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Targeted and imaging-guided in vivo photodynamic therapy for tumors using dual-function, aggregation- induced emission nanoparticles

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Nano Research 2018年第5期11卷 2756-2770页

作者： Xianhe Sun Abudureheman Zebibula Xiaobiao Dong gonghui li Guanxin Zhang Deqing Zhang Jun Qian Sailing He State Key Laboratory of Modern Optical Instrumentations Centre for Optical and Electromagnetic Research Zhejiang University Hangzhou 310058 China Department of Urology Sir Run Run Shaw Hospital College of Medicine Zhejiang University Hangzhou 310016 China Beijing National Laboratory for Molecular Sciences CAS Key Laboratories of Organic Solids and Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China School of Electrical Engineering Royal Institute of Technology OSQULDAS VAG 6 Stockholm SE-10044 Sweden

Imaging-guided photodynamic therapy （PDT） has been regarded as a promising strategy for precise cancer treatment. Because of their excellent modifiability and drug-loading capacity, nanoparticles have played an important role in PDT. Nonetheless, when traditional photosensitizers are made into nanoparticles, both their fluorescence and reactive oxygen species generation efficacy decrease due to a phenomenon known as aggregation-caused quenching. Fortunately, in recent years, several kinds of organic dyes with ＂abnormal＂ properties （termed aggregation-induced emission, AIE） were developed. With enhanced fluorescence emission in the nanoaggregation state, the traditional obstacles mentioned above may be overcome by AIE luminogens. Herein, we provide a better combination of photosensitizers and nanoparticles, namely, dual-function AIE nanopartides capable of producing reactive oxygen species, to implement targeted and imaging-guided in vivo PDT. Good contrast of in vivo imaging and obvious therapeutic efficacy were observed at a low dose of AIE nanoparticles and low irradiance of light, thus resulting in negligible side effects. Our work shows that AIE nanopartides may play a promising role in imaging-guided clinical PDT for cancer in the near future.

关键词： aggregation-induced emission targeted therapy imaging-guided therapy photodynamic therapy tumor

Comparison of combined laparoscopic ureterolithotomy and flexible ureteroscopy with percutaneous nephrolithotomy for removing large impacted upper ureteral stones with concurrent renal stones

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Laparoscopic, Endoscopic and Robotic Surgery 2018年第2期1卷 37-41页

作者： liwei Xu Youyu Zhang Zhenghui Wang gonghui li Shicheng Yu Department of Urology Sir Run Run Shaw HospitalZhejiang University School of MedicineQingchun East Road 3Hangzhou 310016China

Objectives:The present study compared the safety and efficacy of combined laparoscopic ureterolithotomy(LU)and flexible ureteroscopy with percutaneous nephrolithotomy(PCNL)for removing large impacted upper ureteral stones with concurrent renal ***:This study included 52 patients who underwent combined LU and retrograde flexible ureteroscopy for removing renal stones(group A)or PCNL(group B)for removing large upper impacted ureteral stones and concurrent renal stones at our department from January 2014 to December *** demographics,stone characteristics,and procedure-related parameters including stone-free rate,operation time,hospital stay after surgery,mean decrease in hemoglobin levels,visual analog scale(VAS)score,auxiliary procedure rate,and complication rate were compared between groups A and ***:Results of this study showed that both procedures were effective for removing large impacted upper ureteral stones with concurrent renal *** stone-free rate after a single procedure was 95.7%in group A and 89.7%in group B(p?0.62).The operation time was longer in group A than in group B(112.2±23.3 min versus 96.2±16.4 min,p?0.006).However,no significant difference was observed between the two groups with respect to the length of hospital stay after the surgery(5 days versus 6 days,p?0.06).The decrease in hemoglobin levels was significantly higher in group B than in group A(0.64±0.36 g/dL versus1.44±0.65 g/dL,pliary procedure rate was higher in group B than in group A(6.9%versus 0%).Conclusion:These results indicate that both combined LU and flexible ureteroscopy and PCNL are suitable for removing large impacted upper ureteral stones with concurrent renal stones and are associated with a high rate of patients being st

关键词： Laparoscopic ureterolithotomy Flexible ureteroscopy Percutaneous nephrolithotomy Ureteral stone Renal stone

Prevention and management of infection in ophthalmic clinics under COVID-19 epidemic

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中华实验眼科杂志 2020年第3期 261-266页

作者： li Xiaoxin lin Baojiao Chen Yanmang Tao Ping li gonghui Cai Jianhao Chen Haoyu Zhang Mingzhi Xiamen Eye Center Affiliated to Xiamen University Xiamen 361000 China Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong Shantou 515041 China

Since the end of 2019, novel coronavirus disease (COVID-19) outbreak in Wuhan,China and rapidly spread. The pathogen of COVID-19 is novel coronavirus (2019-nCoV), which is virified to be highly homologous with severe acute respiratory?syndrome coronavirus (SARS-CoV) in 2003, and whether the eye surface infectious is associated with the respiratory disease has attracted the attention of researchers. Up to now, the virulence, transmmision way, and infectivity of 2019-nCoV have been understood, but the invasion mode and pathogenesis is under elucidated. The management of infactious source, cutting out of transmmision route and treatment of patients are the primary goal for prevention and control of COVID-19 *** is very important for ophthalmologists to effectively treat the eye diseases and at the same time to pay close attention for medical environment disinfection and personal pretection during the pandemic. In view of the urgent need of ophthalmologists for the proventional precedure, we publish the ‘Ophthalmic Management and Protective Procedure Under the COVID-19 Epidemic’ by li Xiaoxin et al from Xiamen Eye Center and ‘ Strengthening Prevention and Control Measures of Medical Staffs in Ophthalmic Hospital Under the COVID-19 Epidemic’by Zhang Mingzhi et al from Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong as the references for ophthalmologists.

关键词： Novel coronavirus disease Infection Management Prevention Epidemic Ophthalmology

Experimental study of the movement of control fluid in compound perforation

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Petroleum Science 2009年第4期6卷 389-394页

作者： Zhao Xu liu gonghui li Jun Ding Qingxin Key Laboratory of Petroleum Engineering Ministry of EducationChina University of PetroleumBeijing 102249China Beijing Union University Beijing 100010China School of Mechanical and Electronic Engineering China University of PetroleumBeijing 102249China

The interaction between the high pressure gas and the control fluid and the movement mechanism of the control fluid in compound perforation were studied by a series of large-scale experiments, where the movement behavior of the control fluid was observed. The curves of measured pressure were analyzed, a mathematical model for the rigid movement of the control fluid was established, and the movement velocity of control fluid was analyzed. Moreover, the velocity from experimental results and velocity from an analytical solution were contrasted. The movement of the control fluid in the initial stage was similar to the rigid movement; however, the propagation of the pressure wave in the control fluid should be taken into account. Experimental results are significant for research on the movement mechanism of control fluid in compound perforation.

关键词： Compound perforation experimental study control fluid gas and liquid interaction mathematical model

Management of major vascular injury in laparoscopic urology

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Laparoscopic, Endoscopic and Robotic Surgery 2020年第4期3卷 107-110页

作者： Sheng Cheng Qiming Zheng liwei Xu Weiping Zhao gonghui li Guoqing Ding Department of Urology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

Objective:During the past three decades,laparoscopy has played a significant role in the management of urological *** study aims to standardize the management of major vascular injury,which is a life-threatening complication in the laparoscopic urological ***:A total of 8210 patients with the urological disorder,who underwent laparoscopic surgery at Sir Run Run Shaw Hospital from January 2000 to December 2018,were included in this retrospective ***’data of the laparoscopic major vascular injury were collected and analyzed,and the basic principles of the procedure were ***:A total of 15(0.18%)cases of major vascular injury were found among the 8210 patients,and 2 of them were converted to open *** the type of laparoscopic surgery,causes,and management of major vascular injury among the patients were diverse,the main management strategies of major vascular injury in laparoscopic surgery were to keep the vision clear,control bleeding rapidly by clamping and compression,make full preparation for possibly needed liquid resuscitation,and try best to repair under *** necessary,converse to open ***:Although the reported incidence of major vascular injury in laparoscopic urological surgery is extremely low,such injury can result in high morbidity and *** is important to rapidly identify the cause and strictly follow the standardized management for better outcomes.

关键词： Laparoscopic urology Major vascular injury Management

Inadvertent insertion of nephrostomy tube into the renal vein following percutaneous nephrolithotomy: A case report and literature review

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Asian Journal of Urology 2020年第1期7卷 64-67页

作者： Guangju Ge Zhenghui Wang Mingchao Wang gonghui li Zuhao Xu Yukun Wang Shawpong Wan Department of Urology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouChina Department of Urology First People’s Hospital of XiaoshanHangzhouChina

Percutaneous nephrolithotomy(PCNL)is an effective and well accepted procedure for the treatment of large and complex renal *** encountered a patient with a mis-placed percutaneous nephrostomy drainage tube(PNDT)into the contralateral renal vein re-sulting thrombus formation after undergoing right side *** placed a temporary filter to prevent embolism and started anti-coagulation therapy immediately and finally the PNDT was removed without bleeding.

关键词： Complication Inferior vena cava Percutaneous nephrolithotomy Embolization Renal calculus

Development and validation of a risk gene-signature for prediction of recurrence-free survival in clear cell renal cell carcinoma

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Development and validation of a risk gene-signature for pred...

2019年浙江省医学会泌尿外科学、男科学学术大会

作者： Yuanlei Chen gonghui li Sir Run Run Shaw Hospital School of MedicineZhejiang University

Objective Nowadays, gene expression profiling has been widely used and showed great promise in exploring prognostic biomarkers in various types of cancers. We attempt to construct a clinical nomogram based on risk genesignature and clinical features for individual recurrent risk assessment and offer personalized managements in patients with clear cell renal cell carcinoma.

关键词： Development and validation of a risk gene-signature for prediction of recurrence-free survival in clear cell renal cell carcinoma

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我国人类假结核耶氏菌病首例报告

中华流行病学杂志 1989年第3期10卷 146-148页

作者：李功惠唐凤鸣福建省人兽共患病研究室湖南省湘潭县卫生防疫站湖南省卫生防疫站

在我国首次报告一例假结核病例，是根据临床和病原学研究基础上确诊的。从患者分离的假结核耶氏菌为血清Ⅳ型，具有毒力，并发现与小肠结肠炎耶氏菌0 : 36型有共同抗原关系。

关键词：假结核耶尔森氏菌病肠炎

Proteome and phosphorylome analyses reveal potential biomarkers of renal cell carcinoma

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Proteome and phosphorylome analyses reveal potential biomark...