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Non-responsive celiac disease in children on a gluten free diet

World Journal of Gastroenterology 2021年第13期27卷 1311-1320页

作者： gopal veeraraghavan Amelie Therrien Maya Degroote Allison McKeown Paul D Mitchell Jocelyn A Silvester Daniel A Leffler Alan M Leichtner Ciaran P Kelly Dascha C Weir Division of Gastroenterology Hepatology and NutritionBoston Children's HospitalBostonMA 02115United States The Celiac Center Department of Medicine and Division of GastroenterologyBeth Israel Deaconess Medical CenterBostonMA 02215United States Celiac Research Program Harvard Medical SchoolBostonMA 02115United States Institutional Centers for Clinical and Translational Research Boston Children's HospitalBostonMA 02115United States Gastrointestinal Therapeutics Takeda Pharmaceutical International CoCambridgeMA 02139United States

BACKGROUND Non-responsive celiac disease(NRCD) is defined as the persistence of symptoms in individuals with celiac disease(CeD) despite being on a gluten-free diet(GFD). There is scant literature about NRCD in the pediatric *** To determine the incidence, clinical characteristics and underlying causes of NRCD in *** Retrospective cohort study performed at Boston Children’s Hospital(BCH). Children < 18 years diagnosed with CeD by positive serology and duodenal biopsies compatible with Marsh Ⅲ histology between 2008 and 2012 were identified in the BCH’s Celiac Disease Program database. Medical records were longitudinally reviewed from the time of diagnosis through September 2015. NRCD was defined as persistent symptoms at 6 mo after the initiation of a GFD and causes of NRCD as well as symptom evolution were detailed. The children without symptoms at 6 mo(responders) were compared with the NRCD group. Additionally, presenting signs and symptoms at the time of diagnosis of CeD among the responders and NRCD patients were collected and compared to identify any potential predictors for NRCD at 6 mo of GFD *** Six hundred and sixteen children were included. Ninety-one(15%) met criteria for NRCD. Most were female(77%). Abdominal pain [odds ratio(OR) 1.8 95% confidence interval(CI) 1.1-2.9], constipation(OR 3.1 95%CI 1.9-4.9) and absence of abdominal distension(OR for abdominal distension 0.4 95%CI 0.1-0.98) at diagnosis were associated with NRCD. NRCD was attributed to a wide variety of diagnoses with gluten exposure(30%) and constipation(20%) being the most common causes. Other causes for NRCD included lactose intolerance(9%), gastroesophageal reflux(8%), functional abdominal pain(7%), irritable bowel syndrome(3%), depression/anxiety(3%), eosinophilic esophagitis(2%), food allergy(1%), eating disorder(1%), gastric ulcer with Helicobacter pylori(1%), lymphocytic colitis(1%), aerophagia(1%) and undetermined(13%). 64% of children with NRCD

关键词： Celiac disease Non-responsive celiac disease Children Gluten-free diet Constipation Abdominal pain

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Operator Equations Inducing Some Generalizations of Slant Hankel Operators

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Acta Mathematica Sinica,English Series 2024年第8期40卷 2017-2036页

作者： gopal DATT Bhawna Bansal GUPTA Department of Mathematics PGDAV CollegeUniversity of DelhiNew Delhi-110065India Department of Mathematics Miranda HouseUniversity of DelhiDelhi-110007India

An extension of slant Hankel operator,namely,the kth-orderλ-slant Hankel operator on the Lebesgue space L^(2)(T^(n)),where T is the unit circle and n≥1,a natural number,is described in terms of the solution of a system of operator equations,which is subsequently expressed in terms of the product of a slant Hankel operator and a unitary *** study is further lifted in Calkin algebra in terms of essentially kth-orderλ-slant Hankel operators on L^(2)(T^(n)).

关键词： Hankel operator Lebesgue space of n-dimensional torus kth-order slant Hankel operator essentially kth-orderλ-slant Hankel operator

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Efficient processed carbon Soot@MoS2 hybrid Bi-functional electrode for dye-sensitized solar cell and asymmetric supercapacitor devices

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Nano Materials Science 2024年第4期6卷 484-494页

作者： B.Arjun Kumar gopal Ramalingam Salah Addin Burhan Al Omari Zhumabay Bakenov Sambasivam Sangaraju Sangarapani Sudhakar Quantum Material Research Lab (QMRL) Department of Nanoscience and TechnologyAlagappa University Department of Mechanical and Aerospace Engineering United Arab Emirates University Department of Chemical and Materials Engineering Nazarbayev University National Water and Energy Center United Arab Emirates University Department of Physics Alagappa University

A feasible approach to rectify the world's energy demand using sustainable development of adequate energy generation and storage technologies in a single *** this respect,we made a holistic approach with a bifunctional electrode material to perform effectively in energy generation and storage ***2nanosheets were produced by the eco-friendly method and reduced graphene oxide is used to prepared by carbon soot which is derived from castor *** prepared soot and rGO were combined with MoS2nanosheets using a simple sonication *** as-prepared sample was introduced in the supercapacitor and DSSC *** combination MoS2@rGO provides an enhanced conversion efficiency of 11.81%and the reproducibility of DSSC is also ***,MoS2@rGO is used to fabricate an asymmetric supercapacitor to investigate its real-time *** device produced the maximum power density （1666.6 mW/kg） and energy density （25.69 mWh/Kg） at 1 A/*** asymmetric supercapacitor device holds a cyclic stability of 81.4%for 5000 cycles and it powered up an LED device for 4 min.

关键词： Carbon soot Solar cells Supercapacitors MoS 2 DSSC

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Microplastics and heavy metals in freshwater fish species in the southwestern region of Bangladesh:An emerging concern for public health

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Emerging Contaminants 2024年第3期10卷 145-157页

作者： Mst Shamima Akter Tapos Kumar Chakraborty gopal Chandra Ghosh Md Simoon Nice Samina Zaman Abu Shamim Khan Department of Environmental Science and Technology Jashore University of Science and TechnologyJashore 7408Bangladesh Environmental Laboratory Asia Arsenic NetworkJashore 7400Bangladesh

Microplastics(MPs)pollution and its associated toxicity raising concerns among scientists as a result of their toxicological impacts on human health and the *** study aims to investigate the microplastics and heavy metals(HMs)contamination in seventeen freshwater fish species collected from the Southwestern region of *** extracted from these species using the hydrogen peroxide digestion method and characterized by Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy(ATR-FTIR).Atomic Absorption Spectrometry(AAS)was used to determine the concentration of HMs in different species for evaluating human health risks.A total of 142 microplastic particles were extracted with an average concentration of 1.13±0.84 items per individual of fish,where the highest microplastics were found in ***(3.43±3.15 items)and lowest in ***(0.14±0.38 items).Identified microplastics were dominated byCu(0.01e1.14;0.50±0.44)>Pb(0.04e0.58;0.22±0.12)>Cd(0.00e0.11;0.03±0.03),*** metals-based human health risk assessment results show that there are no major non-carcinogenic health risks(THI<1),while higher carcinogenic risks are present for consumers.

关键词： Microplastics Edible fish Polymer type Heavy metals Human health risk Bangladesh

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Network analyses:Inhibition of androgen receptor signaling reduces inflammation in the lung through AR-MAF-IL6 signaling axes

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Genes & Diseases 2024年第3期11卷 140-143页

作者： Albert R.Wang Andrew M.Baschnagel Zijian Ni Sean R.Brennan Hypatia K.Newton Darya Buehler Christina Kendziorski Randall J.Kimple gopal lyer Department of Human Oncology University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Department of Biomedical Engineering University of Wisconsin-MadisonMadisonWI 53705USA University of Wisconsin Carbone Cancer Center MadisonWI 53705USA Department of Biostatistics and Medical Informatics University of Wisconsin-MadisonMadisonWI 53706USA Department of Biology Tufts UniversityMedfordMA 02155USA Department of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA

Androgen receptor(AR)is a major transcription factor that plays a role in inflammatory response including interleukin-6(IL6)signaling.1 While AR regulation through paracrine loop signaling in prostate tissue is well-studied,its impact through an IL6 autocrine loop in the lung has not been wellstudied despite the organ's response to respiratory viral *** inhibition and RNA knockdown of AR identified a bZIP transcription factor MAF to be a common target of inflammation using these perturbations in lung cells.

关键词： inflammation lung respiratory

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Outcome of patients with traumatic cranial nerve palsy admitted to a university hospital in Nepal

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中华神经外科杂志(英文) 2024年第2期10卷 1-7页

作者： Kumari Khusbu Gautam Naveen Parajuli Monika Singh Shreejana Pradhananga Amit Sedai gopal Shilpakar Sushil Sharma Mohan Raj Maharajgunj Medical Campus Institute of Medicine Tribhuvan University Maharajgunj Kathmandu Nepal Department of Research Institute of Medicine Maharajgunj Kathmandu Nepal Department of Neurosurgery Tribhuvan University Teaching Hospital Maharajgunj Kathmandu Nepal

Background Cranial nerve palsy (CNP) is a common complication of traumatic brain injury (TBI). Despite a high incidence of TBI in Nepal (382 per 100,000), literature on the specific management and outcome of CNP is lacking. This study aimed to examine the outcomes of TBI patients involving single versus multiple *** A retrospective chart review of 170 consecutive TBI patients admitted to the tertiary neurosurgical center in Nepal between April 2020 and April 2022 was conducted. Demographic, clinical, and etiological characteristics; imaging findings; and management strategies were recorded, compared, and analyzed using descriptive statistics. The Glasgow Outcome Scale Extended (GOSE) was used to measure the outcomes in two groups of patients (single and multiple CNP) at 3 *** Out of 250 eligible patients, 80 were excluded and CNP was noted in 29 (17.1%) of the remaining 170. The median age was 34.9 years, and falls (60.6%) were the most common cause of trauma. TBI severity was categorized based on GCS: mild (82.4%), moderate (15.9%), and severe (1.8%). Cranial nerve involvement was seen in 29 (17.05%) patients: single cranial nerve involvement in 26 (89.65%) and multiple nerve involvement in 3 (10.34%). The most common isolated cranial nerve involved was the oculomotor nerve (37.9%). CT findings revealed a maximum of skull fractures with no significant association between CNP and CT *** CNP is a common consequence of TBI with the most common etiology being falls followed by RTA. Single CNP was more common than multiple CNP with no significant difference in the outcome in the 3-month GOSE score. Further research is needed to determine the burden of traumatic CNP and establish specific management guidelines for different types of CNP.

关键词： Cranial nerve palsy Nepal Outcome Traumatic brain injury

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Outcome of COVID-19 infection in patients on antihypertensives:A cross-sectional study

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World Journal of Critical Care Medicine 2024年第3期13卷 42-52页

作者： Sakthivadivel Varatharajan gopal K Bohra Pradeep K Bhatia Satyendra Khichar Mahadev Meena Naveenraj Palanisamy Archana Gaur Mahendra K Garg Department of General Medicine All India Institute of Medical Sciences-BibinagarHyderabad 508126TelanganaIndia Department of General Medicine All India Institute of Medical SciencesJodhpur 342005RajasthanIndia Department of Anaesthesiology and Critical Care All India Institute of Medical SciencesJodhpur 342005RajasthanIndia Department of General Medicine All India Institute of Medical SciencesBhopal 462020Madhya PradeshIndia Department of General Medicine ESIC Medical College&HospitalChennai 600021TamilnaduIndia Department of Physiology All India Institute of Medical Sciences-BibinagarHyderabad 508126TelanganaIndia Department of Endocrinology&Metabolism All India Institute of Medical SciencesJodhpur 342005RajasthanIndia

BACKGROUND Patients with coronavirus disease 2019(COVID-19)infection frequently have hypertension as a co-morbidity,which is linked to adverse *** may affect the outcome of COVID-19 *** To assess the effects of antihypertensive agents on the outcomes of COVID-19 *** A total of 260 patients were included,and their demographic data and clinical profile were *** patients were categorized into nonhypertensive,angiotensin-converting enzyme inhibitor/angiotensin receptor blocker(ACEI/ARB),calcium channel blocker(CCB),a combination of ACEI/ARB and CCB,and beta-blocker ***,hematological,and inflammatory markers were *** severity of infection,intensive care unit(ICU)intervention,and outcome were *** The mean age of patients was approximately 60-years-old in all groups,except the nonhypertensive *** were predominant in all *** was the most common presenting *** respiratory distress syndrome was the most common complication,and was mostly found in the CCB *** cases,ICU intervention,and mortality were also higher in the CCB *** logistic regression analysis revealed that age,duration of antihypertensive therapy,erythrocyte sedimentation rate,high-sensitivity C-reactive protein,and interleukin 6 were significantly associated with *** duration of antihypertensive therapy exhibited a sensitivity of 70.8%and specificity of 55.7%,with a cut-off value of 4.5 years and an area under the curve of 0.670(0.574-0.767;95%confidence interval)for COVID-19 *** The type of antihypertensive medication has no impact on the clinical sequence or mortality of patients with COVID-19 ***,the duration of antihypertensive therapy is associated with poor outcomes.

关键词： Antihypertensive COVID-19 Hypertension Mortality Outcome

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In vitro and in silico approach for the evaluation of enzyme inhibitory potential of Kadipatta (Murraya koenigii) collected from western Nepal

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Clinical Traditional Medicine and Pharmacology 2024年第4期5卷 44-53页

作者： Suman Prakash Pradhan Ishan Subedi Kapil Adhikari Ashok GC Sujan Prakash Pradhan Mukti Ram Aryal gopal Prasad Ghimire Bishnu Prasad Pandey Department of Chemical Science and Engineering Kathmandu UniversityPO Box:6250 KavreDhulikhelBagmati Province 45210Nepal Aquatic Ecology Centre Kathmandu UniversityDhulikhel 45210Nepal Department of Environmental Science and Engineering Kathmandu UniversityDhulikhel 45210Nepal Department of Botany Tri-Chandra Multiple CampusKathmandu 44600Nepal Department of Applied Sciences Western Regional CampusPokhara 33700Nepal

Background:Murraya koenigii(L.)Spreng.(Rutaceae)is an evergreen shrub distributed over the sub-tropical to lower temperate climatic zone of Nepal which has been used as spice in culinary practice and traditionally being used to treat bites of poisonous animals,dysentery,skin diseases,vomiting,diarrhea,and ***:The main objective of this study is to study the enzyme inhibition potential of different extracts of *** leaves collected from western ***:Total flavonoid content,total phenolic content,in vitro antioxidant,𝛼α-amylase,lipase,elastase,tyrosinase,and cholinesterase inhibition activities analysis of *** in ethyl acetate,methanol,and water extract were *** addition,high-resolution mass spectrometry-based profiling of flavonoid molecules and their docking analysis were ***:Results revealed the noteworthy radical scavenging activity of ethyl acetate extract against ABTS and *** the analyzed enzymes,*** extracts revealed the highest inhibitory potential towards acetylcholinesterase(AChE)and butyrylcholinesterase(BChE)and only water extract showed the inhibition of *** HPLC-ESI-QTOF-MS analysis revealed the presence of Rutin,Quercetin,Ferulic acid,Hyperoside,Kaempferol-7-O-glucoside,and Morin in ***,in silico docking analysis revealed the significant binding energy of these flavonoid molecules;especially Rutin with ***:The ethyl acetate and methanolic extracts of *** showed paramount flavonoid and phenolic content along with noteworthy potential towardsthe inhibition of neuro-degradative enzymes such as BChE which can be characterized further for pharmacological *** study on the isolation of metabolites and their pharmacological properties from *** is recommended.

关键词： Murraya koenigii 𝛼α-amylase Lipase Elastase Tyrosinase Cholinesrerase

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Sedation reversal trends at outpatient ambulatory endoscopic center vs in-hospital ambulatory procedure center using a triage protocol

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World Journal of Gastrointestinal Endoscopy 2024年第7期16卷 413-423页

作者： Saqib Walayat Peter Stadmeyer Azfar Hameed Minahil Sarfaraz Paul Estrada Mark Benson Anurag Soni Patrick Pfau Paul Hayes Brittney Kile Toni Cruz Deepak gopal Department of Gastroenterology University of IllinoisPeoriaIL 61605United States Department of Gastroenterology University of WisconsinMadisonWI 53792United States Department of Internal Medicine Texas Health DentonDentonTX 76201United States Department of Internal Medicine Allama Iqbal Medical CollegeLahore 042Pakistan Department of Gastroenterology Texas Tech University Health Services CenterEl PasoTX 79911United States Department of Gastroenterology and Hepatology University of WisconsinMadisonWI 53705United States Finance Business Partners UW Health University of WisconsinMadisonWI 53792United States UW Health Digestive Health Center Endoscopy University of WisconsinMadisonWI 53792United States Division of Gastroenterology and Hepatology Department of MedicineUniversity of Wisconsin Hospitals and ClinicsMadisonWI 53705United States

BACKGROUND Routine outpatient endoscopy is performed across a variety of outpatient settings.A known risk of performing endoscopy under moderate sedation is the potential for over-sedation,requiring the use of reversal *** needs to be reported on rates of reversal across different outpatient *** academic tertiary care center utilizes a triage tool that directs higher-risk patients to the in-hospital ambulatory procedure center(APC)for their ***,we report data on outpatient sedation reversal rates for endoscopy performed at an inhospital APC vs at a free-standing ambulatory endoscopy digestive health center(AEC-DHC)following risk stratification with a triage *** To observe the effect of risk stratification using a triage tool on patient outcomes,primarily sedation reversal *** We observed all outpatient endoscopy procedures performed at AEC-DHC and APC from April 2013 to September *** were stratified to their respective sites using a triage *** evaluated each procedure for which sedation reversal with flumazenil and naloxone was *** and characteristics recorded include patient age,gender,body mass index(BMI),American Society of Anesthesiologists(ASA)classification,procedure type,and reason for sedation *** There were 97366 endoscopic procedures performed at AEC-DHC and 22494 at the APC during the study *** these,17 patients at AEC-DHC and 9 at the APC underwent sedation reversals(0.017%vs 0.04%;P=0.06).Demographics recorded for those requiring reversal at AEC-DHC vs APC included mean age(53.5±21 vs 60.4±17.42 years;P=0.23),ASA class(1.66±0.48 vs 2.22±0.83;P=0.20),BMI(27.7±6.7 kg/m^(2) vs 23.7±4.03 kg/m^(2);P=0.06),and female gender(64.7%vs 22%;P=0.04).The mean doses of sedative agents and reversal drugs used at AEC-DHC vs APC were midazolam(5.9±1.7 mg vs 8.9±3.5 mg;P=0.01),fentanyl(147.1±49.9μg vs 188.9±74.1μg;P=0.10),flumazenil(0.3±0.18μg vs 0.17±0.17μg;P=0.13)and naloxo

关键词： Ambulatory care Conscious sedation Endoscopy Colonoscopy Risk assessment Risk factors

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Manifestation of earthquake preparation zone in the ionosphere before 2021 Sonitpur,Assam earthquake revealed by GPS-TEC data

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Geodesy and Geodynamics 2022年第3期13卷 230-237页

作者： gopal Sharma North Eastern Space Applications Centre Umiam793103MeghalayaIndia

Global Positioning System(GPS)Continuously Operating Reference Station(CORS)data analysis shows that the ionosphere’s electron density variability is linked to the deformation and stress accumulation in the Earth’s *** in ionosphere total electron content(TEC)variability before 2021 M6.4 Sonitpur,Assam earthquake were detected using L1 and L2 GPS frequencies that showed three distinct abnormalities on April 3,9,10,***’s correlation coefficient(r)of TEC decreases in the CORS that lies away from the earthquake epicenter,indicating the possibilities of a positive relationship between TEC variability and earthquake *** concentration also decreases towards the epicenter within the earthquake preparation zone(EPZ).It is also observed that the Pearson’s correlation coefficient(r)of TEC decreases linearly near the *** study demonstrates the possibilities of determining the TEC anomalous zone in the ionosphere that coincides with the EPZ in the crustal *** research indicated the possibilities of magnitude estimation of an impending earthquake based on the TEC anomalous zone in the ionosphere using closely spaced dense CORS network data.

关键词： GPS TEC Sonitpur earthquake Ionosphere perturbation TEC anomaly Magnitude estimation

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