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Nitridergic Modulation of the Antinociceptive Activity of Rosuvastatin in Mice

Pharmacology & Pharmacy 2014年第1期5卷 61-68页

作者： Viviana Noriega Fernando Sierralta Juan Carlos prieto Pilar Zanetta Hugo F. Miranda Cardiovascular Department Clinical Hospital Universidad de Chile Santiago Chile Faculty of Medicine Pharmacy School Universidad Andres Bello Santiago Chile Faculty of Medicine Pharmacy School Universidad Andres Bello Santiago Chile Cardiovascular Department Clinical Hospital Universidad de Chile Santiago Chile Faculty of Odontology Universidad Finis Terrae Santiago Chile 4Molecular and Clinical Pharmacology Program Faculty of Medicine Medical School Universidad de Chile Santiago Chile. Molecular and Clinical Pharmacology Program Faculty of Medicine Medical School Universidad de Chile Santiago Chile.

Statins, 3-hydroxy-3 methylglutaryl coenzyme A (HMG-CoA) reductase enzyme inhibitors, are lipid-lowering drugs, often used in the treatment of cardiovascular diseases (hyperlipidemia, atherosclerosis). It has been shown that statins have antiinflammatory effects independent of their lipid-lowering effects and these anti-inflammatory effects inhibit the inflammation and pain process. This study evaluated the antinociceptive and anti-inflammatory effects of rosuvastatin using the acetic acid writhing, the formalin hind paw, the orofacial formalin and the hot plate tests. The following experimental group were used: control, acute (1 day) and chronic (3 days) after oral gavage with rosuvastatin (3, 10, 30, 100 and 300 mg/kg). Rosuvastatin produced a dose-dependent antinociception, with different potency, in all the tests. Additionally, nitric oxide synthase inhibitors (Abbreviationsand aminoguanidine) were used to assess the nitric oxide participation on this induced rosuvastatin antinociception. The data demonstrated the antinociceptive and anti-inflammatory activity of rosuvastatin in algesiometer models of tonic or phasic pain. These activities seem to be induced by modulation of iNOS expression, a result that may be relevant in the pharmacological treatment of human pain where rosuvastatin and nitric oxide synthase inhibitors must be used.

关键词： Antinociception Anti-Inflammation Algesiometer Assays Rosuvastatin L-NAME Aminoguanidine

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现象学、地方与空间转向

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临沂大学学报 2021年第1期43卷 26-34页

作者： [美]Eric prieto 颜红菲(译) 美国加州大学圣巴巴拉分校比较文学系加利福利亚州圣巴巴拉CA93106-4140 南京工程学院外国语学院江苏南京211167

本文回顾了地方概念在现象学方法研究人类空间性中所发挥的核心作用,检视了这一概念自身的弹性张力,以应对怀疑地方是否能作为科学探究的可靠对象的各种挑战。从文学的角度来看,现象学的地方概念对于分析以主体为中心和以人物为主导的... 详细信息

本文回顾了地方概念在现象学方法研究人类空间性中所发挥的核心作用,检视了这一概念自身的弹性张力,以应对怀疑地方是否能作为科学探究的可靠对象的各种挑战。从文学的角度来看,现象学的地方概念对于分析以主体为中心和以人物为主导的文学模式(如抒情诗和第一人称叙事)最有帮助;但是,正如詹姆逊所指出的那样,现象学的观点忽视了影响人类能动性的结构性力量。因此,一个批判性的、可行的地方概念必须在现象学研究的主体中心与对结构性力量(包括生物、地理和经济制约)的更多认识的需求之间取得平衡。

关键词：空间地方文学现象学后结构主义

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Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma

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中国实验血液学杂志 1997年第3期5卷 301-302页

作者： Miguel Idoate Roberto Bilbao Bruno Sangro Oscar Bruna Jesus Vazquez Jesus prieto Experimental Pathology University Clinic and School of Medicine University of Navarra Pamplona SpainDepartment of Internal Medicine Department of Internal Medicine Department of Internal Medicine Experimental Pathology University Clinic and School of Medicine University of Navarra Pamplona SpainDepartment of Internal Medicine

Viral-mediated gene transfer of thymidine kinase ofherpes simplex virus (HSV-tk) has been used to confercytotoxic sensitivity to ganciclovir (GCV) in a variety oftnmor cells. HSV-tk converts GCV into a phosphorylatedc... 详细信息

关键词： thymidine simplex nodules cytotoxic adenovirus nude dividing inhibit orthotopic affects

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Argentinean Commercial Malbec Wines： Regional Sensory Profiles

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Journal of Life Sciences 2014年第2期8卷 134-141页

作者： Ana Carla Aruani Claudia Ines Quini Hugo Ortiz Rodoifo Videla Marcelo Murgo Sebastian prieto Departamento de Estudios Enologieos y Sensoriales Instituto Nacional de Vitivinieultura (INV) Mendoza 5500 Argentina Subgerencia de Investigacion para la Fiscalizacion Instituto Nacional de Vitivinicultura (INV) Mendoza 5500 Argentina

Sensory evaluation was performed on 32 commercial Malbec wines （2008 and 2009 vintages） produced in five provinces of Argentina. Wines from different areas in Mendoza （the most important producer of Malbec） were also included to test possible differences within this province. Ten key attributes were first recognized by descriptive analyses and then carefully evaluated by a trained sensory panel composed of 10 judges. Among the aroma and flavour attributes the analyses focused on plum, red fruits, white pepper, bell pepper, and floral. Three attributes of taste （acidity, astringency, and bitterness） and two attributes of color （red and blue-purple hues） were also analyzed. Statistical differences and similarities in sensory data were tested using analysis of variance （ANOVA）, multiple means comparisons by least significant difference test （Fisher LSD）, and principal component analysis （PCA）. ANOVA and Fisher LSD tests of sensory data showed significant differences （P 〈 0.05） for 6 out of 10 wine attributes： plum, floral, red fruits, astringency, red and blue- purple hues.

关键词： Malbec red wines commercial wines sensory analysis Argentina Mendoza.

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Hematotesticular barrier is altered from early stages of liver cirrhosis:Effect of insulin-like growth factor 1

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World Journal of Gastroenterology 2004年第17期10卷 2529-2534页

作者： Inma Castilla-Cortázar Nieves Diez María García-Fernández Juan Enrique Puche Fernando Diez-Caballero Jorge Quiroga Matías Díaz-Sánchez Alberto Castilla Amelia Díaz Casares Isabel Varela-Nieto Jesǘs prieto Salvador González-Barón Department of Human Physiology University of NavarraPamplonaNavarraSpain Department of Human physiologySchool of MedicineUniversity of MlagaMalagaSpain Department of Human Physiology University of NavarraPamplonaNavarraSpain Department of Human Physiology School of MedicineUniversity of MálagaMalagaSpain Instituto de Investigaciones Biomédicas "Alberto Sols" Consejo Superior de Investigaciones CientificasUniversidad Autónoma de Madrid (CSIC-UAM)MadridSpain Supported by the Spanish Program I+DSAF 99/0072 and SAF 2001/1672 Department of Internal Medicine Hospital SierrallanaTollelavega and School of MedicineUniversity of the Basque Country-Vitoria-GasteizSpain Instituto de Investigaciones Biomedicas"Alberto Sols"Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid(CSIC-UAM) MadridSpain Department of Internal Medicine Liver Unit University of Navarra PamplonaNavarraSpain

AIM:The pathogenesis of hypogonadism in liver cirrhosis is not well *** results from our laboratory showed that IGF-1 deficiency might play a pathogenetic role in hypogonadism of *** administration of IGF-1 for a short period of time reverted the testicular atrophy associated with advanced experimental cirrhosis. The aim of this study was to establish the historical progression of the described alterations in the testes, explore testicular morphology,histopathology,cellular proliferation,integrity of testicular barrier and hypophyso- gonadal axis in rats with no ascitic cirrhosis. METHODS:Male Wistar rats with histologically-proven cirrhosis induced with carbon tetrachloride(CCI_4)for 11 wk, were allocated into two groups(n=12,each)to receive recombinant IGF-1(2 μg/100 gd,sc)for two weeks or *** rats receiving vehicle were used as control group(n=12). RESULTS:Compared to controls,rats with compensated cirrhosis showed a normal testicular size and weight and very few histopathological testicular abnormalities. However,these animals showed a significant diminution of cellular proliferation and a reduction of testicular transferrin *** addition,pituitary-gonadal axis was altered,with significant higher levels of FSH(Pgroup). CONCLUSION:The testicular barrier is altered from an early stage of cirrhosis,shown by a reduction of transferrin expression in Sertoli cells,a diminished cellular proliferation and an altered gonadal *** treatment with IGF-1 could be also useful in this initial stage of testicular disorder associated with compensated cirrhosis.

关键词： Animals Atrophy Carbon Tetrachloride Estrogens Follicle Stimulating Hormone Hypogonadism Insulin-Like growth Factor I Liver Cirrhosis Luteinizing Hormone Male Pituitary Gland Rats Rats, Wistar Research Support, Non-U.S. Gov't Sertoli Cells Testis Testosterone Transferrin

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Capsule endoscopy capture rate: Has 4 frames-per-second any impact over 2frames-per-second?

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World Journal of Gastroenterology 2014年第39期20卷 14472-14478页

作者： Ignacio Fernandez-Urien Cristina Carretero Erika Borobio Ana Borda Emilio Estevez Sara Galter Begoa Gonzalez-Suarez Benito Gonzalez Marisol Lujan Jose Luis Martinez Vanessa Martínez Pedro Menchén Javier Navajas Vicente Pons Cesar prieto Julio Valle Department of Gastroenterology Hospital de Navarra 31008 Pamplona Spain Department of Gastroenterology Clínica Universidad de Navarra 31008 Pamplona Spain Department of Gastroenterology Hospital Juan Canalejo 26131 La Coru?a Spain Department of Gastroenterology Hospital de Tarrasa 08509 Barcelona Spain Department of Gastroenterology Hospital del Mar 08509 Barcelona Spain Department of Gastroenterology Hospital General de Valencia 46367 Valencia Spain Department of Gastroenterology Hospital Puerta de Hierro 28816 Madrid Spain Department of Gastroenterology Hospital La Fe 46367 Valencia Spain Department of Gastroenterology Hospital Gregorio Mara?ón 28816 Madrid Spain Department of Gastroenterology Complejo Hospitalario de Toledo 45591 Toledo Spain

AIM: To compare the current capsule and a new prototype at 2 and 4 frames-per-second, respectively, in terms of clinical and therapeutic impact.

关键词： Capsule endoscopy Small bowel Diagnostic accuracy Frames Lesions Landmarks

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Oxygen Therapy in Critical Care: A Double Edged Sword

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Health 2014年第15期6卷 2035-2046页

作者： Isidro prieto del Portillo Susana Temprano Vázquez Jesús Barea Mendoza Rubén Viejo Moreno Intensive Care Unit Hospital 12 de Octubre Madrid Spain

The oxygen therapy is a universal treatment in the hospital setting, especially in the critical care units. The purpose of this therapy is to avoid hypoxemia and to ensure an adequate supply of oxygen to the tissues. But often we overlook the potential adverse effects of oxygen therapy. Oxygen produces lung damage and induces apoptosis and cell death creating an imbalance between the production of reactive species of oxygen and the antioxidant mechanisms. The oxygen therapy inhibits systemic adaptive changes induced by hypoxia, disrupting compensatory mechanisms and causing deleterious effects. We are faced with a challenge in order to treat patients with respiratory failure, counterbalancing hypoxia with hyperoxia-induced damage and introducing therapy lines that are innovative but not risk-free as permissive hypoxemia. Currently many questions remain unresolved and there are not enough clinical studies that validate the therapeutic optimal oxygenation ranges. These ranges may differ depending on each patient and the underlying disease.

关键词： Oxygen Therapy Oxygen Toxicity Hyperoxia Reactive Oxygen Species Intensive Care Unit

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Electroencephalographic coherences during emotion identification task

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World Journal of Neuroscience 2012年第4期2卷 248-253页

作者： Erzsebet Marosi Holczberger Jorge Bernal Juan Silva Guillermina Yanez Mario Rodríguez Belen prieto Vicente Guerrero National University of Mexico FES IztacalaNeurosciences DepartmentMexico CityMexico

Coherence, a measure of spectral similarity, may estimate cortical coupling between two EEG signals as a function of frequency. The coherence between EEG signals from different brain areas depends on the structural connection and functional coupling between two regions. The theory of hemispheric specialization proposes left hemisphere activation to positive emotions and right one to negative emotions. Other proposal is that right hemisphere activation occurs with emotional stimuli. In the present study EEG coherences were calculated during the presentation of the International Affective Pictures to 36 healthy male university students. The subjects’ task was to determine the valence of the stimuli. Base line recording were done with subjects observing the blank monitor. Our results showed higher coherences during the emotional condition. No differences between negative and positive emotions were obtained. Neutral pictures evoked the highest coherence values. These data suggest that coherences between functionally coupled brain areas do not reflect emotional recognition of the valence of stimuli, but they are internal indicators of different mental processes such as memory, mental effort and arousal. Our findings do not support the theory of hemispheric specialization, neither the theory of right hemisphere;rather they suggest a complex activation pattern that involves mostly frontal areas in connection with the entire cortex.

关键词： EEG Coherences Emotions of Positive and Negative Valence International Affective Pictures

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SALVIA MILTIORRHIZA BUNGE——~1H-NMR METABOLOMICS APPROACH IN TCM QUALITY CONTROL

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World Journal of Traditional Chinese Medicine 2016年第2期 80-81页

作者： Ka Yui Kum Anthony Booker Christine Leon José prieto García Michael Heinrich Biodiversity and Medicines Research Cluster UCL School of Pharmacy Royal Botanic Gardens

Introduction:Many Danshen(DS-Radix Salviae miltiorrhizae-SM)products are found on the global market albeit without suitable quality *** substitutes including Salvia przewalskii Maxim,*** *** Salvia sinica *** similar ... 详细信息

关键词： NMR METABOLOMICS APPROACH IN TCM QUALITY CONTROL TCM SALVIA MILTIORRHIZA BUNGE

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Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort

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World Journal of Gastroenterology 2019年第4期25卷 433-446页

作者： Patricia prieto Rafael I Jaén Daniel Calle María Gómez-Serrano Estefanía Nú?ez María Fernández-Velasco Paloma Martín-Sanz Sergio Alonso Jesús Vázquez Sebastián Cerdán Miguel ángel Peinado Lisardo Boscá Department of Metabolism and Physiopathology of Inflammatory Diseases Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM) Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (Ciber-CV) Instituto de Salud Carlos III (ISCIII) Laboratorio de Imagen Médica Hospital Universitario Gregorio Mara?ón Laboratorio de Proteómica Cardiovascular Centro Nacional de Investigaciones Cardiovasculares (CNIC) Instituto de Investigación Sanitaria del Hospital Universitario la Paz(IdiPaz) Programa de Medicina Predictiva y Personalizada del Cáncer (PMPPC) Fundación Instituto de investigación en ciencias de la salud Germans Trias i PujolCtra Can Ruti

BACKgrOUND Colorectal cancer(CRC) is the second most common cause of cancer death worldwide. It is broadly described that cyclooxygenase-2(COX-2) is mainly overexpressed in CRC but less is known regarding post-translational modifications of this enzyme that may regulate its activity, intracellular localization and stability. Since metabolic and proteomic profile analysis is essential for cancer prognosis and diagnosis, our hypothesis is that the analysis of correlations between these specific parameters and COX-2 state in tumors of a high number of CRC patients could be useful for the understanding of the basis of this cancer in *** To analyze COX-2 regulation in colorectal cancer and to perform a detailed analysis of their metabolic and proteomic *** Biopsies from both healthy and pathological colorectal tissues were taken under informed consent from patients during standard colonoscopy procedure in the University Hospital of Bellvitge(Barcelona, Spain) and Germans Trias i Pujol University Hospital(Campus Can Ruti)(Barcelona, Spain). Western blot analysis was used to determine COX-2 levels. Deglycosylation assays were performed in both cells and tumor samples incubating each sample with peptide N-glycosidase F(PNGase F). Prostaglandin E2(PGE2) levels were determined using a specific ELISA. 1 H high resolution magic angle spinning(HRMAS) analysis was performed using a Bruker AVIII 500 MHz spectrometer and proteomic analysis was performed in a nano-liquid chromatography-tandem mass spectrometer(nano LC-MS/MS) using a QExactive HF orbitrap *** Our data show that COX-2 has a differential expression profile in tumor tissue of CRC patients vs the adjacent non-tumor area, which correspond to a glycosylated and less active state of the protein. This fact was associated to a lesser PGE2 production in tumors. These results were corroborated in vitro performing deglycosylation assays in HT29 cell line where COX-2 protein profile was modified after PN

关键词： Colon Carcinoma Cyclooxygenase Prostaglandin Proteomics High resolution magic angle spinning

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