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Bloodletting Puncture at Hand Twelve Jing-Well Points Relieves Brain Edema after Severe Traumatic Brain Injury in Rats via Inhibiting MAPK Signaling Pathway

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Chinese Journal of Integrative Medicine 2021年第4期27卷 291-299页

作者： LIU Bao-hu ZHOU Dan GUO yi ZHANG Sai GUO Yong-ming GUO Tong-tong CHEN Xu-yi gong yi-nan TANG Hui-ling XU Zhi-fang Research Center of Experim ental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin(301617)China Department of Rehabilitation Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing(100102)China School of Acupuncture&Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin(301617)China College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin(301617)China Tianjin Key Laboratory of Neurotraum a Repair Institution of Brain Trauma and Neurology Disease of People's Armed Police ForceNeurosurgery&Neurology HospitalAffiliated Hospital of Logistics University of People's Armed Police ForceTianjin(300162)China

Objective:To investigate whether blood-brain barrier(BBB)served a key role in the edema-relief effect of bloodletting puncture at hand twelve Jing-well points(HTWP)in traumatic brain injury(TBI)and the potential molecular signaling ***:Adult male Sprague-Dawley rats were assigned to the shamoperated(sham),TBI,and bloodletting puncture(bloodletting)groups(n=24 per group)using a randomized number *** TBI model rats were induced by cortical contusion and then bloodletting puncture were performed at HTWP twice a day for 2 *** neurological function and cerebral edema were evaluated by modified neurological severity score(mNSS),cerebral water content,magnetic resonance imaging and hematoxylin and eosin *** blood flow was measured by laser *** protein levels of aquaporin 4(AQP4),matrix metalloproteinases 9(MMP9)and mitogen-activated protein kinase pathway(MAPK)signaling were detected by immunofluorescence staining and Western ***:Compared with TBI group,bloodletting puncture improved neurological function at 24 and 48 h,alleviated cerebral edema at 48 h,and reduced the permeability of BBB induced by TBI(all P<0.05).The AQP4 and MMP9 which would disrupt the integrity of BBB were downregulated by bloodletting puncture(P<0.05 or P<0.01).In addition,the extracellular signal-regulated kinase(ERK)and p38 signaling pathways were inhibited by bloodletting puncture(P<0.05).Conclusions:Bloodletting puncture at HTWP might play a significant role in protecting BBB through regulating the expressions of MMP9 and AQP4 as well as corresponding regulatory upstream ERK and p38 signaling ***,bloodletting puncture at HTWP may be a promising therapeutic strategy for TBI-induced cerebral edema.

关键词： traumatic brain injury cerebral edema blood brain barrier bloodletting puncture at hand twelve Jing-well points mitogen-activated protein kinase pathway Chinese medicine

Initiation of Acupoint Molecular Mechanisms for Manual Acupuncture Analgesia—Nuclear FactorκB Signaling Pathway

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Chinese Journal of Integrative Medicine 2021年第12期27卷 933-939页

作者： ZHANG Kuo ZHAO Xue YANG Tao ZHANG Yan-fang YAN Ya-wen XU Zhi-fang gong yi-nan LIU Yang-yang GUO Yong-ming GUO yi Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin(300072)China Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin(301617)China Affiliated Hospital of Municipal Institute of Traditional Chinese Medicine of Changzhi City Shanxi Province(046000)China Sanhuai Road Community Health Service Center Tanggu StreetBinhai New AreaTianjin(300451)China School of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin(301617)China

Objective To identify the prominent molecular signaling in acupoints and explore their roles in initiating the analgesia effect of manual acupuncture(MA).Method A three-step study was conducted,the experiment 1 was a genome-wide analysis of the tissue at acupoint Zusanli(ST 36),including 12 Wistar rats which were divided into control,control+MA1,and control+MA7 *** the experiment 2,the paw withdrawal latency(PWL),immunohistochemistry and Western blot analysis of phospho-nuclear factor kappa B(NFκB)p65(p-p65),phospho-NFκB p50(p-p50)at ST 36 were performed on rats of saline,saline+MA,and complete Freund’s adjuvant(CFA)+MA groups(n=6).In experiment 3,24 rats were divided into saline+DMSO,CFA+DMSO,CFA+DMSO+MA,and CFA+BAY 11–7082+MA groups,the PWL and immunofluorescence assay of NFκB p65 at ST 36 was ***(1)The gene:inhibitor of NFκB(Nfkbia),interleukin-1β(Il1b),interleukin-6(Il6),chemokine c-x-c motif ligand 1(Cxcl1),monocyte chemoattractant protein-1(MCP-1/Ccl2)expressions in the control+MA7 group were significantly increased(P<0.05 or P<0.01),and the expression of NFκB p65(Rela),NFκB p50(Nfkb1)were increased in the control+MA7 group(P<0.05).(2)CFA+MA groups showed increased PWL from day 1 to 7(P<0.01 ***),and the Western blot results were consistent with immunohistochemistry,the expression of NFκB p-p65 and NFκB p-p50 were significantly increased in the MA-related groups compared with control and CFA groups(P<0.05).(3)Compared with the CFA+DMSO+MA group,the PWL of the CFA+BAY 11–7082+MA group decreased significantly and continued until day 5 and 7(P<0.05 and P<0.01,respectively),and the NFκB p65 expression of CFA+BAY 11–7082+MA was significantly reduced compared with CFA+DMSO+MA(P<0.01).Conclusion Local NFκB signaling cascade in acupoint caused by MA is an important step in initiating the analgesic effect,which would provide new evidence for the initiation of MA-effect and improve the understanding of the scientific basis of acupuncture analgesia.

关键词： manual acupuncture acupoint analgesia nuclear factor kappa B

Initiation mechanisms of acupuncture effect:a literature review of basic studies

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Journal of Acupuncture and Tuina Science 2020年第1期18卷 75-82页

作者： Zhang Kuo Ding Sha-sha gong yi-nan Zhao Xue Li Kai Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Department of Acupuncture and Physical Therapy Tianjin Nankai Hospital.Tianjin 300100China Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin 301617China Acu-moxibustion and Tuina Department Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Gynaecology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China

Objective:To summarize the research status of the changes in local microenvironment of acupoints caused by acupuncture,provide theoretical guidance for the initiation mechanisms of local acupuncture effect at ***:Using acupuncture,acupoint as key words to search China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP),PubMed and other databases,the representative articles were selected for ***:Acupuncture could excite afferent nerves,activate cells,and promote the release of chemical substances like neuropeptide,hormone,cytokines,*** the local site of ***,it may cause mechanical deformation of connective tissues,and change chemical ions as well as ion ***:The microenvironment changes around acupoints are crucial to acupuncture effect;the concept of'acupoints network'can be used to objectively describe the local changes around the acupoints after acupuncture.

关键词： Acupuncture Therapy Acupuncture Points Research on Acupoints Acupuncture Effect Review Literature

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井穴放血法急救昏迷源流考

中华中医药杂志 2017年第3期32卷 965-968页

作者：余楠楠王振国陈泽林公一囡郭义天津中医药大学实验针灸学研究中心天津300193 西安中医脑病医院西安710032 天津中医药大学针灸推拿学院天津300193

井穴位于四肢末端,是经脉气血之源,历代医家对井穴均非常重视。井穴放血法是中医传统急救昏迷的方法,历史悠久,笔者通过对其源流进行追溯,认为井穴放血法急救昏迷奠基、继承于《黄帝内经》,发扬于魏晋南北朝至隋唐五代,升华于金元,成熟... 详细信息

井穴位于四肢末端,是经脉气血之源,历代医家对井穴均非常重视。井穴放血法是中医传统急救昏迷的方法,历史悠久,笔者通过对其源流进行追溯,认为井穴放血法急救昏迷奠基、继承于《黄帝内经》,发扬于魏晋南北朝至隋唐五代,升华于金元,成熟于明清,新生于当代。井穴放血法可用于一切昏迷急症,堪称"起死回生之妙诀"。目前该疗法已作为临床适宜技术加以推广,有望在中国的急救体系尤其是院前急救中发挥应有的价值。

关键词：井穴刺络放血昏迷急救文献研究

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“陌生化”构建音乐生态课堂

新课程学习(下) 2014年第8期 28-29页

作者：龚易男武汉外国语学校

近年来音乐课堂教学理念不断变革,逐步从传统的单向灌输式教学过渡到以学生为主体的双向式互动教学上来,但是整体教学效果依然亟待提升。用"陌生化"理论来构建音乐生态课堂。在课堂生态系统中,通过"陌生化"师生系统、心理系统、器物系... 详细信息

近年来音乐课堂教学理念不断变革,逐步从传统的单向灌输式教学过渡到以学生为主体的双向式互动教学上来,但是整体教学效果依然亟待提升。用"陌生化"理论来构建音乐生态课堂。在课堂生态系统中,通过"陌生化"师生系统、心理系统、器物系统等子系统,形成协调共振的和谐生态系统,从而构建好音乐生态课堂。

关键词： “陌生化” 构建音乐生态课堂

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论中国手风琴民族音乐作品的创作

内蒙古大学艺术学院学报 2008年第1期5卷 62-64页

作者：巴雅尔龚易男中央民族大学音乐学院北京100081

中国手风琴民族音乐作品创作的特点是:由钢琴作品、声乐作品等改编的手风琴音乐作品;以中国汉族民歌和少数民族的民歌旋律为基础,以传统手法改编创作的作品;运用现代作曲技法创作的具有民族特点的手风琴原创音乐。

关键词：中国手风琴民族音乐作品民族音乐风格现代作曲技法

针灸改善慢性炎性反应的效应规律及机制研究现状与展望

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针刺研究 2023年第2期48卷 111-117页

作者：徐枝芳公一囡窦报敏樊泽至张悦天津中医药大学实验针灸学研究中心天津301617 天津中医药大学针灸推拿学院天津301617

炎性反应在炎性疾病和多种慢性疾病的发生、发展和预后中起着重要作用,长期失控的炎性反应会导致器官组织功能失调或丧失。临床实践和循证证据提示针灸可有效改善多种炎性疾病和慢性疾病的炎性状态。针灸靶器官相关的穴位,可通过调控穴... 详细信息

炎性反应在炎性疾病和多种慢性疾病的发生、发展和预后中起着重要作用,长期失控的炎性反应会导致器官组织功能失调或丧失。临床实践和循证证据提示针灸可有效改善多种炎性疾病和慢性疾病的炎性状态。针灸靶器官相关的穴位,可通过调控穴位微环境启动神经调节。针灸信息在中枢进行整合后,通过神经-内分泌-免疫通路,如胆碱能抗炎通路、迷走神经-肾上腺髓质-多巴胺通路、躯体交感反射和下丘脑-垂体-肾上腺轴等,释放神经递质、激素等并最终作用于免疫细胞,调控单核/巨噬细胞、T细胞亚群的胞内信号通路及极化状态,调控靶器官及机体的免疫稳态。因此,笔者认为针灸抗炎可能是治疗多种疾病的普适性作用途径之一,也是针灸调节阴阳平衡的有力诠释,其作用规律及机制的阐明可更好地实现针灸精准治疗的临床转化。

关键词：针灸慢性疾病炎性疾病抗炎自主神经临床转化

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang nan Zheng Qingming Lin Yan You Zheng gong Yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

瓦韦属10种植物的气孔器类型及其系统学意义

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北京师范大学学报（自然科学版） 2006年第3期42卷 291-294页

作者：巩乙南刘星葛源刘全儒周云龙盖强北京师范大学生命科学学院北京100875

对瓦韦属(Lepisorus)10种代表植物的叶表面结构进行了观察和研究,结果表明瓦韦属中不同植物的叶表皮细胞形状以及垂周壁式样几乎一致;运用表皮细胞长度、宽度、长度与宽度之比,气孔器长度、宽度、长度与宽度比以及气孔指数等变量进行的... 详细信息

对瓦韦属(Lepisorus)10种代表植物的叶表面结构进行了观察和研究,结果表明瓦韦属中不同植物的叶表皮细胞形状以及垂周壁式样几乎一致;运用表皮细胞长度、宽度、长度与宽度之比,气孔器长度、宽度、长度与宽度比以及气孔指数等变量进行的聚类统计表明,这些特征可以作为该属的一项重要特征,并且这些特征也能在一定程度上反映该属不同植物之间的亲缘关系,但是对瓦韦属植物属下划分意义不大;极细胞型在所研究的物种中均有大量分布.

关键词：瓦韦属气孔器类型分类系统学