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复发-缓解型多发性硬化症患者持续16个月受益于大剂量、高频率干扰素β-1a治疗:EVI-dENCE试验的最终比较结果

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世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 24-24页

作者： Panitch H. goodin d Francis G. 李一明 University of Vermont College of Medicine Neurology Health Care Service 1 South Prospect Street Burlington VT 05401 United States

The EVIdENCE trial demonstrated that interferon (IFN)beta-1a, 44 mcg subcutaneously (sc) three times weekly (tiw) (Rebif), was significantly more effective than IFN beta-1a, 30 mcg intramuscularly (im) once weekly (qw) (Avonex), in reducing relapses and magnetic resonance imaging (MRI)activity in patients with relapsing-remitting multiple sclerosis at both 24 and 48 weeks of therapy. We now present final comparative data on these patients, showing that the superior efficacy of IFN beta-1a, 44 mcg sc tiw, for relapse measures and MRI activity, compared with IFN beta-1a, 30 mcg im qw, was sustained for at least 16 months. The development of antibodies to IFN was associated with reduced efficacy on MRI measures and fewer IFN-related adverse events, but did not have an impact on relapse outcomes.

关键词：多发性硬化症 EVI-dENCE试验复发次数肌肉注射数据显示周和

dECOMPOSITION BASEd IMAGING WITH FIBER ANd CCd CAMERA dETECTIONS

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Journal of Innovative Optical Health Sciences 2008年第1期1卷 115-124页

作者： S.d.CAMPBELL I.L.goodin S.d.GROBE Q.SU R.GROBE Intense Laser Physics Theory Unit and department of Physics Illinois State University Normal IL 61790-4560 USA

We generalize a previously proposed imaging scheme to situations for which the set of hidden objects embedded in the highly scattering medium can take arbitrary *** compare the accuracy of images obtained from optical detection fibers with those from a ccd *** latter approach is more efficient and can be applied to non-contact geometries,but it requires an a priori linearization of the obtained digitized *** discuss some details of this calibration for the camera and establish its potential as a new tool for decomposition based imaging.

关键词： scattering details fibers

非裔美国人多发性硬化症患者干扰素β-1a的疗效

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世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 7-7页

作者： Cree B.A.C. Al-Sabbagh A. Bennett R. goodin d. 樊慧婷 Multiple Sclerosis Center University of California San Francisco 350 Parnassus Ave San Francisco CA 94117 United States

Background: African Americans (AAs) with multiple sclerosis (MS) seem to have a more severe disease course than white Americans (WAs). To our knowledge, it is not known to what extent treatment with interferon beta-1a will effect the MS disease course within the AA population. Objective: To compare the response to treatment with interferon beta-1a between AA and WA MS patients. design: This is an exploratory post hoc analysis of the Evidence of Interferon dose-Response: European North American Comparative Efficacy (EVIdENCE) study. Setting: The EVId ENCE study is a randomized controlled trial that compared the efficacy of once weekly, intramuscular, 30-μg interferon beta-1a treatment with thrice weekly, subcutaneous, 44-μg interferon beta-1a therapy in treatment-nave MS subjects. Participants: Thirty-six AA subjects were compared with 616 WA subjects. Main Outcome Measures: The number of MS exacerbatio ns, the proportion of exacerbation-free subjects, and the number of new MS lesions present on brain magnetic resonance imaging were compared between AA and WA subjects at 24 and 48 weeks after initiating treatment with interferon beta-1a. Results: The AA subjects experienced more exacerbations and were less likely to remain exacerbation free (statistical trends). The AA subjects developed more new MS lesions on T2-weighted brain magnetic resonance imaging at 48 weeks (P=.04). Conclusions: despite the small sample size, AA subjects appeared less responsive to treatment than WA subj ects on outcome measures, reaching significance only for T2-weighted lesion count at 48 weeks. However, it is difficult to base these differences solely on response to treatment given the potential differing in MS disease course in AA patients.

关键词：多发性硬化症干扰素治疗非裔美国人析因分析病灶数有效剂量随机对照试验肌肉注射样本量周

棉花细胞悬浮培养胚胎发生和植株再生某些特性的研究

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中国农业科学 1987年第5期 6-11+95页

作者：陈志贤,李淑君,N.L.Trolinder,J.R.goodin 山西省农科院棉花研究所山西省农科院棉花研究所美国农业部耕作制度研究室美国德州理工大学生物系

对棉属28个种或品种在4种不同激素组合的培养基上进行的愈伤组织诱导、体细胞胚胎发生的比较研究表明,栽培品种珂字棉312和陆地棉种系(race)T25(***)两个材料具有较高的胚胎发生能力,且易得到再生植株。鲁棉1、2、3、4号,岱字棉16,爱字... 详细信息

对棉属28个种或品种在4种不同激素组合的培养基上进行的愈伤组织诱导、体细胞胚胎发生的比较研究表明,栽培品种珂字棉312和陆地棉种系(race)T25(***)两个材料具有较高的胚胎发生能力,且易得到再生植株。鲁棉1、2、3、4号,岱字棉16,爱字棉Sj-1、2、5以及遗传标准系TM-1等具有一定的体细胞胚胎发生能力,通过继代远件培养可得到少量再生植株。通过液体悬浮培养,有利于胚性细胞团的增殖以及进一步筛选分离。SH培养基对幼胚生根和根、叶平衡生长有利。从外植体到植株再生的培养程序已经建立。

关键词：胚胎发生愈伤组织形成悬浮培养植株再生

经颅多普勒超声的评价美国神经病学学会治疗和技术评价委员会的报告

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国际脑血管病杂志 2005年第11期13卷 801-814页

作者： M.A. Sloan V.A. Alexandrov C.H. Tegeler M.P. Spencer L.R. Caplan E. Feldmann L.R. Wechsler d.W. Newell C.R. Gomez V.L. Babikian d. Lefkowitz R.S. Goldman C. Armon C.Y. Hsu d.S. goodin 毛成洁程言博刘春风 From Rush University Medical Center Chicago IL University of Texas Houston Medical Center School of Medicine Wake Forest University Winston-Salem NC Institute of Applied Physiology and Medicine Seattle WA Beth Israel deaconess Medical Center Boston MA School of Medicine Brown University Providence RI University of Pittsburgh Medical Center PA University of Washington Seattle Alabama Neurological Institute Birmingham Boston University School of Medicine MA Aurora Medical Group Milwaukee WI Baystate Medical Center Springfield MA Washington University School of Medicine St. Louis MO University of California at San Francisco 苏州大学附属第二医院神经内科

目的:回顾经颅多普勒(TCd)和经颅彩色编码超声(TCCS)在诊断方面的应用。方法:作者检索了以下文献证据:(1)在特殊临床情况下TCd能否提供有用的信息;(2)应用这一信息能否改进临床决策,后者通过患者转归的改善反映出来;(3)在这些临床情况下... 详细信息

目的:回顾经颅多普勒(TCd)和经颅彩色编码超声(TCCS)在诊断方面的应用。方法:作者检索了以下文献证据:(1)在特殊临床情况下TCd能否提供有用的信息;(2)应用这一信息能否改进临床决策,后者通过患者转归的改善反映出来;(3)在这些临床情况下TCd是否优于其他诊断性检查。结果:在筛查2～16岁镰状细胞病患儿的卒中风险(A级推荐,Ⅰ级证据)以及检测和监测自发性蛛网膜下腔出血后的血管痉挛方面(A级推荐,Ⅰ～Ⅱ级证据),TCd具有确定的价值。在检测颅内血管狭窄闭塞性疾病(B级推荐,Ⅱ～Ⅲ级证据)、血管舒缩反应性试验(B级推荐,Ⅱ～Ⅲ级证据)、检测脑循环停止/脑死亡(A级推荐,Ⅱ级证据)、监测颈动脉内膜切除术(B级推荐,Ⅱ～Ⅲ级证据)、监测溶栓治疗(B级推荐,Ⅱ～Ⅲ级证据)和监测冠状动脉旁路移植术(B～C级推荐,Ⅱ～Ⅲ级证据)方面,TCd和TCCS可提供重要的信息并可能有价值。对于心内/心外右向左分流(A级推荐,Ⅱ级证据)、颅内血管闭塞性疾病(B级推荐,Ⅱ～Ⅳ级证据)和出血性脑血管病(B级推荐,Ⅱ～Ⅳ级证据),尽管其他技术可能更优越,但对比增强TCd/TCCS也能提供有用的信息。

关键词：经颅多普勒脑血管造影脑血管疾病镰状细胞贫血

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陆地棉细胞悬浮培养体的体细胞胚胎发生

棉花科学 1987年第2期 41-41页

作者： Trolinder N.L. ,J.R.goodin ,奚元龄江苏省农业科学院

1983年10月从3日龄陆地棉(Gossypiumhirsutum)栽培品种C312,RQSX-1-1,C3110,P784,1303,T25和T169幼苗下胚轴产生的6～8周愈伤组织发现含有球状到心形早期胚,以与陆地棉胚珠的胚显微镜观察比较为准。愈伤组织放入液体培养基,其中T25和C3... 详细信息

1983年10月从3日龄陆地棉(Gossypiumhirsutum)栽培品种C312,RQSX-1-1,C3110,P784,1303,T25和T169幼苗下胚轴产生的6～8周愈伤组织发现含有球状到心形早期胚,以与陆地棉胚珠的胚显微镜观察比较为准。愈伤组织放入液体培养基,其中T25和C3112形成胚胎发生的细胞悬浮体。C312选择为胚发育成成熟植株的典型体系。愈伤组织是从MS 盐类附加100mg/l 肌醇,10mg/l 盐酸硫胺素,1mg/l 菸酸,1mg/l 吡哆醇,30g/l 蔗糖,0.1mg/l 2,4-d 和0.1mg/l 激动素,或0.5mg/l 激动素。装有50ml液体培养基的欧氏三角瓶,接种约0.5g 愈伤组织,旋转振荡120rpm°,培养体经纱布过滤保持,取部分残留物培养在基础培养基上。含有单细胞和小细胞团(10～20细胞)的滤过物,转移到装有基础培养基的瓶内,基础培养基不加荷尔蒙,加谷酰胺,供发育

关键词：陆地棉高原棉愈伤组织创伤组织基础培养基细胞

Gammasphere上裂变丰中子核核结构若干前沿领域的新进展(Ⅱ:第三和第四部分)(英文)

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原子核物理评论 2010年第3期27卷 363-389页

作者：罗亦孝 J.H.Hamilton J.O.Rasmussen A.V.Ramayya C.goodin A.V.daniel N.J.Stone 朱胜江 J.K.Hwang 刘少华 C.J.Beyer 李科 H.L.Crowell d.Al mehed S.Frauendorf A.Covello V.di mitrov 张敬业车兴来姜卓 d.Fong A.Gelberg I.Stefanescu A.Gargano E.F.Jones P.M.Gore I.Y.Lee G.M.Ter-Akopian Yu.Ts.Oganessian M.A.Stoyer R.donangelo 马文超 J.d.Cole J.Kormicki 张学谦 S.C.Wu J.Gilat T.N.Ginter S.J.Asztalos Physics department Vanderbilt University Nashville TN 37235 USA Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Flerov Laboratory for Nuclear Reactions JINR Dubna Russia Joint Institute for Heavy Ion Research Oak Ridge TN 37831 USA department of Physics Oxford University Oxford OX1 3PU United Kingdom department of Physics and Astronomy University of Tennessee Knoxville Tennessee 37996 USA Physics department Tsinghua University Beijing 100084 China department of Physics University of Notre Dame Notre Dame IN 46556 USA Institut far Strahlenphysik FZD-Rossendorf Postfach 510119 D-01314 Dresden Germany dipartimento di Scienze Fisiche Universita di Napoli Federico II and Istituto Nazionale di Fisica Nuclear Complesso Universitario di Monte S. Angelo Via Cintia 80126 Napoli Italy Idaho Accelerator Center Idaho State University Pocatello ID-83209-8263 USA Institut fur Kernphysik Universitat zu Koln 50937 Kdln Germany department of Chemistry and Biochemistry University of Maryland MD 20742 USA Lawrence Livermore National Laboratory Livermore CA 94550 USA Instituto de Fisica Facultad de Ingenieria C. C. 30 11300 Montevideo Uruguay Mississippi State University Drawer 5167 Mississippi State MS 39762 USA Idaho National Laboratory Bldg. IRCPL MS2114 Idaho Falls ID 83415 USA department of Physics National Tsing Hua University Hsinchu Taiwan 30013 China National Superconducting Cyclotron Laboratory Michigan State University East Lansing Michigan 48824 USA Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA

使用Gammasphere多探测器系统对252Cf裂变源瞬发γ射线进行γ-γ-γ和γ-γ(θ)符合测量,A～100(Z～40,N>56)丰中子核区关于形状过渡、形状共存和形状突变的深入研究获得了新的进展。奇-Z核的系统研究揭示了从Z=39(Y)同位素的轴对称大... 详细信息

使用Gammasphere多探测器系统对252Cf裂变源瞬发γ射线进行γ-γ-γ和γ-γ(θ)符合测量,A～100(Z～40,N>56)丰中子核区关于形状过渡、形状共存和形状突变的深入研究获得了新的进展。奇-Z核的系统研究揭示了从Z=39(Y)同位素的轴对称大四极形变到Z=43(Tc),44(Ru)和45(Rh)同位素中具有中等四极形变之大三轴形变的过渡。Nb(Z=41)同位素具有过渡核的特征。根据邻近同位素和同中素带交叉信息的系统性及推转壳模型(CSM)计算,Tc和Rh偶-N同位素中观察到的带交叉产生于一对h11/2中子的转动顺排。首次观察到100Nb(Z=41,N=59)的高自旋能级纲图和形变态,从而证实了100Nb中的形状共存,并确认,在Nb同位素链上,基态形状突变发生于N=58(球形)到N=59(大形变);而在Sr(Z=38),Y(Z=39)和Zr(Z=40)各同位素链上,基态形状突变均发生于N=59(球形)到N=60(大形变)。100Nb具有大形变基态,同现有理论预言相矛盾,其大形变的基态及转动带所具有的很大的和不规则的转动惯量具有重要的理论意义。对奇-质子Cs(Z=55)和La(Z=57)丰中子同位素八极激发的详细研究,发现了141,143,144Cs同位素链上电二极矩d0随中子数增加而减小的急剧变化,此前在145,147La中观察到的电二极矩d0的较缓和的减小似乎亦很陡地下延至148La。在Cs和La同位素中观察到的电二极矩d0的急剧下降很可能同偶-质子核146Ba和224Ra中观察到的电二极矩d0的急剧下降相类似,后者已获反射非对称平均场壳修正理论的成功解释。实验证明,141Cs具有很大电二极矩d0。141Cs和142Xe中观测到的很大的电二极矩d0和仅在141Cs中观察到的电二极矩d0的simplex量子数相关性需要进一步的理论研究。根据转动频率比值ω-(I)/ω+(I)的检定,同Xe同位素一样,认定Cs同位素中包括号143Cs的八极激发为八极振动,而在La同位素中存在八极形变。

关键词：形状过渡轴对称形状三轴形变形状突变带交叉奇-质子八极激发 B(E1)/B(E2)比值电二极矩d0 二极矩的下降八极振动 Cs,La同位素