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The metabolite, alpha-ketoglutarate inhibits non-alcoholic fatty liver disease progression by targeting lipid metabolism

引用

Liver Research 2020年第2期4卷 94-100页

作者： Katsuya Nagaoka Joud Mulla Kevin Cao Zhixiang Cheng Dan Liu William Mueller Amalia Bay grace hildebrand Shaolei Lu Chiung-Kuei Huang Liver Research Center Division of Gastroenterology&Liver Research CenterWarren Alpert Medical School of Brown University and Rhode Island HospitalProvidenceRIUSA Department of Pathology and Laboratory Medicine Warren Alpert Medical School of Brown UniversityRhode Island HospitalProvidenceRIUSA

Background:Non-alcoholic liver disease is of increased concern and contributing to economic burdens not only in developing countries but in developed countries as *** the biomarker of early diagnosis and early intervention approaches for non-alcoholic liver disease is unmet and required further *** the alpha-ketoglutarate(a-KG)is recently proposed to be a potential biomarker in differentiating patients with obesity from those with non-alcoholic liver disease,how a-ketoglutatate is involved in the fatty liver progression is not ***:A high-fat diet(HFD)feeding animal model,liver functional assays,and molecular approaches were adopted to clarify the impact of a-KG in fatty liver ***:In the current study,it was found that dietary a-KG would inhibit weight gain in male and female mice fed with a normal chew or *** feeding caused fatty liver in male mice,but a-KG treatment could substantially inhibit hepatic steatosis *** studies revealed the possible linkage of a-KG protective functions to lipid *** analysis identified the important role of peroxisome proliferator-activated receptors in beneficial a-KG-mediated effects on fatty liver ***:The current study demonstrates the therapeutic potential of a-KG and how it may be used,via dietary supplementation,as a preventive intervention for non-alcoholic liver disease in obese patients.

关键词： Peroxisome proliferator-activated receptor gamma(PPARγ) Steatosis Non-alcoholic fatty liver disease(NAFLD) Non-alcoholic steatohepatitis(NASH) Alpha-ketoglutarate(a-KG) Gender difference C57BL/6 mouse

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