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Obesity in children and adolescents:Overview of the diagnosis and management

Chronic Diseases and Translational Medicine 2023年第2期9卷 122-133页

作者： Joanna Y.L.Tung grace w.k.poon Juan Du kenneth k.Y.wong Department of Paediatrics and Adolescent Medicine The University of Hong KongPokfulamHong KongChina Department of Paediatrics and Adolescent Medicine Hong Kong Children's HospitalHong KongChina Department of Endocrinology Jilin Province People's HospitalJilinChina The Paediatric Precision Medicine Centre Children's Hospital of ChangchunJilinChina Department of Surgery The University of Hong KongPokfulamHong KongChina

Childhood obesity is one of the biggest public health challenges *** is associated with various adverse health consequences throughout *** and early intervention represent the most reasonable and costeffective *** progress has been achieved in the management of obesity in children and adolescents;yet,implementation in the real world remains a *** article aimed to present an overview of the diagnosis and management of obesity in children and adolescents.

关键词： adolescent children diagnosis management obesity

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Novel mitochondrial 16S rRNA mutation, 3200T→C, associated with adult-onset type 2 diabetes

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Chinese Medical Journal 2002年第5期115卷 753-758页

作者：杨涛林青云曾文和汤瑞芬甘尔惠陈婉珊潘妙娟巫向前彭智培 Department of Chemical Pathology the Chinese University of Hong KongHong KongChina Department of Ophthalmology&Visual Sciences the Chinese University of Hong KongHong KongChina Department of Medicine United Christian HospitalHong KongChina Department of Medical Genetics Institute of Basic Medieal SciencesChinese Acadelny of Medical Sciences&Peking Union Medieal CollegeBeijing 100005China Heahh School Shanghai Second Medical UniversityShanghai 2O0025China

Objective To investigate the role of a potential diabetes related mitochondrial region, which includes two previously reported mutations, 3243AG and 3316GA, in Chinese patients with adult onset type 2 diabetes Methods A total of 277 patients and 241 normal subjects were recruited for the study Mitochondrial nt 3116-3353, which spans the 16S rRNA, tRNA leu(UUR) and the NADH dehydrogenase 1 gene, were detected using polymerase chain reaction (PCR), direct DNA sequencing, PCR restriction fragment length polymorphism and allele specific PCR Variants were analyzed by two tailed Fisher exact test The function of the variants in 16S rRNA were predicted for minimal free energy secondary structures by RNA folding software mfold version 3 Results Four homoplasmic nucleotide substitutions were observed, 3200TC, 3206CT, 3290TC and 3316GA Only the 3200TC mutation is present in the diabetic population and absent in the control population No statistically significant associations were found between the other three variants and type 2 diabetes The 3200TC and 3206CT nucleotide substitutions located in 16S rRNA are novel variants The 3200TC caused a great alteration in the minimal free energy secondary structure model while the 3206CT altered normal 16S rRNA structure little Conclusions The results suggest that the 3200TC mutation is linked to the development of type 2 diabetes, but that the other observed mutations are neutral In contrast to the Japanese studies, the 3316GA does not appear to be related to type 2 diabetes

关键词： type 2 diabetes · mitochondrial DNA · 16S ribosomal RNA · RNA secondary structure modeling

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