging colorectal cancer with the TNm 7^(th):The presumption of innocence when applying the m category

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World Journal of Gastroenterology 2013年第8期19卷 1152-1157页

作者： Giacomo Puppa graeme Poston Per Jess Guy F Nash Kenneth Coenegrachts Axel Stang Service de Pathologie Clinique Hpitaux Universitaires de Genève1211 GenevaSwitzerland Department of Surgery Aintree University HospitalsLiverpool L9 7ALUnited Kingdom Department of Surgery Roskilde HospitalUniversity of Copenhagen2200 CopenhagenDenmark Department of Colorectal Surgery Poole General HospitalPoole BH15 2JBUnited Kingdom Department of Radiology AZ St.-Jan Brugge-Oostende AVB-8000 BrugesBelgium Department of Oncology Hematology and Palliative CareAsklepios Hospital Hamburg-Barmbek22291 HamburgGermany

One of the main changes of the current TNm-7 is the elimination of the category mX,since it has been a source of ambiguity and misinterpretation,especially by *** the ultimate staging would be better performed by the patient's clinician who can classify the disease m0(no distant metastasis) or m1(presence of distant metastasis),having access to the completeness of data resulting from clinical examination,imaging workup and pathology *** this important change doesn't take into account the diagnostic value and the challenge of small indeterminate visceral lesions encountered,in particular,during radiological staging of patients with colorectal *** this article the diagnosis of these lesions with multiple imaging modalities,their frequency,significance and relevance to staging and disease management are described in a multidisciplinary *** particular the interplay between clinical,radiological and pathological staging,which are usually conducted independently,is *** integrated approach shows that there are both advantages and disadvantages to abandoning the mX *** avoid ambiguity arising both by applying and interpreting mX category for stage assigning,its abandoning seems *** recognition of the importance of small lesion characterization raises the need for applying a separate category;therefore a proposal for their categorization is put *** using the proposed categorization the lack of consideration for indeterminate visceral lesions with the current staging system will be overcome,also optimizing tailored follow-up.

关键词： Colorectal cancer Staging Indeterminate lesions Imaging metastases

Null Controllability of Some Reaction-Diffusion Systems with Only One Control Force in moving Domains

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Chinese Annals of mathematics,Series B 2016年第1期37卷 29-52页

作者： J. LImACO m. clark A. mARINHO S. B. de mENEZES A. T. LOUREDO Universidade Federal Fluminense IM RJ Brazil Universidade Federal do Piaui DM PI Brazil Universidade Federal do Piaui DM PI Brazil Universidade Federal do Ceara DM CE Brazil Universidade Estadual da Pavaiba DM PB Brazil.

In this article, the authors establish the local null controllability property for semilinear parabolic systems in a domain whose boundary moves in time by a single control force acting on a prescribed subdomain. The proof is based on Kakutani＇s fixed point theorem combined with observability estimates for the associated lineaxized system.

关键词： Kakutani's fixed point theorem Unique continuation Null controllability