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Food and Nutrition Sciences 2018年第6期9卷 633-641页

作者： ernesto e. gonzalez Kayanush Aryana School of Nutrition and Food Sciences Louisiana State University Baton Rouge USA

Manufacture of some cheeses involves the use of Lactococcus lactis. During processing bacteria are subjected to environmental stresses such as acid and salt osmotic conditions. Identifying procedures and mechanisms to develop resistance to these environmental stresses, specifically salt, is important to improve the culture’s growth and performance during food manufacture and storage. Hypothesis was whether salt tolerance of Lactococcus lactis R-604 can be enhanced. Objective was to study the influence of prior salt exposure and lactose deprivation on salt tolerance of L. lactis. The culture was subjected to mild stress induced by lactose starvation or prior salt exposure for 24 hours aerobically at 30°C. A control was conducted without any stress. Cells that were prior mild stressed by lactose starvation or prior salt exposure were transferred to M17 broth with 5 concentrations of NaCl (0, 1, 3, 5 and 7% w/v) and incubated aerobically at 30°C. Plating was conducted immediately after inoculation and every 24 hours for 5 days in M17 agar supplemented with 0.5% of lactose and incubated aerobically at 30°C for 48 hours. Three replications were conducted. There was no need for lactose to grow this culture in M17 broth and it could tolerate prior exposure to 3% w/v NaCl in media without affecting its growth at different salt concentrations. Culture that was exposed to lactose starvation and then subsequently grown in 3% w/v NaCl, at day 3 showed enhanced salt tolerance which can be recommended as a pretreatment condition for obtaining daughter cells with improved salt tolerance.

关键词： Cheese Culture Salt Tolerance

evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs

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Asian Pacific Journal of Tropical Medicine 2016年第1期9卷 20-23页

作者： Ana Vargas-Calla Luis A.Gomez-Puerta Juan Calcina Omar Gonzales-Viera Cesar Gavidia Maria T.Lopez-Urbina Hector H.Garcia Armando e.gonzalez School of Veterinary Medicine Universidad Nacional Mayor de San Marcos Cysticercosis elimination Program and Center for Global Heath Tumbes Universidad Peruana Cayetano Heredia Department of Microbiology School of SciencesUniversidad Peruana Cayetano Heredia

Objective:To assess the efficacy of triclabendazole(TCBZ) in porcine ***:eighteen naturally infected cysticercotic pigs were divided into 3 groups of 6 individuals *** first group was treated orally with TCBZ at a single dose of 30 mg/kg of body weight,the second group was treated orally with oxfendazole at a single dose of 30 mg/kg of body weight and the third group received a placebo(control group).All animals were kept under the same management *** pigs were euthanized 17 wk post-treatment and the number of surviving cysts in muscles was assessed and compared between ***:All pigs treated with oxfendazole had only degenerated cysts in their *** contrast,TCBZ had very little effect against the parasitic *** from pigs in the TCBZ group looked apparently normal after ***,histological evaluation showed a mild to moderate degree of ***:TCBZ is not an efficacious drug against Taenia solium cysticercosis in swine using a single dose.

关键词： Taenia solium Cysticercosis Triclabendazole Oxfendazole Treatment

Cardiac ischemic preconditioning prevents dystrophin proteolysis by MMP-2 inhibition

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BIOCeLL 2016年第1期40卷 43-46页

作者： MANUeL RODRIGUeZ BRUNO BUCHHOLZ VeRONICA D'ANNUNZIO MARTÍN DONATO GeRMAN e.gonzalez MARIA AILIN GOYeNeCHe TAMARA MAZO VIRGINIA PeReZ LUCIANA WILeNSKY RICARDO J.GeLPI 不详

Dystrophin is a membrane-associated protein responsible for structural stability of the sarcolem-ma in cardiac myocytes and is very sensitive to ischemic *** goal of our study was to determine if ischemic preconditioning could prevent dystrophin breakdown through inhibition of matrix metalloprotein-ase-2(MMP-2)*** rabbit hearts were subjected to global ischemia with or without reperfusion in order to evaluate if dystrophin is preserved by ischemic preconditioning through MMP-2 *** preconditioning significantly reduced the infarct size induced by 30 min of ischemia and 180 min of ***,it also diminished dystrophin proteolysis and attenuated MMP-2 activity after 30 min ***,our study shows a novel protective role of ischemic preconditioning as a mechanism of preservation of plasma membrane integrity by inhibiting MMP-2 activation.

关键词： ischemia/reperfusion MMPs membrane associated proteins rabbit

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可靠的高温测井技术

国外油气勘探 1996年第6期8卷 785-786页

作者： Manuel(Manny)e.gonzalez 白梅岭四川石油管理局天然气信息所

Los Alamos国家实验室(LANL)已把地热工程的高温井测井技术改型翻新成适用于深气井套管井测井方法(伽马射线、中子和套管接箍)。实验室的实验表明,这种高温井下井仪器能在400°F(204℃)的井底条件下使工作时间延长3倍。在西俄克拉何马州... 详细信息

Los Alamos国家实验室(LANL)已把地热工程的高温井测井技术改型翻新成适用于深气井套管井测井方法(伽马射线、中子和套管接箍)。实验室的实验表明,这种高温井下井仪器能在400°F(204℃)的井底条件下使工作时间延长3倍。在西俄克拉何马州Beckhom县深气井测井作业期间,标准的套管井测井下井仪器在2～4h内就失效了,而高温井下井仪器成功地进行两个连续的6h(12h)测井作业。在此之后。

关键词：高温地层深层气测井技术

efficient removal of the recalcitrant metamizole contaminant from drinking water by using a CaLaCoO_(9) perovskite supported on recycled polyethylene

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Journal of environmental Sciences 2024年第2期136卷 56-67页

作者： ernesto Valadez-Renteria Christian Perez-Carrasco Dulce Yolotzin Medina-Velazquez Vicente Rodriguez-gonzalez Jorge Oliva CONACYT-División de Materiales Avanzados Instituto Potosino de Investigación Científica y Tecnológica A.C.San Luis PotosíSLP 78216México División de Ciencias Básicas e Ingeniería Universidad Autónoma Metropolitana AzcapotzalcoCol.Reynosa-TamaulipasC.P.MéxicoDF 02200México

Metamizole(MZ)is a widely used anti-inflammatory *** to its common use,this contaminant is found in sewage and *** order to reduce the contamination produced by the MZ,we fabricated in this work a photocatalytic composite using recycled polyethylene(RPe)and the CaLaCoO_(9)(LCCO)*** nanoparticles had a microplate-like morphology and sizes of 1.4–5.5μm according to the analysis of *** photocatalytic properties of the LCCO powders were evaluated under ultraviolet-visible(UV-Vis)irradiation and found a removal efficiency of 96%.When the RPe+LCCO composite was employed for the photocatalytic degradation of MZ,a maximum degradation of 92.5%was *** influence of the pH on the photocatalytic activity was also studied and found that an initial pH=3 produced a total degradation of MZ after 240 min of UV-Vis ***,three reuse cycles were carried out for the pure LCCO powders and for the RPe+LCCO composites and found that the maximum loss of degradation was 5%.Furthermore,scavenger experiments demonstrated that the super oxide and hydroxyl radicals are formed during the photocatalytic reaction and were responsible for the degradation of ***,the X-ray photoelectron-spectroscopy and Raman analysis demonstrated the formation of defects(oxygen vacancies),those ones delayed the electron-hole recombination,which in turn,enhanced the degradation of the ***,the studies performed in this work proved that composites made with recycled plastics and LCCO perovskites are a low-cost and feasible alternative for the cleaning of water sources polluted with pharmaceutical compounds.

关键词： Photocatalysis Metamizole Pharmaceutical contaminant UV-Vis irradiation Perovskite

Laser-induced plasma formation in water with up to 400 mJ double-pulse LIBS

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Plasma Science and Technology 2024年第1期26卷 93-100页

作者： Marion HeNKeL Michelle SIeMeNS Ralf MeTHLING Benjamin eMDe Jörg HeRMSDORF Steffen FRANKe Diego gonzalez Leibniz Institute for Plasma Science and Technology(INP) Felix-Hausdorff-Straße 2Greifswald 17489Germany Laser Zentrum Hannover e.V.(LZH) Hollerithallee 8Hannover 30419Germany

Double-pulse LIBS is a promising technique for deep-sea *** measurements in shallow water with up to 400 mJ each pulse were done to select laser parameters which promote optimized spectral line emission from plasma even at elevated pressures,where line broadening until loss of most of the spectral information can *** emission spectroscopy,using a Czerny-Turner spectrometer,has been applied to investigate the dependence of the emitted radiation on laser parameters and hydrostatic *** has been found,that higher laser pulse energies,especially with short pulse delay as required in high water pressure,can also have an adverse effect on the measured spectrum.

关键词： double-pulse LIBS underwater plasma formation emission spectrosocpy

Temporal stability and directional change in a color cline of a marine snail from NW Spain

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Current Zoology 2024年第2期70卷 163-173页

作者： Juan Gefaell Ramon Vigo A.Honorato gonzalez-Vazquez Juan Galindo emilio Rolan-Alvarez Centro de Investigacion Marina Universidade de VigoDepartamento de BioquimicaGenetica e Inmunologia36310 VigoSpain

The evolution and maintenance of color clines is a classic topic of research in evolutionary ***,studies analyzing the temporal dynamics of such clines are much less frequent,due to the difficulty of obtaining reliable data about past color distributions along environmen-tal *** this article,we describe a case of decades-long temporal stability and directional change in a color cline of the marine snail Littorina saxatilis along the coastal inlet of the Ria de Vigo(NW Spain).*** from this area shows a clear color cline with 3 distinct areas from the innermost to the more wave-exposed localities of the Ria:the inner,protected localities show an abundance of fawn-like individuals;the intermediate localities show a high diversity of colors;and the outer,wave-exposed localities show populations with a high frequency of a black and lineated *** compare data from the 1970s and 2022 in the same localities,showing that the cline has kept relatively stable for at least over half a century,except for some directional change and local variability in the frequency of certain *** regression analyses and biodiversity measures are presented to provide clues into the selective pressures that might be involved in the maintenance of this color *** research avenues to properly test the explanatory power of these selective agents as well as the possible origins of the cline are discussed.

关键词： clinal variation color polymorphism ecological gradient Littorina saxatilis natural selection wave exposure.

Dietary xylo‑oligosaccharides and arabinoxylans improved growth efficiency by reducing gut epithelial cell turnover in broiler chickens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1325-1335页

作者： Carla Castro Shahram Niknafs Gemma gonzalez‑Ortiz Xinle Tan Michael R.Bedford eugeni Roura Centre for Nutrition and Food Sciences Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia AB Vista MarlboroughWiltshire SN84ANUK

Background One of the main roles of the intestinal mucosa is to protect against environmental ***-mentation of xylo-oligosaccharides(XOS)is known to selectively stimulate the growth of beneficial intestinal bacteria and improve gut health and function in *** may have an impact on the integrity of the intestinal epithelia where cell turnover is critical to maintain the compatibility between the digestive and barrier *** aim of the study was to evaluate the effect of XOS and an arabinoxylan-rich fraction(AXRF)supplementation on gut func-tion and epithelial integrity in broiler *** A total of 128 broiler chickens(Ross 308)were assigned into one of two different dietary treatments for a period of 42 d:1)control diet consisting of a corn/soybean meal-based diet;or 2)a control diet supplemented with 0.5%XOS and 1%*** treatment was randomly distributed across 8 pens(n=8)with 8 chickens *** intake and body weight were recorded *** d 42,one male chicken per pen was selected based on aver-age weight and euthanized,jejunum samples were collected for proteomics *** Dietary XOS/AXRF supplementation improved feed efficiency(Ped to the con-trol *** analysis was used to understand the mechanism of improved efficiency uncovering 346 dif-ferentially abundant proteins(DAP)(Padjemented chickens compared to the non-supplemented *** the jejunum,the DAP translated into decreased ATP production indicating lower energy expenditure by the tissue(e.g.,inhibition of glycolysis and tricarboxylic acid cycle pathways).In addition,DAP were associated with decreased epithelial cell differentiation,and migration by reducing the actin polymerization ***-ting the two main pathways together,XOS/AXRF supplementation may decrease around 19%the energy required for the maintenance of the gastrointestinal *** Dietary XOS/AXRF supplementation improved gr

关键词： Actin Arabinoxylans Broiler Cell turnover energy metabolism Jejunum Xylo-oligosaccharides

Blueberry extract Reduces Oxidative Stress in Patients with Metabolic Syndrome

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Journal of Life Sciences 2016年第3期10卷 145-152页

作者： Raul Francisco Pastor gonzalez e Cassini M. S. Pastor I Saure M Saavedra e. Siman Menem M. I. Drago S Iermoli R. H InternalMedicineIVChair HospitaldeClinicas"JosddeSanMartin"UniversityofBuenosAiresBuenosAiresArgentina CentrodeDiagn6sticoMolecularS.A.(MolecularDiagnosisCenter) BuenosAiresArgentina CeSAN(Centrodeendocrinologia SaludAlimentaci6nyNutricidn)CenterforEndocrinologyHealthEatingandNutritionBuenosAiresArgentina

Oxidative stress is a health condition that could potentially harm the patient, and it is defined as the lack of balance between the production of oxygen free radicals, which rises, and antioxidant defenses, which are in decrease. Metabolic syndrome implies a variety of risk factors that are based on abdominal obesity and insulin resistance. Moreover, the importance of metabolic syndrome is emphasized due to the fact that it presents an increase in oxidative stress, which is produced by the sum of alterations that each risk factor produces within the metabolic syndrome pathology. Reducing oxidative stress in these patients is currently one of the most interesting challenges of cardiovascular and metabolic therapeutics, because it is a molecular biology alteration that is not generally diagnosed and, therefore, not treated. The increasing incidence of overweight and obesity cause an increase in the incidence of metabolic syndrome, thus turning into a huge problem that keeps growing at alarming proportions. This syndrome＇s incidence oscillates between 20 and 40%, depending on the gender, age, ethnic group, and diagnostic criteria used for the definition of the disease. Prospective studies show that metabolic syndrome doubles the risk of cardiovascular disease and causes a five-fold increase in the risk of developing type 2 diabetes. With the aim of decreasing the oxidative stress caused by metabolic syndrome, we investigated the effect of antioxidant protection in DNA repair and cell membranes through the use of blueberry extract, which is the fruit with the highest antioxidant capacity, in patients with metabolic syndrome. Thirty patients were studied for a period of 6 months of intervention, and it could be demonstrated that they showed a highly significant decrease in the damage produced to the DNA, which was measured by the urinary excretion of 8-hydroxy-2＇-deoxyguanosine （8-OHdG） and the damage caused to the vascular endothelium and cell membranes, which was meas

关键词： Metabolic syndrome urinary biomarkers of oxidative stress blueberries antioxidants.

Lack of evidence for germline WWP1 pathogenic variants in gastrointestinal polyposis and other phenotypes suggestive of PTeN-hamartoma-tumor syndrome

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Genes & Diseases 2024年第2期11卷 524-527页

作者： Noemi gonzalez-Abuin Tirso Pons Teresa Fuster Isabel Quintana Mariona Terradas Gemma Aiza Joan Brunet Gabriel Capellá Heather Hampel Laura Valle Hereditary Cancer Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain Department of Immunology and Oncology National Center for BiotechnologySpanish National Research Council (CNB-CSIC)Madrid 28049Spain Centro de Investigación Biomédica en Red de Cáncer (CIBeRONC) Madrid 28029Spain Catalan Institute of Oncology IDIBGiGirona 17007Spain Division of Clinical Cancer Genomics Department of Medical Oncology & Therapeutic ResearchCity of Hope National Cancer CenterDuarteCA 91010USA

Germline activating variants in WWP1,which encodes an e3 ubiquitin ligase that antagonizes PTeN tumor suppressive function,have been proposed as an alternative mechanism of PTeN inactivation in PTeN-hamartoma-tumor syndrome(PHTS)-like patients with wildtype PTeN.1 More specifically,heterozygous,potentially activating wwP1 variants were first identified by Lee et al in patients affected with gastrointestinal oligopolyposis,including adenomatous,hyperplastic/serrated,and hamartomatous polyps,and occasionally with colorectal cancer(Table 1).Subsequently,based on the PHTS phenotypic features,wWP1 mutational screening was performed in patients with thyroid nodules,2 or normocephalic autism spectrum disorder(ASD),3 where germline WWP1 variants were also identified(Table S1).

关键词： WWP1 gastrointestinal polyposis