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Geodesy and Geodynamics 2022年第3期13卷 230-237页

作者： Gopal Sharma North Eastern Space Applications Centre Umiam793103MeghalayaIndia

Global Positioning System(GPS)Continuously Operating Reference Station(CORS)data analysis shows that the ionosphere’s electron density variability is linked to the deformation and stress accumulation in the Earth’s crust.Anomalies in ionosphere total electron content(TEC)variability before 2021 M6.4 Sonitpur,Assam earthquake were detected using L1 and L2 GPS frequencies that showed three distinct abnormalities on April 3,9,10,2021.Pearson’s correlation coefficient(r)of TEC decreases in the CORS that lies away from the earthquake epicenter,indicating the possibilities of a positive relationship between TEC variability and earthquake epicenter.TEC concentration also decreases towards the epicenter within the earthquake preparation zone(EPZ).It is also observed that the Pearson’s correlation coefficient(r)of TEC decreases linearly near the EPZ.The study demonstrates the possibilities of determining the TEC anomalous zone in the ionosphere that coincides with the EPZ in the crustal rocks.The research indicated the possibilities of magnitude estimation of an impending earthquake based on the TEC anomalous zone in the ionosphere using closely spaced dense CORS network data.

关键词： GPS TEC Sonitpur earthquake Ionosphere perturbation TEC anomaly Magnitude estimation

Giant exophytic renal angiomyolipoma masquerading as a retroperitoneal liposarcoma: A case report and review of literature

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World Journal of Clinical Oncology 2018年第7期9卷 162-166页

作者： Gopal Sharma Ayush Jain Prerit sharma Sonal sharma Vinita Rathi Pankaj Kumar Garg Department of Surgery University College of Medical Sciences and Guru Teg Bahadur Hospital University of Delhi Department of Pathology University College of Medical Sciences and Guru Teg Bahadur Hospital University of Delhi Department of Radiology University College of Medical Sciences and Guru Teg Bahadur Hospital University of Delhi

A 42-years-old lady, presented with a large retroperitoneal mass which was preoperatively diagnosed as a retroperitoneal liposarcoma following an image guided core biopsy. She underwent a margin-negative resection of the retroperitoneal mass(multi visceral resection-enbloc excision of the retroperitoneal mass with a left nephrectomy and a segmental descending colectomy). The final histopathological examination of the resected specimen confirmed an exophytic renal angiomyolipoma(AML) which was extending into the retroperitoneum. AML is a rare benign tumor arising most commonly from the kidney. It can sometimes present as a diagnostic challenge as it mimics a retroperitoneal liposarcoma or a fat-containing renal cell carcinomas closely. We present this case to share our experience of managing a case of giant exophytic AML which resembled retroperitoneal liposarcoma closely and resulted into an aggressive surgery.

关键词： Angiomyolipoma Retroperitoneum Liposarcoma Diagnosis Biopsy

Quality assessment of Continuous Operating Reference Stations(CORS)-GPS stations in Mexico

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Geodesy and Geodynamics 2022年第3期13卷 275-287页

作者： Daniel Hernández-Andrade Rosendo Romero-Andrade Gopal Sharma Manuel E.Trejo-Soto Juan L.Cabanillas-Zavala Faculty of Earth and Space Sciences Autonomous University of Sinaloa80013Culiacán RosalesSinaloaMexico North Eastern Space Applications Centre Umiam793103MeghalayaIndia

The present analysis provided the quality assessment of 65 Continuous Operating Reference Stations(CORS) situated in and around Mexico using the data of about ten years(January 2010 to January 2020).To accomplish the assessment,we considered 4 quality indexes for performing the quality check,incluing the multipath effect on L1 and L2 bands,signal-to-noise ratio in both bands,cycle slips,and integrity.Meanwhile,a new reference parameter named regio nal values for Mexico(RVM) was calculated for the stations situated in Mexico.Additionally,an exhaustive analysis of the quality indicators in the worst and best cases was performed.The signal degradation was proved by a long-term time series and cru stal defo rmation analysis in GAMIT/GLOBK platform.The results showed a stro ng correlation between integrity,cycle slips and daily observations time,and the multipath effect is strong in the case of outdated systems.The study indicates that the estimated quality indexes and values could be the basis for establishing new CORS in Mexico,and the errors corrections which cannot be mitigated in the postprocessing stage would greatly help utilize the data for different scientific applications.The results were supported by deformation analysis in part of Baja California Peninsula in Mexico indicating northern and eastern velocity vector of -3.08±0.02 mm/yr,-7.85±0.02 mm/yr and-0.07±0.03 mm/yr,-9.33±0.02 mm/yr respectively at MPR1 and INEG stations.

关键词： Multipath effect Signal-to-Noise ratio Cycle slip Integrity Regional quality indicators IGS indicators

Protective effect of Ocimum sanctum Linn. leaf extract on ethanol withdrawal syndrome in Wistar rats

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Asian Pacific Journal of Tropical Medicine 2018年第8期11卷 467-472页

作者： Lalit sharma Aditi sharma G.L.Gupta gopal Singh Bisht Department of Pharmacy Jaypee University of Information Technology School of Pharmaceutical Sciences Sholini University Department of Pharmacology SPPSPTM SVKM'S NMIMS University Department of BT and BI Jaypee University of Information Technology

Objective: To evaluate the effects of Oscimum sanctum L(O. sanctum), an important medicinal herb, on alcohol withdrawal syndrome in Wistar rats. Methods: Liquid diet with 7.2%, v/v ethanol was administered to the rats for 21 d. Control group animals received sucrose as an isocaloric liquid diet. After alcohol withdrawal, rats were examined at 6 th and 24 th hour for major withdrawal signs that included anxiety and hyper locomotor activity. Ethanol withdrawal anxiety was tested using elevated plus maze, light and dark model; the hyper locomotor activity using actophotometer. O. sanctum leaf extract(100, 200 and 300 mg/kg, oral) and diazepam(2 mg/kg, i.p) were administered to the treatment group animals 30 min before alcohol withdrawal estimation. Drug treatment was also given 30 min before the second observation at 24 th hour. On the last day of the protocol, rats were sacrificed by cervical dislocation liver, kidney and brain were isolated and preserved in formalin for further histopathological examination. Results: Findings from the present study revealed that O. Sanctum leaf extract treatment at doses 100, 200 and 300 mg/kg, oral had a significant protective effect on signs and symptoms of ethanol withdrawal in alcohol-dependent rats. However, no remarkable pathological and microscopic alterations were observed in histopathological examination. Conclusions: O. sanctum seems to be an active drug for the treatment of alcohol abstinence syndrome.

关键词： Oscimum sanctum Ethanol withdrawal syndrome Anxiety Hyperlocomotor activity Histopathology

Development and Evaluation of Shelf Stability of Flaxoat Nutty Bar in Different Packaging Materials

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Food and Nutrition Sciences 2013年第5期4卷 538-546页

作者： Ananthan Padmashree gopal Kumar sharma Thimma Govindaraj Department of Cereals and Pulses Technology Defence Food Research Laboratory Mysore India.

Flaxoat nutty bar, a granola cereal bar was developed using oat and wheat as major cereal ingredients and their shelf life was assessed in polypropylene (PP 75 μ), paper (42 GSM) aluminium foil (20 μ) polyethylene (PFP, 37.5 μ) and metallised polyester (MP, 12 μ) low density/linear low density (150 μ) (with and without vacuum) films and stored under ambient temperature conditions and 37℃. Chemical changes in bar under different packaging materials during storage revealed that, the bar remained stable and acceptable for 12 months at ambient conditions irrespective of the packaging materials used, while at 37℃, the bar packed in PP films remained stable for 6 months only and rest of the bars packed in PFP, MP and MP (vacuum) films found stable and acceptable for the entire storage period of 12 months. The effect of aw on lipid peroxidation established the maximum stability of the bar at 0.33 aw. Fourteen fatty acids were identified in which oleic (50.91%), linoleic (22.50%) and palmitic (12.63%) acids were found to be the major fatty acids. Fortification of a bar with vitamin C, B1 and B2 contents to meet 50% RDA enhanced vitamin contents and the maximum retention was observed in bars packed under vacuum in MP films.

关键词： Cereal Bar Packaging Water Activity Chemical Changes Shelf Life

Effect of omeprazole and domperidone on adult asthmatics with gastroesophageal reflux

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World Journal of Gastroenterology 2007年第11期13卷 1706-1710页

作者： Bhavneesh sharma Manisha sharma Mradul Kumar Daga gopal Krishan Sachdev Elliott Bondi Brookdale University Hospital and Medical Center Division of Pulmonary and Critical Care Medicine State University of New York Brooklyn New York 11212 United States University of Delhi Maulana Azad Medical College Divisions of Pulmonary Medicine and Gastroenterology New Delhi 110002 India

AIM: To study the effect of combined omeprazole (Ome) and domperidone (Dom) therapy on asthma symptoms and pulmonary function in asthmatics with gastroesoph- ageal reflux. METHODS: We selected 198 asthmatics with gastroesophageal reflux diagnosed by 24-h esophageal pH monitoring to receive Ome 20 mg twice daily and Dom 10 mg three times daily or placebo for 16 wk (1:1 double-blind randomization). Spirometry was done at baseline and af- ter 16 wk of treatment. The primary outcome measures were: mean daily daytime and nighttime asthma symp- tom scores. Mean daily reflux symptom scores, albuterol use as rescue medication (number of puffs), daytime and nighttime peak expiratory flow rate (PEFR), postbroncho- dilator forced expiratory volume in 1 second (FEV1) and postbronchodilator forced vital capacity (FVC) were secondary outcome measures. RESULTS: Comparison of mean change from baseline between antireflux therapy and placebo groups revealed significant reduction in daytime asthma symptom score (17.4% vs 8.9%), nighttime asthma symptom score (19.6% vs 5.4%), reflux symptom score (8.7% vs 1.6%) and rescue medication use (23.2% vs 3.1%) after antire- flux therapy compared to mean change in placebo group (P < 0.001). There was significant improvement in morn- ing PEFR (7.9% vs 0.2%), evening PEFR (9.8% vs 0.5%), FEV1 (11.1% vs 3.78%) and FVC (9.3% vs 1.52%) in the antireflux therapy group compared to placebo on compar-ing the mean change from baseline after 16 wk (P < 0.01).

关键词：奥美拉唑多潘立酮成年人哮喘伴发胃食管返流

Development of Application Specific Continuous Speech Recognition System in Hindi

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Journal of Signal and Information Processing 2012年第3期3卷 394-401页

作者： Gaurav Gaurav Devanesamoni Shakina Deiv gopal Krishna sharma Mahua Bhattacharya Indian Institute of Information Technology & Management

Application specific voice interfaces in local languages will go a long way in reaching the benefits of technology to rural India. A continuous speech recognition system in Hindi tailored to aid teaching Geometry in Primary schools is the goal of the work. This paper presents the preliminary work done towards that end. We have used the Mel Frequency Cepstral Coefficients as speech feature parameters and Hidden Markov Modeling to model the acoustic features. Hidden Markov Modeling Tool Kit —3.4 was used both for feature extraction and model generation. The Julius recognizer which is language independent was used for decoding. A speaker independent system is implemented and results are presented.

关键词： Automatic Speech Recognition Mel Frequency Cepstral Coefficients Hidden Markov Modeling

Elevation, Slope Aspect and Integrated Nutrient Management Effects on Crop Productivity and Soil Quality in North-west Himalayas, India

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Journal of Mountain Science 2014年第5期11卷 1208-1217页

作者： Birendra Nath GHOSH Narinder Kumar sharma Nurnabi Meherul ALAM Raman Jeet SINGH gopal Prasad JUYAL Central Soil and Water Conservation Research and Training Institute 218 Kaulagarh Road Dehradun-248 195 Uttarakhand India

在农场简历资源上，再循环明确地与保存农业的介绍被给了更大的强调 withclimate 变化情形在西北 Himalaya 区域(NWHR ) 中间山。在这种变化情形，举起，斜坡方面和综合营养素下面，管理(INM ) 可以显著地影响土壤质量和庄稼生产率。研... 详细信息

在农场简历资源上，再循环明确地与保存农业的介绍被给了更大的强调 withclimate 变化情形在西北 Himalaya 区域(NWHR ) 中间山。在这种变化情形，举起，斜坡方面和综合营养素下面，管理(INM ) 可以显著地影响土壤质量和庄稼生产率。研究处于一个 rainfed 条件在 NWHR 的 Ashti 分水岭在 20092010 ～ 20102011 期间被进行在土壤资源和庄稼生产率上检验举起，斜坡方面和综合滋养的管理(INM ) 的影响。二年农场示范试用显示庄稼生产率和土壤质量被举起，斜坡方面和 INM 显著地影响。结果证明改进技术的小麦等价物产量(WEY ) 与常规系统相比由 20%37% 增加了庄稼生产率。与豇豆和大豆玉米杂种由另一 8%17% 提高了产量。诺思方面和更高的举起与南方方面和低举起相比由 15%25% 增加了庄稼生产率(除了稻) 。与豇豆和大豆玉米杂种由另一 8%15% 提高了产量。不管斜坡，举起和收割系统， WEY 由于 INM 技术在这个区域增加了 30% 。举起，斜坡方面和 INM 的影响显著地影响了土壤资源(SQI ) 和土壤碳变化(SCC ) 。 SCC 显著地与 SQI 被相关为常规( R 2 =0.65*)， INM 技术( R 2 =0.81*)并且为两种技术( R 2 =0.73*)。它被推荐那在更高的举起。(除了稻土壤) 与面对斜坡的北方， INM 为更高的庄稼生产率被推荐；土壤资源的保存为 NWHR 的中间的山被推荐；并且 SCC 的单个价值作为为这个区域的 SQI 适当。

关键词：喜马拉雅山区土壤质量低海拔西北部作物生产力管理养分坡度

Evaluation of antimicrobial activity and bronchodialator effect of a polyherbal drug-Shrishadi

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Asian Pacific Journal of Tropical Biomedicine 2012年第11期2卷 905-909页

作者： Divya Kumari Kajaria Mayank Gangwar Dharmendra Kumar Amit Kumar sharma Ragini Tilak gopal Nath Yamini Bhusan Tripathi JS Tripathi SK Tiwari Faculty of Aurveda Department of KayachikitsaInstitute of Medical SciencesBanaras Hindu UniversityVaranasi-221005(Uttar pradesh) Department of Microbiology Institute of Medical SciencesBanaras Hindu UniversityVaranasi- 221005 (Uttar pradesh) Department of Medicinal Chemistry Institute of Medical SciencesBanaras Hindu UniversityVaranasi- 221005 (Uttar pradesh) Faculty of Aurveda Department of KayachikitsaInstitute of Medical SciencesBanaras Hindu University

Objective:To investigate antimicrobial and bronchodialator effect of hydroalcholic extract of polyherbal drug Shirishadi containing Shirisha(Albezzia lebbeck),Nagarmotha(Cyprus ratandus) & Kantakari(Solanum xanthocarpum).Methods:Antimicrobial activity was evaluated by discdiffusion method and MIC,MBC,MFC were calculated by micro dilution method.Hydroalcholic extract of this preparation was investigated for its phytochemical analysis,phenol and Oavonoid were determined by speclrophotometric method and in vivo bronchodilator effect was analysed by convulsion time.Results:The phytochemical tests revealed presence of alkaloids, anthraquinones,carbohydrates,flavonoids,saponins and tannins.The antimicrobial result showed the MIC of 6.25 mg/ml.against Staphylococcus aureus and 12.5 mg/mL.for Escherichia coli and 12.5 mg/mL against remaining bacteria tested,with strong antifungal activity.The maximum inhibition zone is found against Pseudomonas aeruginosa with MIC 16 mg/mL Drug showed significant bronchodilator effect with 27.86%& 36.13%increase in preconvulsion time of guinea pigs prebeated with 100 & 200 mg/kg body weight of extract.Conclusions:The study reveals that the extracts possess antibacterial activity and antifungal activity in a dose dependent manner. This antimicrobial property may be due to presence of several saponins,further studies are highly needed for the drug development.

关键词： Shrishadi-polyherbal drug Phytochemical Phenolic & flavonoid content Candida species Bronchodilator

Shifting paradigm in brain abscess management at tertiary care centre in Nepal

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Neuroimmunology and Neuroinflammation 2018年第6期5卷 10-17页

作者： Prakash Kafle Mohan Raj sharma Sushil Krishna Shilpakar gopal Sedain Amit Pradhanang Ram Kumar Shrestha Binod Raj Bhandari Christine Groves Department of Neurosurgery Nobel Medical College Teaching HospitalBiratnagar56613Nepal Department of Neurosurgery Tribhuvan University Teaching HospitalKathmandu44613Nepal Department of Physical Medicine and Rehabilitation Indiana University School of MedicineIndianapolisIN46202USA

Aim: Brain abscess is a challenging clinical entity with substantial high case fatality rates despite significant advances in imaging techniques,laboratory modalities,surgical interventions,and antimicrobial treatment.Otogenic and cardiogenic sources are among the most common.Classic clinical presentation is seen in very few cases only.Burr hole with aspiration works well with good clinical outcomes.Control of primary source in cases of ear infection in the single setting results in good outcomes,reduces for additional surgery,and decreases the duration of hospital stay.Methods: This is prospective observational study conducted at Institute of Medicine,Tribhuvan University Teaching Hospital,Kathmandu,Nepal over the period of two and a half years(from September 2014 to March 2017).We analyzed the demographic profile,management strategies and outcome of these cases diagnosed with brain abscess using Microsoft Excel 2007.Results: A total of 51 cases were undertaken for surgical management.There were 35 males and 16 females with the male to female ratio of 2.18:1.The mean age of the study population was 16.76 years with age range from 4 months to 60 years.Otogenic source was the most common.Temporal lobe was the most common abscess location.Headache was the most common clinical presentation and was seen in 86.27%of the study population.All cases were initially managed with burrhole and aspiration of the abscess.Only 3.92%(n = 2)of cases subsequently required surgical excision of the abscess wall.Only 11.76%(n = 6)of the cases required multiple aspiration.Only 19.61%(n = 10)showed positive culture.Pseudomonas aeruginosa and E.coli were the most common organisms grown.Mortality rate among the study group was 3.92%.Conclusion: With the advent of modern technology in neuroimaging,mortality due to brain abscess has significantly decreased.Joint involvement of the otorhinolaryngology team and efforts in addressing the primary source have further helped in improving outcomes in cases of otogenic brain abscess.Hence,source c

关键词： Abscess otogenic brain abscess tubercular abscess