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Repression of Polyol Pathway Activity by Hemidesmus indicus *** *** Root Extract,an Aldose Reductase Inhibitor:An In Silico and Ex Vivo Study

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Natural Products and Bioprospecting 2021年第3期11卷 315-324页

作者： Hajira Banu Haroon Vijaybhanu Perumalsamy gouri nair Dhanusha Koppal Anand Rajitha Kolli Joel Monichen Kanchan Prabha Department of Pharmacology Faculty of PharmacyM S Ramaiah University of Applied SciencesGnanagangothri CampusNew BEL RoadBengaluruKarnataka 560054India Department of Pharmaceutical Chemistry Faculty of PharmacyM S Ramaiah University of Applied SciencesGnanagangothri CampusNew BEL RoadBengaluruKarnataka 560054India Department of Pharmaceutics Faculty of PharmacyM S Ramaiah University of Applied SciencesGnanagangothri CampusNew BEL RoadBengaluruKarnataka 560054India

Development of diabetic cataract is mainly associated with the accumulation of sorbitol via the polyol pathway through the action of Aldose reductase(AR).Hence,AR inhibitors are considered as potential agents in the management of diabetic *** study explored the AR inhibition potential of Hemidesmus indicus *** root extract by in silico and ex vivo *** docking studies(Auto Dock tool)betweenβ-sitosterol,hemidesminine,hemidesmin-1,hemidesmin-2,and AR showed thatβ-sitosterol(−10.2 kcal/mol)and hemidesmin-2(−8.07 kcal/mol)had the strongest affinity to AR *** vivo studies were performed by incubating isolated goat lenses in artificial aqueous humor using galactose(55 mM)as cataract inducing agent at room temperature(pH 7.8)for 72 *** treatment with Vitamin E acetate−100μg/mL(standard)and test extract(500 and 1000μg/mL)separately,the estimation of biochemical markers showed inhibition of lens AR activity and decreased sorbitol ***,extract also normalized the levels of antioxidant markers like SOD,CAT,*** results showed evidence that *** *** root was able to prevent cataract by prevention of opacification and formation of polyols that underlines its potential as a possible therapeutic agent against diabetic complications.

关键词： Hemidesmus indicus var.pubescens Aldose reductase Polyol pathway Diabetic cataract

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Clinical outcomes for nasopharyngeal cancer with intracranial extension after taxanebased induction chemotherapy and concurrent chemo-radiotherapy in the modern era

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第1期6卷 25-33页

作者： Sarbani Ghosh-Laskar Avinash Pilar Carlton Johnny Kumar Prabhash Amit Joshi Jai Prakash Agarwal Tejpal Gupta Ashwini Budrukkar Vedang Murthy Monali Swain Vanita Noronha Vijay Maruthi Patil Prathamesh Pai Deepa nair Devendra Arvind Chaukar Shivakumar Thiagarajan gouri Pantvaidya Anuja Deshmukh Pankaj Chaturvedi Sudhir nair Anil D’Cruz Department of Radiation Oncology Tato Memorial HospitalHomi Bhobho National InstituteMumbaiIndia Department of Medical Oncology Tata Memorial HospitalHomi Bhobha Notional InstituteMumbaiIndia Department of Surgical Oncolosy Tota Memorial HospitalHomi Bhabha Notional InstituteMumbait India

Objective:To evaluate the survival outcomes for a cohort of nasopharyngeal cancer with intracranial extension(ICE)treated with induction chemotherapy(ICT)followed by chemo-intensity-modulated radiotherapy(CTRT)at a tertiary cancer ***:We retrospectively analyzed 45 patients with histologically proven,non-metastatic NPC with ICE treated at our institute between October 2008 and October *** were classified as minor ICE or major ICE,based on the extent of *** the patients received 2-3 cycles of a taxane-based ICT regimen followed by *** was delivered with"riskadapted"intensity-modulated radiotherapy(IMRT)technique in all ***:After a median follow up of 45 months(range:8-113 months),the estimated 5-year DFS,LRFS,DMFS,and OS of the entire cohort was 58%,82%,67%and 74%*** multivariate analysis,histological subtype was an independent predictor of LRFS,and age was an independent predictor of *** extent of ICE showed only a trend towards worse DFS(P=0.06).None of the factors significantly predicted for DMFS or ***,N-stage,and response to ICT did not significantly affect any of the *** 2 or worse subcutaneous fibrosis was seen in 22%of patients and grade 2 or worse xerostomia was seen in 24%of patients at last follow ***-three percent of the patients developed clinical hypothyroidism at last follow *** of the patients experienced any neurological or vascular ***:Taxane-based induction chemotherapy followed by chemo-intensity modulated radiotherapy resulted in excellent locoregional control and survival with acceptable toxicities in patients of nasopharyngeal cancer with intracranial *** metastasis continues to be the predominant problem in these patients.

关键词： Nasopharyngeal cancer Intracranial extension Clinical outcomes Induction chemotherapy and intensity-modulated radiotherapy

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