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Lymphoproliferative disorders in inflammatory bowel disease patients on immunosuppression: Lessons from other inflammatory disorders

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World Journal of Gastrointestinal Pathophysiology 2015年第4期6卷 181-192页

作者： grace y lam Brendan P Halloran Anthea C Peters Richard N Fedorak Department of Medicine Division of Internal Medicine University of Alberta Department of Medicine Division of Gastroenterology University of Alberta Department of Medicine Division of HematologyUniversity of Alberta

Immunosuppressive agents, such as thiopurines, methotrexate, and biologics, have revolutionized the treatment of inflammatory bowel disease(IBD). However, a number of case reports, case control studies and retrospective studies over the last decade have identified a concerning link between immunosuppression and lymphoproliferative disorders(LPDs), the oncological phenomenon whereby lymphocytes divide uncontrollably. These LPDs have been associated with Epstein-Barr virus(EBV) infection in which the virus provides the impetus for malignant transformation while immunosuppression hampers the immune system's ability to detect and clear these malignant cells. As such, the use of immunosuppressive agents may come at the cost of increased risk of developing LPD. While little is known about the LPD risk in IBD, more is known about immunosuppression in the post-transplantation setting and the development of EBV associated posttransplantation lymphoproliferative disorders(PTLD). In review of the PTLD literature, evidence is available to demonstrate that certain immune suppressants such as cyclosporine and T-lymphocyte modulators in particular are associated with an increased risk of PTLD development. As well, high doses of immunosuppressive agents and multiple immunosuppressive agent use are also linked to increased PTLD development. Here,we discuss these findings in context of IBD and what future studies can be taken to understand and reduce the risk of EBV-associated LPD development from immunosuppression use in IBD.

关键词： Epstein-Barr virus Immunosuppression Post-transpla

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Effect of Scutellariae Radix extract on experimental dextran-sulfate sodium-induced colitis in rats

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World Journal of Gastroenterology 2007年第42期13卷 5605-5611页

作者： Ho-lam Chung grace Gar-Lee yue Ka-Fai To ya-Lun Su yu Huang Wing-Hung Ko Department of Physiology Faculty of MedicineThe Chinese University of Hong Kong Shatin Hong Kong China Institute of Chinese Medicine The ChineseUniversity of Hong Kong Shatin Hong Kong China Department of Anatomical and Cellular Pathology Faculty of Medicine The Chinese University of Hong KongShatin Hong Kong China Institute of Materia Medica Chinese Academy ofMedical Sciences and Peking Union Medical College Beijing100050 China Department of Physiology and LiKa Shing Institute of Health Sciences Faculty of Medicine TheChinese University of Hong Kong Shatin Hong Kong China

AIM： To investigate the effect of Scutellariae Radix extract （SRE） on ulcerative colitis （UC） in rats induced by dextran-sulfate sodium （DSS）. METHODS： Colitis was induced in male Sprague-Dawley （SD） rats （170-180 g） by 4% dextran sulfate sodium （DSS, wt/v, MW 54000） in drinking water for 8 d. The treated rats received 4% DSS and SRE orally （100 mg/kg per day）. Control rats received either tap water or SRE only. Macroscopic assessment which included body weight changes, fecal occult blood and stool consistency were determined daily. At the appointed time, the rats were sacrificed and the entire colons were removed. The colon length and the myeloperoxidase （MPO） activity were measured. The severity of colitis was graded by morphological and histological assessments. The ion transport activity of the colonic mucosa was assessed by electrophysiological technique. RESULTS： Rats treated with oral administration of 4% DSS regularly developed clinical and macroscopic signs of colitis. Treatment with SRE relieved the symptoms, including the reduction in body weight, shortening 2nd ulceration of the colon. Administration of SRE also significantly reduced the histological damage induced by DSS. Moreover, the Isc responses of the colonic mucosa to forskolin, were suppressed after the induction of colitis. The stimulated ion transport activity of DSS-rats treated with SRE displayed significant improvement in the secretory responsiveness. CONCLUSION： SRE was effective in treating acute DSS- induced ulcerative colitis, as gauged by reduced clinical disease, improved macroscopic and histological damage scores, and enhanced recovery of normal colonic secretory function.

关键词： Ulcerative colitis Scutellariae Radix Inflammatory bowel disease Colonic ion transport Traditional Chinese medicine

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New actions for nicotine in the gastrointestinal tract

New actions for nicotine in the gastrointestinal tract

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中国药理学会第八次全国代表大会

作者：曹之宪 SHIN Vivian - yvonne yE grace yi - Ni LIU Edgar Shiu - lam Department of Pharmacology The University of Hong Kong Hong Kong China

AIM:Previous studies showed that cigarette smoking was associated with gastric *** is one of-the most representative compounds in cigarette smoke, which has long been considered to exhibit many of the tobacco effects including those in the gastrointestinal *** study reports the new actions of nicotine on wound repair and also on the tumorigenesis in the gastrointestinal tract,which could have signifcant clinical implications in ***:*** of cell

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Current status of yttrium-90 microspheres radioembolization in primary and metastatic liver cancer

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Journal of Interventional Medicine 2023年第4期6卷 152-158页

作者： yasaman Anbari Floortje E.Veerman grace Keane Arthur J.A.T.Braat Maarten L.J.Smits Rutger C.G.Bruijnen Wenle Tan ye Li Feng Duan Marnix G.E.H.lam University Medical Center Utrecht Utrechtthe Netherlands Interventional Radiology Department Chinese PLA General HospitalBeijingChina

Liver malignancy,including primary liver cancer and metastatic liver cancer has become one of the most common causes of cancer-related death worldwide due to the high malignant degree and limited systematic treatment *** with yttrium-90(^(90)y)-loaded microspheres is a relatively novel technology that has made significant progress in the local treatment of liver *** different steps in the extensive work-up of radioembolization for patients with an indication for treatment with^(90)y microspheres,from patient selection to follow up,both technically and clinically,are discussed in this *** describes the application and development of^(90)y microspheres in the treatment of liver cancer.

关键词： yttrium-90 microspheres Primary liver cancer Metastatic liver cancer Selective internal radiation therapy Trans-arterial radioembolization

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中国和印度的投资策略——殊途同归

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金融发展评论 2011年第3期 5-25页

作者：沈明高 Aditya Narain Daniel lam Rohini Malkani grace lam Jitender Tokas 花旗集团 Pan-Asia Derivatives/Multi Strategist India Economist

两国共舞——中国和印度两国似乎越来越被认为是全球的动荡因素。长期来看,中国必须依赖于消费增长,而印度则必须加强其基础设施和制造业的发展。这两个新兴巨人能否取得最终成功的关键,均在于如何管理经济增长和进一步完善政府机制。... 详细信息

两国共舞——中国和印度两国似乎越来越被认为是全球的动荡因素。长期来看,中国必须依赖于消费增长,而印度则必须加强其基础设施和制造业的发展。这两个新兴巨人能否取得最终成功的关键,均在于如何管理经济增长和进一步完善政府机制。短期来看,中国和印度是两个不同的经济体。首先,中国更加依赖于全球消费。

关键词：印度经济花旗集团投资策略研究与分析资料来源投资研究股票市场中国政府基础设施外国直接投资

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Perceived roles,benefits and barriers of virtual global health partnership initiatives:a cross-sectional exploratory study

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Global Health Research and Policy 2022年第1期7卷 471-481页

作者： Lisa Umphrey George Paasi William Windsor grace Abongo Jessica Evert Heather Haq Elizabeth M.Keating Suet Kam lam Megan S.McHenry Carolyne Ndila Charles Nwobu Amy Rule Reena P.Tam Daniel Olson Peter Olupot-Olupot Department of Pediatrics University of Colorado School of Medicine13123 E 16th AveB302AuroraCO 80045USA Center for Global Health Colorado School of Public Health13199 E Montview BlvdSte 310A090AuroraCO 80045USA Mbale Clinical Research Institute Plot 2933 PallisaMbaleUganda Child Family Health International 11135 San Pablo Ave#929El CerritoCA 94530USA Department of Pediatrics Baylor College of Medicine1 Baylor PlazaHoustonTX 77030USA Division of Pediatric Emergency Medicine University of Utah School of Medicine30 N 1900 ESalt Lake CityUT 84132USA Cleveland Clinic Lerner College of Medicine Case Western Reserve University School of MedicineEC-10 Cleveland Clinic9501 Euclid AveClevelandOH 44195USA Department of Pediatrics Indiana University School of Medicine340 W 10th StIndianapolisIN 46202USA Child Family Health International AccraGhana Cincinnati Children’s Hospital Medical Center University of Cincinnati College of Medicine3333 Burnet AveCincin-natiOH 45229USA Department of Pediatrics University of Utah School of Medicine30 N 1900 ESalt Lake CityUT 84132USA Busitema University P.O.Box 1460MbaleUganda

Background:Virtual global health partnership initiatives(VGHPIs)evolved rapidly during the COVID-19 pandemic to ensure partnership *** the current landscape for VGHPI use and preference is *** study aimed to increase understanding of GH partners’perspectives on ***:From 15 October to 30 November 2020,An online,international survey was conducted using snowball sampling to document pandemic-related changes in partnership activities,preferences for VGHPIs,and perceived acceptability and *** survey underwent iterative development within a diverse author group,representing academic and clinical institutions,and the non-profit *** from their professional global health networks were invited,including focal points for global health partnerships while excluding trainees and respondents from the European Economic *** stratified responses by country income classification and partnership *** used descriptive statistics to characterize responses,defining statistical significance asα=***:A total of 128 respondents described 219 partnerships.152/219(69%)partnerships were transnational,157/219(72%)were of>5 years duration,and 127/219(60%)included bidirectional site ***-income country(HIC)partners sent significantly more learners to low-to middle-income country(LMIC)partner sites(py,technological capacity,and VGHPI preferences between LMIC and HIC respondents,with a statistically significant difference in VGHPI acceptability(p<0.001).There was no significant difference between groups regarding VGHP

关键词： Global health Partnership Virtual Pandemic

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Upfront consolidation treatment with 131I-mIBG followed by myeloablative chemotherapy and hematopoietic stem cell transplantation in high-risk neuroblastoma

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Pediatric Investigation 2020年第3期4卷 168-177页

作者： Jianhua Feng Frankie WT Cheng Alex WK Leung Vincent Lee Eva WM yeung Hoi Ching lam Jeanny Cheung grace KS lam Terry TW Chow Carol LS yan Chi Kong Li Department of Paediatrics The Chinese University of Hong KongHong KongChina Department of Paediatrics The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Department of Paediatrics and Adolescent Medicine Hong Kong Children’s HospitalHong KongChina Department of Clinical Oncology Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina

Importance:131I-metaiodobenzylguanidine(131I-mIBG)has a significant targeted antitumor effect for ***,currently there is a paucity of data for the use of 131I-mIBG as a"front-line"therapeutic agent in those patients with newly diagnosed high-risk neuroblastoma as part of the conditioning regimen for myeloablative chemotherapy(MAC).Objective:To evaluate the feasibility of upfront consolidation treatment with 131I-mIBG plus MAC and hematopoietic stem cell transplantation(HSCT)in high-risk neuroblastoma ***:A retrospective,single-center study was conducted from 2003-2019 on newly diagnosed high-risk neuroblastoma patients without progressive disease(PD)after the completion of induction *** received 131I-mIBG infusion and MAC followed by ***:A total of 24 high-risk neuroblastoma patients were enrolled with a median age of 3.0 years at *** receiving this sequential consolidation treatment,3 of 13 patients who were in partial response(PR)before 131I-mIBG treatment achieved either complete response(CR)(n=1)or very good partial response(VGPR)(n=2)after *** a median follow-up duration of 13.0 months after 131I-mIBG therapy,the 5-year event-free survival and overall survival rates estimated were 29%and 38%for the entire cohort,and 53%and 67%for the patients who were in CR/VGPR at the time of 131I-mIBG ***:Upfront consolidation treatment with 131I-mIBG plus MAC and HSCT is feasible and tolerable in high-risk neuroblastoma patients,however the survival benefit of this 131I-mIBG regimen is only observed in the patients who were in CR/VGPR at the time of 131I-mIBG treatment.

关键词： Neuroblastoma 131I-mIBG Transplantation

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Applications of High Resolution Magic Angle Spinning (HR/MAS) NMR for Combinational Chemistry

Applications of High Resolution Magic Angle Spinning (HR/MAS...

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8th Chinese International Peptide Symposium

作者： Kit S.lam University of California Davis Cancer Center4501 X StreetSacramentoCalifornia 95817USA

The conditions of HR/MAS NMR on solid-support were systematically evaluated including resins, solvents and temperatures. The results demonstrated that both resin and solvent are critical factors influencing 1H line-widths, however, the temperature is not. Direct O-glycosylation of amino acids bound to TentaGel resin with a number of glycosyl trichloroacetimidate donors were systematically studied through HR/MAS NMR analysis . The results concluded that Gal-Thr, Glu-Ser, Gal-Ser, Lac-Ser, Glu-Tyr, Man-Tyr, Lac-Tyr, and Mal-Tyr on TentaGel resin produced an excess of over 90% yield. HR/MAS NMR studies demonstrated that the conformation of PEGA-bound

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Germination and Early Seedling Growth of Moringa oleifera lam with Different Seeds Soaking Time and Substrates at the yongka Western Highlands Research Garden Park (yWHRGP) Nkwen-Bamenda, North-West Cameroon

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American Journal of Plant Sciences 2016年第15期7卷 2173-2185页

作者： Bernard Palmer Kfuban yerima grace Mbakpor Ayuk Roger Kogge Enang Nicole Guehjung yanick Alphonse Tiamgne Department of Soil Science University of Dschang Dschang Cameroon Department of Crop Production University of Dschang Dschang Cameroon Ministry of Agriculture and Rural Development West Region Cameroon

Moringa oleifera is a multipurpose tree used to remedy problems related to food insecurity and soil fertility degradation. Proper husbandry of this crop is contingent on the use of seedlings of good quality. This study aimed at assessing the germination and early seedling growth with different soaking durations and substrates composition. The seeds were obtained from the Far North region of Cameroon. A randomized complete block design with three replications was used. Two factors were tested;soaking duration with 4 treatment levels of 0 day, 4 days, 8 days and 12 days and substrates with 8 treatment levels: 100% soil, 75% soil + 25% poultry manure (PM), 50% soil + 50% PM, 25% soil + 75% PM, 100% sand, 75% sand + 25% PM, 50% sand + 50% PM and 25% sand + 75% PM. Germinated seeds and growth parameters were collected after every 5 days. The results showed that soaking duration and substrate composition influence germination and initial development of M. oleifera (p ≤ 0.05). At 25 days after soaking (DAS), soaking durations of 0 day (68.7%) and 8 days (53.1%) showed the highest germination percentages while seeds soaked for 12 days occupied the least position with 37.5%. At the same time, 75% soil + 25% PM (68.7%), 100% sand (64.5%) and 100% soil (60.5%) with the unsoaked seeds showed the highest germination percentages. The least germination percentages were represented by 50% sand + 50% PM and 25% sand + 75% PM with 35.5% and 27%, respectively. Unsoaked seeds with the substrates of 50% soil + 50% PM are the best practice for M. oleifera seedling production in the nursery.

关键词： Soaking Substrate Composition Germination Initial Growth Western Highlands

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澳门社区专科护士培训的发展及反思

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中华护理教育 2014年第3期11卷 205-208页

作者：林爱贞孟丽荣澳门理工学院高等卫生学校

社区专科护士是医疗团队中的重要成员,在个人、家庭和社区健康促进、疾病预防的初级卫生保健服务中担当重要角色。该文旨在描述澳门特别行政区社区专科护士培训的起源和发展,分析现状,展望未来,并对社区专科护士培训提出建议。

关键词：社区卫生服务专科护士教育,护理

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