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Plasma response to supersonic molecular beam injection in j-TEXT

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Plasma response to supersonic molecular beam injection in J-...

Mobility of charge carriers in mineral oil and ester fluids

第十六届全国等离子体科学技术会议暨第一届全国等离子体医学研讨会

作者： j.S.Xiao Z.j.Yang G.Zhuang M.H.Liu State Key of Laboratory of Advanced Electromagnetic Engineering and Technology Huazhong University of Science and Technology

Recently,hydrogen fueling experiments with Supersonic Molecular Beam Injection (SMBI) system were performed on the j-TEXT *** these experiments, besides the density increasing,several interesting phenomenon were *** the first place,when moderate SMB used,electron density increased with a large margin, accompanying that the scale of magnetic island slightly *** rotation,which measured by the velocity of CV ion with a spectroscopy(r/a= 0.7-0.8),accelerated from 8km/s to 12km/s(counter-current direction) during SMBI.A higher electron density than pre-SMBI maintained for long period,indicating plasma confinement may *** another hand,while the amount of SMB is sufficient enough,it can trigger the tearing *** the electron density increased *** of CV ion decreased,even reversed towards co-current *** electron temperature changed like non-local have been ***,we need to find more evidence to prove it.

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High Voltage 2021年第6期6卷 1040-1050页

作者： Qingjiang Xue Igor Timoshkin Mark PWilson Martin Given Scott j.MacGregor Department of Electronic and Electrical Engineering University of StrathclydeGlasgowUK

New,more stringent environmental requirements for electrical insulation liquids have led to the development of novel,more environment‐friendly liquid *** fluids,introduced several decades ago,provide a viable alternative to traditional mineral insu-lating *** order to expand the practical applications of these novel dielectric fluids,their dielectric and electrical parameters should be *** of the critical pa-rameters that affects and governs the development of pre‐breakdown processes in insulating liquids is the mobility of charge *** the present paper,the mobility of charge carriers in commercially available synthetic and natural insulating ester fluids and in a mineral insulating oil were obtained using two methods,the time of flight and the space charge saturation current *** mobility was obtained for a wide range of electrical field *** was found that the mobility of charge carriers is greater in the mineral oil than in both,the natural and synthetic,ester *** was also established that the mobility is higher for higher applied electric *** results of this work will help in characterizing liquid dielectrics and in optimizing high‐voltage systems in which liquid dielectrics,including natural and synthetic ester fluids,are used.

关键词： field. charge liquids

An ETD Method for American Options under the Heston Model

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Computer Modeling in Engineering & Sciences 2020年第8期124卷 493-508页

作者： Rafael Company Vera N.Egorova Lucas jódar Ferran Fuster Valls Instituto de Matemática Multidisciplinar Universitat Politècnica de ValènciaValencia46022Spain Depto.de Matemática Aplicada y Ciencias de la Computación Universidad de CantabriaSantander39005Spain Nfoque Advisory Services Madrid28001Spain

A numerical method for American options pricing on assets under the Heston stochastic volatility model is developed.A preliminary transformation is applied to remove the mixed derivative term avoiding known numerical drawbacks and reducing computational *** boundary is treated by the penalty *** nonlinear partial differential equation is solved numerically by using the method of *** full discretization the exponential time differencing method is *** analysis establishes the stability and positivity of the proposed *** numerical convergence behaviour and effectiveness are investigated in extensive numerical experiments.

关键词： Heston model American option pricing exponential time differencing semi-discretization

Protein kinase small molecule inhibitors for rheumatoid arthritis: Medicinal chemistry/clinical perspectives

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World journal of Orthopedics 2014年第4期5卷 496-503页

作者： Charles j Malemud David E Blumenthal The Arthritis Research Laboratory Department of Medicine Division of Rheumatic Diseases Case Western Reserve University Cleveland OH 44106-5076 United States Department of Anatomy Case Western Reserve University Cleveland OH 44106-5076 United States School of Medicine Division of Rheumatology Veteran’s Administration Medical Center Cleveland OH 44106 United States

Medicinal chemistry strategies have contributed to the development, experimental study of and clinical trials assessment of the first type of protein kinase small molecule inhibitor to target the janus kinase/Signal Transducers and Activators of Transcription(jAK/STAT) signaling pathway. The orally administered small molecule inhibitor, tofacitinib, is the first drug to target the jAK/STAT pathway for entry into the armamentarium of the medical therapy of rheumatoid arthritis. The introduction of tofacitinib into general rheumatologic practice coupled with increasing understanding that additional cellular signal transduction pathways including the mitogen-activated protein kinase and phosphatidylinositide-3-kinase/Akt/mammalian target of rapa-mycin pathways as well as spleen tyrosine kinase also contribute to immune-mediated inflammatory in rheumatoid arthritis makes it likely that further development of orally administered protein kinase small molecule inhibitors for rheumatoid arthritis will occur in the near future.

关键词： Clinical trials Protein kinase Signal transduction Small molecule inhibitor Rheumatoid arthritis

Structure-based protein-protein interaction networks and drug design

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Frontiers of Electrical and Electronic Engineering in China 2013年第3期8卷 183-191页

作者： Hammad Naveed jingdong j. Han Chinese Academy of Sciences Key Laboratory of Computational Biology Chinese Academy of Sciences-Max Planck PartnerInstitute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai200031 China

Proteins carry out their functions by interacting with other proteins and small molecules, forming a complex interaction network. In this review, we briefly introduce classical graph theory based protein-protein interaction networks. We also describe the commonly used experimental methods to construct these networks, and the insights that can be gained from these networks. We then discuss the recent transition from graph theory based networks to structure based protein-protein interaction networks and the advantages of the latter over the former, using two networks as examples. We further discuss the usefulness of structure based protein-protein interaction networks for drug discovery, with a special emphasis on drug repositioning.

关键词： protein-protein interaction network structure-based drug design drug reposition

A new way to construct topological invariants of non-Hermitian systems with the non-Hermitian skin effect

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Chinese Physics B 2020年第1期29卷 119-123页

作者： j S Liu Y Z Han C S Liu Hebei Key Laboratory of Microstructural Material Physics School of ScienceYanshan UniversityQinhuangdao 066004China

The non-Hermitian skin effect breaks the conventional bulk–boundary correspondence and leads to non-Bloch topological *** by the fact that the topological protected zero modes are immune to perturbations,we construct a partner of a non-Hermitian system by getting rid of the non-Hermitian skin *** adjusting the imbalance hopping,we find that the existence of zero-energy boundary states still dictate the bulk topological invariants based on the band-theory *** non-Hermitian Su–Schrieffer–Heeger(SSH)models are used to illuminate the ***,we obtain the winding numbers in analytical form without the introduction of the generalized Brillouin *** work gives an alternative method to calculate the topological invariants of non-Hermitian systems.

关键词： non-Hermitian skin effect Su–Schrieffer–Heeger(SSH)model bulk–boundary correspondence topological invariant

Cystic fibrosis associated liver disease in children

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World journal of Hepatology 2021年第11期13卷 1727-1742页

作者： joseph j Valamparampil Girish L Gupte Liver Unit Birmingham Children’s HospitalBirmingham B46NHUnited Kingdom

Cystic fibrosis(CF)is an autosomal recessive disorder caused by mutations in the CF transmembrane conductance regulator *** liver disease develops in 5%-10%of patients with CF and is the third leading cause of death among patients with CF after pulmonary disease or lung transplant *** review the pathogenesis,clinical presentations,complications,diagnostic evaluation,effect of medical therapies especially CF transmembrane conductance regulator modulators and liver transplantation in CF associated liver disease.

关键词： Cystic fibrosis liver disease Portal hypertension Cirrhosis Liver transplantation Cystic fibrosis transmembrane conductance regulator modulators Distal intestinal obstructive syndrome

Cuticular hydrocarbon profiles differ between ant body parts:implications for communication and our understanding of CHC diffusion

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Current Zoology 2021年第5期67卷 531-540页

作者： Philipp P.SPRENGER Lisa j.GERBES jacqueline SAHM Florian MENZEL Institute of Organismic and Molecular Evolution(iomE) Johannes Gutenberg-University MainzHanns-Dieter Husch-Weg 15Mainz55128Germany Department of Evolutionary Animal Ecology University of BayreuthUniversitatsstraße 30Bayreuth95477Germany Senckenberg Research Institute Senckenberganlage 2560325 Frankfurt am MainGermany

Insect cuticular hydrocarbons(CHCs)serve as communication signals and protect against *** form complex blends of up to 150 different *** to differences in molecular packing,CHC classes differ in melting *** is especially important in social insects like ants,which use CHCs to communicate within the colony and to recognize *** recognition models often assume a homogenous colony odor,where CHCs are collected,mixed,and redistributed in the postpharyngeal gland(PPG).Via diffusion,recognition cues should evenly spread over the body ***,CHC composition should be similar across body parts and in the *** test this,we compared CHC composition among whole-body extracts,PPG,legs,thorax,and gaster,across 17 ant species from 3 *** CHC composition differed between body parts,with consistent patterns across species and CHC ***-melting CHC classes were most abundant in the *** contrast,whole body,gaster,thorax,and legs had increasing proportions of CHC classes with higher melting *** CHC variation was highest for rather solid,late-melting CHC classes,suggesting that CHCs differ in their diffusion rates across the body *** results show that body parts strongly differ in CHC composition,either being rich in rather solid,late-melting,or rather liquid,early-melting *** implies that recognition cues are not homogenously present across the insect ***,the unequal diffusion of different CHCs represents a biophysical mechanism that enables caste differences despite continuous CHC exchange among colony members.

关键词： nestmate recognition Formicidae eusocial insects melting temperature cuticle regionalization pheromones

EDGE LOCALIZATION BY MULTIPLE OF GAUSSIANs THEORY

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journal of Electronics(China) 1995年第4期12卷 367-373页

作者：高峰 Lucas j. van Vliet Xi'an Institute of Optics & Precision Mechanics Academia Sinica Xi'an 710068 Faculty of Applied Physics Delft University of Technology 2600 GA Delft The Netherlans

Zero-crossing of a derivative of Gaussian filter is a well-known edge location criterion. Examples are the Laplacian, the second derivative in the gradient direction (SDGD) and the sum of the Laplacian and SDGD (PLUS). Derivative operators can easily be implemented by convoluting the primitive image with a derivative of a Gaussian. Gaussian filter displaces the equipotential of half height inwards for convex edge and outwards for concave edges. A Difference-of-Gaussian (DoG) filter is similar to the Laplacian-of-Gaussian but with opposite sign and causes a convex edge shift inwards. This paper introduces the Multiple-of-Gaussian niters to reduce curvature-based location error. Using a linear combination of N Gaussians(N>2) with proper weights, the edge shifts can be reduced to 1/(2N-3) of the ones produced by a similar Laplacian-of-Gaussian filter.

关键词： Edge location Multiple-of-Gaussians Pseudo-second-derivative filter Zero-crossing