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Investigation of FOXP3 (rs3761548) polymorphism with the risk of preeclampsia and recurrent spontaneous abortion: A systemic review and meta-analysis

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Asian pacific Journal of Reproduction 2022年第3期11卷 117-124页

作者： govinda sri varshini Sivakumar Harshini Muhammed Ali Siham govindaraj Krishnamurthy Tejaswini Yasam Santhosh Kumar Langeswaran Kulanthaivel Gowtham Kumar Subbaraj Faculty of Allied Health Sciences Chettinad Hospital and Research InstituteChettinad Academy of Research and Education(Deemed to be University)KelambakkamTamil Nadu 603103India Department of Bioinformatics Alagappa UniversityKaraikudi-630003Tamil NaduIndia

Objective:To investigate the association between forkhead box P3(FOXP3)(rs3761548)polymorphism and the risk of preeclampsia and recurrent spontaneous ***:Literature on the association of FOXP3 gene polymorphisms and susceptibility to preeclampsia and unexplained recurrent spontaneous abortion was retrieved by searching databases such as PubMed,Science Direct,Google Scholar and Embase from 2000 to *** association measure was analyzed using an odds ratio(OR)and 95%confidence interval(CI).All the statistical analyses were executed using RevMan 5.4 ***:In the present meta-analysis,11 articles were *** pooled results showed no association between FOXP3 gene polymorphism(rs3761548)and preeclampsia risk in allelic,recessive,dominant and over dominant contrast ***3 gene polymorphism(rs3761548)showed an association with recurrent abortion in allelic,recessive and dominant models(OR 1.85,CI 1.59-2.14;OR 2.02,95%CI 1.56-2.62;OR 2.69,95%CI 1.50-4.83,respectively),while no association in the over dominant contrast model(OR 1.35,CI 0.87-2.10).Conclusions:In the present study,FOXP3 gene(rs3761548)polymorphism is associated with risk of recurrent spontaneous abortion but not ***,larger sample size and multiracial studies are needed in the future to confirm the findings.

关键词： Preeclampsia FOXP3 gene Single nucleotide polymorphism rs3761548 Unexplained recurrent spontaneous abortion

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Evaluation on Microstructure and Mechanical Behaviour of Al6061-Al<sub>2</sub>O<sub>3</sub>-Gr Hybrid Composites

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Open Journal of Composite Materials 2019年第3期9卷 285-299页

作者： Rajanna Manjunatha Doddarasinakere Kempaiah Ravishankar govinda Panduranga Murthy Setty Bengaluru Siddalingaiah Rakesh Chalya Mallappaji Shiva Prasad Rajesh Kumar Department of Mechanical Engineering Vivekananda Institute of Technology Bangalore India Department of Chemistry Sri Mahadeshwara Government First Grade College (Affiliated to University of Mysore) Kollegal Karnataka India Department of Engineering Chemistry Maharaja Institute of Technology Thandavapura Nanjangud Taluk Karnataka India Department of Chemistry Government First Grade College for Women Mysuru India Department of Chemistry Ranchi University Ranchi India

Metal matrix composites (MMCs) are gaining widespread recognition in numerous technological fields owing to its superior mechanical properties when compared with conventional metals/alloys. The aluminium based hybrid composites are increasingly being used in the transport, aerospace, marine, automobile and mineral processing industries, owing to the improved strength, stiffness and wear resistance properties. In the present research work, the composites were prepared using the liquid metallurgy technique, in which 2 - 10 weight percentage of Al2O3 particulates and 1 weight percentage of Graphite were dispersed in the base Al6061 alloy. The Casted hybrid composites were subjected to machining process to prepare the specimens according to ASTM standards. Then, the prepared specimens are subjected for assessing the Microstructure followed by its Mechanical behaviors such as, Hardness, Tensile strength, Compressive strength respectively. The microstructure analysis confirms that homogenous distribution of Al2O3 and Gr in the Al6061 matrix alloy and there was a momentous enhancement in decisive tensile strength, compressive strength and hardness properties of the hybrid composite. However, a substantial increase in the compressive strength was noticed in graphite reinforced composites as the graphite content was increased and there was a significant diminution in hardness coupled with monotonic increases in the ductility. Further, the ultimate tensile strength and compressive strength of the composite was noticed;thus the outcome of the study will provide explicit rationalizations for these observable facts. Therefore, the proposed way out in the study can provide ample of approaches to minimize the existing problem by employing this newer hybrid composites.

关键词： Hybrid Composites Casting Liquid Metallurgy Characterization of Al6061-Al2O3-Gr Microstructure Mechanical Behaviors Quality Assessment

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