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CCS Chemistry 2024年第7期6卷 1662-1671页

作者： Tamara Rodríguez-prieto Darren Wragg Nicole Heiduk Mihyun Park Nicole Strittmatter Roland A.Fischer Angela Casini Guillermo Moreno-Alcántar Chair of Medicinal and Bioinorganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Professorship for Analytical Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Chair of Inorganic and MetalOrganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Munich Data Science Institute(MDSI) Technical University of Munich85748 Garching b.München

The use of three-dimensional self-assembled metallacages(MCgs)as multimodal drug platforms holds great ***,the synthesis of MCgs with increased complexity and functionality is a great challenge since understanding of the interaction of MCgs with biological targets is still *** this context,this work reports on the integration of a gold(III)porphyrin scaffold into a prismatic MCg structure and explores its application for multimodal therapy of cancer in vitro,namely enabling both photodynamic therapy and *** experimental approaches with a state-of-the-art metadynamics theoretical study,we discovered that the gold cage shows unprecedented host-guest interaction-driven selective stabilization of guanine-quadruplex(G4)structures-validated anticancer drug targets-disclosing a new mechanism to pursue in the design of supramolecular drugs.

关键词： gold metallacages porphyrins G4stabili-zation host-guestchemistry anticanceragents

Therapeutic potential of lysosomal cathepsins for neurodegenerative diseases

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中国神经再生研究：英文版 2023年第8期18卷 1713-1714页

作者： Susy prieto Huarcaya Friederike Zunke Department of Molecular Neurology University Hospital ErlangenFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Lysosomes are ubiquitous and dynamic organelles with a central role in degradation and recycling of damaged cell components and misfolded proteins,otherwise known as *** plays a fundamental role in the process of correcting cell homeostasis and cellular ***,this process is essential in the central nervous system,as neurons are not able to easily eliminate altered proteins given their post-mitotic state.

关键词： homeostasis diseases otherwise

Bofedal response to climate variability, local management, and water extraction: A case study of Chucuyo, Northern Chile

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Journal of Mountain Science 2022年第1期19卷 241-252页

作者： URIBE-ÁLVAREZ Monserrat C prieto Manuel MESEGUER-RUIZ Oliver Departamento de Ciencias Históricas y Geográficas Universidad de TarapacáArica 1010069Chile Departamento de Ciencias Históricas y Geográficas Universidad de TarapacáIquique 1101783Chile

Andean high-altitude wetlands are important ecosystems that serve a range of socialecological functions. In the Andes, bofedales, a specific type of peat-producing wetland, are essential for the sustainability of mountain ecosystems and indigenous pastoralist communities. The Chucuyo bofedal in northern Chile is affected by climatic variability and water extraction for agricultural uses via the Lauca canal. Herders in the local community also actively manage this wetland according to their traditional ecological knowledge to ensure permanent fodder for their animals. In this article, we analyze the annual behavior of the Chucuyo bofedal after the wet season. Based on precipitation data, extracted water flows, vegetation vigor from satellite images, and an ethnographic approach, we determined that the bofedal’s productivity was negatively correlated with the amount of precipitation and positively correlated with the surface area of the wetland. However, water extraction via the Lauca channel had no significant relationship with either surface area or vegetation vigor. We identify community practices and traditional ecological knowledge as key elements in the maintenance of these ecosystems. This situation is critical in the context of an aging population and the current pattern of migration out of the region to urban areas. The results provide substantial empirical evidence for future decision-making regarding the conservation of these ecosystems.

关键词： Atacama Bofedales Indigenous people Lauca canal Normalized Difference Vegetation Index

Combination of Interleaved Single-input Multiple-output DC-DC Converters

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CSEE Journal of Power and Energy Systems 2022年第1期8卷 132-142页

作者： Eladio Dur´an Aranda Salvador P´erez Litr´an Mar´ıa Bella Ferrera prieto Electronic Engineering Computer Systems and Automation DepartmentUniversity of HuelvaHuelvaSpain Electrical and Thermal Engineering Design and Projects DepartmentUniversity of HuelvaHuelvaSpain

This paper analyses,simulates and verifies an experimental prototype of a four-phase interleaved DC-DC *** is based on a SEPIC-Cuk *** developed prototype has been used in single-input multiple-output(SIMO)*** combined converter allows obtaining dual output voltages of the same value,from a single input DC voltage and with only a power *** interleaved DC-DC converters achieve a better dynamic response and low ripple,maintaining their *** converter is connected in parallel,thereby managing their losses by distributing them between more components,which facilitates the thermal management of the multiphase converter and allows handling high power values in small sizes with respect to solutions for a single *** control strategies were applied:synchronous operation mode(SOM)and interleaved operation mode(IOM).The simulation results allow the comparison of both operational modes,verifying that the IOM presents advantages with respect to the ripple at the input and output *** experimental prototype was designed for a distributed power architecture and bipolar DC microgrid(MG).

关键词： Bipolar DC DC-DC converter interleaved

A computer vision system for early detection of anthracnose in sugar mango(Mangifera indica)based on UV-A illumination

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Information Processing in Agriculture 2023年第2期10卷 204-215页

作者： Leonardo Ramırez Alberto Carlos Eduardo Cabrera Ardila Flavio Augusto prieto Ortiz Facultad de Ingenierı´a Universidad Nacional de ColombiaBogota´D.C.111321Colombia

The present work describes the development of a computer vision system for the early detection of anthracnose in sugar mango based on Ultraviolet A illumination(UV-A).Anthracnose,a disease caused by the fungus Colletotrichum sp,is commonly found in the fruit of sugar mango(Mangifera indica).It manifests as surface defects including black spots and is responsible for reducing the quality of the ***,it decreases its commercial *** more detail,this study poses a system that begins with image acquisition under white and ultraviolet ***,it proposes to analyze the Red,green and Blue color information(R,G,B)of the pixels under two types of illumination,using four different methods:RGB-threshold,RGB-Linear Discriminant Analysis(RGBLDA),UV-LDA,and *** analysis produces an early semantic segmentation of healthy and diseased areas of the mango *** results showed that the combination of the linear discriminant analysis(LDA)and UV-A light(called UV-LDA method)in sugar mango images allows early detection of ***,this method achieves the identification of the disease one day earlier than by an expert with respect to the scale of anthracnose severity implemented in this work.

关键词： Sugar mango Anthracnose LDA UV-A light grading Image processing

Evaluation of remote radiologist-interpreted point-of-care ultrasound for suspected dengue patients in a primary health care facility in Colombia

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Infectious Diseases of Poverty 2023年第5期12卷 45-57页

作者： Lyda Osorio Iñigo prieto Daniela Zuluaga Deliana Ropero Neelesh Dewan Jonathan D.Kirsch Epidemiology and Population Health Research group(GESP) School of Public HealthUniversidad del ValleCaliColombia Department of Radiology School of MedicineUniversidad del ValleCaliColombia Division of General Internal Medicine Department of Internal MedicineUniversity of Minnesota Medical SchoolMinneapolisMN 55455USA Department of Internal Medicine University of Miami Miller School of MedicineMiamiFLUSA

Background Early identification of plasma leakage may guide treatment decisions in dengue *** study evaluated the value of point-of-care ultrasound(POCUS)to detect plasma leakage and predict hospitalization or referral to a higher level of care in suspected dengue patients under routine conditions at a primary care facility in *** We conducted a cohort study between April 2019 and March 2020 in a primary care hospital in Cali,*** prospectively included and followed 178 patients who were at least 2 years old with fever of less than 10 days and clinician-suspected dengue.A trained general practitioner performed a standardized POCUS *** were quality-rated and overread by an expert radiologist,and her results and those of the general practitioner were compared using the Kappa *** regression was used to identify factors associated with plasma leakage at enrollment and explore its prognostic value regarding hospital admission or referral to a higher level of *** Half(49.6%)POCUS images were of suitable quality to be *** proportion of plasma leakage reported by the radiologist was 85.1%(95%CI:78.6-90.2%)and 47.2%by the study physician(Kappa=0.25,95%CI:0.15-0.35).The most frequent ultrasound findings were ascites(hepatorenal 87.2%,splenorenal 64%,or pelvic 21.8%)and gallbladder wall thickening(10.5%).Plasma leakage was higher in subjects with thrombocytopenia(aOR=4,95%CI:1.3-12.1)and lower in patients 30-59 years old(aOR=0.1,95%CI:0.0-0.4)than in those 18 years old or *** evidence of plasma leakage(aOR=8.2,95%CI:2.2-29.9),thrombocytopenia(aOR=6.3,95%CI:2.4-16.0)and pulse pressure(aOR=1.1,95%CI:1.07-1.2)were associated with hospital admission or referral to a higher level of *** Ultrasound is useful to detect plasma leakage in primary care and,challenges remain to guarantee high-quality images and diagnostic accuracy,for which a standardized dengue POCUS protocol and training pr

关键词： Dengue Ultrasound Plasma leakage Primary care Colombia

Gene Therapy of Cancer:Induction of Anti-Tumor Immunity

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Cellular & Molecular Immunology 2004年第2期1卷 105-111页

作者： Jesus prieto Division

Many malignancies lack satisfactory treatment and new therapeutic options are urgently *** therapy is a new modality to treat both inherited and acquired diseases based on the transfer of genetic material to the *** gene therapy strategies against cancers have been developed.A considerable number of preclinical studies indicate that a great variety of cancers are amenable to gene *** these strategies, induction of anti-tumor immunity is the most promising *** therapy with cytokines has reached unprecedented success in preclinical models of *** rather than additive effects have been demonstrated by combination of gene transfer of cytokines/chemokines,costimulatory molecules or adoptive cell *** progress in vector technology and in imaging techniques allowing in vivo assessment of gene expression will facilitate the development of clinical applications of gene therapy,a procedure which may have a notorious impact in the management of cancers lacking effective *** & Molecular Immunology.2004;1(2):105-111.

关键词： gene therapy anti-tumor immunity cytokines costimulatory molecules dendritic cell

Philippine retinoblastoma initiative multi-eye center study 2010-2020

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： Roland Joseph D.Tan Gary John V.Mercado Patricia E.Cabrera Paulita Pamela P.Astudillo Rolando Enrique D.Domingo Josept Mari S.Poblete Charmaine grace M.Cabebe Adriel Vincent R.Te Melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amanda K.Comia Josemaria M.Castro Mara Augustine S.Galang Aldous Dominic C.Cabanlas Benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo Michael Maniwan Andrei P.Martin Calvin Y.Martinez John Alfred H.Lim Rena Ivy Bascuna Rachel M.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz M.prieto Department of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philippines Department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines Department of Ophthalmology Manila Doctors HospitalManila 1000Philippines Department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines Department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines Department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines Department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines Department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines Department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines Department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and Mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon,Vizayas and Mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(Pgraphical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).Delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

Colorectal cancer screening and surveillance in patients with inflammatory bowel disease in 2021

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World Journal of Gastroenterology 2022年第5期28卷 502-516页

作者： Jose Maria Huguet Luis Ferrer-Barceló Patrícia Suárez Eva Sanchez Jose David prieto Victor Garcia Javier Sempere Department of Digestive Disease General University Hospital of ValenciaValencia 46014Spain

The detection of dysplasia in patients with inflammatory bowel disease(IBD)continues to be important given the increased risk of colorectal cancer in this ***,in 2017,we performed a review and update of the recommendations for the management and follow-up of patients with IBD based on the clinical practice guidelines of various scientific *** present manuscript focuses on new aspects of the detection,follow-up,and management of dysplasia according to the latest studies and *** chromoendoscopy with targeted biopsy continues to be the technique of choice for the screening and detection of dysplasia in IBD,the associated difficulties mean that it is now being compared with other techniques(virtual chromoendoscopy),which yield similar results with less technical ***,the emergence of new endoscopy techniques that are still being researched but seem promising(e.g.,confocal laser endomicroscopy and full-spectrum endoscopy),together with the development of devices that improve endoscopic visualization(e.g.,Endocuff Vision),lead us to believe that these approaches can revolutionize the screening and follow-up of dysplasia in patients with ***,further studies are warranted to define the optimal follow-up strategy in this patient population.

关键词： Colitis surveillance Colitis screening Chromoendoscopy Colorectal cancer Inflammatory bowel disease Ulcerative colitis

Phylogeny,taxonomy and diversification events in the Caliciaceae

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Fungal Diversity 2017年第1期82卷 221-238页

作者： Maria prieto Mats Wedin Department of Botany Swedish Museum of Natural HistoryPO Box 5000710405 StockholmSESweden Departamento de Biología y Geología Física y Química InorgánicaUniversidad Rey Juan CarlosC/Tulipan s/n28933 MostolesMadridSpain

Although the high degree of non-monophyly and parallel evolution has long been acknowledged within the mazaediate Caliciaceae(Lecanoromycetes,Ascomycota),a natural re-classification of the group has not yet been *** we constructed a multigene phylogeny of the Caliciaceae-Physciaceae clade in order to resolve the detailed relationships within the group,to propose a revised classification,and to perform a dating *** few characters present in the available fossil and the complex character evolution of the group affects the interpretation of morphological traits and thus influences the assignment of the fossil to specific nodes in the phylogeny,when divergence time analyses are carried *** fossil assignments resulted in very different time estimates and the comparison with the analysis based on a secondary calibration demonstrates that the most likely placement of the fossil is close to a terminal node rather than a basal placement in the Calicium *** dating analysis show two successive events giving rise to main clades of mazaediate taxa within the Caliciaceae,in the Upper-Lower Cretaceous boundary and in the *** a result of this study,Cyphelium is synonymized with Calicium,Acolium is resurrected,and the new genera Allocalicium and Pseudothelomma are *** new combinations are proposed:Acolium karelicum,Acolium marcianum,Allocalicium adaequatum,Calicium carolinianum,Calicium lecideinum,Calicium lucidum,Calicium notarisii,Calicium pinicola,Calicium trachyliodes,Pseudothelomma occidentale,Pseudothelomma ocellatum and Thelomma brunneum.A key for the mazaedium-producing Caliciaceae is included.

关键词： Allocalicium gen nov Calicium fossil Divergence time estimates Lichens Multigene Pseudothelomma gen nov