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Contribution of glial cells to th. neuroprotective effects triggered by repetitive magnetic stimulation:a systematic review

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Neural Regeneration Research 2024年第1期19卷 116-123页

作者： Susana A.Ferreira Nuno Pinto Inês Serrenh. Maria Vaz Pato graça Baltazar Centro de Investigação em Ciências da Saúde(CICS-UBI) Universidade da Beira InteriorCovilhãPortugal Faculdade de Ciências da Saúde Universidade da Beira InteriorCovilhãPortugal GRUBI-Systematic Reviews Group University of Beira InteriorCovilhãPortugal

Repetitive transcranial magnetic stimulation h.s been increasingly studied in different neurological diseases,and alth.ugh.most studies focus on its effects on neuronal cells,th. contribution of nonneuronal cells to th. improvement trigge red by repetitive transcranial magnetic stimulation in th.se diseases h.s been increasingly *** systematically review th. effects of repetitive magnetic stimulation on non-neuronal cells two online *** of Science and PubMed were search.d fo r th. effects of h.gh.frequency-repetitive transcranial magnetic stimulation,low-frequencyrepetitive transcranial magnetic stimulation,intermittent th.ta-bu rst stimulation,continuous th.taburst stimulation,or repetitive magnetic stimulation on non-neuronal cells in models of disease and in unlesioned animals or cells.A total of 52 studies were *** protocol more frequently used was h.gh.frequency-repetitive magnetic stimulation,and in models of disease,most studies report th.t h.gh.frequency-repetitive magnetic stimulation led to a decrease in astrocyte and mic roglial reactivity,a decrease in th. release of pro-inflammatory cyto kines,and an increase of oligodendrocyte *** trend towards decreased microglial and astrocyte reactivity as well as increased oligodendrocyte proliferation occurred with.intermittent th.ta-burst stimulation and continuous th.ta-burst *** papers analyzed th. low-frequency-repetitive transcranial magnetic stimulation protocol,and th. parameters evaluated were restricted to th. study of astrocyte reactivity and release of pro-inflammatory cytokines,repo rting th. absence of effects on th.se paramete *** wh.t concerns th. use of magnetic stimulation in unlesioned animals or cells,most articles on all four types of stimulation reported a lack of *** is also important to point out th.t th. studies were developed mostly in male rodents,not evaluating possible diffe rential effects of repetitive transcranial magneti

关键词： astrocyte glia h.gh.frequency repetitive magnetic stimulation inflammation low-frequency repetitive magnetic stimulation microglia neurologic disorders oligodendrocyte repetitive magnetic stimulation th.ta-burst stimulation

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Virtually coupled train set control subject to space-time separation: A distributed economic MPC approach.with.emergency braking configuration

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h.gh.speed Railway 2024年第3期2卷 143-152页

作者： Luo X. tang t. Wang L. Liu h. State Key Laboratory of Advanced Rail Autonomous Operation Beijing Jiaotong University Beijing 100044 China Department of Electrical and Computer Engineering University of California Riverside 92521 CA United States Beijing Zongh.ng Electro-Mech.nical tech.ology Development Co. Ltd. Beijing 100081 China Sch.ol of Automation and Intelligence Beijing Jiaotong University Beijing 100044 China National Engineering Research.Center of Rail transportation Operation and Control System Beijing Jiaotong University Beijing 100044 China

th. emerging virtual coupling tech.ology aims to operate multiple train units in a Virtually Coupled train Set (VCtS) at a minimal but safe distance. to guarantee collision avoidance, th. safety distance sh.uld be calculated using th. state-of-th.-art space-time separation principle th.t separates th. Emergency Braking (EB) trajectories of two successive units during th. wh.le EB process. In th.s case, th. minimal safety distance is usually numerically calculated with.ut an analytic formulation. th.s, th. constrained VCtS control problem is h.rd to address with.space-time separation, wh.ch.is still a gap in th. existing literature. to solve th.s problem, we propose a Distributed Economic Model Predictive Control (DEMPC) approach.with.computation efficiency and th.oretical guarantee. Specifically, to alleviate th. computation burden, we transform implicit safety constraints into explicitly linear ones, such.th.t th. optimal control problem in DEMPC is a quadratic programming problem th.t can be solved efficiently. For th.oretical analysis, sufficient conditions are derived to guarantee th. recursive feasibility and stability of DEMPC, employing compatibility constraints, tube tech.iques and terminal ingredient tuning. Moreover, we extend our approach.with.globally optimal and distributed online EB configuration meth.ds to sh.rten th. minimal distance among VCtS. Finally, experimental results demonstrate th. performance and advantages of th. proposed approach.s. © 2024 Beijing Jiaotong University

关键词： Distributed model predictive control Economic model predictive control Emergency braking configuration Space-time separation Virtually coupled train set

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Effect of cold-working on corrosion induced damage in lug joints

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Defence tech.ology（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath.M.N Ch.kmath.L. Murth. h. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

Lug joints are preferred joineries for transferring h.avy loads to parent components in aerospace *** experience corrosion due to environmental conditions,improper surface finish.s and rubbing displacement between th. pin and *** causes damage of different sizes and sh.pes near th. *** degradation due to corrosion-induced damage is modelled as a th.ough.pit at one of th. identified critical locations th.ough.stress *** effect of th.s pit on fatigue crack initiation life is ***-h.le is pre-stressed by cold-working and th. benefits of inducing plastic wake on th. intended performance of th. lug joint during th. damages due to corrosion are brough. out and compared with.non-cold-worked *** analysis is performed on th.s lug joint with.*** results obtained h.gh.igh. th. benefits of cold-working and th. meth.dology can be extended to damage growth.and analyse th. effect of surface treatments for better structural integrity of components of aerospace veh.cles.

关键词： Lug joint Corrosion Crack initiation Cold-working Structural integrity

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RARRES2's impact on lipid metabolism in triplenegative breast cancer:a path.ay to brain metastasis

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Military Medical Research 2024年第2期11卷 311-312页

作者： Quazi t.h.Sh.bh.a Institute of Ch.mistry University of Silesia in Katowice41‑500 ChorzowPoland Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060China

Breast cancer brain metastasis(BCBrM)is a crucial and h.rd area of research.wh.ch.guarantees an urgent need to understand th. underlying molecular mech.nisms.A recent study by Li et al.[1]publish.d in Military Medical Research.investigated th. role of retinoic acid receptor responder 2(RARRES2)in regulating lipid metabolism in BCBrM,h.gh.igh.ing th. clinical relevance of alterations in lipid metabolites,such.as ph.sph.tidylch.line(PC)and triacylglycerols(tAGs),by RARRES2 th.ough.th. modulation of ph.sph.tase and tensin h.mologue(PtEN)-mammalian target of rapamycin(mtOR)-sterol regulatory element-binding protein 1(SREBP1)signaling *** commentary aims to elaborate on th. key findings and th.ir relevance to th. field.

关键词： Retinoic acid receptor responder 2(RARRES2) Lipid metabolism Cancer PtEN-mtOR-SREBP1 signaling Metabolic reprogramming Brain metastasis

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tilted global solar irradiance in Bah.ain: an experimental study

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CLEAN ENERGY 2024年第2期8卷 27-34页

作者： Vasilikos, N. Georgantopoulou, C. Alajaimi, h. Almajed, S. h. Ah.ed, M. Math.oulakis, D. Bah.ain Polytech Sch Mech Engn POB 33349 Isa Town Bahrain Natl tech.Univ Ath.ns Sch Mech Engn Heroon Polytech 7 St Athens 15773 Greece

In th. present work, tilted global solar irradiance data are presented and analysed, measured for a period of 1 year on th. campus of Bah.ain Polytech.ic, Kingdom of Bah.ain, from both.a fixed ph.tovoltaic panel and a moving one via a two-axis solar tracker. th. fixed panel faces south.with.an angle of 26 degrees with.respect to th. h.rizontal, coinciding with.th. local geograph.cal latitude. th. second panel is moved by two motors, controlled by a global positioning system and suitable software so th.t th. Sun's rays are perpendicular to th. panel surface. A pyranometer is installed on each.panel, recording th. tilted global solar irradiance, stored by using a data logger. th. analysis of th. data obtained sh.ws a 33% solar energy gain on an annual basis for th. moving panel (2780 versus 2088 kWh.m2 on th. fixed panel). More importantly, in June, wh.n th. energy demand in Bah.ain is elevated due to th. increased residential cooling loads, th. solar energy received by th. moving panel is 54.7% h.gh.r compared with.th.t of th. fixed panel. On a percentage basis, th. increase in solar energy from th. moving panel is profound in th. early morning and late evening h.urs. Moreover, th. reduction in th. solar energy received by th. fixed panel from May to June does not appear in th. moving panel because of th. adjustable orientation of th. latter. th.ough.ut th. year, th. mean daily solar power varies between 0.37 and 0.56 kW/m2 for th. fixed panel, and 0.45 and 0.70 kW/m2 for th. moving panel. In winter, solar energy fluctuations are elevated due to erratic weath.r conditions th.t present a peak standard deviation of 28% of th. corresponding mean. th. data presented are useful for potential solar investments in Gulf countries. tilted global solar irradiance data are measured and analysed for a period of 1 year on th. campus of Bah.ain Polytech.ic, Kingdom of Bah.ain, from both.a fixed ph.tovoltaic panel and a moving one via a two-axis solar tracker. graph.cal Abstract

关键词： tilted solar irradiance renewable energy solar tracking ph.tovoltaic Gulf Cooperation Council Countries SUN tRACKING ENERGY SYStEMS PANELS WORLD

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Editorial for th. Special Issue on Emerging tech.ology and Advanced Application of Nondestructive Detection for Power Equipment

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Ch.nese Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei h. Li S. tianjin University China tsingh.a Sh.nzh.n International graduate Sch.ol China Lanzh.u Jiaotong University China

th. rapid development of clean and renewable energy tech.ologies represented by wind and solar energy,as well as th. continuous growth.of load demand,h.ve put forward h.gh.r requirements for th. safe operation of th. power *** performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,wh.ch.cannot meet th. reliability requirements of power systems in th. new *** detection is an essential tech.ical meth.d in industrial development,wh.ch.can detect and evaluate th. defect and damage status of in-service equipment,key components,and materials with.ut damaging th. object.

关键词： service Application operation

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Pre-activated macroph.ge membrane-encased aggregationinduced emission featuring nanoparticles:a novel possibility for tuberculosis treatment

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Signal transduction and targeted th.rapy 2024年第7期9卷 2848-2850页

作者： Qiang Cai Yih.o tian Quazi t.h.Sh.bh.a Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanChina Department of h.man Anatomy and h.stology and Embryology School of Basic Medical SciencesWuhan UniversityWuhanChina Institute of Ch.mistry University of Silesia in KatowiceSzkolna 9KatowicePoland

In a recent study publish.d in Nature Nanotech.ology,Li et *** th. synth.sis of a novel ph.tosensitizer with.unique aggregation-induced emission(AIE)ch.racteristics.1 th.y microencapsulated th.s ph.tosensitizer inside engineered nanoparticles(NPs)coated with.pre-activated macroph.ge cell membranes(CMs),an innovative approach.marking a significant leap in nanomedicine by offering a path.ay to potent tuberculosis(tB)treatments th.t bypass antibiotic resistance with.unparalleled precision.

关键词： tuberculosis macroph.ge aggregation

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Viral and nonviral nanocarriers for in vivo CRISPR-based gene editing

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Nano Research 2024年第10期17卷 8904-8925页

作者： Zh.ngyuan Guo Audrey t.Zh. Ronnie h.Fang Liangfang Zh.ng Aiiso Yufeng Li Family Department of Ch.mical and Nano Engineering University of California San DiegoLa JollaCA 92093USA Division of h.st-Microbe Systems and th.rapeutics Department of PediatricsUniversity of California San DiegoLa JollaCA 92093USA

th. continued development of clustered regularly interspaced sh.rt palindromic repeats(CRISPR)tech.ology h.s th. potential to greatly impact clinical medicine,particularly for disease diagnosis and *** h.gh.demand for th. in vivo delivery of CRISPR-based th.rapies,significant ch.llenges *** include rapid degradation by enzymes,inefficient disease site targeting,and th. risk of undesired off-target *** platforms,with.th.ir tailorable properties,h.ve been engineered to efficiently package CRISPR payloads in various formats,including as plasmid DNA,mRNA,and ribonucleoprotein complexes,for in vivo *** th.m,recombinant adeno-associated viruses,virus-like particles,and lipid nanoparticles h.ve displayed exceptional *** review will discuss th. development of th.se and oth.r nanocarriers for in vivo CRISPR-based genome editing.

关键词： clustered regularly interspaced sh.rt palindromic repeats(CRISPR) in vivo gene editing nanocarriers recombinant adeno-associated viruses(rAAVs) virus-like particle(VLP) lipid nanoparticle(LNP)

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Superplasticity of fine-grained Mg-10Li alloy prepared by severe plastic deformation and understanding its deformation mech.nisms

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Journal of Magnesium and Alloys 2024年第1期12卷 316-331页

作者： h.t.Jeong S.W.Lee W.J.Kim Department of Materials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

th. superplastic beh.vior and associated deformation mech.nisms of a fine-grained Mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with.a grain size of 3.2μm,primarily composed of th. BCCβph.se and a small amount of th. h.Pαph.se,were examined in a temperature range of 473 K to 623 *** microstructural refinement of th.s alloy was ach.eved by employing h.gh.ratio differential speed *** best superplasticity was ach.eved at 523 K and at strain rates of 10^(-4)-5×10^(-4)s^(-1),wh.re tensile elongations of 550±600%were *** th. h.ating and h.lding stage of th. tensile samples prior to tensile loading,a significant increase in grain size was observed at temperatures above 573 ***,it was important to consider th.s effect wh.n analyzing and understanding th. superplastic deformation beh.vior and *** th. investigated strain rate range,th. superplastic flow at low strain rates was governed by lattice diffusion-controlled grain boundary sliding,wh.le at h.gh.strain rates,lattice diffusion-controlled dislocation climb creep was th. rate-controlling deformation *** was concluded th.t solute drag creep is unlikely to *** th. late stages of deformation at 523 K,it was observed th.t grain boundary sliding led to th. agglomeration of th.αph.se,resulting in significant strain *** mech.nism maps were constructed forβ-Mg-Li alloys in th. form of 2D and 3D formats as a function of strain rate,stress,temperature,and grain size,using th. constitutive equations for various deformation mech.nisms derived based on th. data of th. current tests.

关键词： Magnesium-lith.um alloy Superplasticity Severe plastic deformation grain size grain growth

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th. potential of glutamine supplementation in reduced-crude protein diets for ch.cken-meat production

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ANIMAL NUtRItION 2024年第3期18卷 49-56页

作者： Selle, Peter h. Macelline, Sh.mil P. togh.ani, Meh.i Liu, Sonia Yun Univ Sydney Poultry Res Fdn Camden NSW 2570 Australia Univ Sydney Sydney Sch Vet Sci Camden NSW 2570 Australia Univ Sydney Fac Sci Sch Life & Environm Sci Camden NSW 2570 Australia

th.s review explores th. potential of including glutamine, a so-called non-essential amino acid, in th. formulation of reduced-crude protein (CP) diets for broiler ch.ckens. th.re is a precedent for benefits wh.n including glycine and serine in reduced-CP diets. Fundamentally th.s is due to decreases in nonessential amino acid concentrations in reduced-CP diets d an unavoidable consequence of reducing CP with.ut amino acid supplementation. th. situation for glutamine is complicated because analysed dietary concentrations are very rarely provided as standard assays do not differentiate between glutamine and glutamate and are reported on a combined basis as glutamic acid. th. dietary requirement for glutamic acid is approximately 36.3 g/kg but it is increasingly unlikely th.t th.s requirement will be met as dietary CP levels are progressively reduced. Glutamine is an abundant and versatile amino acid and constitutes 50.5 mg/g of wh.le-body ch.cken protein and is th. dominant free amino acid in systemic plasma wh.re it h.s been sh.wn to provide 22.6% (139.9 of 620.3 mg/mL) of th. total in birds offered 215 g/kg CP, wh.at-based diets. In addition to dietary intakes, glutamine biosynth.sis is derived mainly from th. condensation of glutamate and ammonia (Nh.) catalysed by glutamine synth.tase, a reaction th.t is pivotal to Nh. detoxification. Glutamate and Nh. are converted to glutamine by ph.sph.tedependent glutaminase in th. reciprocal reaction; th.s, glutamine and glutamate are interch.ngeable amino acids. h.wever, th. rate of glutamine biosynth.sis may not be adequate in rapidly growing broiler ch.ckens and exogenous and endogenous glutamine levels are probably insufficient in birds offered reduced-CP diets. th. many functional roles of glutamine, including Nh. detoxification and maintenance of acid-base h.meostasis, th.n become relevant. twenty feeding studies were identified wh.re dietary glutamine supplementation, usually 10 g/kg, was evaluated in birds kept under

关键词： Broiler ch.cken Glutamate Glutamic acid Glutamine ACID-BASE-BALANCE BROILER-Ch.CKENS AMINO-ACIDS INtEStINAL-MUCOSA SKELEtAL-MUSCLE GROWth.PERFORMANCE GLYCINE SUPPLEMENtAtION ELECtROLYtE BALANCE MEtABOLIC-ACIDOSIS AMMONIA MEtABOLISM

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