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Is There a Link between Circadian Clock Protein PERIOD 3 (PER3) (rs57875989) Variant and the Severity of COVID-19 Infection?

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Current Medical Science 2021年第6期41卷 1075-1080页

作者： gozde yesil sayin Sacide PEHLIVAN Istemi SERIN Alpay MEDETALIBEYOGLU Murat ROSE Ali AGACFIDAN Naci SENKAL Ummihan ISOGLU-ALKAC Tufan TUKEK Department of Medical Genetics Istanbul Faculty of MedicineIstanbul UniversityIstanbul 34098Turkey Department of Medical Biology Istanbul Faculty of MedicineIstanbul UniversityIstanbul 34098Turkey Department of Hematology Istanbul Training and Research HospitalUniversity of Health SciencesIstanbul 34098Turkey Department of Internal Medicine Istanbul Faculty of MedicineIstanbul UniversityIstanbul 34098Turkey Department of Microbiology Istanbul Faculty of MedicineIstanbul UniversityIstanbul 34098Turkey Department of Physiology Istanbul Faculty of MedicineIstanbul UniversityIstanbul 34098Turkey

Objective:Corona Virus Disease-2019(COVID-19)has been among the major infectious events of the *** today’s literature where COVID-19 and host factor effects are frequently examined,we aimed to examine another factor:Circadian Clock Protein PERIOD 3(PER3).There is a significant correlation between PER3 gene polymorphism and circadian rhythm disturbances and immune system ***:In our study,we recruited 200 patients diagnosed with COVID-19 in our hospital between April-June 2020,and 100 volunteers without known comorbidities to create a healthy control *** comparing the initial gene polymorphisms of the patients with healthy controls,three separate clinical subgroups were *** polymorphism distribution and statistical significance were examined in the formed patient ***:No significant difference was found between the patient group and the healthy controls(P>0.05,for all).When patients were divided into two separate clinical subgroups as exitus/alive according to their last condition during their 28-day follow-up,the 4R/5R genotype was significantly more common in patients with a mortal course(P=0.007).The PER34R75R genotype was found at a significantly higher rate in the group of patients with the need for intensive care(P=0.034).Conclusion:The 4R/5R genotype may be associated with the need for intensive care and mortality in COVID-19 *** important results will be a guide for future studies.

关键词： corona virus disease 2019 circadian rhythm PER3 prognosis

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