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儿童嗓音障碍行为学干预的研究进展

听力学及言语疾病杂志 2024年第2期32卷 176-181页

作者：刘恒鑫王华郝建萍阳杨庞子建傅思颖国家儿童医学中心首都医科大学附属北京儿童医院耳鼻咽喉头颈外科儿童耳鼻咽喉头颈外科疾病北京市重点实验室北京100045 北卡罗来纳中央大学成都中医药大学北京语言大学中国台湾台北美国学校马偕医学院中国台湾

本文对儿童嗓音障碍的概况、影响及评估进行了概述,并根据语言治疗及听力学领域临床成果研究的五个模式,将儿童嗓音障碍行为学干预的研究进行了梳理。模式一为治疗选择及疗效预估研究;模式二为疗效探索及临床试验准备研究;模式三为临床... 详细信息

本文对儿童嗓音障碍的概况、影响及评估进行了概述,并根据语言治疗及听力学领域临床成果研究的五个模式,将儿童嗓音障碍行为学干预的研究进行了梳理。模式一为治疗选择及疗效预估研究;模式二为疗效探索及临床试验准备研究;模式三为临床实施及疗效验证研究;模式四为探索不同治疗方式的比较性研究;模式五为分析社会成本的研究。通过该模式的梳理为科研及临床人员给与参考。

关键词：儿童嗓音障碍声带小结嗓音评估嗓音行为学干预

Neurocognitive Profile of People Living with Human Immunodeficiency Virus Initiating Treatment in Kinshasa in the Dolutegravir Era, Democratic Republic of Congo

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Neuroscience & Medicine 2024年第1期15卷 1-22页

作者： Candide About Kabamba Berry Ikolango Bongenya Jocelyn Ewuti Nonga Lambert Omombo Losenga Noëlla Maketi Dikati Thérèse Kasaka Ntumba grace Ipaya Booto Rosalie Djamba Dembo Stéphanie Mauwa Selenge Benoit Obel Kabengele Guy Makila Mabe Bumoko Marie-Thérèse Ayane Safi Sombo Erick Ntambwe Kamangu Department of Neurology Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Faculty of Medicine Bel Campus Technological University Kinshasa Democratic Republic of Congo “Focus HIV/AIDS” Research Group Kinshasa Democratic Republic of Congo Department of Internal Medicine University Clinic of Kinshasa Kinshasa Democratic Republic of Congo Molecular Biochemistry Department Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo

Context: Antiretroviral therapies improve the prognosis of NeuroAIDS contrasting with a high frequency of Minor Neurocognitive Disorders (MND) even in aviremic subjects. Objective: The objective of this study is to present the neurological and cognitive profile of People Living with HIV (PLHIV) initiating antiretroviral treatment in Kinshasa in the era of Dolutegravir (DTG). Methods: This is a multicenter, cross-sectional study with a descriptive aim carried out in 16 HIV Outpatient Treatment Centers (OTC) in Kinshasa from October 4, 2021 to February 15, 2022. The International HIV Dementia Scale (IHDS) correlated with the Activities of Daily Living (IADL) scale facilitated the categorization of NeuroCognitive Disorders (NCD) of PLHIV evaluated after carrying out a summary neurological examination. Results: Of the 96 patients recruited, 56.3% were women with a sex ratio of 0.68. The average age was 40.1 ± 12.1 years. The secondary education level was the majority at 64.6%. Malaria (44.8%) and tuberculosis (32.3%) were more common as opportunistic infections. They were alcoholics in (30.2%). Their history was heart disease (15.6%), high blood pressure (18.8%);drug abuse (10.4%). The IHDS score was light in 55.2% of cases. The correlation between IHDS/IADL watches asymptomatic neurocognitive impairments (ANI) in 77.1%, almost all of subjects are found with normal overall functioning (94.8%) and a disturbed neurological examination in 53.1% of cases with a predominance of motor impairments in 79.1%. Conclusion: In view of these results, early and systematic screening of NCD and associated factors remains necessary in our context. .

关键词： IHDS Dolutegravir Initiation Kinshasa Neurological Profile PLHIV

Brain-derived neurotrophic factor and inflammation in depression:Pathogenic partners in crime?

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World Journal of Psychiatry 2022年第1期12卷 77-97页

作者： grace A Porter Jason C O’Connor Department of Pharmacology UT Health San AntonioSan AntonioTX 78229United States Department of Pharmacology University of Texas Health San AntonioSan AntonioTX 78229United States Audie L.Murphy VA Hospital South Texas Veterans Health SystemSan AntonioTX 78229United States

Major depressive disorder is a debilitating disorder affecting millions of people each ***-derived neurotrophic factor(BDNF)and inflammation are two prominent biologic risk factors in the pathogenesis of depression that have received considerable *** clinical and animal studies have highlighted associations between low levels of BDNF or high levels of inflammatory markers and the development of behavioral symptoms of ***,less is known about potential interaction between BDNF and inflammation,particularly within the central nervous *** evidence suggests that there is bidirectional regulation between these factors with important implications for the development of depressive symptoms and antidepressant *** levels of inflammatory mediators have been shown to reduce expression of BDNF,and BDNF may play an important negative regulatory role on inflammation within the *** this interaction more fully within the context of neuropsychiatric disease is important for both developing a fuller understanding of biological pathogenesis of depression and for identifying novel therapeutic *** we review these two prominent risk factors for depression with a particular focus on pathogenic implications of their interaction.

关键词： Brain-derived neurotrophic factor Microglia Neuroinflammation Growth factors Depression

Towards an actionable One Health approach

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贫困所致传染病(英文) 2024年第2期13卷 1-6页

作者： Zhang Xiao-Xi Lederman Zohar Han Le-Fei Schurer Janna M. Xiao Li-Hua Zhang Zhi-Bing Chen Qiu-Lan Pfeiffer Dirk Ward Michael P. Sripa Banchob Gabri?l Sarah Dhama Kuldeep Acharya Krishna Prasad Robertson Lucy J. Deem Sharon L. Aenishaenslin Cécile Dantas-Torres Filipe Otranto Domenico grace Delia Wang Yang Li Peng Fu Chao Poeta Patrícia Rahman Md. Tanvir Kassegne Kokouvi Zhu Yong-Zhang Yin Kun Liu Jiming Wang Zhao-Jun Guo Xiao-Kui Gong Wen-Feng Schwartl?nder Bernhard Ren Ming-Hui Zhou Xiao-Nong School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Institute of One Health Shanghai Jiao Tong University Shanghai People’s Republic of China Medical Ethics and Humanities Unit Hong Kong University Hong Kong People’s Republic of China Center for One Health University of Global Health Equity Butaro Rwanda College of Veterinary Medicine South China Agricultural University Guangzhou People’s Republic of China School of Ecology and Environment Hainan University Haikou Hainan People’s Republic of China Branch of animal and vector-borne diseases Division of Infectious Disease Control Chinese Center for Disease Control and Prevention Beijing People’s Republic of China Centre for Applied One Health Research and Policy Advice Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong Hong Kong SAR People’s Republic of China Department of Pathobiology and Population Sciences Royal Veterinary College London United Kingdom Sydney School of Veterinary Science The University of Sydney Camden Australia Tropical Disease Research Center Department of Tropical Medicine Faculty of Medicine Khon Kaen University Khon Kaen Thailand Laboratory of foodborne parasitic zoonoses Department of translational physiology infectiology and public health Chair Faculty Committee on Internationalisation Faculty of Veterinary Medicine Ghent University Merelbeke Belgium Division of Pathology ICAR-Indian Veterinary Research Institute (IVRI) Bareilly Uttar Pradesh India Department of Livestock Services Animal Quarantine Office-Kathmandu Budhanilkantha Kathmandu Nepal Parasitology Department of Paraclinical Sciences Faculty of Veterinary Medicine Norwegian University of Life Sciences ?s Norway One Government Drive Saint Louis Zoo Institute for Conservation Medicine St. Louis USA Groupe de Recherche en épidémi

Background Despite the increasing focus on strengthening One Health capacity building on global level, challenges remain in devising and implementing real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action Commission (OHAC) was established as an academic community for One Health action with an emphasis on research agenda setting to identify actions for highest *** text This viewpoint describes the agenda of, and motivation for, the recently formed OHAC. Recognizing the urgent need for evidence to support the formulation of necessary action plans, OHAC advocates the adoption of both bottom-up and top-down approaches to identify the current gaps in combating zoonoses, antimicrobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health *** By promoting broader engagement and connection of multidisciplinary stakeholders, OHAC envisions a collaborative global platform for the generation of innovative One Health knowledge, distilled practical experience and actionable policy advice, guided by strong ethical principles of One Health.

关键词： One Health Global Health One Health Action Commission Research agenda

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重庆家具销售企业员工保留率的影响因素研究

质量与市场 2024年第2期 125-128页

作者：陈棵棵玛丽格蕾丝·卡里多圣路易斯大学高级研究学院

员工保留率是企业发展的重要指标,其直接关系着企业的稳定性和可持续发展。因此,如何留住核心员工,激励他们不断创新创造,成为企业和组织急需解决的问题。本文采用了问卷调查的方法,收集了重庆8家著名家具销售企业的372名员工的问卷,综... 详细信息

员工保留率是企业发展的重要指标,其直接关系着企业的稳定性和可持续发展。因此,如何留住核心员工,激励他们不断创新创造,成为企业和组织急需解决的问题。本文采用了问卷调查的方法,收集了重庆8家著名家具销售企业的372名员工的问卷,综合分析了被调查者的封闭式问题答案,并结合分析结果评估了员工保留率的影响因素。问卷调查结果显示,外部因素、内部因素和个人因素均对员工保留率产生重要影响。

关键词：家具销售企业员工保留率外部因素内部因素个人因素

Understanding health literacy from a traditional Chinese medicine perspective

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Journal of Integrative Medicine 2023年第3期21卷 215-220页

作者： Zhiyi Qian grace Y.Wang Marcus Henning Yan Chen Centre for Medical and Health Science Education University of AucklandAuckland 1010New Zealand School of Psychology and Wellbeing University of Southern QueenslandToowoombaQueensland 4350Australia

Health literacy is critical to improving individual and public ***,indigenous perceptions of health are largely absent from Western-derived measurements,contributing to disparities in health outcomes between indigenous and non-indigenous *** is the country with the world's largest population and only officially introduced the term"health literacy"in *** measures of health literacy in China are primarily based on Western-derived constructs,which have been shown to have poor comparability to the unique dual medical system in *** its significant importance to health management globally,understanding health perceptions from a traditional Chinese medicine perspective is *** review explores the concept and core elements of indigenous health literacy,evaluates the existing definitions and measurement tools as applied to the concept,and proposes a new model of traditional Chinese medicine health literacy.

关键词： Traditional Chinesemedicine Health literacy Conceptual model Measurement

Risk profiles and outcomes of patients receiving antibacterial cardiovascular implantable electronic device envelopes:A retrospective analysis

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World Journal of Cardiology 2022年第3期14卷 177-186页

作者： David A Woodard grace Kim Kent R Nilsson Department of Cardiology Piedmont Heart InstituteAthensGA 30606United States Department of Medicine Augusta University-University of Georgia Medical PartnershipAthensGA 30606United States

BACKGROUND Cardiovascular implantable electronic devices(CIEDs)are implanted in an increasing number of patients each year,which has led to an increase in the risk of CIED *** CIED envelopes locally deliver antibiotics to the implant site over a short-term period and have been shown to reduce the risk of implant site *** envelopes are derived from either biologic or nonbiologic *** is a paucity of data examining patient risk profiles and outcomes from using these envelope materials in the clinical setting and comparing these results to patients receiving no envelope with their CIED *** To evaluate risk profiles and outcomes of patients who underwent CIED procedures with an antibacterial envelope or no *** After obtaining Internal Review Board approval,the records of consecutive patients who underwent a CIED implantation procedure by a single physician between March 2017 and December 2019 were retrospectively collected from our hospital.A total of 248 patients within this period were identified and reviewed through 12 mo of follow *** CIED procedures used either no envelope(n=57),a biologic envelope(CanGaroo®,Aziyo Biologics)that was pre-hydrated by the physician with vancomycin and gentamicin(n=89),or a non-biologic envelope(Tyrx^(TM),Medtronic)that was coated with a resorbable polymer containing the drug substances rifampin and minocycline by the manufacturer(n=102).Patient selection for receiving either no envelope or an envelope(and which envelope to use)was determined by the treating *** analyses were performed between the 3 groups(CanGaroo,Tyrx,and no envelope),and also between the No Envelope and Any Envelope groups by an independent,experienced *** On average,patients who received any envelope(biologic or non-biologic)were younger(70.7±14.0 vs 74.9±10.6,P=0.017),had a greater number of infection risk factors(81.2%vs 49.1%,P<0.001),received more high-

关键词： Cardiovascular implantable electronic device envelope Defibrillator Extracellular matrix Implantable cardioverter-defibrillator Infection Pacemaker

Stimuli-Responsive Organic Phase Change Materials:Molecular Designs and Applications in Energy Storage

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Accounts of Materials Research 2022年第6期3卷 634-643页

作者： My Le grace G.D.Han Department of Chemistry Brandeis UniversityWalthamMassachusetts 02453United States

Achieving a stable latent heat storage over a wide temperature range and a long period of time as well as accomplishing a controlled heat release from conventional phase change materials have remained prominent challenges in thermal energy *** the conventional phase change materials have the fixed phase transition temperatures under the standard ambient pressure,the latent heat storage is only viable at temperatures higher than their melting and crystallization *** the latent heat is stored in the liquid phase of materials,it is imperative to maintain the temperature of the system above its crystallization point to prolong the heat *** the continuous energy input or extensive insulation,the crystallization of liquid occurs spontaneously,leading to the loss of latent heat and a short heat storage ***,there exists a critical need to develop methods that enable the control over the phase transition of materials,unrestricted by the temperature of the *** successful development of such methods and materials in recent years has been viable through the incorporation of molecular switches that respond to external stimuli,notably light,electrochemical bias,and ions,by reversible structural *** have discovered novel functional organic material systems that exhibit solid-to-liquid phase transitions controlled by optical and electrical stimulation,along with other research *** development and optimization of such materials are enabled by the judicious molecular designs and *** this Account,we will introduce the cutting-edge design principles of controllable phase change materials that have demonstrated the storage of thermal energy for up to a couple of months without crystallization over a wide temperature range,from subzero to over 100℃,which addresses the major weakness of conventional phase change *** particular,materials that are controlled by solar irradiation and compounds that exhibit sub

关键词： crystallization latent Storage

Acute kidney injury and the compensation of kidney function after nephrectomy in living donation

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World Journal of Transplantation 2022年第8期12卷 223-230页

作者： Kenji Okumura Holly grace Hiroshi Sogawa Shigeyoshi Yamanaga Department of Surgery Westchester Medical Center/New York Medical CollegeValhallaNY 10595United States Department of Surgery New York Medical CollegeValhallaNY 10595United States Department of Surgery Japanese Red Cross Kumamoto HospitalKumamoto 861-8520Japan

Acute kidney injury(AKI)incidence is growing rapidly,and AKI is one of the predictors of inpatient *** nephrectomy,all the patients have decreased kidney function with AKI and recover from ***,the characteristic and behavior of AKI is different from usual AKI and compensatory kidney function has been well known in the postoperative setting,especially in living *** this review,we have focused on the compensation of kidney function after nephrectomy in living *** discuss factors that have been identified as being associated with kidney recovery in donors including age,sex,body mass index,remnant kidney volume,estimated glomerular filtration rate,and various comorbidities.

关键词： Acute kidney injury Kidney transplant donor Compensation Kidney function