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Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng grace lui Lowell Ling Agnes S.Y.Leung Chit Chow Siaw Shi Boon Wendy C.S.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li David Shu Cheong Hui Paul Kay Sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq Subgenomic RNA(sgRNA)

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Clinical features and treatment outcomes of endogenous Klebsiella endophthalmitis:a 12-year review

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1933-1940页

作者： Chun Yue Mak Mary Ho Lawrence Pui-leung Iu Helena Pui-yee Sin Li Jia Chen grace lui Marten Erik Brelen Alvin Lerrmann Young Department of Ophthalmology and Visual Sciences Prince of Wales HospitalNew TerritoriesHong KongChina Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongNew TerritoriesHong KongChina Division of Infectious Diseases Department of Medicine and Therapeuticsthe Chinese University of Hong KongNew TerritoriesHong KongChina

AIM:To identify the clinical features and treatment outcomes of endogenous Klebsiella pneumoniae endophthalmitis and investigate prognostic factors of poor visual ***:The clinical records of all patients diagnosed with endogenous Klebsiella endophthalmitis between January 2007 to December 2018 in Prince of Wales Hospital,Hong Kong,China were retrospectively *** ophthalmological examination findings were recorded in the case note,including visual acuity testing,slit-lamp examination,indirect ophthalmoscopy and B-scan ultrasonography if media opacity precluded fundus ***:A total of 18 eyes in 14 patients were *** involvement was noted in 4 patients(28.6%).Hepatobiliary sepsis was the source in 9 patients(64.3%).Culture of intraocular fluid was positive in 5 out of 18 eyes(27.8%).Mortality was noted in 2 patients(14.3%).Mean final visual acuity was 20/*** out of 16 eyes had total loss of sight(37.5%)and 3 eyes required evisceration(18.8%).Multivariate linear regression revealed poor presenting visual acuity(P=0.031)and lack of fundus view due to vitritis(P=0.02)as prognostic factors of poor visual ***:Visual outcome of endogenous Klebsiella endophthalmitis is *** presenting visual acuity and lack of fundus view predict poor visual *** index of suspicion for endophthalmitis is important in Klebsiella sepsis patients with complaints of ocular *** screening is recommended in noncommunicable patients with Klebsiella sepsis.

关键词： Klebsiella pneumoniae endogenous endophthalmitis screening liver abscess sepsis

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The impact of urological resection and reconstruction on patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)

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Asian Journal of Urology 2018年第3期5卷 194-198页

作者： grace Hwei Ching Tan Nicholas B.Shannon Claramae Shulyn Chia lui Shiong Lee Khee Chee Soo Melissa Ching Ching Teo Division of Surgical Oncology National Cancer Centre SingaporeSingapore Duke-NUS Medical School Singapore Department of Urology Singapore General HospitalSingapore

Objective:Cytoreductive surgery(CRS)and hyperthermic intraperitoneal chemotherapy(HIPEC)are increasingly being used to treat peritoneal *** resections and reconstruction(URR)are occasionally performed during the *** aim to evaluate the impact of these procedures on peri-operative outcomes of CRS and HIPEC ***:A retrospective review of a prospectively maintained database of all patients who underwent CRS-HIPEC from April 2001 to February 2016 was *** between patients who had surgery involving,and not involving URR were *** outcomes were the rate of major complications and the duration of stay in the intensive care unit(ICU)and *** outcomes were that of overall survival(OS)and prognostic factors that would indicate a need for ***:A total of 214 CRS-HIPEC were performed,21 of which involved a *** clinical characteristics did not vary between the groups(URR *** URR).Urological resections comprised of 52%bladder resections,24%ureteric resections,and 24%involving both bladder and ureteric *** bladder defects were closed primarily while ureteric reconstructions consisted of two end-to-end anastomoses,one ureto-uretostomy,five direct implantations into the bladder and three boari *** were more frequently required in patients with colorectal peritoneal disease(p Z 0.029),but was not associated with previous pelvic surgery(76%vs.54%,p Z 0.065).Patients with URR did not suffer more serious complications(14%vs.24%,p Z 0.42).ICU(2.2 days vs.1.4 days,p Z 0.51)and hospital stays(18 days vs.25 days,p Z 0.094)were not significantly *** a URR did not affect OS(p Z 0.99),but was associated with increased operation time(570 min vs.490 min,p Z 0.046).Conclusion:While concomitant URR were associated with an increase in operation time,there were no significant differences in postoperative complications or *** with colorectal peritoneal metastases a

关键词： Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Peritoneal carcinomatosis Urological procedures Urological reconstruction

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Overview of methodologies and statistical strategies in observational studies and meta-analyses on the risk of hepatocellular carcinoma in patients with chronic hepatitis B on entecavir or tenofovir therapy

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Hepatoma Research 2022年第1期8卷 143-156页

作者： Terry Cheuk-Fung Yip Vincent Wai-Sun Wong Mandy Sze-Man Lai Vicki Wing-Ki Hui Yee-KitTse grace Lai-Hung Wong Medical Data Analytics Centre Department of Medicine and TherapeuticsThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics 9/F Lui Che Woo Clinical Sciences BuildingPrince of Wales Hospital30-32 Ngan Shing StreetShatinHong KongChina Institute of Digestive Disease The Chinese University of Hong KongHong KongChina

Entecavir(ETV)and tenofovir disoproxil fumarate(TDF)are first-line antiviral therapies for patients with chronic hepatitis B(CHB)and reduce the risk of disease progression and liver-related complications,as well as improve survival by effectively suppressing viral ***,since the first publication in 2019 on a lower risk of hepatocellular carcinoma(HCC)in Korean patients receiving TDF than those receiving ETV,the topic has remained a hot and unsettled *** studies and meta-analyses have yielded conflicting *** HCC takes time to develop,studies are mainly observational to benefit from a larger sample size and longer follow-up that provides a higher statistical power to compare the two ***,TDF was available to CHB patients a few years later than ETV in most countries,thus leading to a difference in follow-up ***,despite studying the same topic,the difference in data sources and available parameters,inclusion and exclusion criteria,and use of statistical methods complicated the interpretation and comparison of the findings and contributed to between-study heterogeneity in *** review describes some caveats in interpreting and comparing the results from these observational studies and *** studies should explore better designed observational studies with high-quality data sources,and aggregation of patient data in metaanalysis to tackle between-study heterogeneity.

关键词： Bias confounding hepatitis B virus hepatocellular carcinoma liver cancer nucleos(t)ide analogues propensity score

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歧视感知、社会支持和希望对多民族种族群体消极情感的影响

歧视感知、社会支持和希望对多民族种族群体消极情感的影响

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第二十一届全国心理学学术会议

作者：蒋欣颖徐健捷 Edward C.Chang Olivia D.Chang Jerin Lee Abigael G.Lucas Mingqi Li K.Malulani Castro Savannah Pham grace Y.Cho Yena S.Purmasir Elizabeth A.Yu Kaidi Wu P.Priscilla lui David Rollock Paul Kwon Xinjie Chen Jameson K.Hirsch Elizabeth L.Jeglic 北京师范大学心理学部 Department of Psychology University of Michigan Department of Psychology Skidmore College Department of Psychology University of Maryland Department of Psychology Stanford University Department of Psychology Harvard University Department of Population Health NYU Langone Medical Center Department of Psychology Southern Methodist University Department of Psychological Sciences Purdue University Department of Psychology Washington State University Department of Psychology East Tennessee State University

多民族种族群体是指按照生活经验和传统民族分类,认同两种及以上民族遗产的群体。在美国,多民族人群增长速度是一般群体的三倍以上。以往研究表明,多民族种族个体的心理和行为问题比单一民族和少数民族群体更为严重。针对这一现状,研究... 详细信息

多民族种族群体是指按照生活经验和传统民族分类,认同两种及以上民族遗产的群体。在美国,多民族人群增长速度是一般群体的三倍以上。以往研究表明,多民族种族个体的心理和行为问题比单一民族和少数民族群体更为严重。针对这一现状,研究者们找到了多个保护性因素,但目前还没有人考虑过"希望"这一重要变量。希望在个体对消极心理问题的认知中起着重要作用,有助于缓解一系列消极心理适应问题。本研究采用了一般种族歧视量表(GEDS),两项来自于社交网络列表的问题(SNL:测量家庭和朋友支持),希望量表(HS:包含两个维度:希望效能(hope agency)和希望手段(hope pathways)),宾夕法尼亚州立大学忧虑问卷(PSWQ),贝克抑郁量表(BDI)对203名(164名女性,39名男性)多民族成人群体进行调查,以检验种族歧视,社会支持(即家庭支持和朋友支持)和希望(即希望效能和希望手段)在消极心理适应问题(如忧虑和抑郁症状)中的作用。对忧虑(PSWQ)和抑郁(BDI)的评分进行了一系列的层次回归分析,以确定控制了种族歧视和社会支持后,希望是否对消极心理适应问题起到缓解作用。结果表明:1)控制了社会人口统计学变量后,种族歧视可以显著预测多民族种族个体忧虑和抑郁。2)控制社会人口变量和民族歧视后,家庭支持可以显著负向预测多民族种族群体的忧虑和抑郁,朋友支持仅能负向预测多民族种族群体中的抑郁。3)在控制了社会人口因素、种族歧视和社会支持后,希望效能仍可以显著预测多民族种族成人的忧虑和抑郁,但希望手段不可以。综上,本研究首次强调了在多民族种族群体中,在控制民族歧视,社会支持的情况下,希望仍可以缓解多民族种族群体的消极心理适应问题,这对缓解数量激增的多民族种族群体日益严重的心理问题有实际意义。

关键词：多民族群体歧视感知社会支持希望消极心理适应

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