检索结果-南通市图书馆

Gestational heat stress alters skeletal muscle gene expression profiles and vascularity in fetal pigs in a sexually dimorphic manner

引用

Journal of Animal science and Biotechnology 2022年第6期13卷 1785-1798页

作者： Weicheng Zhao Mark P.Green Christina D.Marth Fan Liu Hieu H.Le Gordon s.Lynch Alan W.Bell Brian J.Leury Frank R.Dunshea Jeremy J.cottrell school of Agriculture and Food Faculty of Veterinary and Agricultural SciencesThe University of MelbourneParkvilleVIC 3010Australia school of Biosciences Faculty of ScienceThe University of MelbourneParkvilleVIC 3010Australia Melbourne Veterinary school Faculty of Veterinary and Agricultural SciencesThe University of MelbourneWerribeeVIC 3030Australia Rivalea Australia Pty Ltd CorowaNSW 2646Australia Centre for Muscle Research Department of Anatomy and PhysiologyThe University of MelbourneParkville 3010Australia Department of Animal science Cornell UniversityIthacaNY 14853-4801USA Faculty of Biological sciences The University of LeedsLeeds LS29JTUK

Background: There is evidence that sow heat stress(Hs) during gestation affects fetal development with implications for impaired muscle growth. We have previously demonstrated that maternal Hs during early to midgestation compromised muscle fibre hyperplasia in developing fetal pigs. Thus, we hypothesised these phenotypic changes are associated with a change in expression of genes regulating fetal skeletal muscle development and metabolism. To test this, at d 60 of gestation, RNA sequencing and immunohistochemistry were performed on fetal longissimus dorsi(LD) muscle biopsies collected from pregnant gilts that had experienced either thermoneutral control(CON, 20 ℃, n = 7 gilts, 18 LD samples) or controlled Hs(cyclic 28 to 33 ℃, n = 8 gilts, 23 LD samples)conditions for 3 ***: A total of 282 genes were differentially expressed between the Hs and CON groups in female LD muscles(false discovery rate(FDR) ≤ 0.05), whereas no differentially expressed genes were detected in male LD muscles between the two groups(FDR > 0.05). Gestational Hs increased the expression of genes associated with transcription corepressor activity, adipogenesis cascades, negative regulation of angiogenesis and pro-inflammatory signalling in female LD muscles. Immunohistochemical analyses revealed a decreased muscle vascularity density in fetuses from Hs group for both sexes compared to those from the CON group(P = 0.004).Conclusions: These results reveal gilt Hs during early to mid-gestation altered gene expression profiles in fetal LD muscles in a sexually dimorphic manner. The molecular responses, including transcription and angiogenesis repressions and enhanced adipogenesis cascades, were exclusively observed in females. However, the associated reductions in muscle vascularity were observed independently of sexes. Collectively this may indicate female fetal pigs are more adaptive to gestational Hs in terms of gene expression changes, and/or there may be sexually dimorphic differences

关键词： Adipogenesis Angiogenesis Fetal pig Gestation Heat stress sexual dimorphism skeletal muscle sows

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Objective and subjective scar aesthetics with topical Manuka honey post-thyroidectomy:A randomized control study

引用

World Journal of Otorhinolaryngology-Head and Neck surgery 2016年第4期2卷 -页

作者： Andrew Thamboo graeme Mulholland Kathleen Matthews Noel Ayoub Donald Anderson Department of 0tolaryngology e Head and Neck surgery Stanford University School of Medicine 801 Welch Road Stanford CA 94305 USA

Objective:Leptospermum Honey (Manuka honey) has proven to be effective in improving acute and chronic wound healing presumably due to its antibacterial and anti-inflammatory properties. The aim is to determine if Manuka honey decreases scar formation and results in a cosmetically appealing scar. Methods:A prospective single-blinded randomized control trial was performed. All patients received an 8 cm incision. Patients randomized to honey treatment were instructed to apply Manuka honey paste topically to the incision site once per day post surgery for 4 weeks. The patients’ scar was then analyzed objectively by a blinded observer and subjectively at 4 and 8 weeks postoperatively. The primary outcome measure used was the Patient and Observer scar Assessment scale (POsAs). Results:A total of 21 patients completed the entire scar analysis (honey treatment Z 9, stan-dard treatment Z 12). There was no statistically significant difference between patient scar assessment scale and observer scar assessment scale at 4 and 8 weeks ***: Despite Leptospermum Honey’s reported anti-inflammatory and antibacterial properties, this study did not show a difference in scar appearance when applied.

关键词： Thyroid Thyroidectomy scar Aesthetics Honey Topical Wound healing Naturopathic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Patterning Functionalized surfaces of 2D Materials by Nanoshaving

引用

Nanomanufacturing and Metrology 2022年第1期5卷 23-31页

作者： Katie O'Neill Rob Greig Rita Tilmann Lisanne Peters Conor P.Cullen graeme Cunningham Cian Bartlam Cormac O Coileain Niall McEvoy Georg s.Duesberg school of Physics Trinity College DublinDublin 2 D02 PN40Ireland AMBER Centre CRANN InstituteTrinity College DublinDublin 2Ireland Institute of Physics EIT 2Faculty of Electrical Engineering and Information TechnologyUniversitat der Bundeswehr Miinchen85579 NeubibergGermany school of Chemistry Trinity College DublinDublin 2Ireland

Atomic force microscopy(AFM)and scanning probe lithography can be used for the mechanical treatment of various surfaces,including polymers,metals,and *** technique of nanoshaving,in which materials are removed using the AFM tip,is employed in this work to produce nanopatterns of self-assembled monolayers(sAMs)on two-dimensional(2D)*** materials used are monolayers of transition metal dichalcogenides(TMDs),namely,Mos_(2)and Ws_(2),which are noncovalently functionalized with perylene diimide(PDI),a perylene *** approach involves rastering an AFM probe across the surface at a controlled increased load in ambient *** a result of the strong bond between PDI sAM and TMD,loads in excess of 1|1N are required to pattern the *** predefined patterns,including a grating pattern with feature sizes below 250 nm,are *** indicate the high precision of nanoshaving as an accurate and nondestructive lithographic technique for 2D *** work functions of shaved heterostructures are also examined using Kelvin probe force microscopy.

关键词： Nanoshaving AFM KPFM Perylene diimide 2D materials Mos_(2) Ws_(2) Noncovalent functionalization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of ammonium chloride on leaching behavior of alkaline anion and sodium ion in bauxite residue

引用

Transactions of Nonferrous Metals society of China 2018年第10期28卷 2125-2134页

作者： Yi-wei LI Jun JIANG sheng-guo XUE graeme J.MILLAR Xiang-feng KONG Xiao-fei LI Meng LI Chu-xuan LI school of Metallurgy and Environment Central South UniversityChangsha 410083China Chinese National Engineering Research Center for Control&Treatment of Heavy Metal Pollution Central South UniversityChangsha 410083China Institute for Future Environments Science and Engineering FacultyQueensland University of Technology(QUT)Brisbane Qld 4000Australia

This study focused on leaching behavior of alkaline anion and sodium in bauxite residue through ammonium chloride *** results showed that the pH of bauxite residue decreased from 10.49 to 8.93,total alkaline anion(HCO3^-,CO3^2-,OH^-,AlO2^-)concentration reduced from 38.89 to 25.50 mmol/L,leaching rate of soluble sodium was 80.86%with ammonium chloride addition of 0.75%,liquid/solid(L/s)ratio of 3(mL/g),temperature of 30°C and reaction time of 18 h;L/s ratio was the main factor affecting the removal of alkaline anion and the leaching of ***,ammonium chloride promoted the dissolution of diaspore and changed the micro/morphological characteristics with the increase of massive *** findings of this work will contribute to achieve soil-formation of bauxite residue.

关键词： bauxite residue ammonium chloride leaching behavior alkaline regulation soil formation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neuromyelitis optica spectrum disorders and anti-myelin oligodendrocyte glycoprotein positive optic neuropathies

引用

International Journal of Ophthalmology(English edition) 2022年第7期15卷 1095-1107页

作者： Patrick Murtagh Amy Coman Kirk stephenson Maria Gaughan David Ryan graeme McNeill Christopher McGuigan Lorraine Cassidy Royal Victoria Eye and Ear Hospital Adelaide RoadDublin 2D02 XK51Republic of Ireland st Vincent’s University Hospital Elm ParkDublin 4D04 N2E0Republic of Ireland

AIM: To describe the clinical characteristics and treatments associated with antibody positive optic neuropathies including anti-myelin oligodendrocyte glycoprotein(MOG) and anti-aquaporin 4(AQP4), alongside diagnostic modalities, investigations, and outcomes. METHODs: A cross-sectional single-centre retrospective case series consisting of 16 patients including 12 antiMOG positive patients and 4 anti-AQP4 positive patients. Each of these patients had clinical signs and symptoms of optic neuritis and consisted of all patients who had a positive blood antibody result in our centre. Clinical findings including presence of a relative afferent pupillary defect, colour vision and disc assessment were recorded. structured clinical exam and multimodal imaging was undertaken sequentially on each. Optical coherence tomography(OCT) scanning was preformed to examine the correlation between ganglion cell layer(GCL) thickness and visual acuity(VA) at presentation and as a determinant of final visual outcome in both groups. Initial and long-term treatment is also summarised. REsULTs: A total of 16 patients were included in the study consisting of 12 anti-MOG and 4 anti-AQP4 positive patients. Nine of the 16 patients were female and the average age of onset was 29.2 y in the MOG group and 42 y in the AQP4 group. There was no statistically significant correlation(Pearson correlation) between GCL thickness and presenting and final VA [r(10)=0.081, P=0.08 and r(10)=0.089, P=0.34 respectively]. The same statistical analysis was performed for the correlation between retinal nerve fibre layer(RNFL) and VA and similar outcomes wereobserved [r(10)=0.04, P=0.22 and r(10)=0.09, P=0.04]. No correlation was seen for initial RNFL thickness and final visual outcome in this group either [r(2)=0.19, P=0.38]. Visual field testing and radiological findings for each group are described. CONCLUsION: No correlation between initial VA or RNFL and final visual outcome is identified. A broad range of visu

关键词： neuromyelitis anti-myelin oligodendrocyte glycoprotein antibody anti-aquaporin 4

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High-intensity Interval Training for the Management of Nonalcoholic steatohepatitis: Participant Experiences and Perspectives

引用

Journal of Clinical and Translational Hepatology 2023年第5期11卷 1050-1060页

作者： shelley E.Keating Ilaria Croci Matthew P.Wallen Emily R.Cox Jeff s.Coombes Nicola W.Burton graeme A.Macdonald Ingrid J.Hickman Centre for Research on Exercise Physical Activity and HealthSchool of Human Movement and Nutrition SciencesThe University of QueenslandBrisbaneAustralia K.G.Jebsen Center of Exercise in Medicine Norwegian University of science and Technology Department of Circulation and Medical ImagingFaculty of MedicineTrondheimNorway Department of sport Exercise and HealthUniversity of BaselBaselSwitzerland Caring Futures Institute College of Nursing and Health SciencesFlinders UniversityAdelaideAustralia Institute of Health and Wellbeing Federation UniversityMount HelenAustralia school of Environmental and Life sciences University of NewcastleOurimbahAustralia school of Applied Psychology Griffith UniversityMt GravattAustralia Menzies Health Institute Griffith UniversityGold CoastAustralia Centre for Mental Health Griffith UniversityBrisbaneAustralia Department of Gastroenterology and Hepatology Princess Alexandra HospitalBrisbaneAustralia Faculty of Medicine The University of QueenslandBrisbaneAustralia Department of Nutrition and Dietetics Princess Alexandra HospitalBrisbaneAustralia

Background and Aims:High-intensity interval training(HIIT)is a therapeutic option for people with nonalcoholic steatohepatitis(NAsH).However,the perspectives and experiences of HIIT for people with NAsH are unknown,limiting translation of *** explored the experiences and perspectives of both professionally supervised and self-directed HIIT in people with NAsH and evaluated participant-reported knowledge,barriers,and enablers to commencing and sustaining ***:Twelve participants with NAsH underwent 12 weeks of supervised HIIT(3 days/week,4×4 minutes at 85–95%maximal heart rate,interspersed with 3 minutes active recovery),followed by 12-weeks of selfdirected(unsupervised)***-on-one,semistructured participant interviews were conducted by exercise staff prior to HIIT and following both supervised and self-directed HIIT to explore prior knowledge,barriers,enablers,and outcomes at each *** were audio-recorded,transcribed,coded,and thematically analyzed by two independent ***:Four dominant themes were identified:(1)no awareness of/experience with HIIT and ambivalence about exercise capabilities;(2)multiple medical and social barriers to commencing and continuing HIIT;(3)exercise specialist support was a highly valued enabler,and(4)HIIT was enjoyed and provided holistic ***:People with NAsH may lack knowledge of and confidence for HIIT,and experience multiple complex barriers to commencing and continuing *** specialist support is a key enabler to sustained *** factors need to be addressed in future clinical programs to augment the uptake and long-term sustainability of HIIT by people with NAsH so they can experience the range of related benefits.

关键词： Nonalcoholic fatty liver disease NAFLD Exercise Lifestyle Qualitative Patient-reported outcomes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanostructure and thermal power of highly-textured and single-crystal-like Bi_(2)Te_(3) thin films

引用

Nano Research 2022年第3期15卷 2382-2390页

作者： Heng Zhang Jamo Momand Joshua Levinsky Qikai Guo Xiaotian Zhu Gert H ten Brink graeme R.Blake George Palasantzas Bart J.Kooi Zernike Institute for Advanced Materials University of GroningenNijenborgh 49747 AG GroningenThe Netherlands

Bi_(2)Te_(3)-based alloys are known to have outstanding thermoelectric *** structure–property relations have been studied,still,detailed analysis of the atomic and nano-scale structure of Bi_(2)Te_(3)thin film in relation to their thermoelectric properties remains poorly ***,highly-textured(HT)and single-crystal-like(sCL)Bi_(2)Te_(3)films have been grown using pulsed laser deposition(PLD)on si wafer covered with(native or thermal)siOx and mica *** films are highly textured with c-axis out-of-plane,but the in-plane orientation is random for the films grown on oxide and single-crystal-like for the ones grown on *** power factor of the film on thermal oxide is about four times higher(56.8μW·cm^(−1)·K^(−2))than that of the film on mica(12.8μW·cm^(−1)·K^(−2)),which is comparable to the one of the polycrystalline ingot at room temperature(RT).Reduced electron scattering in the textured thin films results in high electrical conductivity,where the sCL film shows the highest ***,its seebeck coefficient shows a low *** measured properties are correlated with the atomic structure details unveiled by scanning transmission electron *** instance,the high concentration of stacking defects observed in the HT film is considered responsible for the increase of seebeck coefficient compared to the sCL *** study demonstrates the influence of nanoscale structural effects on thermoelectric properties,which sheds light on tailoring thermoelectric thin films towards high performance.

关键词： Bi_(2)Te_(3)films highly-textured structure single-crystal-like structure thermoelectric properties pulsed laser deposition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A comparison of financial and operational efficiency between smart and traditional insufflation for laparoscopic surgery: A granular analysis

引用

Laparoscopic, Endoscopic and Robotic surgery 2023年第3期6卷 97-102页

作者： Aazad Abbas Imran saleh graeme Hoit Gurjovan sahi sam Park Jihad Abouali Cari Whyne Jay Toor Division of Orthopaedic surgery University of Toronto149 College Street Room 508-ATorontoONM5T 1P5Canada Orthopaedic Biomechanics Lab Sunnybrook Research Institute2075 Bayview AvenueTorontoONCanada Department of Mechanical and Industrial Engineering University of Toronto5 King's College RoadTorontoONM5S 3G8Canada Faculty of Medicine University of Toronto1 King's College CircleTorontoONM5S 1A8Canada University of Toronto Orthopaedics sports Medicine Women's College Hospital76 Grenville StTorontoONCanada Division of Orthopaedic surgery Michael Garron Hospital825 Coxwell AvenueTorontoONM4C 3E7Canada Division of Orthopaedic surgery Sunnybrook Health Science Centre2075 Bayview AvenueTorontoONCanada Department of Orthopaedic surgery University of Manitoba820 Sherbrook StreetWinnipegMBCanada

Objective:smart insufflation(sI)techniques relying on valve and membrane-free insufflation are increasing in *** considerable literature exists demonstrating the benefits of sI on procedural ease and patient outcomes,there remains a paucity describing the financial impact of these *** purpose of this study was to determine the financial and efficiency impact of these devices on the operating room and inpatient wards of a ***:A discrete event simulation model representing a typical mid-sized North American hospital comparing sI to traditional insufflation(TI)was *** National surgical Quality Improvement database from 2015 to 2019 was used to populate the model with data supplemented from the *** included length of stay(LOs),duration of surgery(DOs),annual procedure volume,profit,return on investment(ROI),and gross profit margin(GPM).From the literature review,DOs savings were 10e32 minutes/case,while LOs savings were 0e3 days/***:Implementation of an sI led to an increase in annual throughput of 42e346(4.4%e36.6%)cases for all procedures and 38 to 297(4.3%e33.3%)cases for complex *** was found to be decreased by 175e614(18.3%e64.2%)days for all procedures and 231 to 614(35.6%e77.9%)cases for complex procedures with the implementation of an ***,this resulted in an increase in net profit of$104,685 per *** ROI of sI over the TI device was>1000%,and the GPM for the TI was 90.0%,while the GPM for the sI was 71.7%.Conclusion:Despite the initial financial investment being greater,the implementation of sI offsets these expenses and yields significant financial *** study demonstrates the financial benefits of sI over TI and illustrates how granular operational and financial analyses of technologies are essential to aid in sound healthcare procurement decision making.

关键词： Insufflation Airseal surgical efficiency Financial impact

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease

引用

World Journal of Hepatology 2016年第27期8卷 1137-1148页

作者： Ilaria Croci Nuala M Byrne Veronique s Chachay Andrew P Hills Andrew D Clouston Trisha M O'Moore-sullivan Johannes B Prins graeme A Macdonald Ingrid J Hickman school of Human Movement and Nutrition sciences University of Queensland Translational Research Institute the University of Queensland Diamantina Institute Bond Institute of Health and sport Bond University Institute of Health and Biomedical Innovation Queensland University of Technology school of Health sciences University of Tasmania Mater Research Institute University of Queensland school of Medi-cine the University of Queensland Department of Gastroenterology and Hepatology Princess Alexandra Hospital Translational Research Institute Department of Nutrition and Dietetics Princess Alexandra Hospital

AIM To investigate the independent effects of 6-mo of dietary energy restriction or exercise training on wholebody and hepatic fat oxidation of patients with nonalcoholic fatty liver disease(NAFLD).METHODs Participants were randomised into either circuit exercise training(EX;n = 13;3 h/wk without changes in dietary habits),or dietary energy restriction(ER) without changes in structured physical activity(ER;n = 8).Respiratory quotient(RQ) and whole-body fat oxidation rates(Fatox) were determined by indirect calorimetry under basal,insulin-stimulated and exercise *** of disease and steatosis was determined by liver histology;hepatic Fatox was estimated from plasma β-hydroxybutyrate ***;cardiorespiratory fitness was expressed as VO2 ***-case analysis was performed(EX:n = 10;ER:n = 6).REsULTs Hepatic steatosis and NAFLD activity score decreased with ER but not with EX.β-hydroxybutyrate concentrations increased significantly in response to ER(0.08 ± 0.02 mmol/L vs 0.12 ± 0.04 mmol/L,P = 0.03) but remained unchanged in response to EX(0.10 ± 0.03 mmol/L vs 0.11 ± 0.07 mmol/L,P = 0.39).Basal RQ decreased(P = 0.05) in *** EX,while this change was not significant after ER(P = 0.38).VO_(2peak)(P se(P = 0.03) improved with EX but not with ER(P > 0.05).The increase in β-hydroxybutyrate concentrations was correlated with the reduction in hepatic steatosis(r =-0.56,P = 0.04).CONCLUsION ER and EX lead to specific benefits on fat metabolism of patients with *** hepatic Fat_(ox) in response to ER could be one mechanism through which the ER group achieved reduction in steatosis.

关键词： Non-alcoholic steatohepatitis steatosis Fat and carbohydrate oxidation Exercise Fitness Beta-hydroxybutyrate Ketone bodies Fatty acid oxidation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

synthesis of tungsten ditelluride thin films and highly crystalline nanobelts from pre-deposited reactants

引用

Tungsten 2020年第3期2卷 321-334页

作者： John B.Mc Manus Cansu Ilhan Bastien Balsamo Clive Downing Conor P.Cullen Tanja stimpel‑Lindner graeme Cunningham Lisanne Peters Lewys Jones Daragh Mullarkey Igor V.shvets Georg s.Duesberg Niall McEvoy school of Chemistry Trinity College DublinDublin 2 D02 PN40Ireland AMBER Centre CRANN InstituteTrinity College DublinDublin 2 D02 PN40Ireland sIGMA Clermont UniversitéClermont Auvergne63000 Clermont–FerrandFrance Institute of Physics EIT 2Faculty of Electrical Engineering and Information TechnologyUniversität der Bundeswehr München85579 NeubibergGermany school of Physics Trinity College DublinDublin 2 D02 PN40Ireland

Tungsten ditelluride(WTe_(2))is a layered transition metal dichalcogenide(TMD)that has attracted increasing research inter-est in recent ***_(2) has demonstrated large non-saturating magnetoresistance,potential for spintronic applications and promise as a type-II Weyl *** majority of works on WTe_(2) have relied on mechanically exfoliated flakes from chemical vapour transport(CVT)-grown crystals for their *** producing high-quality samples,this method is hindered by several disadvantages including long synthesis time,high-temperature annealing and an inherent lack of *** this work,a synthesis method is demonstrated that allows the production of large-area polycrystalline films of WTe_(2).This is achieved by the reaction of pre-deposited films of W and Te at a relatively low temperature of 550℃.sputter X-ray photoelectron spectroscopy reveals the rapid but self-limiting nature of the oxidation of these WTe_(2) films in ambient *** WTe_(2) films are composed of areas of micrometre-sized nanobelts that can be isolated and offer potential as an alternative to CVT-grown *** nanobelts are highly crystalline with low defect densities indicated by transmission electron microscopy and show promising initial electrical results.

关键词： Two-dimensional materials Tungsten ditelluride Film conversion Electrodeposition Nanoelectronics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：