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Systems Biology: The take, input, vision, concerns and hopes

Journal of Biomedical Science and Engineering 2009年第2期2卷 78-79页

作者： graeme tucker Lighthouse Laboratories SABC Loneragan Building Murdoch University South Street Murdoch Western Australia 6150

Systems Biology is a relatively new branch of biology that brings together an interdisciplinary team of scientist, computer engineers and mathematicians. Biomedicine can gain much from the input of Systems Biology. The object and aims of this article centre on clarification and direction for Systems Biology, notably in regard to human health and disease.

关键词： Systems Biology

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Carbon dioxide insufflation during colonoscopy in deeply sedated patients

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World Journal of Gastroenterology 2012年第25期18卷 3250-3253页

作者： Rajvinder Singh Eu Nice Neo Nazree Nordeen Ganesananthan Shanmuganathan Angelie Ashby Sharon Drummond Garry Nind Elizabeth Murphy Andrew Luck graeme tucker William Tam Division of Gastroenterology Department of MedicineLyell McEwin HospitalSouth Australia 5070Australia Department of Medicine University of AdelaideSouth Australia 5070Australia Colorectal Unit Department of SurgeryLyell McEwin HospitalSouth Australia 5070Australia Pantai Hospital Kuala Lumpur 50000Malaysia Health Statistics Unit South Australia Health CenterSouth Australia 5000Australia

AIM:To compare the impact of carbon dioxide(CO2) and air insufflation on patient tolerance/safety in deeply sedated patients undergoing ***:Patients referred for colonoscopy were randomized to receive either CO2 or air insufflation during the *** the colonoscopist and patient were blinded to the type of gas *** the procedure,insertion and withdrawal times,caecal intubationrates,total sedation given and capnography readings were *** level of sedation and magnitude of patient discomfort during the procedure was assessed by a nurse using a visual analogue scale(VAS)(0-3).Patients then graded their level of discomfort and abdominal bloating using a similar *** during and after the procedure were ***:A total of 142 patients were randomized with 72 in the air arm and 70 in the CO2 *** age between the two study groups were *** time to the caecum was quicker in the CO2 group at 7.3 min vs 9.9 min with air(P = 0.0083).The average withdrawal times were not significantly different between the two *** intubation rates were 94.4% and 100% in the air and CO2 groups respectively(P = 0.012).The level of discomfort assessed by the nurse was 0.69(air) and 0.39(CO2)(P = 0.0155) and by the patient 0.82(air) and 0.46(CO2)(P = 0.0228).The level of abdominal bloating was 0.97(air) and 0.36(CO2)(P = 0.001).Capnography readings trended to be higher in the CO2 group at the commencement,caecal intubation,and conclusion of the procedure,even though this was not significantly different when compared to readings obtained during air *** were no complications in both ***:CO2 insufflation during colonoscopy is more efficacious than air,allowing quicker and better cecal intubation *** discomfort and bloating were significantly less with CO2 insufflation.

关键词： Colonoscopy Carbon dioxide Air Insuffla-tions, Patient tolerance Safety, Efficacy

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Single-center study comparing computed tomography colonography with conventional colonoscopy

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World Journal of Gastroenterology 2008年第3期14卷 469-473页

作者： Ian C Roberts-Thomson graeme R tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton Department of Gastroenterology The Queen Elizabeth Hospital South Australia Australia Department of Health South Australia Australia Department of Colorectal Surgery The Queen Elizabeth Hospital South Australia Australia Department of Radiology The Queen Elizabeth Hospital South Australia Australia

AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients.

关键词： Colorectal polyps Colorectal cancer Computed tomography colonography Colonoscopy

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