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Short and long term corneal biomechanical analysis after overnight orthokeratology

International Journal of Ophthalmology(English edition) 2022年第7期15卷 1128-1134页

作者： Amelia Nieto-Bona Paloma Porras-Ángel Adela Elena Ayllón-Gordillo gonzalo carracedo David P Piñero Department of Optometry&Vision Optics and Optometry FacultyComplutense University of MadridMadrid 28037Spain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicante 03690Spain

AIM: To investigate the short and long term corneal biomechanical changes after overnight orthokeratology(OK) and compare them with those occurring in subjects not wearing contact ***: Retrospective case control study enrolling 54 subjects that were divided into three groups 18 subjects each: control group(CG), short term(15 nights) OK(STOK) group, and long term(more than 1 y of OK wear) OK(LTOK) group. Corneal biomechanics were characterized using the Cor Vis? ST system(Oculus), recording parameters such as time [first/second applanation time(AT1, AT2)], speed [velocity of corneal apex at the first/second applanation time(AV1, AV2)], and amplitude of deformation(AD1, AD2) in the first and second corneal flattening, corneal stiffness(SPA1), biomechanically corrected intraocular pressure(b IOP) and corneal(CBI) and tomographic biomechanical indices(TBI).RESULTS: Significantly lower AD1 and standard deviate on of Ambrosio’s relational average thickness related to the horizontal profile(ARTh) values were found in the OK groups compared to CG(P<0.05). Likewise, significantly higher values of CBI were found in STOK and LTOK groups compared to CG(P<0.01). No significant differences between groups were found in integrated radius index(P=0.24), strain stress index(P=0.22), tomographic biomechanical index(P=0.91) and corneal stif fness parameter(SPA1, P=0.97). Significant inverse correlations were found between corneal thickness and CBI in STOK(r=-0.90, P<0.01) and LTOK groups(r=-0.71, P<0.01).CONCLUSION: OK does not seem to alter significantly the corneal biomechanical properties, but special care should be taken when analyzing biomechanical parameters influenced by corneal thickness such as amplitude of deformation, ARTh or CBI, because they change significantly after treatment but mainly due to the reduction and pachymetric progression induced by the corneal molding secondary to OK treatment.

关键词： overnight orthokeratology corneal biomechanics pachymetry corneal biomechanical index CorVis?ST tomographic biomechanical index

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Dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： gonzalo Flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea Judith Vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

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EVOLUTION FILTRATION PROBLEMS WITH SEAWATER INTRUSION: TWO-PHASE FLOW DUAL MIXED VARIATIONAL ANALYSIS

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Acta Mathematica Scientia 2015年第5期35卷 1142-1162页

作者： gonzalo ALDUNCIN Instituto de Geofísica Universidad Nacional Autónoma de México

Tow-phase flow mixed variational formulations of evolution filtration problems with seawater intrusion are analyzed. A dual mixed fractional flow velocity-pressure model is considered with an air-fresh water and a fresh water-seawater characterization. For analysis and computational purposes, spatial decompositions based on nonoverlapping multidomains, above and below the sea level, are variationally introduced with internal boundary fluxes dualized as weak transmission constraints. Further, parallel augmented and exactly penalized duality algorithms, and proximation semi-implicit time marching schemes, are established and analyzed.

关键词： two-phase flow in coastal aquifers fractional two-phase flow dual mixed variational analysis macro-hybrid variational formulations augmented exactly penalized duality algorithms proximation semi-implicit time marching schemes

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Curcuma longa L. extract improves the cortical neural connectivity during the aging process

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Neural Regeneration Research 2017年第6期12卷 875-880页

作者： gonzalo Flores Laboratorio de Neuropsiquiatría Instituto de Fisiología Benemérita Universidad Autónoma de Puebla

Turmeric or Curcuma is a natural product that has anti-inflammatory, antioxidant and anti-apoptotic pharmacological properties. It can be used in the control of the aging process that involves oxidative stress, inflammation, and apoptosis. Aging is a physiological process that affects higher cortical and cognitive functions with a reduction in learning and memory, limited judgment and deficits in emotional control and social behavior. Moreover, aging is a major risk factor for the appearance of several disorders such as cerebrovascular disease, diabetes mellitus, and hypertension. At the brain level, the aging process alters the synaptic intercommunication by a reduction in the dendritic arbor as well as the number of the dendritic spine in the pyramidal neurons of the prefrontal cortex, hippocampus and basolateral amygdala, consequently reducing the size of these regions. The present review discusses the synaptic changes caused by the aging process and the neuroprotective role the Curcuma has through its anti-inflammatory, antioxidant and anti-apoptotic actions.

关键词： Curcuma longa cortical curcumin hippocampus synaptic antioxidant spine connectivity cortex

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Tree diametric-species diversity is affected by human impact in old Scots pine dominated forest in boreal Fennoscandia

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Forest Ecosystems 2020年第1期7卷 92-103页

作者： gonzalo de Quesada Timo Kuuluvainen Department of Forest Ecology University of HelsinkiP.O.Box 24FIN-00014 HelsinkiFinland

Background:Forest structural and compositional variability is of fundamental importance for forest ecosystem functioning and species *** purpose of this research was to examine how human impact has affected the compositional-structural diversity of mature pine-dominated boreal forest in boreal *** this a new approach was used,based on the classification of tree sizes by the diameter at breast height(dbh)and tree species,resulting in a new variable,the diametric-species,the variation of which describes the compositional-structural diversity of the *** variable was used to compare the structural-compositional diversity among three forest classes with different degree of human influence,using rarefaction as the main tool of analysis,complemented by analyses based on common diversity ***:The results showed that the near-natural forest was the most diverse and the managed forest the least *** the other hand,the diversity of near-natural and selectively logged forests were similar,suggesting that selectively logged forests are equal to the natural forest in their compositional-structural *** analysis solely on tree species showed no significant differences among the forest classes of different human *** Shannon diversity index showed no significant difference between the forest classes for the diametric-species and tree species classifications only,but the Simpson index signaled a slight difference between the selectively logged and managed forest classes for the diametric-species ***,the Sorensen index detected a difference among forest classes in the diametric-species ***:Forest utilization had an adverse impact on forest compositional-structural diversity of mature Scots pine *** analysis also shows that the novel approach based on diametric-species classification could be a useful tool for forest diversity analysis and comparison,especially in speci

关键词： Diametric-species Boreal forest diversity Rarefaction analysis Human intervention Compositional-structural diversity

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EFFECTIVE NETWORKS FOR REAL-TIME DISTRIBUTED PROCESSING

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Journal of Systems Science & Complexity 2011年第1期24卷 39-50页

作者： gonzalo TRAVIESO Luciando da Fontoura COSTA Instituto de Fisica de Sao Carlos Universidade de Sao Paulo Av. do Trabalhador SSo-Carlensc 400 13566 - 590 Sao Carlos SP Brazil.

This paper applies the concepts and methods of complex networks to the development of models and simulations of master-slave distributed real-time systems by introducing an upper bound in the allowable delivery time of the packets with computation results. Two representative intercom nection models are taken into account： Uniformly random and scale free （Barabasi-Albert）, including the presence of background traffic of packets. The obtained results include the identification of the uniformly random interconnectivity scheme as being largely more efficient than the scale-free counterpart. Also, increased latency tolerance of the application provides no help under congestion.

关键词： Complex networks distributed computing real-time.

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Molecular complexity of visual mapping: a challenge for regenerating therapy

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Neural Regeneration Research 2020年第3期15卷 382-389页

作者： Mara Medori gonzalo Spelzini Gabriel Scicolone CONICET–Universidad de Buenos Aires Instituto de Biología Celular y Neurociencias“Prof.E.De Robertis”(IBCN)Ciudad Autónoma de Buenos AiresArgentina Universidad de Buenos Aires Facultad de MedicinaDepartamento de Biología CelularHistologíaEmbriología y GenéticaCiudad Autónoma de Buenos AiresArgentina

Investigating the cellular and molecular mechanisms involved in the development of topographically ordered connections in the central nervous system constitutes an important issue in neurobiology because these connections are the base of the central nervous system normal *** dominant model to study the development of topographic maps is the projection from the retinal ganglion cells to the optic tectum/*** expression pattern of Eph/ephrin system in opposing gradients both in the retina and the tectum,labels the local addresses on the target and gives specific sensitivities to growth cones according to their topographic origin in the *** rigid precision of normal retinotopic mapping has prompted the chemoaffinity hypothesis,positing axonal targeting to be based on fixed biochemical affinities between fibers and ***,several lines of evidence have shown that the mapping can adjust to experimentally modified targets with flexibility,demonstrating the robustness of the guidance *** we discuss the complex ways the Ephs and ephrins interact allowing to understand how the retinotectal mapping is a precise but also a flexible process.

关键词： axon growth axon guidance development Eph and ephrin mapping regeneration retinal ganglion cells retino-tectal system

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Risk factors for suicidal behaviour in late-life depression:A systematic review

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World Journal of Psychiatry 2022年第1期12卷 187-203页

作者： Veronica Fernandez-Rodrigues Yolanda Sanchez-Carro Luisa Natalia Lagunas Laura Alejandra Rico-Uribe Andres Pemau Patricia Diaz-carracedo Marina Diaz-Marsa gonzalo Hervas Alejandro de la Torre-Luque Department of Psychology Universidad Complutense de MadridMadrid 28223Spain Department of Psychiatry Universidad Autonoma de MadridMadrid 28046Spain Centre for Biomedical Research in Mental Health(CIBERSAM) Madrid 28029Spain Department of Legal Medicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28046Spain of Psychology La Rioja International UniversityLogrono 26006Spain Institute of Psychiatry and Mental Health San Carlos Clinical HospitalMadrid 28040Spain

BACKGROUND Suicide is a leading cause of preventable death worldwide,with its peak of maximum incidence in later *** often puts an individual at higher risk for suicidal *** turn,depression deserves particular interest in old age due to its high prevalence and dramatic impact on health and *** To gather integrated evidence on the potential risk factors for suicide behaviour development in depressive older adults,and to examine the effects of depression treatment to tackle suicide behaviour in this *** A systematic review of empirical studies,published from 2000 onwards,was *** behaviour was addressed considering its varying forms(i.e.,wish to die,ideation,attempt,and completed suicide).RESULTS Thirty-five papers were selected for review,comprising both clinical and epidemiological *** of studies focused on suicidal ideation(60%).The studies consistently pointed out that the risk was related to depressive episode severity,psychiatric comorbidity(anxiety or substance use disorders),poorer health status,and loss of *** social support and loneliness were also associated with suicide behaviour in depressive older ***,the intervention studies showed that suicidal behaviour was a robust predictor of depression treatment *** in suicidal ideation were moderated by reductions in risk factors for suicide *** To sum up,common and age-specific risk factors seem to be involved in suicide development in depressive older adults.A major effort should be made to tackle this serious public health concern so as to promote older people to age healthily and well.

关键词： Late-life depression Suicide behaviour Disability Chronic disease Loneliness

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The Maximal Graded Left Quotient Algebra of a Graded Algebra

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Acta Mathematica Sinica,English Series 2006年第1期22卷 261-270页

作者： gonzalo ARANDA PINO Mercedes SILES MOLINA Departamcnto de Algebra Geometriay Topologia Universidad de Mdlaga 29071 Mdlaga Espana

We construct the maximal graded left quotient algebra of every graded algebra A without homogeneous total right zero divisors as the direct limit of graded homomorphisms （of left A-modules） from graded dense left ideals of A into a graded left quotient algebra of A. In the case of a superalgebra, and with some extra hypothesis, we prove that the component in the neutral element of the group of the maximal graded left quotient algebra coincides with the maximal left quotient algebra of the component in the neutral element of the group of the superalgebra.

关键词： graded algebra graded left quotient algebra maximal graded left quotient algebra left quotieat algebra maximal left quotient algebra superalgebra

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Atypical antipsychotics, more than just an antipsychotic

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Neural Regeneration Research 2020年第8期15卷 1477-1478页

作者： Hiram Tendilla-Beltrán gonzalo Flores Laboratorio de Fisiología de la Conducta Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCDMXMexico Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaMexico

Antipsychotics are the prescribed drugs for *** first substance used for antipsychotic purposes appeared in 1952 and it was a general anesthetic:*** use of this drug was mainly because of its effects on violent behavior instead of sedation in patients,which“controls”the psychotic episodes and prevents psychosis *** then,pharmaceutical antipsychotics have been developed,producing second-generation or atypical *** drugs arose with the synthesis of clozapine in the late‘50s,which represented(and still represent)the“guide molecule”for the development of these substances,because of its effectiveness on the symptomatology of the disease.

关键词： prescribed synthesis drugs

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