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Analysis of the Identification of Local Agriculture Products in the Municipality of Aileu, Manufahi, and Ainaro That Have Potential for Export and Attract Foreign Investments in Agricultural Sector

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Agricultural Sciences 2023年第2期14卷 145-153页

作者： Vicente De Paulo Correia José Nelson Salsinha Oscar Da Silva Carlos Da Conceição De Deus Mateus De Jesus gomes graciano soares gomes Decio R. Sarmento National Center for Scientific Research (CNIC) National University of Timor Lorosa’e (UNTL) Dili Timor-Leste Lecturers of Agriculture Faculty National University of Timor Lorosa’e (UNTL) Dili Timor-Leste TradeInvest Dili Timor-Leste

The objective of this study is to identify and collect information on local agriculture products and identify local potential agriculture and livestock that can attract foreign investments. Used Stratified Random Sampling and data was collected from both primary and secondary data (both quantitative and qualitative data. The data analyzed used qualitative and quantitative analysis. The supply chain analysis was carried out to develop a description of the value chain to identify potential high-value market areas and current and potential products in the domestic and export markets. The results of the study revealed that most farmers in the research location grow different types of crops and livestock. In particular for Aileu and Ainaro where most of the areas are up-land, therefore, horticulture crops (mustard, cabbage, carrots, and tomato) and coffee are dominated in these areas. For Manufahi, some parts are lowland areas, where most crops grown are maize, cassava, and paddy rice. The study reveals that local potential agriculture products and livestock in the municipalities of Aileu, Ainaro, and Manufahi are vegetable, coffee, maize, and paddy rice, banana, shallot, tangerine, cabbage, carrot, cattle, mung-bean, and banana. To accelerate economic growth, in these municipalities, there is a need to modernize agricultural production, requiring markets for both inputs supply and for the sale of output products. Opportunities to increase the productivity of these products are feasible and this can be done through the use of high-variety seeds and better farm management, and the government and private sector can play an important role in improving productivity as this will have a further implication in improving food security.

关键词： Potential Product Investment Agriculture Livestock Market

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Study of Factors That Influence the Sustainability of Agricultural Development in the Bobonaro Municipality, Timor-Leste

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Agricultural Sciences 2022年第2期13卷 105-116页

作者： graciano soares gomes Carlito De Araújo Mali Code Vicente De Paulo Correia Oscar Da Silva Agostinho Da Cunha Moniz José Adriano Marçal Claudino Ninas Nabais Department of Animal Science National University of East Timor—UNTL Díli Timor-Leste Department of Agro Economic National University of East Timor—UNTL Díli Timor-Leste Department of Agronomy National University of East Timor—UNTL Díli Timor-Leste East Timor National Institute of Science and Technology—INCT-TL Díli Timor-Leste

The aim of the study is to assess the factors that influence the sustainability of agricultural development. The study was carried out in the municipality of Bobonaro for about four months, from July to October 2021. Slovin’s method was used to determine the sample size, with a desired percentage of 10% of the total population. Thus, 154 producers were interviewed as respondents and key persons in the area of agriculture. The variables interviewed are the main factors of agricultural productivity and the factors that affect sustainable agricultural development. The results of the descriptive statistical analysis of the data showed that about 94.87% of the respondents’ productive area is in operation, with an average of 1.84 ha per respondent and the abandoned area around 0.11 ha per respondent. The average value of rice production is 2.38 ton per ha and corn 1.07 ton per ha. About 87% of producers raised the main types of animals such as cattle, pigs, goats with an average density of 2 to 5 animals per establishment. About 61% of producers have access to the market at a normal price for agricultural products. The factors that hinder less successful agricultural development, such as: those of nature with the greatest impact are climate changes, which influence changes in cultivation sessions and in the characteristics of productive soils, availability of water for irrigation and animal feed. On the socioeconomic side, it includes the willingness or interest of young people who want to work as farmers, less investment and the impact of the Covid-19 pandemic. It is concluded that natural and socioeconomic impacts can reduce agricultural productivity, so that this will be a major challenge for the development of the agricultural sector in the future.

关键词： Land Productivity Sustentability Agricultural Production Factors

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Characterization Production Systems and Productivity Indices of Local Pigs of East Timor

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Journal of Agricultural Science and Technology(A) 2020年第3期10卷 147-150页

作者： graciano soares gomes Carlito de Araujo Mali Code Department of Animal Science Faculty of AgricultureNational University Timor Lorosa'eP.O.Box 10000DiliEast Timor

The objective of this study was to evaluate the production system and productivity indices of local swine raised in subsistence production system in East *** 1,096 respondents were interviewed in fitting villages in eight *** each village,10%of breeders were interviewed as respondents,using simple random method and the interviews based on established *** was observed that about 80%-90%of total respondents still used subsistence production *** result of descriptive statistical analysis showed that the average of piglets per litter was 4-6 and weight of piglets at birth was 0.97±0.22 *** age of weaning of piglets and the weaning weight was 3.94±0.72 months and 5.56±0.88 kg,*** age of the first breeding gilts was 8-10 months;calving interval was 6-12 *** period of females was 3-12 years,and the number of mortality rate of piglets was 0.17%to 1%per production *** it was concluded that the subsistence production system could affect the productivity level of local pigs.

关键词： Production subsistence systems productivity indices local pigs

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Agricultural Sciences（农业科学） 2023年第2期

作者： Vicente De Paulo Correia José Nelson Salsinha Oscar Da Silva Carlos Da Conceição De Deus Mateus De Jesus gomes graciano soares gomes Decio R. Sarmento

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Supergiant Barocaloric Effects in Acetoxy Silicone Rubber over a Wide Temperature Range:Great Potential for Solid-state Cooling

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Chinese Journal of Polymer Science 2020年第9期38卷 999-1005,I0008页

作者： William Imamura Erik Oda Usuda Lucas soares Paixao Nicolau Molina Bom Angelo Marcio gomes Alexandre Magnus gomes Carvalho Faculdade de Engenharia Mec(a)nica UNICAMPCEP 13083-860CampinasSPBrazil Universidade Federal de Sāo Paulo UNIFESPCEP 09913-030DiademaSPBrazil Instituto de Física Gleb Wataghin UNICAMPCEP 13083-859CampinasSPBrazil Catalan Institute of Nanoscience and Nanotechnology ICN208860 BelaterraBarcelonaSpain The Institute of Photonic Sciences ICFO08193 CastelldefelsBarcelonaSpain Instituto de Física UFRJCEP 21941-972Rio de JaneiroRJBrazil Departamento de Engenharia Mec(a)nica UEMCEP 87020-900MaringáPRBrazil

Solid-state cooling based on caloric effects is considered a viable alternative to replace the conventional vapor-compression refrigeration *** barocaloric materials,recent results show that elastomers are promising candidates for cooling applications around *** the present paper,we report supergiant barocaloric effects observed in acetoxy silicone rubber—a very popular,low-cost and environmentally friendly *** values of adiabatic temperature change and reversible isothermal entropy change were obtained upon moderate applied pressures and relatively low *** huge barocaloric changes are associated both to the polymer chain rearrangements induced by confined compression and to the first-order structural *** results are comparable to the best barocaloric materials reported so far,opening encouraging prospects for the application of elastomers in near future solid-state cooling devices.

关键词： Solid-state cooling Barocaloric effect Elastomer Silicone rubber Crystalline-amorphous transition

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Development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

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Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： Maria Renata Valente Brandão Freire Natália Marchesan Bexiga Marco Antonio Stephano João Ezequiel Oliveira Carlos Roberto Jorge soares Ana Cláudia Camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza Laura Fernanda Garcia Luiz Felipe S. Teixeira Maria Helena Marumo Bellini Natanael gomes da Silva Luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. The development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. The direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ITG and Eckert & Ziegler). The radiochemical purity was evaluated by TLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ITG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. The results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane Antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PET Imaging

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High Frequency of Antiviral Resistance Mutations in HBV Genotypes A2 and H: Multidrug Resistance Strains in Mexico

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1023-1034页

作者： Alexis Jose-Abrego Sonia Roman João Renato Rebello Pinho Michele soares gomes-Gouvêa Arturo Panduro Department of Genomic Medicine in Hepatology Civil Hospital of Guadalajara“Fray Antonio Alcalde”GuadalajaraJaliscoMexico Health Sciences Center University of GuadalajaraGuadalajaraJaliscoMexico LIM07 Department of GastroenterologyUniversity of São PauloSão PauloBrazil Hospital Israelita Albert Einstein São PauloBrazil

Background and Aims:Lamivudine(3TC),telbivudine(LdT),entecavir(ETV),adefovir(ADF),and tenofovir(TFV)are drugs used to treat hepatitis B virus(HBV)infection,but specific mutations allow some viruses to become resistant to antiviral drugs or to acquire immune escape *** mutations have not been thoroughly investigated in *** study aimed to estimate the prevalence of HBV antiviral resistance and escape ***:This cross-sectional study analyzed 158 *** DNA was extracted,amplified,and sequenced in serum samples using the spin column method,PCR assay,and Sanger’s sequencing,*** genotypes were determined,and HBV mutations were tested using the Geno2pheno ***:Overall,68.4%(108/158)of HBV patients were infected with genotype H,followed by G(11.4%,18/158),A2(10.8%,17/158),F1b(6.9.0%,11/158),D(1.9%,3/158),and E(0.6%,1/158),and 5.1%(8/158)had evidence of *** prevalence of resistance mutations was 8.2%(13/158)and the most common combined mutation was rt180M+***,we found the combinations rt180M+rt204V+rt173L(n=2)and rt180M+rt204V+rt202G(n=1)that confer multidrug resistance to 3TC,LdT,and *** mutations were found in genotypes A2(11.8%,2/17),and H(10.2%,11/108),and escape mutations were detected in HBV genotypes A2(11.8%,2/17),H(10.2%,11/108),F1b(9.1%,1/11)and G(5.6%,1/18).Conclusions:The highest prevalence of antiviral resistance mutations or escape mutations was detected in HBV genotypes A2 and *** earliest cases of HBV multidrug resistance were detected in Mexico.

关键词： Hepatitis B virus Drug resistance mutations Multidrug resistance strain Immune escape

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Waste Tire Rubber-based Refrigerants for Solid-state Cooling Devices

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Chinese Journal of Polymer Science 2020年第7期38卷 769-775,I0007页

作者： Nicolau Molina Born Erik Oda Usuda Mariana da Silva Gigliotti Denílson JoséMarcolino de Aguiar William Imamura Lucas soares Paixao Alexandre Magnus gomes Carvalho Catalan Institute of Nanoscience and Nanotechnology(ICN2) 08860BellaterraBarcelonaSpain The Institute of Photonic Sciences(ICFO) 08193CastelldefelsBarcelonaSpain Universidade Federal de Sāo Paulo(UNIFESP) 00972-270DiademaSPBrazil Instituto de Física"Gleb Wataghin" Universidade Estadual de Campinas(UNICAMP)13083-970CampinasSPBrazil Universidade Tecnológica Federal do Paraná(UTFPR) 84017-220Ponta GrossaPRBrazil Faculdade de Engenharia Mec(a)nica Universidade Estadual de Campinas(UNICAMP)13083-860CampinasSPBrazil Departamento de Engenharia Mec(a)nica Universidade Estadual de Maringá(UEM)870-900MaringáPRBrazil

Management of discarded tires is a compelling environmental issue *** there are several approaches developed to recycle waste tire rubbers,their application in solid-state cooling is still *** the high barocaloric potential verified for elastomers,the use of waste tire rubber(WTR)as a refrigerant in solid-state cooling devices is very ***,we investigated the barocaloric effects in WTR and polymer blends made of vulcanized natural rubber(VNR)and WTR,to evaluate its feasibility for solid-state cooling *** adiabatic temperature changes and the isothermal entropy changes reach giant values,as well as the performance parameters,being comparable or even better than most barocaloric materials in ***,pure WTR and WTR-based samples also present a faster thermal exchange than VNR,consisting of an additional advantage of using these discarded ***,the present findings evidence the encouraging perspectives of employing waste rubbers in solid-state cooling based on barocaloric effects,contributing to both the recycling of polymers and the sustainable energy technology field.

关键词： Waste tire rubber Solid-state cooling Barocaloric effect Tire recycling Sustainable energy

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Acute calculous cholecystitis: Review of current best practices

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World Journal of Gastrointestinal Surgery 2017年第5期9卷 118-126页

作者： Carlos Augusto gomes Cleber soares Junior Salomone Di Saveiro Massimo Sartelli Michel Denis Kelly Camila Couto gomes Felipe Couto gomes Lívia Dornellas Correa Camila Brandao Alves Samuel de Fádel Guimaraes Surgery Depart-ment Hospital Universitário Therezinha de Jesus Faculdade de Ciências Médicas e da Saúde Juiz de Fora Trauma Surgery Unit Maggiore Hospital Department of Surgery Macerata Hospital Acute Surgical Unit Canberra Hospital Surgery Department Hospital Gover-nador Israel Pinheiro (HGIP IPSEMG) Internal Medicine Unit Hospital Universitário Therezinha de Jesus Faculdade de Ciências Médicas e da Saúde Juiz de Fora

Acute calculous cholecystitis(ACC) is the most frequent complication of cholelithiasis and represents one-third of all surgical emergency hospital admissions, many aspects of the disease are still a matter of debate. Knowledge of the current evidence may allow the surgical team to develop practical bedside decision-making strategies, aiming at a less demanding procedure and lower frequency of complications. In this regard, recommendations on the diagnosis supported by specific criteria and severity scores are being implemented, to prioritize patients eligible for urgency surgery. Laparoscopic cholecystectomy is the best treatment for ACC and the procedure should ideally be performed within 72h. Early surgery is associated with better results in comparison to delayed surgery. In addition, when to suspect associated common bile duct stones and how to treat them when found are still debated. The antimicrobial agents are indicated for high-risk patients and especially in the presence of gallbladder necrosis. The use of broad-spectrum antibiotics and in some cases with antifungal agents is related to better prognosis. Moreover, an emerging strategy of not converting to open, a difficult laparoscopic cholecystectomy and performing a subtotal cholecystectomy is recommended by adept surgical teams. Some authors support the use of percutaneous cholecystostomy as an alternative emergency treatment for acute Cholecystitis for patients with severe comorbidities.

关键词： Cholecystitis Cholelithiasis Biliary stones Cholecystectomy Laparoscopy

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On the ＂good understanding＂ of the Scientific Spirit： The Use of Metaphors and Images in the Physical Sciences

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Journal of Philosophy Study 2011年第5期1卷 327-333页

作者： Aiamare Maiare Marques soares Allan Esteves gomes Filipe soares da Cruz ＂Readings in Human Sciences＂ Group of the ICT-UFVJM

In Bachelard＇s thought, the understanding ＂of the other＂ in scientific thought is given usually by means of empirical or rational discourse. However, it is not unusual to realize the emphasis of scientific thought as rationally justifiable. Certainly, the dynamics of scientific thought throughout history has not been indifferent to other possibilities of epistemological construction. We cannot escape the facts： Science needs linguistic devices to strengthen its principles and criteria for validation. The aim of this paper is to answer, based on a new conception of metaphor, under what conditions metaphor can be a ＂physical metaphor＂ and the extent to which the symbolism in general brings a special light gain of sense to the understanding of physical reality that surrounds us.

关键词： Bachelard Benjamin physics raetaphor image

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