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Detection of the Production of Klebsiella Pneumoniae Carbapenemase, New Delhi Metallo-Beta-Lactamase and Oxacillinase-48-Type Carbapenemases by gram-Negative Bacilli in Resource-Limited Setting

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Advances in Microbiology 2021年第10期11卷 579-590页

作者： Cecile Okalla ebongue Gabin Gaël Simo Jean Pierre Nda Mefo’o gra.e da.le ngondi emmanuel Roddy Mengue Guy Pascal Ngaba Dieudonne Adiogo Laboratory of Clinical Biology General Hospital Douala Cameroon Department of Biological Sciences Faculty of Medicine and Pharmaceutical Sciences Douala Cameroon Laboratory Unit Laquintinie Hospital Douala Cameroon Laboratory Unit Gyneco-Obstetric and Pediatric Hospital Douala Cameroon

Background: The increasing resistance of bacteria to various antibiotics is a worldwide public health issue. Carbapenems that have elicited great hope in treating infections caused by multidrug-resistant germs have seen their efficacy narrowed over time with the emergence of other novel resistance mechanisms, notably the production of Carbapenemases. Methods: A prospective cross-sectional study was conducted from May 2017 to May 2018 in Douala (Cameroon) to detect carbapenemase-producing gram-negative bacilli. Isolated strains were identified using the Vitek2TM system. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion method on agar plates with 20 selected commercially available antibiotic discs. The bacterial strains were tested for the production of three Carbapenemases (OXA-48, NDM, KPC), using an immuno-chromatographic technique, with the “ReSIST-3 O.K.N. K-SeT” rapid detection kit. Results: During the study period, 1687 strains of gram-negative bacilli were isolated in selected laboratories with a total of 200 multi-resistant strains identified (11.9%). Among the multi-resistant strains, e. coli was the species most represented in enterobacteriaceae (27.5%) followed by K. pneumoniae (15.5%) and the non-fermenting gram-negative bacilli were predominantly P. aeruginosa (20.5%). These strains mainly came from urine and pus, i.e. 41% and 32% respectively. Thirty-two (16%) strains produced one of the Carbapenemases with a higher frequency at the General Hospital (84%). NDM-type carbapenemase was the most frequently identified (8.5%), OXA-48 type 7.5%, and no KPC production was observed. Among the enterobacteriaceae 22.9% produced Carbapenemases and only 5.1% of the non-fermenting bacilli produced these enzymes. The isolates strains were completely resistant to all antibiotics except Amikacin and Fosfomycin. The strains producing the NDM-type carbapenemase

关键词： Carbapenemases gram-Negative Bacilli Multidrug-Resistance Cameroon

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