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Targeting brain tumors with innovative nanocarriers:bridging the gap through the blood-brain barrier

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Oncology Research 2024年第5期32卷 877-897页

作者： KAraN WADHWA PAYAL CHAUHAN SHOBHIT KUMAR raKESH PAHWA raVINDER VERMA raJAT GOYAL govind singh ARCHANA SHARMA NEHA raO DEEPAK KAUSHIK Department of Pharmaceutical Sciences Maharshi Dayanand UniversityRohtak124001India Department of Pharmaceutical Technology Meerut Institute of Engineering and Technology(MIET)NH-58Delhi-Roorkee HighwayMeerut250005India Institute of Pharmaceutical Sciences Kurukshetra UniversityKurukshetra136119India Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani127021India MM College of Pharmacy Maharishi Markandeshwar(Deemed to be University)Mullana-AmbalaHaryana133207India Delhi Pharmaceutical Sciences and Research University(DIPSAR) Delhi Pharmaceutical Sciences and Research UniversityNew Delhi110017India

Background:Glioblastoma multiforme(GBM)is recognized as the most lethal and most highly invasive *** high likelihood of treatment failure arises fromthe presence of the blood-brain barrier(BBB)and stemcells around GBM,which avert the entry of chemotherapeutic drugs into the ***:Recently,several researchers have designed novel nanocarrier systems like liposomes,dendrimers,metallic nanoparticles,nanodiamonds,and nanorobot approaches,allowing drugs to infiltrate the BBB more efficiently,opening up innovative avenues to prevail over therapy problems and radiation ***:Relevant literature for this manuscript has been collected from a comprehensive and systematic search of databases,for example,PubMed,Science Direct,Google Scholar,and others,using specific keyword combinations,including“glioblastoma,”“brain tumor,”“nanocarriers,”and several ***:This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM *** of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.

关键词： Glioblastoma Brain tumor Blood-brain barrier Liposomes Metallic nanoparticles Nanocarriers

Assessment of the carbon emissions reduction potential in Thailand’s power sector with high penetration of variable renewable energy sources and electric vehicles in the year 2030

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Clean Energy 2023年第6期7卷 1391-1401页

作者： Niphit Phothisourinh Jai govind singh Department of Energy Environment and Climate ChangeSchool of EnvironmentResources and DevelopmentAsian Institute of TechnologyPathum ThaniThailand

The power sector has substantial carbon emissions reduction potential that could achieve the new nationally determined contribution target in 2030 by increasing low-carbon technologies,*** renewable energy sources and electric vehicles(EVs).Therefore,two approaches were suggested in this *** the first approach,Thailand’s power sector was modelled by using PLEXOS software to find the impact of the high penetration of variable renewable energy(RE)and EV charging load for the projected year *** second approach proposed a demand-response and energy storage system solution with carbon pricing in the model to assess the *** a result,the electricity demand from charging EVs will cause a new peak demand at night,while the high variable RE penetration will cause curtailment in the power system due to excess supply at ***,Thailand’s power sector has the potential for carbon emissions reduction by 45%with clean energy technologies,which could increase to 68%with carbon pricing,easily achievable by the nationally determined contribution target in ***,these benefits could only be derived if various entities involved in the energy regulatory,transport and power sectors coordinate to implement the required technological and financial policies.

关键词： Thailand power sector CO_(2)reduction carbon neutrality low-carbon technologies PLEXOS carbon pricing demand-response electric vehicles

Factors affecting electric vehicle acceptance,energy demand and CO_(2)emissions in Pakistan

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Green Energy and Intelligent Transportation 2023年第3期2卷 3-15页

作者： Muhammad Huzaifa Butt Jai govind singh Department of Energy Environment and Climate ChangeSchool of Environment and Resources DevelopmentAsian Institute of TechnologyThailand

This work aims to investigate the factors accelerating electric vehicle(EV)acceptance at the consumer end in Pakistan and analyzes the implications for policymakers for a fast-track EV *** study further in-vestigates the high EV penetration scenario resulting from the technology acceptance model(TAM's 80%EV)and its impact on energy demand and CO_(2)*** study design used a quantitative analysis method with the survey as an instrument for data collection regarding EV *** model under investigation was adapted from the famous Technology-Acceptance Models(TAMs)and modified with other significant predictors evidenced in the *** and stepwise regression were performed with a multicollinearity check for model hypothesis *** of six predictors,only four factors were significant in accelerating the EV *** policies were found to be highly significant,followed by environmental concern,facilitating conditions and perceived ease of *** research then used exponential smoothing forecasts for transport demand and developed an EV penetration scenario based on modified TAM *** results highlight the significant in-crease in transport demand and the opportunity for Pakistan to limit passenger transport emissions to 36.6 MT instead of 61.6 MT by 2040.

关键词： Pakistan electric vehicle adoption Technology acceptance model Electric vehicle adoption Public acceptance Pakistan transport energy demand Pakistan transport emissions

A novel inertia emulator to reduce the rate of change of frequency for power systems with solar PV and battery energy storage

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Clean Energy 2023年第4期7卷 873-884页

作者： R raja Nivedha Jai govind singh Weerakorn Ongsakul Department of Energy Environment and Climate ChangeAsian Institute of TechnologyThailand

Energy access,climate change and public health issues are some major drivers for the need for renewable ***,most renewable sources,excluding large hydro,have zero or negligible rotational inertia,which is critical to stabilizing the power system after ***,this paper proposes a droop-based inertia emulator to reduce the rate of change of frequency and frequency *** robustness of the controller is analysed by applying various uncertainties and disturbances of power system components that were carried out using DIgSILENT PowerFactory *** obtained results are compared with existing literature and the desired performance shows an improvement in the rate of change of frequency of 34.78%for an IEEE 6-bus system,24.32%for a 12-bus system and 18%for a 39-bus system.

关键词： control of the rate of change of frequency low-inertia power system inertia emulator control rate of change of frequency impact of solar PV on frequency control impact of battery storage on inertia and frequency control

Impact of interconnections and renewable energy integration on the Philippine-Sabah Power Grid systems

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Global Energy Interconnection 2023年第3期6卷 253-272页

作者： Tristan G.Magallones,Jr. Jai govind singh Department of Energy Environment and Climate ChangeSERDAsian Institute of TechnologyPathumthani 12120Thailand Department of Electrical Engineering Central Mindanao UniversityBukidnon 8710Philippines

This study presents a comprehensive impact analysis of the rotor angle stability of a proposed international connection between the Philippines and Sabah,Malaysia,as part of the Association of Southeast Asian Nations(ASEAN)Power *** study focuses on modeling and evaluating the dynamic performance of the interconnected system,considering the high penetration of renewable *** flow,small signal stability,and transient stability analyses were conducted to assess the ability of the proposed linked power system models to withstand small and large disturbances,utilizing the Power Systems Analysis Toolbox(PSAT)software in *** components used in the model are documented in the PSAT ***,there is a lack of publicly available studies regarding the implementation of this specific ***,the study investigates the behavior of a system with a high penetration of renewable energy *** on the findings,this study concludes that a system is generally stable when interconnection is realized,given its appropriate location and dynamic component ***,the critical eigenvalues of the system also exhibited improvement as the renewable energy sources were augmented.

关键词： Modeling of ASEAN Power Grid Rotor angle stability of asynchronous Philippine-Sabah interconnection in ASEAN Power Grid The impact of renewable energy integration on Philippine-Sabah interconnection in ASEAN Power Grid

Who to screen and how to screen for celiac disease

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World Journal of Gastroenterology 2022年第32期28卷 4493-4507页

作者： Prashant singh Achintya Dinesh singh Vineet Ahuja govind K Makharia Department of Gastroenterology University of MichiganAnn ArborMI 48109United States Department of Medicine Cleveland ClinicClevelandOH 44195United States Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029India

Celiac disease(CeD)is a chronic gluten-induced enteropathy with plethoric *** typical manifestations of CeD such as chronic diarrhea and malabsorption are widely recognized,however,many patients have atypical manifestations like iron deficiency anemia,idiopathic short stature,hypertransaminesemia or infertility,*** patients often present to the primary care physicians and/or non-gastrointestinal ***,due to a lack of awareness among the healthcare professionals about the various atypical manifestations,many patients are not screened for *** this review,we have summarized the available literature about the prevalence of CeD in various gastrointestinal(chronic diarrhea)and non-gastrointestinal conditions(iron deficiency anemia,short stature,cryptogenic hypertransaminesemia,cryptogenic cirrhosis or idiopathic ataxia etc.)where the diagnosis of CeD should be *** addition,we also discuss special scenarios where screening for CeD should be considered even in absence of symptoms such as patients with type 1 diabetes,Down’s syndrome,and first-degree relatives of patients with ***,we discuss the diagnostic performance and limitations of various screening tests for CeD such as IgA anti-tissue transglutaminase antibodies,antiendomysial antibodies and anti-deamidated gliadin *** on the current recommendations,we propose a diagnostic algorithm for patients with suspected CeD.

关键词： Screening Diagnosis Serology High-risk group Small intestine Enteropathy

Cellular and molecular insights into microbiota-mitochondriainterplay, therapeutic biomarkers and interventional approachesin COVID-19: A review

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BIOCELL 2023年第10期47卷 2141-2149页

作者： VIBHAV VARSHNEY PraSHANT singh KUSHWAH NEETU AGraWAL AHSAS GOYAL govind singh Institute of Pharmaceutical Research GLA UniversityMathuraIndia Department of Pharmaceutical Sciences Maharshi Dayanand UniversityRohtakIndia

The persistent global pandemic,COVID-19,stems from the pathogenic influence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),yielding an unprecedented worldwide *** reference to a WHO report,the count of COVID-19 cases had exceeded 754 million by February 03,***,emerging research has spotlighted the intricate interplay of gut microbiota and mitochondrial entities,acting as potent immunomodulatory factors at the cellular and molecular *** interconnection operates through a series of dynamic ***-CoV-2 infection perturbs the delicate equilibrium of gut microbiota,leading to dysbiosis—a signature *** imbalance is intrinsically linked to exacerbated COVID-19 ***,this microbial dysbiosis triggers aberrant immune responses,marked by cytokine storms,while also inducing mitochondrial *** activities crucial to energy production and immunoregulation are *** dual perturbation of microbiota and mitochondria contributes to disease *** review provides a comprehensive overview of these interconnected mechanisms,illuminating how microbiota-mitochondria interplay serves as both a diagnostic biomarker and a promising therapeutic target in the realm of COVID-19.

关键词： Microbiota Mitochondria SARS-CoV-2 COVID-19 Dysbiosis

Impact of glucagon-like peptide receptor agonists on endoscopy and its preoperative management: Guidelines, challenges, and future directions

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 292-296页

作者： Sahib singh Vishnu Charan Suresh Kumar Ganesh Aswath Department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States Division of Gastroenterology and Hepatology State University of New York Upstate Medical UniversitySyracuseNY 13210United States

Glucagon-like peptide receptor agonists(GLP-1ra)are used to treat type 2 diabetes mellitus and,more recently,have garnered attention for their effect-iveness in promoting weight *** have been associated with several gastrointestinal adverse effects,including nausea and *** side effects are presumed to be due to increased residual gastric *** the potential risk of aspiration and based on limited data,the American Society of Anesthesi-ologists updated the guidelines concerning the preoperative management of patients on GLP-1ra in *** included the duration of mandated cessation of GLP-1ra before sedation and usage of“full stomach”precautions if these medications were not appropriately held before the *** has led to additional challenges,such as extended waiting time,higher costs,and increased risk for *** this editorial,we review the current societal guidelines,clinical practice,and future directions regarding the usage of GLP-1ra in patients undergoing an endoscopic procedure.

关键词： Glucagon-like peptide receptor agonists Endoscopy Adverse events Intubation Aspiration Semaglutide Healthcare burden Guidelines

Discovering hidden patterns:Association rules for cardiovascular diseases in type 2 diabetes mellitus

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World Journal of Methodology 2024年第2期14卷 97-106页

作者： Pradeep Kumar Dabla Kamal Upreti Dharmsheel Shrivastav Vimal Mehta Divakar singh Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchDelhi 110002India Department of Computer Science CHRISTGhaziabad 201003India Department of Cardiology Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchDelhi 110002India Barkatullah University Institute of Technology Barkatullah UniversityBhopal 462026India

BACKGROUND It is increasingly common to find patients affected by a combination of type 2 diabetes mellitus(T2DM)and coronary artery disease(CAD),and studies are able to correlate their relationships with available biological and clinical *** aim of the current study was to apply association rule mining(ARM)to discover whether there are consistent patterns of clinical features relevant to these *** leverages clinical and laboratory data to the meaningful patterns for diabetic CAD by harnessing the power help of data-driven algorithms to optimise the decision-making in patient *** To reinforce the evidence of the T2DM-CAD interplay and demonstrate the ability of ARM to provide new insights into multivariate pattern *** This cross-sectional study was conducted at the Department of Biochemistry in a specialized tertiary care centre in Delhi,involving a total of 300 consented subjects categorized into three groups:CAD with diabetes,CAD without diabetes,and healthy controls,with 100 subjects in each *** participants were enrolled from the Cardiology IPD&OPD for the sample *** study employed ARM technique to extract the meaningful patterns and relationships from the clinical data with its original *** The clinical dataset comprised 35 attributes from enrolled *** analysis produced rules with a maximum branching factor of 4 and a rule length of 5,necessitating a 1%probability increase for *** patterns emerged,highlighting strong links between health indicators and diabetes likelihood,particularly elevated HbA1C and random blood sugar *** ARM technique identified individuals with a random blood sugar level>175 and HbA1C>6.6 are likely in the“CAD-with-diabetes”group,offering valuable insights into health indicators and influencing factors on disease *** The application of this method holds promise for healthcare practitioners to offer valuable insights for enhanc

关键词： Coronary artery disease Type 2 diabetes mellitus Coronary angiography Association rule mining Artificial intelligence