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Insights into induction of the immune response by the hepatitis B vaccine

World Journal of Gastroenterology 2022年第31期28卷 4249-4262页

作者： Federico Alejandro Di Lello Alfredo pedro Martínez Diego Martín Flichman Microbiology Universidad de Buenos Aires.Facultad de Farmacia y Bioquímica.Instituto de Investigaciones en Bacteriología y Virología MolecularBuenos Aires C1113AADArgentina consejo Nacional de Investigaciones científicas y Técnicas Buenos Aires C1425FQBArgentina Virology Section Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno“CEMIC”Buenos Aires C1431FWOArgentina Microbiology Universidad de Buenos AiresInstituto de Investigaciones Biomédicas en Retrovirus y Síndrome de Inmunodeficiencia AdquiridaBuenos Aires C1121ABGArgentina

After more than four decades of hepatitis B virus(HBV)vaccine implementation,its safety and efficacy in preventing HBV infection have been proven and several milestones have been *** countries have included HBV immunization schedules in their health policies and progress has been made regarding universalization of the first HBV vaccine dose at *** of these actions have significantly contributed to reducing both the incidence of HBV infection and its related ***,there are still many drawbacks to *** main concerns are the deficient coverage rate of the dose at birth and the large adult population that has not been reached timely by universal ***,the current most widely used second-generation vaccines do not induce protective immunity in 5%to 10%of the population,particularly in people over 40-years-old,obese(body mass index>25 kg/m2),heavy smokers,and patients undergoing dialysis or infection with human immunodeficiency *** developed and approved novel vaccine formulations using more potent adjuvants or multiple antigens have shown better performance,particularly in difficult *** advances re-launch the expectations of achieving the World Health Organization’s objective of completing hepatitis control by 2030.

关键词： Hepatitis B virus Vaccine Immune response Antibodies Neutralizing

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High Accurate Howland current Source: Output constraints Analysis

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circuits and Systems 2013年第7期4卷 451-458页

作者： pedro Bertemes-Filho Alexandre Felipe Volney c. Vincence Department of Electrical Engineering State University of Santa Catarina (UDESC) Joinville Brazil

Howland circuits have been widely used as powerful source for exciting tissue over a wide frequency range. When a Howland source is designed, the components are chosen so that the designed source has the desired characteristics. However, the operational amplifier limitations and resistor tolerances cause undesired behaviors. This work proposes to take into account the influence of the random distribution of the resistors in the modified Howland circuit over the frequency range of 10 Hz to 10 MHz. Both output current and impedance of the circuit are deduced either considering or the operational amplifiers parameters. The probability density function due to small changes in the resistors of the circuit was calculated by using the analytical modeling. Results showed that both output current and impedance are very sensitive to the resistors variations. In order to get higher output impedances, high operational amplifier gains are required. The operational amplifier open-loop gain increases as increasing the sensitivity of the output impedance. The analysis done in this work can be used as a powerful co-adjuvant tool when projecting this type of circuit in Spice simulators. This might improve the implementations of practical current sources used in electrical bioimpedance.

关键词： Howland current Source Electrical Bioimpedance Probability Density Function Resistors Mismatching

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SET-VALUED EXTENSION OF OPERATORS VIA STEINER SELEcTIONS (Ⅰ)-THEORETIcAL RESULTS

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Applied Mathematics and Mechanics(English Edition) 2002年第5期23卷 568-579页

作者： Tern, pedro, L  pez_Dían, Miguel (Facultad de ciencias, Universidad de Oviedo, c/calvo Sotelo, s/n 33007 Oviedo Spain) (communicated by ZHANG Shi_sheng) Facultad de ciencias Universidad de Oviedo C/Calvo Sotelo Oviedo Spain

A way to extend operators in spaces of continuous functions to spaces of continuous set_valued functions is proposed. This extension is developed through the Steiner selections of the set_valued functions. Their properties and characteristics of the convergence of sequences of operators of this class are studied. In Part Ⅱ of this series some applications to approximation theory will be shown.

关键词： set_valued extension steiner selection operator

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Phyllosticta capitalensis,a widespread endophyte of plants

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Fungal Diversity 2013年第3期60卷 91-105页

作者： Saowanee Wikee Lorenzo Lombard pedro W.crous chiharu Nakashima Keiichi Motohashi Ekachai chukeatirote Siti A.Alias Eric H.c.McKenzie Kevin D.Hyde School of Science Mae Fah Luang UniversityChiangrai 57100Thailand Institute of Excellence in Fungal Research Mae Fah Luang UniversityChiangrai 57100Thailand cBS-KNAW Fungal Biodiversity centre Uppsalalaan 83584 CT UtrechtThe Netherlands Microbiology Department of BiologyUtrecht UniversityPadualaan 83584 CH UtrechtThe Netherlands Laboratory of Phytopathology Wageningen University and Research Centre(WUR)Droevendaalsesteeg 16708 PB WageningenThe Netherlands Graduate School of Bioresources Mie UniversityKurima-machiya 1577TsuMie 514-8507Japan Electron Microscope center Tokyo University of AgricultureSakuraoka 1-1-1SetagayaTokyo 156-8502Japan Institute Ocean and Earth Sciences Institute for Postgraduate StudiesUniversity MalayaKuala Lumpur 50603Malaysia Landcare Research Private Bag 92170Auckland Mail CentreAuckland 1142New Zealand

Phyllosticta capitalensis is an endophyte and weak plant pathogen with a worldwide distribution presently known from 70 plant *** study isolated *** from different host plants in northern Thailand,and determined their different life *** strains of *** were isolated as endophytes from 20 *** additional 30 strains of *** from other hosts and geographic locations were also obtained from established culture *** analysis using ITS,AcTand TEF gene data confirmed the identity of all *** tests with five strains of *** originating from different hosts were completed on their respective host *** all cases there was no infection of healthy leaves,indicating that this endophyte does not cause disease on healthy,unstressed host *** *** is often isolated as an endophyte has important implications in fungal biology and plant *** to its endophytic nature,*** commonly found associated with lesions of plants,and often incorrectly identified as a species of quarantine importance,which again has implications for trade in agricultural and forestry production.

关键词： Guignardia Leaf spot Morphology Molecular phylogeny Quarantine

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Searching for ductile superconducting Heusler X_(2)YZ compounds

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npj computational Materials 2023年第1期9卷 919-927页

作者： Noah Hoffmann Tiago F.T.cerqueira pedro Borlido Antonio Sanna Jonathan Schmidt Miguel A.L.Marques Institut für Physik Martin-Luther-Universität Halle-WittenbergD-06099 HalleGermany cFisUc Department of PhysicsUniversity of CoimbraRua Larga 3004-516 CoimbraPortugal Max-Planck-Institut für Mikrostrukturphysik Weinberg 2D-06120 HalleGermany

Heusler compounds attract a great deal of attention from researchers thanks to a wealth of interesting properties,among which is *** we perform an extensive study of the superconducting and elastic properties of the cubic(full-)Heusler family using a mixture of ab initio methods,as well as interpretable and predictive machine-learning *** analyzing the statistical distributions of these properties and comparing them to anti-perovskites,we recognize universal behaviors that should be common to all conventional superconductors while others turn out to be specific to the material *** total,we discover a total of eight hypothetical materials with critical temperatures above 10 K to be compared with the current record of T_(c)=4.7 K in this ***,we expect most of these materials to be highly ductile,making them potential candidates for the manufacture of wires and tapes for superconducting magnets.

关键词： ductile compounds superconducting

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Engineering bionic T cells: signal 1, signal 2, signal 3, reprogramming and the removal of inhibitory mechanisms

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cellular & Molecular Immunology 2020年第6期17卷 576-586页

作者： Iñaki Etxeberria Irene Olivera Elixabet Bolaños Asunta cirella Álvaro Teijeira pedro Berraondo Ignacio Melero Program of Immunology and Immunotherapy Center for Applied Medical Research(CIMA)PamplonaSpain Navarra Institute for Health Research(IDISNA) PamplonaSpain centro de Investigación Biomédica en Red de cáncer(cIBERONc) MadridSpain Department of Immunology and Immunotherapy Clínica Universidad de NavarraPamplonaSpain

Gene engineering and combinatorial approaches with other cancer immunotherapy agents may confer capabilities enabling full tumor rejection by adoptive T cell therapy(AcT).The provision of proper costimulatory receptor activity and cytokine stimuli,along with the repression of inhibitory mechanisms,will conceivably make the most of these treatment *** this sense,T cells can be genetically manipulated to become refractory to suppressive mechanisms and exhaustion,last longer and differentiate into memory T cells while endowed with the ability to traffic to malignant *** antitumor effects can be dramatically augmented with permanent or transient gene transfer maneuvers to express or delete/repress genes.A combination of such interventions seeks the creation of the ultimate bionic T cell,perfected to seek and destroy cancer cells upon systemic or local intratumor delivery.

关键词： Adoptive cell therapy T cell engineering cancer immunotherapy

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Biotinylated polyurethane-urea nanoparticles for targeted theranostics in human hepatocellular carcinoma

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Nano Research 2015年第5期8卷 1729-1745页

作者： Genoveva MorraI-Ruiz pedro Melgar-Lesmes Andrea Lopez-Vicente conxita Solans Maria Jose Garcia-celma Department of Pharmacy and Pharmaceutical Technology Faculty of Pharmacy University of Barcelona Av Joan XXIII s/n 08028 Barcelona Spain Institute of Advanced chemistry of catalonia (IQAc) CS/C Jordi Girona 18-26 08034 Barcelona Spain Networking Research center on Bioengineering Biomaterials and Nanomedicine CIBER-BBN Spain

Over the past years, significant efforts have been devoted to explore novel drug delivery and detection strategies for simultaneous therapy and diagnostics. The development of biotinylated polyurethane-urea nanoparticles as theranostic nanocarriers for targeted drug and plasmid delivery, for fluorescence detection of human hepatocellular carcinoma cells, is described herein. These targeted nanoparticles are specifically designed to incorporate biotin into the polymeric matrix, since many tumor types overexpress receptors for biotin as a mechanism to boost uncontrolled cell growth. The obtained nanoparticles were spherical, exhibited an average diameter ranging 110-145 nm, and showed no cytotoxicity in healthy endothelial cells. Biotinylated nanoparticles are selectively incorporated into the perinuclear and nuclear area of the human hepatocellular carcinoma cell line, HepG2, in division, but not into growing, healthy, human endothelial cells. Indeed, the simultaneous incorporation of the anticancer drugs, phenoxodiol or sunitinib, together with plasmid DNA encoding green fluorescent protein, into these nanoparticles allows a targeted pharmacological antitumor effect and furthermore, selective transfection of a reporter gene, to detect these cancer cells. The combined targeted therapy and detection strategy described here could be exploited for liver cancer therapy and diagnostics, with a moderate safety profile, and may also be a potential tool for other types of cancer.

关键词： cancer therapy DNA nanoparticles polyurethane theranostics

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ca-based materials derived from calcined cigarette butts for cO_(2)capture and thermochemical energy storage

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Journal of Environmental Sciences 2024年第6期140卷 230-241页

作者： Nabil Amghar Virginia Moreno pedro E.Sánchez-Jiménez Antonio Perejón Luis A.Pérez-Maqueda Instituto de ciencia de Materiales de Sevilla C.S.I.C.-Universidad de SevillaC.Américo Vespucio4941092 SevillaSpain Instituto de Tecnología de Materiales(ITM) Universitat Politècnica de València(UPV)Plaza Ferrándiz y Carbonell 1AlcoyAlicante 03801Spain Departamento de Química Inorgánica Facultad de QuímicaUniversidad de Sevilla41012 SevillaSpain

cigarette butts(cBs)are one of the most common types of litter in the *** to the toxic substances they contain,the waste generated poses a harmful risk to the environment,and therefore there is an urgent need for alternative solutions to landfill ***,this work presents a possible revalorization of this waste material,which implies interesting environmental *** were used as sacrificial templates for the preparation of caO-based materials by impregnation with calcium and magnesium nitrates followed by flaming *** materials presented enhanced porosity for their use in the calcium Looping process applied either to thermochemical energy storage or cO_(2)capture *** influence of the concentration of ca and Mg in the impregnating solutions on the multicycle reactivity of the samples was *** improved multicycle performance was obtained in terms of conversion for both applications.

关键词： cigarette butts calcium-Looping cO_(2)capture Thermochemical energy storage

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A Two-Point Boundary Value Problem by Using a Mixed Finite Element Method

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Applied Mathematics 2015年第12期6卷 1996-2003页

作者： pedro Pablo cárdenas Alzate José Rodrigo González Granada Department of Mathematics Universidad Tecnoloacute gica de Pereira Pereira Colombia

This paper describes a numerical solution for a two-point boundary value problem. It includes an algorithm for discretization by mixed finite element method. The discrete scheme allows the utilization a finite element method based on piecewise linear approximating functions and we also use the barycentric quadrature rule to compute the stiffness matrix and the L2-norm.

关键词： Two-Point BVP Galerkin’s Method Non-Symmetric Problem

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Modeling and Simulation of Molecular Mechanism of Action of Dietary Polyphenols on the Inhibition of Anti-Apoptotic PI3K/AKT Pathway

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computational Molecular Bioscience 2013年第3期3卷 39-52页

作者： pedro Pablo González-Pérez Maura cárdenas-García Departamento de Matemáticas Aplicadas y Sistemas Universidad Autónoma Metropolitana México D.F. México Facultad de Medicina Benemérita Universidad Autónoma de Puebla Puebla México

In recent years, the role of dietary phenolic compounds in the regulation of cellular metabolism in normal and pathological conditions has become increasingly important in cancer research. In most cases, the molecular mechanism of action related to the anticarcinogenic effect of phenolic compounds has been studied in vitro and in animal models, but these studies are still not complete. It is precisely here where in silico approaches can be an invaluable tool for complementing in vitro and in vivo research. In this paper, we adopt a tuple space-based modeling and simulation approach, and show how it can be applied to the simulation of complex interaction patterns of intracellular signaling pathways. Specifically, we are working to explore and to understand the molecular mechanism of action of dietary phenolic compounds on the inhibition of the PI3K/AKT anti-apoptotic pathway. As a first approximation, using the tuple spaces- based in silico approach, we model and simulate the anti-apoptotic PI3K/AKT pathway in the absence and presence of phenolic compounds, in order to determine the effectiveness of our platform, to employ it in future prediction of experimentally non visualized interactions between the pathway components and phenolic compounds.

关键词： Anti-Apoptotic Intracellular Signaling Pathway computer Simulation Self-Organizing coordination

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