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Comparison of PPIs and H_2-receptor antagonists plus prokinetics for dysmotility-like dyspepsia

World Journal of Gastroenterology 2012年第13期18卷 1517-1524页

作者： Masahiro Sakaguchi Miyuki Takao Yasuo Ohyama Hiroshi Oka Hiroshi Yamashita Takumi Fukuchi Kiyoshi Ashida Masahiro Murotani Masuyo Murotani Kazuo Majima Hiroshi Morikawa Takashi Hashimoto Keisuke Kiyota Hirohiko Esaki Kanji Amemoto gouhei isowa Fumiyuki Takao Department of Gastroenterology Moriguchi Keijinkai HospitalMoriguchiOsaka 570-0021Japan Department of Gastroenterology Osaka Saiseikai Nakatsu HospitalOsaka 530-0012Japan Murotani Clinic KadomaOsaka 571-0008Japan Majima Clinic NeyagawaOsaka 572-0084Japan Morikawa Clinic HirakataOsaka 573-0058Japan Hashimoto Clinic MoriguchiOsaka 570-0079Japan Kiyota Clinic MatsubaraOsaka 580-0004Japan Department of Gastroenterology Arisawa General HospitalHirakataOsaka 573-1195Japan Amemoto Clinic MoriguchiOsaka 570-0021Japan isowa Clinic NeyagawaOsaka 572-0062Japan Mii Clinic NeyagawaOsaka 572-0019Japan

AIM:To compare efficacy of proton pump inhibitors(PPIs)with H2-receptor antagonists(H2RAs)plus prokinetics(Proks)for dysmotility-like symptoms in functional dyspepsia(FD).METHODS:Subjects were randomized to receive openlabel treatment with either rabeprazole 10 mg od(n= 57)or famotidine 10 mg bid plus mosapride 5 mg tid(n=57)for 4 *** primary efficacy endpoint was change(%)from baseline in total dysmotility-like dyspepsia symptom *** secondary efficacy endpoint was patient satisfaction with ***:The improvement in dysmotility-like dyspep-sia symptom score on day 28 was significantly greater in the rabeprazole group(22.5%±29.2%of baseline) than the famotidine+mosapride group(53.2%± 58.6%of baseline,P<0.0001).The superior benefit of rabeprazole treatment after 28 d was consistent regardless of Helicobacter pylori *** more subjects in the rabeprazole group were satisfied or very satisfied with treatment on day 28 than in the famotidine+mosapride group(87.7%vs 59.6%,P= 0.0012).Rabeprazole therapy was the only significant predictor of treatment response(P<0.0001),defined as a total symptom score improvement≥50%.CONCLUSION:PPI monotherapy improves dysmotility-like symptoms significantly better than H2RAs plus Proks,and should be the treatment of first choice for Japanese FD.

关键词： H2受体拮抗剂消化不良功能障碍指数和生产者配合治疗不良症状运动

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Mathematically modelling and controlling prostate cancer under intermittent hormone therapy

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Asian Journal of Andrology 2012年第2期14卷 270-277页

作者： Yoshito Hirata gouhei Tanaka Nicholas Bruchovsky Kazuyuki Aihara Institute of Industrial Science University of Tokyo Tokyo 153-8505 Japan Vancouver Prostate Centre Vancouver General Hospital Vancouver BC V6H 3Z6 Canada

In this review, we summarize our recently developed mathematical models that predict the effects of intermittent androgen suppression therapy on prostate cancer （PCa）. Although hormone therapy for PCa shows remarkable results at the beginning of treatment, cancer cells frequently acquire the ability to grow without androgens during long-term therapy, resulting in an eventual relapse. To circumvent hormone resistance, intermittent androgen suppression was investigated as an alternative treatment option. However, at the present time, it is not possible to select an optimal schedule of on- and off-treatment cycles for any given patient. In addition, clinical trials have revealed that intermittent androgen suppression is effective for some patients but not for others. To resolve these two problems, we have developed mathematical models for PCa under intermittent androgen suppression. The mathematical models not only explain the mechanisms of intermittent androgen suppression but also provide an optimal treatment schedule for the on- and off-treatment periods.

关键词： diagnosis intermittent androgen suppression mathematical models personalized treatment schedule prognosis prostate cancer

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Near Real-Time Calculation of Ionospheric Electric Fields and Currents Using GEDAS

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Chinese Journal of Astronomy and Astrophysics 2003年第4期3卷 375-380页

作者： H.Shirai Y.Kamide E.A.Kihn B.Hausman M.Shinohara H.Nakata M.isowa T.K.Takada Y.Watanabe S.Masuda Solar-Terrestrial Environment Laboratory Nagova UniversityToyokawaAichi 442-8507Japan Now at Ichinoseki National College of TechnologyIchinosekiIwate 021-8511JapanSolar-Terrestrial Environment LaboratoryNagoya UniversityToyokawaAichi 442-8507JapanNOAA National Geophysical Data CenterBoulderColorado 80303-3328U.S.A.Department of Physics and AstronomyRice UniversityHoustonDexas 77005-1892U.S.A.Solar-Terrestrial Environment LaboratoryNagoya UniversityToyokawaAichi 442-8507Japan Now at Communications Research LaboratoryKoganeiTokyo 184-8795JapanSolar-Terrestrial Environment LaboratoryNagoya UniversityToyokawaAichi 442-8507Japan Now at Chiba UniversityChibaChiba 263-8522JapanSolar-Terrestrial Environment LaboratoryNagoya UniversityToyokawaAichi 442-8507JapanSolar-Terrestrial Environment LaboratoryNagoya UniversityToyokawaAichi 442-8507JapanSolar-Terrestrial Environment LaboratoryNagoya UniversityToyokawaAichi 442-8507JapanSolar-Terrestrial Environment LaboratoryNagoya UniversityToyokawaAichi 442-8507Japan

This paper presents the recent progress in our project of estimating near real-time electric fields and currents in the ionosphere through our computer system called the Geospace Environment Data Analysis System (GEDAS). We show a new technique in which data from ground magnetometers are collected by the system and used as input for the KRM and AMIE programs to calculate the distribution of ionospheric electric fields and currents, as well as of other ionospheric parameters, such as electric potential patterns. One of the goals of this project is to specify ionospheric processes. Examples of the near real-time calculation and the data flow of our scheme are presented.

关键词： data analysis-solar-terrestrial relations

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Perceived happiness level influences evocation of positive emotions

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Natural Science 2011年第8期3卷 723-727页

作者： Masahiro Matsunaga Hiroki Murakami Kaori Yamakawa Tokiko isowa Seisuke Fukuyama Jun Shinoda Jitsuhiro Yamada Hideki Ohira Division of Cerebral Integration Department of Cerebral Research National Institute for Physiological Sciences Aichi Japan

Happiness is a positive feeling characterized by satisfaction, joy, pleasure, or love. Perceived happiness level is likely associated with health and well-being. However, the neurobiological mechanisms underlying the positive effects of happiness on psychological and physiological wellness remain obscure. In this study, we found that the medial prefrontal cortex (MPFC) was strongly activated and positive emotions were strongly evoked in individuals with high perceived happiness levels compared to those with low perceived happiness levels when either looked at a favorite person. Moreover, positive mood changes were positively correlated with MPFC activity. These results show that perceived happiness level is associated with positive emotion evocation by means of the MPFC function, which may be involved in psychological and physiological wellness. Therefore, happiness may play an important role in psychological and physiological wellness.

关键词： Happiness Medial Prefrontal Cortex Attraction Positron Emission Tomography

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isowa公司用冒险精神品牌重塑和新的徽标庆祝成立100周年

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上海包装 2020年第6期 17-19页

作者： HIDEYUKI isowa 陈正耀(译) 日本爱知县isowa公司不详

由于您的持续和热情的支持,isowa公司在2020年庆祝其100成立周年。我向大家致以最诚挚的谢意,并分享我们公司的一些历史。自公司成立以来,我们一直努力表达我们的企业身份,公开宣布我们是谁,我们是什么,我们在这世界上想成为什么。今天... 详细信息

由于您的持续和热情的支持,isowa公司在2020年庆祝其100成立周年。我向大家致以最诚挚的谢意,并分享我们公司的一些历史。自公司成立以来,我们一直努力表达我们的企业身份,公开宣布我们是谁,我们是什么,我们在这世界上想成为什么。今天,这被称为“品牌”。

关键词：品牌重塑冒险精神 ISO 庆祝成立

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