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Non-small Cell Lung Cancer Epigenomes Exhibit Altered DNA Methylation in Smokers and Neversmokers

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Genomics, Proteomics & Bioinformatics 2023年第5期21卷 991-1013页

作者： Jennifer A.Karlow Erica C.Pehrsson Xiaoyun Xing Mark Watson Siddhartha Devarakonda Ramaswamy govindan Ting Wang Department of Genetics Washington University School of MedicineSt.LouisMO 63110USA The Edison Family Center for Genome Sciences and Systems Biology Washington University School of MedicineSt.LouisMO 63110USA Department of Pathology and Immunology Washington University School of MedicineSt.LouisMO 63110USA Department of Medicine Washington University School of MedicineSt.LouisMO 63110USA McDonnell Genome Institute Washington University School of MedicineSt.LouisMO 63108USA

Epigenetic alterations are widespread in cancer and can complement genetic alterations to influence cancer progression and treatment *** determine the potential contribution of DNA methylation alterations to tumor phenotype in non-small cell lung cancer(NSCLC)in both smoker and never-smoker patients,we performed genome-wide profiling of DNA methylation in 17 primary NSCLC tumors and 10 matched normal lung samples using the complementary assays,methylated DNA immunoprecipitation sequencing(MeDIP-seq)and methylation sensitive restric-tion enzyme sequencing(MRE-seq).We reported recurrent methylation changes in the promoters of several genes,many previously implicated in cancer,including FAM83A and SEPT9(hy-pomethylation),as well as PCDH7,NKX2-1,and SOX17(hypermethylation).Although many methylation changes between tumors and their paired normal samples were shared across patients,several were specific to a particular smoking *** example,never-smokers displayed a greater proportion of hypomethylated differentially methylated regions(hypoDMRs)and a greater number of recurrently hypomethylated promoters,including those of ASPSCRI,TOP2A,DPP9,and USP39,all previously linked to *** outside of promoters were also widespread and often recurrent,particularly methylation loss over repetitive elements,highly enriched for ERV1 *** hypoDMRs were enriched for several transcription factor binding motifs,often for genes involved in signaling and cell *** example,71%of recurrent promoter hypoDMRs contained a motif for ***,the majority of DMRs were located within an active chromatin state in tissues profiled using the Roadmap Epigenomics data,suggesting that methylation changes may contribute to altered regulatory programs through the adaptation of cell type-specific expression programs.

关键词： Non-small cell lung cancer Epigenomics M&M methylCRF DNA methylation

The Occurrence of Ophiocnemis marmorata (Echinodermata:Ophiuroidea) Associated with the Rhizostome Medusa Rhopilema hispidum (Cnidaria:Scyphozoa)

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Journal of Ocean University of China 2008年第4期7卷 421-424页

作者： govindan Kanagaraj Pithchai Sampath Kumar André C. Morandini Center of Advanced Study in Marine Biology Annamalai University Nucleus of Ecology and Social-Environmental Development of Macaé (NUPEM/UFRJ) Federal University of Rio de Janeiro (UFRJ)C. P. 119331Macaé27910-970RJBrazil

The association of scyphomedusae with invertebrates has been long known in the literature; especially with hyperiids amphipods. The association of echinoderms with jellyfish is not common and rarely recorded. We reported the association of the ophiuroid Ophiocnemis marnmrata with the rhizostome scyphomedusa Rhopilema hispidum collected in Vellar estuary （on the southeast coast of India）. O. marmorata is supposed to be a filter feeding ophiuroid, quite common in soft bottom of shallow waters. The brittle stars possibly seek for food supply, shelter and protection through the association.

关键词： association jellyfish brittle star India

Molecular characterization and antibacterial effect of endophytic actinomycetes Nocardiopsis sp. GRG1 (KT235640) from brown algae against MDR strains of uropathogens

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Bioactive Materials 2016年第2期1卷 140-150页

作者： govindan Rajivgandhi Ramachandran Vijayan Marikani Kannan Malairaja Santhanakrishnan Natesan Manoharan Department of Marine Science Bharathidasan UniversityTiruchirappalli 24Tamil NaduIndia School of Life Sciences Jawaharlal Nehru UniversityNew Delhi 67India Department of Microbiology VHNSN CollegeVirudunagar 01Tamil NaduIndia Department of Marine and Coastal Studies Madurai Kamaraj UniversityMadurai 21Tamil NaduIndia

Our study is to evaluate the potential bioactive compound of Nocardiopsis ***1(KT235640)and its antibacterial activity against multi drug resistant strains(MDRS)on urinary tract infections(UTIs).Two brown algae samples were collected and were subjected to isolation of endophytic actinomycetes.100 strains of actinomycetes were isolated from algal samples based on observation of morphology and physiological characters.40 strains were active in antagonistic activity against various clinical *** the strains,10 showed better antimicrobial activity against MDRS on *** secondary metabolite of Nocardiopsis ***1(KT235640)has showed tremendous antibacterial activity against UTI pathogens compared to other *** of various growth parameters were used for synthesis of secondary metabolites,such as optimum pH 7,incubation time 5e7 days,temperature(30C),salinity(5%),fructose and mannitol as the suitable carbon and nitrogen *** 100 μg/ml concentration MIC of Nocardiopsis ***1(KT235640)showed highest percentage of inhibition against Proteus mirabilis(85%),and ***,Staphylococcus auerues,Psuedomonas aeroginasa,Enterobactor sp and Coagulinase negative staphylococci 78e85%respectively.

关键词： Endophytes Multi-drug resistant strains Urinary tract infections Minimal inhibitory concentration

Erratum to:Phase-pure two-dimensional Fe_(x)GeTe_(2)magnets with near-roomtemperature T_(C)

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Nano Research 2024年第6期17卷 5757-5757页

作者： govindan Kutty Rajendran Nair Zhaowei Zhang Fuchen Hou Ali Abdelaziem Xiaodong Xu Steve Wu Qing Yang Nan Zhang Weiqi Li Chao Zhu Yao Wu Heng Weiling Lixing Kang Teddy Salim Jiadong Zhou Lin Ke Junhao Lin Xingji Li Weibo Gao Zheng Liu School of Material Science and Engineering Nanyang Technological University50 Nanyang Ave639798Singapore Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological University21 Nanyang Link637371Singapore Department of Physics Southern University of Science and TechnologyShenzhen 518055China Institute of Materials Research and Engineering Agency for Science Technology and Research(A*STAR)2 Fusionopolis Way138634Singapore School of Material Science and Engineering School of PhysicsHarbin Institute of TechnologyHarbin 150001China Shenzhen Key Laboratory of for Advanced Quantum Functional Materials and Devices Southern University of Science and TechnologyShenzhen 518055China National Institute of Laser Enhanced Sciences(NILES) Cairo UniversityGiza 12613Egypt CINTRA CNRS/NTU/THALES UMI 3288Research Techno Plaza637553Singapore School of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang Ave639798Singapore

The affiliation of three authors is unfortunately miswritten on the first page of this article and in the ESM. © Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2021.

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Field and Laboratory Observations on Predation and Prey Selectivity of the Scyphomedusa Chrysaora *** in Southeast Indian Waters

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Journal of Ocean University of China 2011年第1期10卷 47-54页

作者： govindan Kanagaraj Pazhaniyappan Ezhilarasan Pitchai Sampathkumar André C.Morandini Velayudhan pillai Sivakumar Southeastern Institute of Marine Biology Thomas Nagar Department of Zoology V.O.Chidambaram College Centre of Advanced Study in Marine Biology Departamento de Zoologia Instituto de BiociênciasUniversidade de So Paulo

Chrysaora ***,one of the most abundant medusae species in India,seems to be an important predator in the coastal waters of Bay of *** ability of Chrysaora *** to feed at maximum rate in high prey concentrations implies that this jellyfish can efficiently exploit dense prey patches,at least for a short *** study presents preliminary information regarding digestion and feeding rate upon copepods in a warm water *** ingestion rate of the average-sized medusae Chrysaora *** is well balanced in nature,which in turn implies that this jellyfish is tuned for optimal utilization of available prey *** with earlier research indicates that prey escape speed is one important factor governing which prey will be captured.A full understanding of predation mechanics awaits further investigation of both predator and prey ***,because of the scarcity of long-term quantitative population data most insights have to be made ***,low abun-dance of Chrysaora *** in the water column during summer (May 2007) and the overall annual abundance seem not to con-siderably affect the zooplankton population,especially *** present work contributes to the knowledge of prey-predator relationship of the forgotten fauna in Indian waters,which is especially crucial for understanding the process of ecological recovery of coastal water environment.

关键词： predation prey selectivity jellyfish Bay of Bengal copepods

A topologically substituted boron nitride hybrid aerogel for highly selective CO2 uptake

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Nano Research 2018年第12期11卷 6325-6335页

作者： R.govindan Kutty Sivaramapanicker Sreejith Xianghua Kong Haiyong He Hong Wang Junhao Lin Kazu Suenaga Chwee Teck Lim Yanli Zhao Wei Ji Zheng Liu Center for Programmable Materials School of Materials Sdence and EngineeringNanyang Technological UniversitySO Nanyang Avenue639798Singapore School of Materials Science and EngineeringNanyang Technological UniversitySingapore 639798Singapore Center for Advanced 2D Materials and Graphene Research Center National University of Singapore6Science Drive 2Singapore117546Singapore Biomedical Institute for Global Health Research and Technology National University of Singapore14Medical DriveSingapore 117599Singapore Department of Physics and Beijing Key Laboratory of Optoelectronic Functional Materials & Micro-Nano Devices Renmin University of ChinaBeijing 100872China National Institute of Advanced Industrial Science and Technology (AIST) AIST Central 5Tsukuba305-8565-Japan Division of Chemistry and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological University21-Nanyang LinkSingapore 637371Singapore Department of Biomedical Engineering National University of SingaporeSingapore 117543Singapore

A topologically mediated synthesis of porous boron nitride aerogel has been experimentally and theoretically investigated for carbon dioxide (CO2) uptake. Replacement of the carbon atoms in a precursor aerogel of graphene oxide and carbon nanotubes was achieved using an elemental substitution reaction, to obtain a boron and nitrogen framework. The newly prepared BN aerogel possessed a specific surface area of 716.56 m2/g and exhibited an unprecedented twentyfold increase in CO2 uptake over N2, adsorbing 100 cc/g at 273 K and 80 cc/g in ambient conditions, as verified by adsorption isotherms via the multipoint Brunauer-Emmett-Teller (BET) method. Density functional theory calculations were performed to give hints on the mechanism of such high selectivity of CO2 over N2 adsorption in BN aerogel, which may be due to the interaction between the intrinsic polar nature of B–N bonds and the high quadrupole moment of CO2 over N2.

关键词： boron nitride boron nitride nanotube aerogel quadrupole moment selective CO 2 adsorption

Nutraceuticals as potential therapeutic agents for colon cancer: a review

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Acta Pharmaceutica Sinica B 2014年第3期4卷 173-181页

作者： Palaniselvam Kuppusamy Mashitah M.Yusoff Gaanty Pragas Maniam Solachuddin Jauhari Arief Ichwan Ilavenil Soundharrajan Natanamurugaraj govindan Mammalian Cell Technology Laboratory Faculty of Industrial Sciences and TechnologyUniversiti Malaysia PahangLebuhraya Tun Razak 26300GambangKuantanPahangMalaysia Kulliyyah of Dentistry International Islamic University MalaysiaBandar Indera Mahkota 25200KuantanPahangMalaysia Department of Biochemistry National Institute of Animal ScienceSuwon-siGyeonggi-do 441706South Korea

Colon cancer is a world-wide health problem and the second-most dangerous type of cancer,affecting both men and *** modern diet and lifestyles,with high meat consumption and excessive alcohol use,along with limited physical activity has led to an increasing mortality rate for colon cancer *** a result,there is a need to develop novel and environmentally benign drug therapies for colon ***,nutraceuticals play an increasingly important role in the treatment of various chronic diseases such as colon cancer,diabetes and Alzheimer's *** are derived from various natural sources such as medicinal plants,marine organisms,vegetables and *** have shown the potential to reduce the risk of colon cancer and slow its *** dietary substances target different molecular aspects of colon cancer ***,this review briefly discusses the medicinal importance of nutraceuticals and their ability to reduce the risk of colorectal carcinogenesis.

关键词： Colon cancer Nutraceuticals Therapeutics Marine organisms Plant derivatives

Effect of Lithium Doping on the Properties L-Citrulline Oxalate Monohydrate Nonlinear Optical Crystals

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Open Journal of Metal 2012年第4期2卷 82-86页

作者： Vallath govindan Sreevalsa Sankaran Jayalekshmi Division for Research in Advanced Materials Department of Physics Cochin University of Science and Technology Cochi India

Single crystals of pure and Li+ doped L-citrulline oxalate (LCO) crystals are grown successfully by slow evaporation technique. The effect of lithium doping on crystal properties has been studied. The samples are characterized by X-ray powder diffraction, TGA, FTIR, Raman and UV-Vis spectroscopic techniques. The presence of lithium in Li+ doped LCO crystals is estimated using AES. The thermal stability and the optical transparency region are found to be enhanced for the doped samples. The second harmonic generation efficiency of the doped crystal has improved considerably compared to pure L-citrulline oxalate. Lithium doping can hence be considered as a simple and advantageous technique to improve the thermal, optical and non linear optical (NLO) properties of the LCO single crystals.

关键词： Doping X-Ray Diffraction Growth from Solutions Single Crystal Growth Nonlinear Optic Material

Application of Taguchi’s Orthogonal Array in Multi Response Optimization of NO<sub>x</sub>Emission of Crude Rice Bran Oil Methyl Ester Blend as a CI Engine Fuel

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Open Journal of Optimization 2012年第2期1卷 25-33页

作者： Subramani Saravanan govindan Nagarajan Santhanam Sampath Department of Automobile Engineering Rajalakshmi Engineering College Thandalam India Department of Automobile Engineering Sri Venkateswara College of Engineering Sriperumbudur India Department of Mechanical Engineering College of Engineering Anna University Chennai India

In this work an attempt was made to minimize the NOx emission of a crude rice bran oil methyl ester (CRBME) blend with less sacrifice on smoke density and brake thermal efficiency. Three factors namely fuel injection timing, percentage EGR and fuel injection pressure were chosen as the influencing factors for the set objective. Experiments were designed by employing design of experiments method and Taguchi’s L9 orthogonal array was used to test the engine. MRSN ratio was calculated for the response variables and the optimum combination level of factors was obtained simultaneously using Taguchi’s parametric design. ANOVA was employed to analyze the variance of MRSN and the most influencing factor for the set objective was taken from the ANOVA table. Obtained combination was confirmed experimentally and significant improvement was observed in the response variables.

关键词： Diesel Engine Emission Crude Rice Bran Oil Biodiesel Taguchi’s Orthogonal Array MRSN DOE