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Biochemical synthesis of silver nanoprticles using filamentous fungi Penicillium decumbens (MTCC-2494) and its efficacy against A-549 lung cancer cell line

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Chinese Journal of Natural Medicines 2016年第8期14卷 615-620页

作者： Shahnaz Majeed Mohd Syafiq bin Abdullah gouri kumar dash Mohammed Tahir Ansari Anima Nanda Faculty of Pharmacy and Health Universiti Kuala Lumpur Royal college of Medicine Ipoh Perak Malaysia 30450 Faculty of Bioscience and chemical Engineering Sathyabama University Rajiv Gandhi Salai Chennai 600119 India

Biosynthesis of silver and other metallic nanoparticles is one of the emerging research area in the field of science and technology due to their potentiality, especially in the field of nano-biotechnology and biomedical sciences in order to develop nanomedicine. In our present study, Penicillium decumbens(MTCC-2494) was brought from Institute of Microbial Technology(IMTECH) Chandigarh and employed for extracellular biological synthesis of silver nanoparticles. Ag-NPs formation was appeared with a dark brown color inside the conical flask. Characterization of Ag-NPs were done by UV-Spectrophotometric analysis which showed absorption peak at 430 nm determines the presence of nanoparticles, Fourier transform infrared(FT-IR) spectroscopic analysis, showed amines and amides are the possible proteins involved in the stabilization of nanoparticles as capping agent. Atomic force Microscopy(AFM) confirmed the particle are spherical, size was around 30 to 60 nm and also the roughness of nanoparticles. Field emission scanning electron microscopy(FE-SEM) showed the topology of the nanoparticles and were spherical in shape. The biosynthesis process was found fast, ecofriendly and cost effective. Nano-silver particle was found to have a broad antimicrobial activity and also it showed good enhancement of antimicrobial activity of Carbenicillin, Piperacillin, Cefixime, Amoxicillin, Ofloxacin and Sparfloxacin in a synergistic mode. These Ag-NPs showed good anti-cancer activity at 80 μg·m L^(-1) upon 24 hours of incubation and toxicity increases upon 48 hours of incubation against A-549 human lung cancer cell line and the synergistic formulation of the antibiotic with the synthesized nanoparticles was found more effective against the pathogenic bacteria studied.

关键词： Silver nanoparticles Penicillium decumbens(MTCC-2494) Antibacterial Anti-cancer

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Cytogenetic studies of chromium(Ⅲ) oxide nanoparticles on Allium cepa root tip cells

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Journal of Environmental Sciences 2015年第12期27卷 150-157页

作者： Deepak kumar A.Rajeshwari Pradeep Singh Jadon gouri Chaudhuri Anita Mukherjee Natarajan Chandrasekaran Amitava Mukherjee Centre for Nanobiotechnology VIT University Centre of Advanced Study Department of BotanyUniversity of Calcutta

The current study evaluates the cytogenetic effects of chromium（Ⅲ） oxide nanoparticles on the root cells of Allium *** root tip cells of *** were treated with the aqueous dispersions of Cr2O3 nanoparticles（NPs） at five different concentrations（0.01,0.1,1,10,and 100 μg/m L） for 4 *** colloidal stability of the nanoparticle suspensions during the exposure period were ascertained by particle size *** 4 hr exposure to Cr2O3 NPs,a significant decrease in mitotic index（MI） from 35.56%（Control） to 35.26%（0.01 μg/m L）,34.64%（0.1 μg/m L）,32.73%（1 μg/m L）,29.6%（10 μg/m L） and 20.92%（100 μg/m L） was *** optical,fluorescence and confocal laser scanning microscopic analyses demonstrated specific chromosomal aberrations such as-chromosome stickiness,chromosome breaks,laggard chromosome,clumped chromosome,multipolar phases,nuclear notch,and nuclear bud at different exposure *** concentration-dependent internalization/bio-uptake of Cr2O3 NPs may have contributed to the enhanced production of anti oxidant enzyme,superoxide dismutase to counteract the oxidative stress,which in turn resulted in observed chromosomal aberrations and cytogenetic *** results suggest that *** root tip assay can be successfully applied for evaluating environmental risk of Cr2O3 NPs over a wide range of concentrations.

关键词： A.cepa Bio-uptake Chromosomal aberration C2O3 nanoparticles Mitotic index SOD

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Smart Fraud Detection in E-Transactions Using Synthetic Minority Oversampling and Binary Harris Hawks Optimization

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Computers, Materials & Continua 2023年第5期75卷 3171-3187页

作者： Chandana gouri Tekkali Karthika Natarajan School of Computer Science and Engineering VIT-AP University522237Andhra PradeshIndia

Fraud Transactions are haunting the economy of many individuals with several factors across the *** research focuses on developing a mechanism by integrating various optimized machine-learning algorithms to ensure the security and integrity of digital *** research proposes a novel methodology through three ***,Synthetic Minority Oversampling Technique(SMOTE)is applied to get balanced ***,SMOTE is fed to the nature-inspired Meta Heuristic(MH)algorithm,namely Binary Harris Hawks Optimization(BinHHO),Binary Aquila Optimization(BAO),and Binary Grey Wolf Optimization(BGWO),for feature *** has performed well when compared with the other ***,features from BinHHO are fed to the supervised learning algorithms to classify the transactions such as fraud and *** efficiency of BinHHO is analyzed with other popular MH *** BinHHO has achieved the highest accuracy of 99.95%and demonstrates amore significant positive effect on the performance of the proposed model.

关键词： Metaheuristic algorithms K-nearest-neighbour binary aquila optimization binary grey wolf optimization BinHHO optimization support vector machine

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Developments of Rill Networks: An Experimental Plot Scale Study

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Journal of Water Resource and Protection 2013年第2期5卷 133-141页

作者： Pravat kumar Shit gouri Sankar Bhunia Ramkrishna Maiti Department of Geography & Environment Management Vidyasagar University Medinipur India Senior Research Fellow (ICMR) Rajendra Memorial Research Institutes of Medical Sciences (ICMR) Bihar India

Enumerating the relative proportions of soil losses due to rill erosion processes during monsoon and post-monsoon season is a significant factor in predicting total soil losses and sediment transport and deposition. Present study evaluated the rill network with simulated experiment of treatments on varying slope and rainfall intensity to find out the rill erosion processes and sediment discharge in relation to slope and rainfall intensity. Results showed a significant relationship between the rainfall intensity and sediment yield (r = 0.75). Our results illustrated that due to increase in rainfall intensity represent the development of efficient rill network while, no rill was found with a slope of 20° and a rainfall intensity of 60 mm·h-1. The highest rill length was observed in plot E with 20° slope and 120 mm·h-1 rainfall intensity at 360 minutes. Positive and strong correlation (R2 = 0.734, P 0.001) was observed between the cumulative rainfall intensity and sediment discharge. A longitudinal profile was delineated and showed that the depth and numbers of depressions amplified with time and were more prominent for escalating rainfall intensity for its steeper slopes. Information derived from the study could be applied to estimate longer-term erosion stirring over larger areas possessing parallel landforms.

关键词： Rill Network Slope Gradient Rainfall Simulation Sediment Yield

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Risk factors for severity and mortality in patients with MERS-CoV:Analysis of publicly available data from Saudi Arabia

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Virologica Sinica 2016年第1期31卷 81-84页

作者： gouri Rani Banik Amani Salem Alqahtani Robert Booy Harunor Rashid National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (NCIRS) The Children’s Hospital at Westmead and the Discipline of Paediatrics and Child Health Sydney Medical School The University of Sydney University of Technology Sydney School of Medical and Molecular Biosciences School of Public Health The University of Sydney Marie Bashir Institute for Infectious Diseases and Biosecurity School of Biological Sciences and Sydney Medical School The University of Sydney WHO Collaborating Centre for Mass Gatherings and High Consequence/High Visibility Events Flinders University

Dear Editor,Middle East respiratory syndrome coronavirus(MERS-CoV)has affected over 1600 people across four continents;it has a fatality rate of about 36%(WHO,2015).Approximately 75%of MERS-CoV patients have a preexis... 详细信息

关键词： severity mortality publicly coronavirus Middle concomitant confidence illness likely cohort

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Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells

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蛋白质与细胞:英文版 2023年第8期14卷 591-602页

作者： Liangwen Zhong Miriam Gordillo Xingyi Wang Yiren Qin Yuanyuan Huang Alexey Soshnev Ritu kumar gouri Nanjangud Daylon James C.David Allis Todd Evans Bryce Carey Duancheng Wen Department of Reproductive Medicine Ronald O.Perelman and Claudia Cohen Center for Reproductive MedicineWeill Cornell MedicineNew YorkNY 10065USA Department of Surgery Weill Cornell Medical College1300 York AvenueNew YorkNY 10065USA Laboratory of Chromatin Biology and Epigenetics The Rockefeller UniversityNew YorkNY 10065USA Cold Spring Harbor Laboratory Cold Spring HarborNY 11724USA Molecular Cytogenetics Core.Memorial Sloan Kettering Cancer Center New YorkNY 10065USA Department of Neuroscience Developmental and Regenerative BiologyUniversity of Texas at San AntonioOne UTSA CircleSan AntonioTX 78249USA Gladstone Institutes 1650 Owens StSan FranciscoCA94158USA

While Mek1/2 and Gsk3βinhibition("2i")supports the maintenance of murine embryonic stem cells(EsCs)in a homogenous naive state,prolonged culture in 2i results in aneuploidy and DNA hypomethylation that impairs developmental ***,2i fails to support derivation and culture of fully potent female *** we find that mouse ESCs cultured in 2i/LIF supplemented with lipid-rich albumin(AlbuMAx)undergo pluripotency transition yet maintain genomic stability and full potency over long-term ***,lipids in AlbuMAx impact intracellular metabolism including nucleotide biosynthesis,lipid biogenesis,and TCA cycle intermediates,with enhanced expression of DNMT3s that prevent DNA *** induce a formative-like pluripotent state through direct stimulation of Erk2 phosphorylation,which also alleviates X chromosome loss in female ***,both male and female"all-ESc"mice can be generated from de novo derived ESCs using AlbuMAXbased *** findings underscore the importance of lipids to pluripotency and link nutrient cues to genome integrity in early development.

关键词： mouse pluripotent stem cells lipids pluripotency transition genomic stability developmental potency nucleotide pool depletion 2i medium X chromosome loss femaleall-EsC mice

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Assessment of Factors Affecting Ephemeral Gully Development in Badland Topography: A Case Study at Garbheta Badland (Pashchim Medinipur,

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International Journal of Geosciences 2013年第2期4卷 461-470页

作者： Pravat kumar Shit gouri Sankar Bhunia Ramkrishna Maiti Department of Geography & Environment Management Vidyasagar University Medinipur India Rajendra Memorial Research Institutes of Medical Sciences (ICMR) Patna Bihar India

Gully erosion in the Paschim Medinipur district of West Bengal, Indiahas been an issue of anxiety, formed by the amputation of soil from narrow channels through the accretion of surface runoff. Here, we attempted to investigate the erosion variability of gully in a micro catchment area, and also scrutinized the gully cross-sectional areas as distinct components of gully volumes. Twelve gullies were randomly selected in different slopes. To determine the geometric growth of the gully dimensions and soil loss, the initial length of gully, the width of the gully and depth of respective gullies was monitored in different seasons. Univariate analysis was conducted to measure the association between gully head retreat and vegetation coverage, slope, rainfall volume and runoff contributing area. We found strong and significant relation between the slope of gully head and linear retreat in the pre monsoon (p 0.008) and post monsoon (p 0.024) season respectively. Conversely, rainfall volume and gully head retreat showed a strong relationship in the pre monsoon (r = 0.80), monsoon (r = 0.66) and post-monsoon period (r = 0.94);while meager relationship was observed with rainfall intensity (r = 0.06). Results also illustrated that the overall retreat of gully head had very strong and positive relationship with the runoff contributing area (r = 0.89, p 0.001), and maximum gully erosion was observed in the monsoon period (55.67%). These results indicate that slope, rainfall and runoff contributing area have a strong positive influence on gully erosion in Paschim Medinipur district, since the initiation of the gully.

关键词： Gully Erosion Gully Heads Rainfall Runoff Contributing Area Sediment Yield

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Fabrication and Characterization of Graphene Based Nanocomposite for Electrical Properties

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Advances in Materials Physics and Chemistry 2015年第1期5卷 22-30页

作者： Manoj kumar Pati Puspalata Pattojoshi gouri Sankar Roy Department of Physics KIIT University Odisha India Department of Physics College of Engineering and Technology Bhubaneswar Odisha India

In the present study, we have described the synthesis of acid functionalized graphene (GE) which was grafted to chitosan (CH) by first reacting the oxidized GE with thionyl chloride to form acyl-chlorinated GE. This product was subsequently dispersed in chitosan and covalently grafted to form GE-chitosan. GE-chitosan was further grafted onto poly(anthranilic acid) (PAA) by free radical polymerization conditions, to yield GE-g-chitosan-g-PAA for our investigations. The structure of GE-CH-PAA composites was characterized by X-ray diffraction (XRD) pattern, Fourier transform infrared (FTIR) spectroscopy, thermo gravimetric analysis (TGA), cyclovoltammetrie (CV) and transmission electron microscopy (TEM). XRD report suggested the strongly crystalline character of the specimen prepared. The performance of cycle voltammeter was attributed to the GE-CH-PAA, which provided a large number of active sites and good electrical conductivity. Experimental results suggested that nanocomposites could be combined together for industrial applications.

关键词： Graphene Chitosan Poly(Anthranilic Acid) Electrical Conductivity

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Assessment of School Infrastructure at Primary and Upper Primary Level: A Geospatial Analysis

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Journal of Geographic Information System 2012年第5期4卷 412-424页

作者： gouri Sankar Bhunia Pravat kumar Shit Soumen Dubai Department of Geography & Environment Management Vidyasagar University Medinipur India Office of the Sarva-Siksha-Mission (SSM) Paschim Medinipur India Rajendra Memorial Research Institutes of Medical Sciences (ICMR) Bihar India

With the introduction of powerful and high-speed personal computers, proficient techniques for infrastructure development and management have advanced, of which Geoinformatics technology is of great significance. An attempt has been made for broad mapping and analysis of existing infrastructures in the context of planning scheme in Paschim Medinipur district, and to delineate the development zones of educational infrastructure facilities. The thematic layers considered in this study are infrastructure accessibility, type and condition of classroom and number of classroom allocated for the educational system at primary and upper primary level. Moran’s I statistics was used to estimate the spatial distribution of elementary infrastructure across the district. All these themes and their individual features were then assigned weights according to their relative importance in educational development and corresponding normalized weights were obtained based on the Saaty’s analytical hierarchy process. The thematic layers were finally integrated in GIS software based on multi-criteria approach to yield educational development infrastructure index. Moran’s I statistics shows girl’s toilet, electric and boundary wall facility within the district are clustered in pattern at primary level. At the upper primary level, only electric and computer facilities shows the clustered distribution across the district. However, four different zones have been delineated, namely ‘very good’, ‘good’, ‘moderate’ and ‘poor’. The block covered by very good elementary educational infrastructure facility is Daspur –I and Dantan –II at primary level and Keshiary block at upper primary level in Paschim Medinipur district. Finally, it is concluded that the Geoinformatics technology is very efficient and useful for the identification of infrastructure development.

关键词： Educational Infrastructure Spatial Auto-Correlation Saaty’s Analytical Hierarchy Process Multi-Criteria Approach

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In silico screening for As/Se-free ovonic threshold switching materials

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npj Computational Materials 2023年第1期9卷 1359-1366页

作者： Sergiu Clima Daisuke Matsubayashi Taras Ravsher Daniele Garbin Romain Delhougne gouri Sankar Kar Geoffrey Pourtois imec Kapeldreef 75B-3001 LeuvenBelgium Device Technology Research&Development Center Future Memory Development DepartmentKIOXIA CorporationShin-sugita-cho 8Isogo-kuYokohamaJapan KU Leuven Celestijnenlaan 200DB-3001 LeuvenBelgium

Restricted use of hazardous environmental chemicals is one important challenge that the semiconductor industry needs to face to improve its *** threshold switching(OTS)ternary compound materials used in memory selector devices contain As and *** these elements out of these materials requires significant research *** facilitate this process,we performed systematic material screening for As/Se-free ternary materials,based on ab-initio *** limit the large amount of possible chemical compositions to fewer promising candidates,we used physics-based material parameter filters like material stability,electronic properties,or change in *** OTS gauge concept is introduced as a computed parameter to estimate the probability of a material to show an OTS *** a result,we identified 35 As/Se-free ternary alloy compositions for stand-alone OTS memory applications,as well as 12 compositions for RRAM selector *** work aims seeding the development of As/Se-free OTS materials.

关键词： alloy ternary free

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