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Food and Nutrition Sciences 2018年第6期9卷 633-641页

作者： ernesto e. gonzalez Kayanush Aryana School of Nutrition and Food Sciences Louisiana State University Baton Rouge USA

Manufacture of some cheeses involves the use of Lactococcus lactis. During processing bacteria are subjected to environmental stresses such as acid and salt osmotic conditions. Identifying procedures and mechanisms to develop resistance to these environmental stresses, specifically salt, is important to improve the culture’s growth and performance during food manufacture and storage. Hypothesis was whether salt tolerance of Lactococcus lactis R-604 can be enhanced. Objective was to study the influence of prior salt exposure and lactose deprivation on salt tolerance of L. lactis. The culture was subjected to mild stress induced by lactose starvation or prior salt exposure for 24 hours aerobically at 30°C. A control was conducted without any stress. Cells that were prior mild stressed by lactose starvation or prior salt exposure were transferred to M17 broth with 5 concentrations of NaCl (0, 1, 3, 5 and 7% w/v) and incubated aerobically at 30°C. Plating was conducted immediately after inoculation and every 24 hours for 5 days in M17 agar supplemented with 0.5% of lactose and incubated aerobically at 30°C for 48 hours. Three replications were conducted. There was no need for lactose to grow this culture in M17 broth and it could tolerate prior exposure to 3% w/v NaCl in media without affecting its growth at different salt concentrations. Culture that was exposed to lactose starvation and then subsequently grown in 3% w/v NaCl, at day 3 showed enhanced salt tolerance which can be recommended as a pretreatment condition for obtaining daughter cells with improved salt tolerance.

关键词： Cheese Culture Salt Tolerance

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可靠的高温测井技术

国外油气勘探 1996年第6期8卷 785-786页

作者： Manuel(Manny)e.gonzalez 白梅岭四川石油管理局天然气信息所

Los Alamos国家实验室(LANL)已把地热工程的高温井测井技术改型翻新成适用于深气井套管井测井方法(伽马射线、中子和套管接箍)。实验室的实验表明,这种高温井下井仪器能在400°F(204℃)的井底条件下使工作时间延长3倍。在西俄克拉何马州... 详细信息

Los Alamos国家实验室(LANL)已把地热工程的高温井测井技术改型翻新成适用于深气井套管井测井方法(伽马射线、中子和套管接箍)。实验室的实验表明,这种高温井下井仪器能在400°F(204℃)的井底条件下使工作时间延长3倍。在西俄克拉何马州Beckhom县深气井测井作业期间,标准的套管井测井下井仪器在2～4h内就失效了,而高温井下井仪器成功地进行两个连续的6h(12h)测井作业。在此之后。

关键词：高温地层深层气测井技术

evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs

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Asian Pacific Journal of Tropical Medicine 2016年第1期9卷 20-23页

作者： Ana Vargas-Calla Luis A.Gomez-Puerta Juan Calcina Omar Gonzales-Viera Cesar Gavidia Maria T.Lopez-Urbina Hector H.Garcia Armando e.gonzalez School of Veterinary Medicine Universidad Nacional Mayor de San Marcos Cysticercosis elimination Program and Center for Global Heath Tumbes Universidad Peruana Cayetano Heredia Department of Microbiology School of SciencesUniversidad Peruana Cayetano Heredia

Objective:To assess the efficacy of triclabendazole(TCBZ) in porcine ***:eighteen naturally infected cysticercotic pigs were divided into 3 groups of 6 individuals *** first group was treated orally with TCBZ at a single dose of 30 mg/kg of body weight,the second group was treated orally with oxfendazole at a single dose of 30 mg/kg of body weight and the third group received a placebo(control group).All animals were kept under the same management *** pigs were euthanized 17 wk post-treatment and the number of surviving cysts in muscles was assessed and compared between ***:All pigs treated with oxfendazole had only degenerated cysts in their *** contrast,TCBZ had very little effect against the parasitic *** from pigs in the TCBZ group looked apparently normal after ***,histological evaluation showed a mild to moderate degree of ***:TCBZ is not an efficacious drug against Taenia solium cysticercosis in swine using a single dose.

关键词： Taenia solium Cysticercosis Triclabendazole Oxfendazole Treatment

Cardiac ischemic preconditioning prevents dystrophin proteolysis by MMP-2 inhibition

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BIOCeLL 2016年第1期40卷 43-46页

作者： MANUeL RODRIGUeZ BRUNO BUCHHOLZ VeRONICA D'ANNUNZIO MARTÍN DONATO GeRMAN e.gonzalez MARIA AILIN GOYeNeCHe TAMARA MAZO VIRGINIA PeReZ LUCIANA WILeNSKY RICARDO J.GeLPI 不详

Dystrophin is a membrane-associated protein responsible for structural stability of the sarcolem-ma in cardiac myocytes and is very sensitive to ischemic *** goal of our study was to determine if ischemic preconditioning could prevent dystrophin breakdown through inhibition of matrix metalloprotein-ase-2(MMP-2)*** rabbit hearts were subjected to global ischemia with or without reperfusion in order to evaluate if dystrophin is preserved by ischemic preconditioning through MMP-2 *** preconditioning significantly reduced the infarct size induced by 30 min of ischemia and 180 min of ***,it also diminished dystrophin proteolysis and attenuated MMP-2 activity after 30 min ***,our study shows a novel protective role of ischemic preconditioning as a mechanism of preservation of plasma membrane integrity by inhibiting MMP-2 activation.

关键词： ischemia/reperfusion MMPs membrane associated proteins rabbit

Blueberry extract Reduces Oxidative Stress in Patients with Metabolic Syndrome

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Journal of Life Sciences 2016年第3期10卷 145-152页

作者： Raul Francisco Pastor gonzalez e Cassini M. S. Pastor I Saure M Saavedra e. Siman Menem M. I. Drago S Iermoli R. H InternalMedicineIVChair HospitaldeClinicas"JosddeSanMartin"UniversityofBuenosAiresBuenosAiresArgentina CentrodeDiagn6sticoMolecularS.A.(MolecularDiagnosisCenter) BuenosAiresArgentina CeSAN(Centrodeendocrinologia SaludAlimentaci6nyNutricidn)CenterforEndocrinologyHealthEatingandNutritionBuenosAiresArgentina

Oxidative stress is a health condition that could potentially harm the patient, and it is defined as the lack of balance between the production of oxygen free radicals, which rises, and antioxidant defenses, which are in decrease. Metabolic syndrome implies a variety of risk factors that are based on abdominal obesity and insulin resistance. Moreover, the importance of metabolic syndrome is emphasized due to the fact that it presents an increase in oxidative stress, which is produced by the sum of alterations that each risk factor produces within the metabolic syndrome pathology. Reducing oxidative stress in these patients is currently one of the most interesting challenges of cardiovascular and metabolic therapeutics, because it is a molecular biology alteration that is not generally diagnosed and, therefore, not treated. The increasing incidence of overweight and obesity cause an increase in the incidence of metabolic syndrome, thus turning into a huge problem that keeps growing at alarming proportions. This syndrome＇s incidence oscillates between 20 and 40%, depending on the gender, age, ethnic group, and diagnostic criteria used for the definition of the disease. Prospective studies show that metabolic syndrome doubles the risk of cardiovascular disease and causes a five-fold increase in the risk of developing type 2 diabetes. With the aim of decreasing the oxidative stress caused by metabolic syndrome, we investigated the effect of antioxidant protection in DNA repair and cell membranes through the use of blueberry extract, which is the fruit with the highest antioxidant capacity, in patients with metabolic syndrome. Thirty patients were studied for a period of 6 months of intervention, and it could be demonstrated that they showed a highly significant decrease in the damage produced to the DNA, which was measured by the urinary excretion of 8-hydroxy-2＇-deoxyguanosine （8-OHdG） and the damage caused to the vascular endothelium and cell membranes, which was meas

关键词： Metabolic syndrome urinary biomarkers of oxidative stress blueberries antioxidants.

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古巴共和国的结核病:可能被消除

国际结核病与肺部疾病杂志 1995年第1期 26-32页

作者： e.gonzalez L.Armas A.Alonso 何汉清 Group for epidemiological Surveillance and Research on Acute Respiratory Infections and Tuberculosis Ochoa Group for epidemiological Surveillance and Research on Acute Respiratory Infections and Tuberculosis Department of Statistics and Computation Institute Pedro KouriHavanaCuba

背景:多数发达国家都把消除结核病作为首要任务,尽管其中有些国家因AIDS病流行和耐药性而遭受困挠。发展中国家的结核病则是更严重的问题。目的:通过对1979—1991年期间新报告病例趋势按临床类型和年龄组的分析评价古巴结核病流行病学... 详细信息

背景:多数发达国家都把消除结核病作为首要任务,尽管其中有些国家因AIDS病流行和耐药性而遭受困挠。发展中国家的结核病则是更严重的问题。目的:通过对1979—1991年期间新报告病例趋势按临床类型和年龄组的分析评价古巴结核病流行病学形势。设计:以简单回归模式用于从国家监测系统获得的‘新病例’率的时间系列资料。估算每年变化百分比。结果:1979—91年结核病下降59.5％(从11.6下降到4.7/100000人口/年)。下降发生于所有年龄组;1991年新病例的60％属于45岁及以上,其中3O％为65岁及以上。结核分支杆菌菌株耐药性(1989年为2.49％)仍少见,全民中HIV感染(1991年为0.009％)亦罕见。结论:除良好的耐药性趋势和全民中低HIV感染之外,迄今报告的新病例数持续稳定的下降表示国家结核病控制规程今后仍将确实可能保持其有效性,从而有理由制订消除结核病的新战略。

关键词：结核病控制结核分支杆菌 HIV感染新病例化学治疗结核病发病率病例发现共和国年感染率结核感染率

持续性单形室性心动过速患者瘢痕组织中的心动过速相关通路:瘢痕电压界定的影响

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世界核心医学期刊文摘（心脏病学分册） 2005年第3期1卷 34-35页

作者： Arenal A. Del Castillo S. gonzalez-Torrecilla e. 梁磊 Laboratorio de electrofisiologia Departamento de Cardiologa Hosp. Gen. Univ. Gregorio Maranon C/Dr Esquerdo 46 28007 Madrid Spain Dr.

Background-endocardial mapping before sustained monom-orphic ventricular tachycardia(SMVT) induction may reduce mapping time during tachycardia and facilitate the ablation of unmappable VT. Methods and Results-Left ventricular electroanatomic voltage maps obtained during right ventricular apex pacing in 26 patients with chronic myocardial infarction referred for VT ablation were analyzed to identify conducting channels(CCs) inside the scar tissue. A CC was defined by the presence of a corridor of consecutive electrograms differentiated by higher voltage amplitude than the surrounding area. The effect of different levels of voltage scar definition, from 0.5 to 0.1mV,was analyzed. Twenty-three channelswere identified in 20 patients. The majority of CCs were identified when the voltage scar definition was ≤0.2 mV. electrograms with ≥2 components were recorded more frequently at the inner than at the entrance of CCs(100%versus 75%, P≤0.01). The activation time of the latest component was longer at the inner than at the entrance of CCs(200±40 versus 164±53 ms, P≤0.001). Pacing from these CCs gave rise to a long-stimulus QRS interval (110±49 ms). Radiofrequency lesion applied to CCs suppressed the inducibility in 88%of CC-related tachycardias. During a follow-up of 17±11 months, 23%of the patients experienced a VT recurrence. Conclusions-CCs represent areas of slow conduction that can be identified in 75%of patients with SMVT. A tie red decreasing-voltage definition of the scar is critical for CC identification.

关键词：瘢痕组织标测单形右室心尖部起搏持续性射频消融次室激活时间

Selecting suitable solid organ transplant donors: Reducing the risk of donor-transmitted infections

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World Journal of Transplantation 2014年第2期4卷 43-56页

作者： Christopher S Kovacs Jr Christine e Koval David van Duin Amanda Guedes de Morais Blanca e gonzalez Robin K Avery Steven D Mawhorter Kyle D Brizendine eric D Cober Cyndee Miranda Rabin K Shrestha Lucileia Teixeira Sherif B Mossad Department of Infectious Diseases Medicine InstituteCleveland ClinicClevelandOH 44195United States Division of Infectious Diseases Immunocom-promised Host Infectious Disease ProgramUniversity of North CarolinaChapel HillNC 27599United States Infectious Disease and Internal Medicine Augusta HealthFishersvilleVA 22939United States Department of Pediatric Infectious Diseases Cleveland Clinic Children’sClevelandOH 44195United States Division of Infectious Disease (Transplant/On-cology) Johns HopkinsBaltimoreMD 21205United States

Selection of the appropriate donor is essential to a successful allograft recipient outcome for solid organ transplantation. Multiple infectious diseases have been transmitted from the donor to the recipient via transplantation. Donor-transmitted infections cause increased morbidity and mortality to the recipient. In recent years, a series of high-profile transmissions of infections have occurred in organ recipients prompt-ing increased attention on the process of improving the selection of an appropriate donor that balances the shortage of needed allografts with an approach that mitigates the risk of donor-transmitted infection to the recipient. Important advances focused on improving donor screening diagnostics, using previously excluded high-risk donors, and individualizing the selection of allografts to recipients based on their prior infection history are serving to increase the donor pool and improve outcomes after transplant. This article serves to review the relevant literature surrounding this topic and to provide a suggested approach to the selection of an appropriate solid organ transplant donor.

关键词： Donor selection Infection Transplantation Mass screening Treatment outcome

青少年社区获得性耐甲氧西林的金黄色葡萄球菌感染时的严重葡萄球菌性脓毒症

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世界核心医学期刊文摘（儿科学分册） 2006年第11期2卷 43-44页

作者： gonzalez B.e. Martinez-Aguilar G. Hulten K.G. S.L. Kaplan 王经纬 Texas Children's Hospital Mail Code 3-2371 6621 Fannin St Houston TX 77030 United States Dr.

Objective. More than 70%of the community-acquired (CA)-staphylococcal infections treated at Texas Children’s Hospital are caused by methicillin-resistant Staphylococcus aureus (MRSA). Since September 2002, an increase in the number of severely ill patients with S aureus infections has occurred. This study provides a clinical description of severely ill adolescent patients and an analysis of their isolates using molecular methods. Methods. We identified adolescent patients meeting criteria for severe sepsis requiring admission to the PICU. Patient records were reviewed, and isolates were obtained for susceptibility testing and DNA extraction. Isolates were tested for the presence of virulence genes (cna, tst, lukS-PV, and lukFPV) and enterotoxin genes (sea, seb, sec, sed, seh, and sej) by polymerase chain reaction. Genomic fingerprints were determined by repetitive-element polymorphism polymerase chain reaction and pulse-field gel electrophoresis. SCCmec cassette type was determined. Results. Fourteen adolescents with severe CA S aureus infections were identified between August 2002 and January 2004. All were admitted to the PICU with sepsis and coagulopathy. Twelve patients had CA-MRSA infections; 2 had CA methicillin-susceptible Staphylococcus aureus (MSSA) infections. The mean age was 12.9 years (range: 10-15 years). Thirteen patients had pulmonary involvement and/or bone and joint infection; 10 patients had ≥2 bones or joints infected (range: 2-10); 4 patients developed vascular complications (deep venous thrombosis);and 3 patients died. All isolates were identical or closely related to the previously reported predominant clone in Houston, Texas (multilocus sequence type 8, USA300), and carried lukS-PV and lukF-PV genes as well as the SCCmec type IVa cassette (12 MRSA isolates) but did not contain cna or tst. Only 1 strain carried enterotoxin genes (sed and sej). Conclusions. Severe staphylococcal infections in previously healthy adolescents without predisposing

关键词：脓毒症甲氧西林聚合酶链反应分离物基因表型儿童医院德克萨斯州 PICU 病程记录分子学

Simultaneous optimization of even flow and land and timber value in forest planning:a continuous approach

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Forest ecosystems 2021年第4期8卷 645-658页

作者： Jose M.gonzalez-gonzalez Miguel e.Vazquez-Mendez Ulises Dieguez-Aranda Departamento de enxenaria Agroforestal Universidade de Santiago de Compostela.Escola Politecnica Superior de EnxenariaR/Benigno Ledo27002 LugoSpain Departamento de Matematica Aplicada Instituto de MatematicasUniversidade de Santiago de Compostela.Escola Politecnica Superior de EnxenariaR/Benigno Ledo27002 LugoSpain

Background:Forest management planning involves deciding which silvicultural treatment should be applied to each stand and at what time to best meet the objectives established for the *** this,many mathematical formulations have been proposed,both within the linear and non-linear programming frameworks,in the latter case generally considering integer variables in a combinatorial *** present a novel approach for planning the management of forests comprising single-species,even-aged stands,using a continuous,multi-objective formulation(considering economic and even flow)which can be solved with gradient-type ***:The continuous formulation has proved robust in forest with different structures and different number of *** results obtained show a clear advantage of the gradient-type methods over heuristics to solve the problems,both in terms of computational time(efficiency)and in the solution obtained(effectiveness).Their improvement increases drastically with the dimension of the problem(number of stands).Conclusions:It is advisable to rigorously analyze the mathematical properties of the objective functions involved in forest management planning *** continuous bi-objective model proposed in this paper works with smooth enough functions and can be efficiently solved by using gradient-type *** advantages of the new methodology are summarized as:it does not require to set management prescriptions in advance,it avoids the division of the planning horizon into periods,and it provides better solutions than the traditional combinatorial ***,the graphical display of trade-off information allows an a posteriori articulation of preferences in an intuitive way,therefore being a very interesting tool for the decision-making process in forest planning.

关键词： even-aged forest management Forest-level optimization Continuous optimization Gradient-type algorithms