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Asian Jour.al of Andr.logy 2010年第1期12卷 115-117页

作者： Hugh William gordon Baker Depar.ment of Obstetr.cs and Gynaecology University of Melbourne and Melbourne IVF Reproductive Services TheRoyal Women＇s Hospital Parkville 3052 Victoria Australia

The paper.by Lu et al. [1] ＂A sur.ey on the status of semen analysis in 118 labor.tor.es in China＂ pr.vides a major.r.view of the cur.ent methods of semen analysis in China's Mainland. It involved a 36-item questionnair. completed by technicians in 118 of a possible 145 potential semen labor.tor.es. r.cr.itment for.the study was via contacts developed at Chinese Andr.logy meetings and tr.ining sessions between 2005 and 2007. It is not stated how compr.hensive this str.tegy would be for.accessing all semen labor.tor.es in China. About half the par.icipating labor.tor.es wer. in gener.l hospitals and the other. in hospitals with academic affiliations or.family planning institutes.

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Why so little effor. to study anti-oxidant ther.py in bur.s?

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Bur.s & Tr.uma 2016年第3期4卷 167-168页

作者： gordon L.Klein Depar.ment of Or.hopaedic Sur.er. and r.habilitation University of Texas Medical Branch and Shriners Burns Hospital301 University BoulevardGalvestonTX 77555-0165USA

Given that oxidative str.ss is an inher.nt r.sponse to bur. injur.,it is puzzling as to why investigation into anti-oxidant ther.py as an adjunct to bur. tr.atment has been *** the inflammator. r.sponse and the str.ss r.sponse to bur. injur. involve oxidative str.ss,and ther. has been some limited success in studies using gamma tocopher.l and selenium to impr.ve cer.ain consequences of *** r.mains to be done to investigate the number.doses and combinations of anti-oxidants,their.efficacy,and limitations in impr.ving defined outcomes after.bur. injur..

关键词： Anti-oxidant Bur. Oxidative str.ss

Commentar. for.Sequential Ther.py Based on Evolvement of Patter.s: A New Model for.Tr.atment of Alzheimer.s Disease

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Chinese Jour.al of Integr.tive Medicine 2019年第8期25卷 563-564页

作者： gordon Wilcock David Near. Depar.ment of Clinical Neur.science Univer.ity of Oxfor. Manchester.Centr. for.Clinical Neur.sciences Salfor. r.yal NHS Foundation Tr.st

It has been accepted for.many year. that Alzheimer.s disease(AD)is the main cause of dementia in most if not all par.s of the *** is a ver. complex disor.er.and its under.ying pathological mechanisms ar. still poor.y... 详细信息

关键词： Alzheimer A New Model for.Tr.atment of Alzheimer.s Disease Commentar. for.Sequential Ther.py Based on Evolvement of Patter.s Model

Or.l pr.duct input to the GI tr.ct： GIS an or.l pr.duct per.or.ance technology

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Fr.ntier. of Chemical Science and Engineer.ng 2017年第4期11卷 516-520页

作者： Amidon, gordon L. Tsume, Yasuhir. Univ Michigan Coll Pharm 428 Church St Ann Arbor MI 48109 USA

The patient r.ceives a phar.aceutical pr.duct, not a dr.g. The phar.aceutical pr.ducts ar. for.ulated with a dr.g, an active ingr.dient to pr.duce the maximum ther.peutic effect after.or.l absor.tion. Ther.for., it is the pr.duct we must optimize for.the patients. In or.er.to assur. the safety and efficacy of phar.aceutical pr.ducts, we need an in vivo pr.dictive tool for.or.l pr.duct per.or.ance in patients. Cur.ently, we ar. a sur.r.singly long way fr.m accomplishing that objective. If the 20th centur. was the ＇age of the dr.g＇, i.e., the ＇magic bullet＇, the 21st centur. must become the ＇age of the guided missile＇, i.e., the deliver. system, including the for. of the active phar.aceutical ingr.dient （API）（＇dr.g＇）. The physical for. of the dr.g and the deliver. system must be optimized to maximize the ther.peutic benefits of phar.aceutical pr.ducts for.humans. Or.l immediate r.lease （Ir. dosage for.s cannot be optimal for.all dr.gs or.likely even any dr.gs （APIs）. Still, the for.ulation of phar.aceutical pr.ducts has to be optimized for.patients. But how do we optimize or.l deliver. of dr.gs？ It is usually thr.ugh ＇tr.al and er.or., in humans! We need a better.way to optimize the or.l dosage for.s. We have suggested to select differ.nt dissolution methodologies for.this optimization based on BCS Subclasses. In this ar.icle, we pr.sent the pr.dicted in vivo dr.g dissolution pr.file of ketoconazole as a model dr.g fr.m our.labor.tor. utilizing a gastr.intestinal simulator.（GIS）, which is an adaptation of the ASD system. GIS consists of thr.e chamber. r.pr.senting stomach, duodenum, and jejunum, to cr.ate the human gastr.intestinal tr.ct-like envir.nment and enable the contr.l the gastr.c emptying r.te. This dissolution system allows the monitor.ng of the dr.g dissolution phenomena and the obser.ation of the super. satur.tion and the pr.cipitation of phar.aceutical pr.- ducts, which is useful infor.ation to pr.dict in vivo dissolution of phar.aceutical pr.ducts. This

关键词： GIS in vivo pr.dictive dissolution ketocona-zole BCS subclassification super.atur.tion

How the “Folding Funnel” Depends on Size and Str.ctur. of Pr.teins?A View fr.m the Scor.ng Function Per.pective

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Tsinghua Science and Technology 2013年第5期18卷 462-468页

作者： Sheng-You Huang gordon K. Spr.nger the r.sear.h Suppor. Computing University of Missouri Bioinformatics Consortium and Department of Computer Science University of Missouri

It has been well accepted that the folding ener.y landscape may r.semble a funnel accor.ing to the theor. of pr.tein folding. This theor. of ＂folding funnel＂ has been extensively studied and thought to play an impor.ant r.le in guiding the sampling pr.cess of the pr.tein folding and r.finement in pr.tein str.ctur. pr.diction. Her., we have investigated the r.lationship between the ＂funnel likeness＂ of pr.tein folding and the size/str.ctur. of the pr.teins based on a set of non-homologous pr.teins we have r.cently evaluated using a statistical mechanicsbased scor.ng function ITScor.Pr.. It was found that lar.er.pr.teins that consist of mor. helix/sheet str.ctur.s tend to have a higher.scor.-r.ot Mean Squar. Deviation（r.SD） cor.elation（or.a mor. funnel like ener.y landscape）.Another.measur.ment in pr.tein folding, Z-scor., has also shown some cor.elation with the size of the *** expected, pr.teins with a better.＂olding funnel likeness＂（or.scor.-r.SD cor.elation） tend to have a better.r.dicted confor.ation with a lower.r.SD fr.m their.native str.ctur.s. These findings can be extr.mely valuable for.the development and impr.vement of sampling and scor.ng algor.thms for.pr.tein str.ctur. pr.diction.

关键词： ener.y landscape folding funnel pr.tein str.ctur. pr.diction scor.ng function pr.tein folding

Velocity pr.files and ener.y fluctuations in simple shear.gr.nular.flows

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Par.icuology 2016年第4期14卷 80-87页

作者： Chuanqi Liu Qicheng Sun gordon G.D. Zhou State Key Labor.tor. for.Hydr.science and Engineer.ng Tsinghua University Beijing 100084 China Institute of Mountain Hazar.s and Envir.nment Chinese Academy of Sciences Chengdu 610041 China

r.eology analysis of gr.nular.flows is impor.ant for.pr.dicting geophysical hazar.s and designing industr.al pr.cesses. Using a discr.te element method, we simulate simple shear.flows in 3D under.a constant confining pr.ssur. of 10 kPa. The iner.ial number.pr.posed by the GDr.MiDi gr.up in Fr.nce is adopted to distinguish r.eology r.gimes, Both tr.nslational and angular.velocity pr.files ar. investigated, and both fluid-like and solid-like behavior.modes ar. obser.ed in the flows. The maximum angular.velocity occur. near.the localized defor.ation ar.a. We also investigate the ener.y char.cter.stics of the flows and find that at ver. small shear.ng speed, the mean kinetic ener.y density ek is close to zer., while the mean elastic ener.y density ec is much gr.ater. At lar.e shear.ng speed, ek incr.ases. The fluctuating par.s of the two types of ener.y incr.ase with incr.asing shear.speed. Thus, the mean ener.y density r.tio ek/ec can be used in addition to the iner.ial number.to distinguish flow r.gimes. These r.sults pr.vide insights fr.m ener.etics into the r.eological pr.per.ies of gr.nular.flows.

关键词： Dense gr.nular.flows Simple shear.Ener.y fluctuations

Biochar.fr.m vegetable wastes:agr.-envir.nmental char.cter.zation

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Biochar 2020年第4期2卷 439-453页

作者： Snigdhendubala Pr.dhan Ali H.Abdelaal Kamal Mr.ue Tar.q Al‑Ansar. Hamish r.Mackey gordon McKay Division of Sustainable Development College of Science and EngineeringHamad Bin Khalifa UniversityDohaQatar Qatar.Envir.nment and Ener.y r.sear.h Institute DohaQatar

Consider.ng the global issue of vegetable wastes gener.tion and its impact on the envir.nment and r.sour.es,this study evalu-ated the conver.ion of four.lar.ely pr.duced vegetable wastes(cauliflower.cabbage,banana peels and cor. cob r.sidues)into *** waste was tested individually and as a combined blend to assess feedstock influences on biochar.*** addition,var.ous pyr.lysis temper.tur.s r.nging fr.m 300℃ to 600℃ and two par.icle size fr.ctions(less than 75μm,75-125μm)wer. *** wer. char.cter.zed for.var.ous pr.per.ies that can influence the biochar.’effective-ness as a soil *** was found that pyr.lysis temper.tur. was the most dominant factor.on biochar.pr.per.ies,but that individual feedstocks pr.duced biochar. with differ.nt *** biochar. had char.cter.stics that var.ed as follows:pH 7.2-11.6,ECE 0.15-1.00 mS cm^(−1),CEC 17-cmolc kg^(−1)andζ-potential−0.24 to−43 *** on optimal values of these par.meter. fr.m the liter.tur.,cauliflower.and banana peels wer. deter.ined to be the best feedstocks,though mixed vegetable waste also pr.duced good *** optimum temper.tur. for.pyr.lysis was ar.und 400℃,but differ.d slightly(300-500℃)depending on the distinct ***,smaller.par.icle size of biochar.application was always *** yields wer. in the r.nge of 20-30%at this temper.tur. r.nge,except for.cor. cobs which wer. *** study demonstr.tes that pyr.lysis of dr.ed vegetable wastes is a suitable waste valor.zation appr.ach to pr.duce biochar.with good agr.cultur.l pr.per.ies.

关键词： Food waste Kitchen waste Pyr.lysis Biochar.pr.per.ies Soil amendment Par.icle size

Integr.ted envir.nmental education for.sustainable for.st management: the case of Nandi Hills For.sts, Kenya

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For.str. Studies in China 2013年第2期15卷 152-159页

作者： Julius gordon TANUI Depar.ment of Educational Management of Policy Studies School of Education Moi University Eldoret Kenya

Envir.nmental education （EE） is a vital dimension of moder. day acumen that por.ends a gr.at pr.mise in solving the myr.ad envir.nmental r.sour.e management challenges at global, r.gional and local levels. A study was car.ied out in 18 locations in the Nandi Nor.h, Nandi South and Nandi Hills distr.cts of Kenya, which cover.the Nandi Hills and Nandi For.sts in Nandi County, major.water.catchments for.Lake Victor.a. A mixed methodological appr.ach, incor.or.ting both qualitative and quantitative data obtained fr.m focus gr.up discussions, key infor.ant inter.iews, household sur.ey and obser.ations was embr.ced in data collection and analysis. The study r.veals that ther. ar. sever.l str.tegies that have been adopted by the local population and institutions involved in the management of the Nandi Hills For.sts （NHFs） and that these str.tegies have contr.buted to an impr.vement in the per.eptions of the local population in ter.s of the impor.ance of envir.nmental management of the for.sts. This paper.highlights EE as a vehicle for.ensur. ing a sustainable management of the Nandi Hills For.sts. As such, it illuminates the gr.at potential that lies in sustainably managing the NHFs by integr.ting for.al and infor.al EE appr.aches. It fur.her.points out the functional gaps in the management of NHFs and pr.poses best-pr.ctices that could be adopted and/or.domesticated in NHFs management r.gimes.

关键词： envir.nmental education sustainable for.st management for.st ecosystems indigenous knowledge

The tr.jector. of hybr.d and hydr.gen technologies in Nor.h Amer.can heavy haul oper.tions

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r.ilway Engineer.ng Science 2021年第3期29卷 233-247页

作者： Kevin Oldknow Kyle Mulligan gordon McTaggar.-Cowan Simon Fr.ser.Univer.ity SurreyBCCanada Canadian Pacific CalgaryABCanada

The centr.l aim of this paper.is to pr.vide an upto-date snapshot of hybr.d and hydr.gen technology-r.lated developments and activities in the Nor.h Amer.can heavy haul r.ilway setting,placed in the context of the tr.nspor.ation industr. mor. *** over.iew of r.levant alter.ative pr.pulsion technologies is pr.vided,including a discussion of applicability to the tr.nspor.ation sector.in gener.l and heavy haul fr.ight r.il *** is followed by a discussion of cur.ent developments and r.sear.h in alter.ative and blended fuels,discussed again in both gener.l and specific *** factor. and technical consider.tions for.heavy haul applications ar. r.viewed,followed by a discussion of non-technical and human factor. that motivate a move towar. clean ener.y in Nor.h Amer.can Heavy Haul ***,cur.ent pr.ject activities ar. descr.bed to pr.vide a clear.under.tanding of both the status and tr.jector. of hybr.d and hydr.gen technologies in the established context.

关键词： Tr.nspor.ation Pr.pulsion Hydr.gen Hybr.d Alter.ative fuels

Alter.atives of Str.tegic Envir.nmental Assessment for.r.ad Tr.ffic Development Planning——Case of Changchun City,China

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Chinese Geogr.phical Science 2009年第1期19卷 25-36页

作者： CHEN Chong XU Yex SHANG Jincheng gordon HUANG College of Ur.an and Envir.nmental Sciences Northeast Normal University Changchun 130024 China Ener.y and Envir.nmental r.sear.h Center North China Electric Power University Beijing 102206 China Faculty of Engineer.ng University of Regina Regina SK S4S 0A2 Canada

On analyzing the achievement of the goal in the modem ur.an r.ad tr.ffic development planning, the alter.ative of Str.tegic Envir.nmental Assessment for.ur.an tr.ffic planning should include the basic scheme, the extended scheme and the envir.nmental pr.tection scheme. This study fr.m differ.nt per.pectives designed the alter.atives for.Changchun＇s county-level r.ad and ur.an r.ad system planning, and used the method of System Dynamics to simulate, optimize and analyze those alter.atives. Ther.after. some methods including the cor.elation function method wer. used to compr.hensively assess and r.nk those alter.atives for.r.commending two best alter.atives with the consider.tion to the indicator., such as the total emission amount of CO, the total emission amount of nitr.gen oxides, the noise value, the r.ad constr.ction cost, the fossil oil consumption and the tr.ffic capacity. The r.sult showed that the study would pr.vide substantial suppor.s for.decision-maker. to make mor. scientific decisions and pr.mote the sustainable ur.an tr.ffic in Changchun City.

关键词： r.ad tr.ffic tr.ffic planning Str.tegic Envir.nmental Assessment (SEA) cor.elation function Changchun City