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Non-responsive celiac disease in children on a gluten free diet

World Journal of Gastroenterology 2021年第13期27卷 1311-1320页

作者： gopal veeraraghavan Amelie Therrien Maya Degroote Allison McKeown Paul D Mitchell Jocelyn A Silvester Daniel A Leffler Alan M Leichtner Ciaran P Kelly Dascha C Weir Division of Gastroenterology Hepatology and NutritionBoston Children's HospitalBostonMA 02115United States The Celiac Center Department of Medicine and Division of GastroenterologyBeth Israel Deaconess Medical CenterBostonMA 02215United States Celiac Research Program Harvard Medical SchoolBostonMA 02115United States Institutional Centers for Clinical and Translational Research Boston Children's HospitalBostonMA 02115United States Gastrointestinal Therapeutics Takeda Pharmaceutical International CoCambridgeMA 02139United States

BACKGROUND Non-responsive celiac disease(NRCD) is defined as the persistence of symptoms in individuals with celiac disease(CeD) despite being on a gluten-free diet(GFD). There is scant literature about NRCD in the pediatric *** To determine the incidence, clinical characteristics and underlying causes of NRCD in *** Retrospective cohort study performed at Boston Children’s Hospital(BCH). Children < 18 years diagnosed with CeD by positive serology and duodenal biopsies compatible with Marsh Ⅲ histology between 2008 and 2012 were identified in the BCH’s Celiac Disease Program database. Medical records were longitudinally reviewed from the time of diagnosis through September 2015. NRCD was defined as persistent symptoms at 6 mo after the initiation of a GFD and causes of NRCD as well as symptom evolution were detailed. The children without symptoms at 6 mo(responders) were compared with the NRCD group. Additionally, presenting signs and symptoms at the time of diagnosis of CeD among the responders and NRCD patients were collected and compared to identify any potential predictors for NRCD at 6 mo of GFD *** Six hundred and sixteen children were included. Ninety-one(15%) met criteria for NRCD. Most were female(77%). Abdominal pain [odds ratio(OR) 1.8 95% confidence interval(CI) 1.1-2.9], constipation(OR 3.1 95%CI 1.9-4.9) and absence of abdominal distension(OR for abdominal distension 0.4 95%CI 0.1-0.98) at diagnosis were associated with NRCD. NRCD was attributed to a wide variety of diagnoses with gluten exposure(30%) and constipation(20%) being the most common causes. Other causes for NRCD included lactose intolerance(9%), gastroesophageal reflux(8%), functional abdominal pain(7%), irritable bowel syndrome(3%), depression/anxiety(3%), eosinophilic esophagitis(2%), food allergy(1%), eating disorder(1%), gastric ulcer with Helicobacter pylori(1%), lymphocytic colitis(1%), aerophagia(1%) and undetermined(13%). 64% of children with NRCD

关键词： Celiac disease Non-responsive celiac disease Children Gluten-free diet Constipation Abdominal pain

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WISH:wavefront imaging sensor with high resolution

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Light(Science & Applications) 2019年第1期8卷 818-827页

作者： Yicheng Wu Manoj Kumar Sharma Ashok veeraraghavan Department of Electrical and Computer Engineering Rice UniversityHoustonTXUSA Applied Physics Program Rice UniversityHoustonTXUSA

Wavefront sensing is the simultaneous measurement of the amplitude and phase of an incoming optical *** wavefront sensors such as Shack-Hartmann wavefront sensor(SHWFS)suffer from a fundamental tradeoff between spatial resolution and phase estimation and consequently can only achieve a resolution of a few thousand *** break this tradeoff,we present a novel computational-imaging-based technique,namely,the Wavefront Imaging Sensor with High resolution(WISH).We replace the microlens array in SHWFS with a spatial light modulator(SLM)and use a computational phase-retrieval algorithm to recover the incident *** wavefront sensor can measure highly varying optical fields at more than 10-megapixel resolution with the fine phase *** the best of our knowledge,this resolution is an order of magnitude higher than the current noninterferometric wavefront *** demonstrate the capability of WISH,we present three applications,which cover a wide range of spatial ***,we produce the diffraction-limited reconstruction for long-distance imaging by combining WISH with a large-aperture,low-quality Fresnel ***,we show the recovery of high-resolution images of objects that are obscured by ***,we show that WISH can be used as a microscope without an objective *** study suggests that the designing principle of WISH,which combines optical modulators and computational algorithms to sense high-resolution optical fields,enables improved capabilities in many existing applications while revealing entirely new,hitherto unexplored application areas.

关键词： estimation. field. resolution

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Manifestation of earthquake preparation zone in the ionosphere before 2021 Sonitpur,Assam earthquake revealed by GPS-TEC data

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Geodesy and Geodynamics 2022年第3期13卷 230-237页

作者： gopal Sharma North Eastern Space Applications Centre Umiam793103MeghalayaIndia

Global Positioning System(GPS)Continuously Operating Reference Station(CORS)data analysis shows that the ionosphere’s electron density variability is linked to the deformation and stress accumulation in the Earth’s *** in ionosphere total electron content(TEC)variability before 2021 M6.4 Sonitpur,Assam earthquake were detected using L1 and L2 GPS frequencies that showed three distinct abnormalities on April 3,9,10,***’s correlation coefficient(r)of TEC decreases in the CORS that lies away from the earthquake epicenter,indicating the possibilities of a positive relationship between TEC variability and earthquake *** concentration also decreases towards the epicenter within the earthquake preparation zone(EPZ).It is also observed that the Pearson’s correlation coefficient(r)of TEC decreases linearly near the *** study demonstrates the possibilities of determining the TEC anomalous zone in the ionosphere that coincides with the EPZ in the crustal *** research indicated the possibilities of magnitude estimation of an impending earthquake based on the TEC anomalous zone in the ionosphere using closely spaced dense CORS network data.

关键词： GPS TEC Sonitpur earthquake Ionosphere perturbation TEC anomaly Magnitude estimation

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Approaches for enhancing the photocatalytic activities of barium titanate:A review

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Journal of Energy Chemistry 2022年第10期31卷 160-188,I0004页

作者： gopal Panthi Mira Park Carbon Composite Energy Nanomaterials Research Center Woosuk UniversityWanjuChonbuk 55338Republic of Korea Woosuk Institute of Smart Convergence Life Care(WSCLC)Woosuk UniversityWanjuChonbuk 55338Republic of Korea

Barium titanate(Ba TiO_(3)),a dielectric/ferroelectric semiconductor with perovskite structures is the most widely used photocatalyst in the field of environmental applications due to its low-cost,chemical stability,and *** types and forms of Ba TiO_(3)have shown their great potential toward the significant photocatalytic reactions owing to the several beneficial properties,including appropriate band positions,high oxygen vacancies,multiple crystal structures,the feasibility of size and morphology tailoring,spontaneous polarization,rapid migration of photogenerated charge carriers,and band ***,the large band gap and recombination of photogenerated charge carriers limit the overall photocatalytic efficiency of Ba TiO_(3).These difficulties can be further overcome by modifying the electronic band structure of Ba TiO_(3)to broaden its absorption to the visible region of the ***,this review encompasses various strategies,including modification of sizes and morphologies of particles by varying the reaction time and synthesis temperature,doping with non-metals/metals,loading with noble metals,and forming heterojunctions for enhancing the photocatalytic activities of Ba TiO_(3)-based photocatalysts possessing the effective capability of charge carrier separation,trapping and their transfer to the surface of ***,this review highlights the photocatalytic applications of Ba TiO_(3)-based photocatalysts along with the proposed mechanism in dyes/drugs degradation,H_(2)production,and bacteria killing.

关键词： Electrospinning BaTiO_(3)-photocatalyst Ferroelectricity Heterojunction Environmental remediation

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Improvement on the Multihop Shareholder Discovery for Threshold Secret Sharing in MANETs

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Journal of Computer Science & Technology 2011年第4期26卷 711-721页

作者： Seleviawati Tarmizi Prakash veeraraghavan Somnath Ghosh Department of Computer Science and Computer Engineering La Trobe University

The collaboration of at least a threshold number of secret shareholders in a threshold secret sharing scheme is a strict requirement to ensure its intended functionality. Due to its promising characteristics, such a scheme has been proposed to solve a range of security problems in mobile ad hoc networks. However, discovering a sufficient number of secret shareholders in such dynamic and unpredictable networks is not easy. In this paper, we propose a more efficient shareholder discovery mechanism compared to our previous work. The discovery process is performed in a multihop fashion to adapt to the mobile ad hoc network environment. We introduce batch extension that gradually extends the shareholders＇ collaboration boundary by more than one hop at a time around the service requestor, to find at least the threshold number of the unknown shareholders. Through the batch extension, reply aggregation is applicable, hence reducing the redundancy use of reply routes, decreasing the required packet transmission, and lessening the service delay, compared to the previously proposed mechanism. Our simulation results show that, with the appropriate batch size, the latest mechanism is more efficient with an insignificant increase of control overhead.

关键词： multihop shareholder discovery threshold secret sharing multihop secret sharing

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Hydrothermal synthesis of Zn-Mg-based layered double hydroxide coatings for the corrosion protection of copper in chloride and hydroxide media

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International Journal of Minerals,Metallurgy and Materials 2021年第12期28卷 1991-2000页

作者： Nikhil gopal Ji Rajiv Prakash School of Materials Science and Technology Indian Institute of Technology(BHU)VaranasiVaranasi-221005Uttar PradeshIndia Centre for advanced studies Dr.APJAKTU LucknowU.P.-226031India

Layered double hydroxides(LDHs)hinder corrosive elements by forming a double layer and locking them between its ***,LDHs are interesting materials in corrosion *** this work,Zn-Mg-based LDHs are grown over a copper substrate by using a hydrothermal *** types of Zn-Mg-based LDH coating are prepared based on hydrothermal reaction *** types are characterized through Fourier transform infrared spectroscopy,Raman spectroscopy,high-resolution scanning electron microscopy,energy dispersive X-ray analysis,atomic force microscopy,and X-ray *** show that the two types of LDH coating are successfully grown on copper;however,they differ in thickness and structural *** testing of the LDH coatings is executed in 0.1 M Na Cl and 0.1 M Na OH through alternating current impedance measurements and Tafel polarization *** show that L48 gives more than 90%protection to copper,which is higher than the protection provided by ***,both LDH coatings(L24 and L48)are more effective corrosion inhibitors in Na Cl than in Na OH,suggesting that the LDH coatings can more efficiently exchange Cl ions than OH ions.

关键词： corrosion coating copper

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Mysteries of R^ik=0： A novel paradigm in Einstein＇s theory of gravitation

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Frontiers of physics 2014年第1期9卷 98-112页

作者： Ram gopal Vishwakarma Unidad Academica de Matemdticas Universidad Autdnoma de Zacatecas C.P. 98068 Zacatecas ZAC Mexico

Despite a century-long effort, a proper energy-stress tensor of the gravitational field, could not have been discovered. Furthermore, it has been discovered recently that the standard formulation of the energy-stress tensor of matter, suffers from various inconsistencies and paradoxes, concluding that the tensor is not consistent with the geometric formulation of gravitation [Astrophys. Space Sci., 2009, 321： 151; Astrophys. Space Sei., 2012, 340： 373]. This perhaps hints that a consistent theory of gravitation should not have any bearing on the energy-stress tensor. It is shown here that the so-called ＂vacuum＂ field equations Rik = 0 do not represent an empty spacetime, and the energy, momenta and angular momenta of the gravitational and the matter fields are revealed through the geometry, without including any formulation thereof in the field equations. Though, this novel discovery appears baffling and orthogonal to the usual understanding, is consistent with the observations at all scales, without requiring the Moreover, the resulting theory circumvents the besides explaining some unexplained puzzles. hypothetical dark matter, dark energy or inflation long-standing problems of the standard cosmology

关键词： general relativity and gravitation - fundamental problems and general formalism cos-mological observations

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Mysteries of the geometrization of gravitation

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Research in Astronomy and Astrophysics 2013年第12期13卷 1409-1422页

作者： Ram gopal Vishwakarma Unidad Acad'emica de Matem'aticas Universidad Aut'onoma de Zacatecas

As we now know, there are at least two major difficulties with general rel- ativity （GR）. The first one is related to its incompatibility with quantum mechanics, in the absence of a consistent, widely accepted theory that combines the two theo- ries. The second problem is related to the requirement of the dark sectors-inflaton, dark matter and dark energy by the energy-stress tensor, which are needed to explain a variety of astronomical and cosmological observations. Research has indicated that the dark sectors themselves do not have any non-gravitational or laboratory evidence. Moreover, the dark energy poses, in addition, a serious confrontation between funda- mental physics and cosmology. Guided by theoretical and observational evidences, we are led to an idea that the source of gravitation and its manifestation in GR should be modified. The result is in striking agreement with not only the theory, but also the ob- servations, without requiring the dark sectors of the standard approach. Additionally, it provides natural explanations to some unexplained puzzles.

关键词： general relativity and gravitation -- fundamental problems and generalformalism -- cosmology: observations

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Nonlinear mixing-based terahertz emission in inclined rippled density plasmas

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Chinese Physics B 2023年第6期32卷 384-390页

作者： K gopal A P Singh S Divya Rajdhani College Department of Physics&ElectronicsUniversity of DelhiNew DelhiIndia Computational Plasma Dynamics Laboratory Rajdhani CollegeDepartment of Physics&ElectronicsUniversity of DelhiNew DelhiIndia

We propose to investigate the THz field generation using nonlinear mixing mechanism of laser beat wave with inclined rippled density *** laser pulses with frequencies(ω_(1),ω_(2)) and wave vectors(k_(1),k_(2)) co-propagate and resultant laser beat wave forms at beat frequency(ω_(1)-ω_(2)).Laser beat wave imparts a nonlinear force on the ambient electrons and pushes them outward with nonlinear velocity v_(NL).Coupling of induced density perturbation and nonlinear velocity v_(NL)generates nonlinear currents at laser beat frequency that further generates electromagnetic field E_((ω_(1)-ω_(2))) in terahertz(THz)*** the present scheme,density ripples are introduced at an angle with respect to laser propagation and flat Gaussian index(f) is introduced in laser field profile that transform curved top of Gaussian field envelope into flat top field *** combined effect of flat laser pulses with inclined density ripples in plasmas shows 10-fold enhancement in THz field amplitude when flat-Gaussian index(f) varies from 1 to ***,the THz field intensifies when density ripples inclination increases upto a certain angle and then decreases.

关键词： terahertz inclined ripple flat laser laser plasma interaction

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Experimental investigation on concrete overlaid with textile reinforced mortar:Influences of mix,temperature,and chemical exposure

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Frontiers of Structural and Civil Engineering 2023年第2期17卷 271-283页

作者： Smitha GOPINATH Ramesh gopal Hemalatha THIYAGARAJAN CSIR-Structural Engineering Research Centre Chennai 600113India

Textile reinforced mortar is widely used as an overlay for the repair,rehabilitation,and retrofitting of concrete ***,textile reinforced concrete has been identified as a suitable lining material for improving the durability of existing concrete *** this study,we developed a textile-reinforced mortar mix using river sand and evaluated the different characteristics of the textile-reinforced mortar under various exposure *** were carried out in two *** the first phase,the pullout strength,temperature resistance,water absorption,and compressive and bending strength values of three different textile-reinforced mortar mixes with a single type of textile reinforcement were *** the second phase,the chemical resistance of the mix that showed the best performance in the abovementioned tests was examined for use as an overlay for a concrete *** were performed on three different thicknesses of the textile reinforced mortar overlaid on concrete specimens that were subjected to acidic and alkaline *** flexural responses and degradations of the textile reinforced mortar overlaid specimens were examined by performing bending *** experimental findings indicated the feasibility of using textile reinforced mortar as an overlay for durable concrete construction practices.

关键词： textile reinforced mortar bending tests acid and alkaline environment concrete overlay

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