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Implications of receptor for advanced glycation end products for progression from obesity to diabetes and from diabetes to cancer

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World Journal of Diabetes 2023年第7期14卷 977-994页

作者： Andrea Garza-Campos José Roberto prieto-Correa José Alfredo Domínguez-Rosales Zamira Helena Hernández-Nazará Programa de Doctorado en Ciencias en Biología Molecular en Medicina Universidad de GuadalajaraGuadalajara 44340JaliscoMexico Departamento de Biología Molecular y Genómica Instituto de Investigación en Enfermedades Crónico-DegenerativasUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico

Obesity and type 2 diabetes mellitus(T2DM)are chronic pathologies with a high incidence *** share some pathological mechanisms,including hyperinsulinemia,the production and release of hormones,and *** above,over time,affects other systems of the human body by causing tissue hypoxia,low-grade inflammation,and oxidative stress,which lay the pathophysiological groundwork for *** leading causes of death globally are T2DM and *** main alterations of this pathological triad include the accumulation of advanced glycation end products and the release of endogenous alarmins due to cell death(i.e.,damage-associated molecular patterns)such as the intracellular proteins high-mobility group box protein 1 and protein S100 that bind to the receptor for advanced glycation products(RAGE)-a multiligand receptor involved in inflammatory and metabolic and neoplastic *** review analyzes the latest advanced reports on the role of RAGE in the development of obesity,T2DM,and cancer,with an aim to understand the intracellular signaling mechanisms linked with cancer *** review also explores inflammation,oxidative stress,hypoxia,cellular senescence,RAGE ligands,tumor microenvironment changes,and the“cancer hallmarks”of the leading tumors associated with *** assimilation of this information could aid in the development of diagnostic and therapeutic approaches to lower the morbidity and mortality associated with these diseases.

关键词： Type 2 diabetes Cancer Obesity Advanced glycation end product receptor Receptor for advanced glycation end products Glycation end products,advanced

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Local renin angiotensin system and sperm DNA fragmentation

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Asian Journal of Andrology 2022年第2期24卷 139-146页

作者： María Victoria Aparicio prieto María Victoria Rodríguez Gallego Asier Valdivia Palacín Yosu Franco Iriarte Gotzone Hervás Barbara Enrique Echevarría Orella Luis Casis Saenz Human Reproduction Unit Cruces University HospitalBarakaldo 48903Spain Human Reproduction Unit San Pedro HospitalLogroño 26006Spain Department of Physiology Faculty of Medicine and NursingUniversity of the Basque Country(UPV/EHU)Leioa 48940Spain Human Reproduction Unit Ruber International HospitalMadrid 28034Spain

The renin angiotensin system(RAS)appears to influence male fertility at multiple *** this work,we analyzed the relationship between the RAS and DNA *** male volunteers were divided into two groups(25 each):control(DNA fragmentation≤20%)and pathological(DNA fragmentation>20%)*** of five peptidases controlling RAS were measured fluorometrically:prolyl endopeptidase(which converts angiotensin[A]I and A II to A 1–7),neutral endopeptidase(NEP/CD10:A I to A 1–7),aminopeptidase N(APN/CD13:A III to A IV),aminopeptidase A(A II to A III)and aminopeptidase B(A III to A IV).Angiotensin-converting enzyme(A I to A II),APN/CD13 and NEP/CD10 were also assessed by semiquantitative cytometry and quantitative flow cytometry assays,as were the receptors of all RAS components:A II receptor type 1(AT1R),A II receptor type 2(AT2R),A IV receptor(AT4R or insulin-regulated aminopeptidase[IRAP]),(pro)renin receptor(PRR)and A 1–7 receptor or Mas receptor(MasR)None of the enzymes that regulate levels of RAS components,except for APN/CD13(decrease in fragmented cells),showed significant differences between both *** of RAS receptors revealed no significant differences in immunolabeling patterns between normozoospermic and fragmented *** of AT1R(94.3%normozoospermic vs 84.1%fragmented),AT4R(96.2%vs 95.3%)and MasR(97.4%vs 87.2%)was similar between the ***2R(87.4%normozoospermic vs 63.1%fragmented)and PRR(96.4%vs 48.2%)were higher in non-fragmented *** findings suggest that fragmented DNA spermatozoa have a lower capacity to respond to bioactive RAS peptides.

关键词： DNA fragmentation local renin angiotensin system sperm fertility

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On the road towards the global analysis of human synapses

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Neural Regeneration Research 2017年第10期12卷 1586-1589页

作者： G.Aleph prieto Carl W.Cotman Institute for Memory Impairments and Neurological Disorders University of CaliforniaIrvineCAUSA

Synapses are essential units for the flow of information in the *** the last 70 years,synapses have been widely studied in multiple animal models including worms,fruit flies,and *** comparison,the study of human synapses has evolved significantly slower,mainly because of technical ***,three novel methods allowing the analysis of molecular,morphological,and functional properties of human synapses may expand our knowledge of the human ***,we briefly describe these methods,and evaluate how the information provided by each unique approach may contribute to the functional and anatomical analysis of the synaptic component of human brain *** particular,using tissue from cryopreserved human brains,synaptic plasticity can be studied in isolated synaptosomes by fluorescence analysis of single-synapse long-term potentiation（FASS-LTP）,and subpopulations of synapses can be thoroughly assessed in the ribbons of brain tissue by array tomography（AT）.Currently,it is also possible to quantify synaptic density in the living human brain by positron emission tomography（PET）,using a novel synaptic ***,data provided by FASS-LTP,AT,and PET may significantly contribute to the global understanding of synaptic structure and function in both healthy and diseased human brains,thus directly impacting translational research.

关键词： fluorescence analysis of single-synapse long-term potentiation array tomography positron emission tomography synaptosomes flow cytometry microscopy [11C]UCB-J[(R)-1-((3-(11C-methyl-11C)pyridin-4-yl)methyl)-4-(3 4 5-trifluorophenyl)pyrrolidin-2-one]

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Fagus sylvatica and Quercus pyrenaica:Two neighbors with few things in common

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Forest Ecosystems 2023年第2期10卷 162-175页

作者： Sergio de Tomás Marín Jesús Rodríguez-Calcerrada Salvador Arenas-Castro Iván prieto Guillermo González Luis Gil Enrique G.de la Riva Department of Ecology Brandenburgische Technische Universität Cottbus-SenftenbergKonrad-Wachsmann-Allee 603046CottbusGermany Forest Genetics and Ecophysiology Research group School of Forestry EngineeringUniversidad Politécnica de MadridMadridSpain Area of Ecology Botany DepartmentEcology and Plant PhysiologyFaculty of SciencesUniversidad de CórdobaCórdobaSpain Ecology Department Faculty of Biology and Environmental SciencesUniversidad de LeónLeónSpain

Background:The Iberian Peninsula comprises one of the largest boundaries between Mediterranean and Eurosiberian vegetation,known as sub-Mediterranean *** ecotone hosts many unique plant species and communities and constitutes the low-latitude(warm)margin of numerous central European species which co-occur with Mediterranean *** of the main species found in this region are the Eurosiberian European beech(Fagus sylvatica L.)and the Mediterranean Pyrenean oak(Quercus pyrenaica Willd.).It remains unclear how the different physiological and adaptive strategies of these two species reflect their niche partitioning within a subMediterranean community and to what extent phenotypic variation(intraspecific variability)is driving niche partitioning across Eurosiberian and Mediterranean ***:We quantified functional niche partitioning,based on the n-dimensional hypervolume to nine traits related to resource acquisition strategies(leaf,stem and root)plus relative growth rate as an additional wholeplant trait,and the environmental niche similarity between Pyrenean oak and European ***,we analyzed the degree of phenotypic variation of both target species and its relationship with relative growth rates(Rgr)and environmental *** recruitment was measured for both target species as a proxy for the average ***:Species’functional space was highly segregated(13.09%overlap),mainly due to differences in niche breadth(59.7%)rather than niche replacement(25.6%),and beech showed higher trait variability,i.e.,had larger functional ***,both species shared the environmental space,i.e.,environmental niches were *** plant traits were not related to abiotic variables or Rgr,neither did Rgr to plant ***:Both target species share similar environmental space,however,show notably different functional resource-use strategies,promoting a high complementarity that contributes to maintaining a high functiona

关键词： Environmental niche European beech Forest dynamics Functional niche Hypervolume Pyrenean oak Species coexistence Sub-Mediterranean community

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Credibility&Trust of the Citizens ——The Strategic Communication of the Bolivarian National Armed Forces(FANB)

Credibility&Trust of the Citizens ——The Strategic Communic...

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作者： Eduard Andree Espinoza prieto 中国传媒大学

学位级别：硕士

在所有组织中,都需要良好的组织沟通,以适应他们日常生活中的社会环境和时代。社交网络的兴起、影响力和多功能性一直在影响机构传统上与其利益集团沟通和互动的方式,而武装部队作为当权者的遗产使得他们必须使用有效沟通的策略,强调机... 详细信息

在所有组织中,都需要良好的组织沟通,以适应他们日常生活中的社会环境和时代。社交网络的兴起、影响力和多功能性一直在影响机构传统上与其利益集团沟通和互动的方式,而武装部队作为当权者的遗产使得他们必须使用有效沟通的策略,强调机构与公民(观众)保持良好公共关系的战略沟通,可以抵消私人媒体精心策划的明显社会两极分化。现在,社交网络比以往任何时候都更加强大,对于组织的声誉和公众形象,对于客户、消费者和公民的意见、投诉和索赔,它们从未像现在这样重要。因此,即使在委内瑞拉,也有一些公共组织的沟通计划可以改进并适应他们的文化和背景,这表明潜在需要研究沟通策略以及从社交网络Twitter投射的机构沟通,以获取公众知识。从更普遍的传播角度来看,这项研究代表了解决新的普遍制度和战略形象投射动态问题的解决方案,以及如何将它们提升到组织需要克服这个信息技术平台时代的水平和通讯。本次调查通过使用内容分析方法和对通信管理办公室关键人员的访谈获得的调查结果在SWOT矩阵中进行对比,以确定优势和劣势。结果显示,玻利瓦尔海军在Twitter上的大部分内容都将重点放在制度价值观上(59.73%),而防御和作战能力(30.2%)仍然停留在后台,第三层面的战略沟通(10.6%)反映了弱点在机构形象的管理和投射方面。尽管有这些结果,但并非所有事情都可以进行负面评估,因为玻利瓦尔海军在11月和12月期间在社交网络Twitter上获得了良好的接受度,这为机构预测方面的改进提供了很大的余地。这个军事部分的形象。这项研究提出的建议包括生成可暴露组织和作战实力的视听内容,以及通过该平台使“海军力量”变得有形的视听内容,以及增加投射安全和防御的视听内容(视频)的创建的国家,但同时专注于制作更多具有情感内容的军事性质的推文,能够让观众和这些相互关联的观众参与进来。除此之外,重要的是通过社交网络上呈现的广泛现实,在随后的传播研究中深入研究军事和地缘政治问题,以便针对不同文化和纬度的多种社会问题提出不同的解决方案。

关键词：玻利瓦尔海军机构形象机构传播战略传播内容分析

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Newly self-administered two-step tool for screening cognitive function in an ageing Chinese population:an exploratory cross-sectional study

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General Psychiatry 2023年第1期36卷 28-35页

作者： Jing Nie Yang Yang Yining Gao Wenwen Jiang Aisikeer Aidina Fei Sun Lucas R prieto Jie Yu Kang Ju Lisheng Song Xia Li Department of Geriatric Psychiatry Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina School of Social Work Michigan State UniversityEast LansingMichiganUSA Department of Psychiatry Shanghai Changning Mental Health CenterShanghaiChina Department of Psychiatry Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina

Background Early screening of cognitive function is critical to dementia treatment and ***,traditional tests require face-to-face administration and are often limited by implementation costs and *** This study aimed to assess whether the Thoven Cognitive Self-Assessment(TCSA),a novel,innovative two-step touchscreen-based cognition assessment tool,could identify early cognitive impairment due to dementia in older *** The TCSA was administered to 61 healthy controls(HCs),46 participants with mild cognitive impairment(MCI)and 44 participants diagnosed with dementia recruited from *** outcome measures were generated from the TCSA test:the TCSA_(primary task)score and the TCSA_(secondary task)*** The total average scores in the control group for the TCSA_(primary task)and TCSA_(secondary task)were significantly higher than those in the MCI and dementia groups(TCSA_(primary task):HCs vs MCI group vs dementia group,8.58±1.76 vs 5.40±2.67 vs 2.74±2.11,F=75.40,pgroup vs dementia group,23.02±3.31 vs 17.95±4.93 vs 11.93±5.50,F=76.46,p<0.001).Moreover,receiver operating characteristic analysis showed that a score below 7.5 for the TCSA_(primary task)and a score below 22.5 for the TCSA_(secondary task)were indicators of *** The TCSA appears to be efficacious for the detection of cognitive impairment in older *** demonstrates the potential for large-scale cognition screening in community service settings.

关键词： function sectional cognitive

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Affinity-Based Network Interfaces for Efficient Communication on Multicore Architectures

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Journal of Computer Science & Technology 2013年第3期28卷 508-524页

作者： Andrés Ortiz Julio Ortega Antonio F.Díaz Alberto prieto Department of Communications Engineering University of Málaga Department of Computer Architecture and Technology/CITIC University of Granada

Improving the network interface performance is needed by the demand of applications with high communication requirements （for example, some multimedia, real-time, and high-performance computing applications）, and the availability of network links providing multiple gigabits per second bandwidths that could require many processor cycles for communication tasks. Multicore architectures, the current trend in the microprocessor development to cope with the difficulties to further increase clock frequencies and microarchitecture efficiencies, provide new opportunities to exploit the parallelism available in the nodes for designing efficient communication architectures. Nevertheless, although present OS network stacks include multiple threads that make it possible to execute network tasks concurrently in the kernel, the implementations of packet-based or connection-based parallelism are not trivial as they have to take into account issues related with the cost of synchronization in the access to shared resources and the efficient use of caches. Therefore, a common trend in many recent researches on this topic is to assign network interrupts and the corresponding protocol and network application processing to the same core, as with this affinity scheduling it would be possible to reduce the contention for shared resources and the cache misses. In this paper we propose and analyze several configurations to distribute the network interface among the different cores available in the server. These alternatives have been devised according to the affinity of the corresponding communication tasks with the location （proximity to the memories where the different data structures are stored） and characteristics of the processing core. As this approach uses several cores to accelerate the communication path of a given connection, it can be seen as complementary to those that consider several cores to simultaneously process packets belonging to either the same or different connections.

关键词： interrupt affinity processor affinity network interface offioading, SIMICS

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Lichinodium is a new lichenized lineage in the Leotiomycetes

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Fungal Diversity 2019年第1期94卷 23-39页

作者： Maria prieto Matthias Schultz Ibai Olariaga Mats Wedin Department of Botany Swedish Museum of Natural HistoryPO Box 5000710405 StockholmSweden Departamento de Biologia y Geologia Fısica y Quimica InorganicaUniversidad Rey Juan CarlosC/Tulipan s/n28933 MostolesMadridSpain Herbarium Hamburgense Institute for Plant Science and MicrobiologyUniversity of HamburgOhnhorststr.1822609 HamburgGermany

Here,we show that Lichinodium(Lichinaceae,Lichinomycetes,Ascomycota)constitutes a formerly unrecognized lineage within the Leotiomycetes,thus being the first lichenized lineage recognized in the superclass Sordariomyceta(Leotiomycetes,Laboulbeniomycetes and Sordariomycetes).To infer the position of Lichinodium,we constructed two multilocus phylogenies based on six and five gene regions(nuLSU rDNA,nuSSU rDNA,mtSSU rDNA,RPB1,RPB2 and MCM7)including main Pezizomycotina groups in the first analysis and focusing secondly on a comprehensive selection of *** results show that Lichinodium is sister to *** discuss the morphological and ecological similarities between Lichinodium and other Leotiomycetes,and describe the new order Lichinodiales and family *** sister relationship between Sordariomycetes and Laboulbeniomycetes is here supported as it is the relationship between this clade and the *** results also support the polyphyly of Helotiales,the recognition of the Leotiales in a strict sense or the inclusion of the Triblidiales in *** photobionts of Lichinodium were sequenced for two genetic markers(rbcLX and 16S rDNA)and identified as Rhizonema,a recently described genus of filamentous cyanobacteria belonging to *** studies revealed that the mycobiont-cyanobiont interface in Lichinodium does not produce haustoria,thus differing from a typical Lichinomycete(***).

关键词： Discomycetes Haustoria Lichenized fungi Lichinomycetes Lichinodiaceae Lichinodiales Pezizomycotina

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Collaborative learning via social computing

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Frontiers of Information Technology & Electronic Engineering 2019年第2期20卷 265-282页

作者： Ricardo S.ALONSO Javier prieto óscar GARCíA Juan M.CORCHADO BISITE Research group University of Salamanca

Educational innovation is a field that has been greatly enriched by using technology in its processes, resulting in a learning model where information comes from numerous sources and collaboration takes place among multiple students. One attractive challenge within educational innovation is the design of collaborative learning activities from the social computing point of view, where collaboration is not limited to student-to-student relationships, but includes student-to-machine interactions. At the same time, there is a great lack of tools that give support to the whole learning process and are not restricted to specific aspects of the educational task. In this paper, we present and evaluate context-aware framework for collaborative learning applications(CAFCLA) as a solution to these problems. CAFCLA is a flexible framework that covers the entire process of developing collaborative learning activities, taking advantage of contextual information and social interactions. Its application in the experimental case study of a collaborative WebQuest within a museum has shown that, among other benefits, the use of social computing improves the learning process, fosters collaboration, enhances relationships, and increases engagement.

关键词： Context-awareness Collaborative learning Social computing Virtual organizations Wireless sensor networks Real time location system

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Caspase-3 activation as a bifurcation point between plasticity and cell death

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Neuroscience Bulletin 2012年第1期28卷 14-24页

作者： Shikha Snigdha Erica D Smith G Aleph prieto Carl W Cotman Institute for Memory Impairments and Neurological Disorders University of CaliforniaIrvineIrvineCalifornia 92697-4540USA

Death-mediating proteases such as caspases and caspase-3 in particular, have been implicated in neurodegenerative processes, aging and Alzheimer＇s disease. However, emerging evidence suggests that in addition to their classical role in cell death, caspases play a key role in modulating synaptic function. It is remarkable that active caspases-3, which can trigger widespread damage and degeneration, aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death. Here, we evaluate this dichotomy, and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling, able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling. We propose that temporal, spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons. This concept has implications for differential roles of caspase-3 activation across the lifespan. Specifically, we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain.

关键词： caspase-3 neurodegeneration cognition memory synaptic function

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