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World Journal of Gastroenterology 2025年第3期31卷 73-83页

作者： Zhen-Yu Xu Zhong-Shang Dai Guo-Zhong gong Min Zhang Department of Infectious Diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

bACKGROUND C-X-C chemokine receptor type 5(CXCR5)+CD8+T cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting b cell *** their importance,the specific role of CXCR5+CD8+T cells in chronic hepatitis b(CHb),particularly during interferon-alpha(IFN-α)treatment,is not fully *** study aims to elucidate the relationship between CXCR5+CD8+T cells and sustained serologic response(SR)in patients undergoing 48 weeks of pegylated IFN-α(peg-IFN-α)treatment for *** To elucidate the relationship between CXCR5+CD8+T cells and sustained SR in patients undergoing 48 weeks of peg-IFN-αtreatment for *** This study enrolled 60 patients with hepatitis be antigen(HbeAg)-positive CHb undergoing 48 weeks of peg-IFN-α*** were assessed for eligibility based on criteria such as persistent HbsAg-positive status for at least six months,HbeAb-negative,hepatitis b virus DNA levels exceeding 2×104 copies/mL,and alanine aminotransferase(ALT)levels between 2 and 10 times the upper limit of *** samples were collected at baseline and at weeks 12,24,48,and a 24-week treatment-free follow-up(week 72)to measure serum interleukin(IL)-21 concentration via ELISA and to analyze CXCR5 and programmed death-ligand 1(PD-L1)expression on CD8+T cells by flow cytometry,CXCR5 is a chemokine receptor that directs immune cells to specific tissues,while PD-L1 is a protein that regulates immune responses by inhibiting T cell *** Patients with CHb exhibited significantly lower levels of circulating CXCR5+CD8+T cells compared to healthy controls(Pbly,CXCR5+CD8+T cells were prominently expressed in patients who achieved sustained SR compared to non-SR(NSR).A significant correlation was observed between CXCR5 and PD-L1 expression(r=-0.189,P=0.002).However,there was no significant correlation between serum IL-21 levels and CXCR5+CD8+lymphocytes(r=-0.03,P=0.62

关键词： C-X-C chemokine receptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interferon-alpha Chronic hepatitis b

Integrative cross-species transcriptome analysis reveals earlier occurrence of myelopoiesis in pre-circulation primates compared to mice

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ZOOLOGICAL RESEARCH 2024年第6期45卷 1276-1286页

作者： Du, Junjie Li, Zongcheng gong, yandong Lan, Yu Liu, bing Chinese Peoples Liberat Army Gen Hosp Chinese PLA Med Sch Beijing 100853 Peoples R China Chinese Peoples Liberat Army Gen Hosp Sr Dept Hematol State Key Lab Expt Hematol Haihe Lab Cell EcosystMed Ctr 5 Beijing 100071 Peoples R China Jinan Univ Sch Med Key Lab Regenerat Med Minist EducInst Hematol Guangzhou 510632 Guangdong Peoples R China

Hematopoiesis originates in the yolk sac, which forms prior to the establishment of blood circulation and exhibits distinct developmental processes between primates and mice. Despite increasing appreciation of yolk sac hematopoiesis for its lifelong contribution to the adult hematopoietic system and its regulatory roles in organogenesis, cross-species differences, particularly before the onset of blood circulation, remain incompletely understood. In this study, we constructed an integrative cross-species transcriptome atlas of pre-circulation hematopoiesis in humans, monkeys ( Macaca fascicularis), and mice. This analysis identified conserved populations between primates and mice, while also revealing more differentiated myeloid, erythroid, and megakaryocytic lineages in pre-circulation primates compared to mice. Specifically, SPP1-expressing macrophages were detected in primates before the onset of blood circulation but were absent in mice. Cell-cell communication analysis identified CSF1 + extraembryonic mesoderm cells as a potential supportive niche for macrophage generation, with ligand-receptor interactions between macrophages and other cell populations in the human yolk sac. Interestingly, pre-circulation SPP1+ macrophages exhibited hallmark signatures reminiscent of a macrophage subset that positively regulates hematopoietic stem cell generation. Our findings provide a valuable cross-species resource, advancing our understanding of human pre-circulation yolk sac hematopoiesis and offering a theoretical basis for the regeneration of functional blood cells.

关键词： Yolk sac Hematopoiesis Macrophage Integrative analysis Single-cell RNA sequencing

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He Zhen Wang Yuchen Wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge Xu gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

AN EFFICIENT SOLUTION FOR bUILDING POLYGONAL ObJECTS

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Geo-Spatial Information Science 1999年第1期2卷 63-67页

作者： Wu Huayi Wang yandong gong Jianya National Laboratory for Information Engineering in Surveying Mapping and Remote Sensing Wuhan University

Polygonal object is a fundamental type of geometric data in vector GIS. The key step of cleaning topological relationship after data collection of polygonal layer is to build polygonal objects from digital arcs. The raw digital arcs may intersect with each other. The algorithm for building polygonal objects after the raw arcs have been split at all intersections is presented. The build-up of polygonal objects in this paper is designed to be implemented by two steps. The first step is to extract all the polygons needed for build-up of polygonal objects from arcs. The second step is to organize polygonal objects from these polygons. For the first step,a tracing algorithm is proposed. The algorithm merely extracts the polygons needed for the build-up of polygonal objects, which is a subset of all the possible polygons that can be induced from the arcs. For the second step, an algorithm based on a specially designed order of polygons is advanced. All the topological relationships among the polygons are shown in a single scan. Experiments show that the two algorithms together offer a robust and efficient solution for building polygonal objects from intersected arcs.

关键词： GIS algorithm polygonal objects

A scheme for realizing nonreciprocal interlayer coupling in bilayer topological systems

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Frontiers of Optoelectronics 2023年第4期16卷 71-80页

作者： Xiaoxiao Wang Ruizhe Gu yandong Li Huixin Qi Xiaoyong Hu Xingyuan Wang Qihuang gong State Key Laboratory for Mesoscopic Physics and Department of Physics Collaborative Innovation Center of Quantum Matter&Frontiers Science Center for Nano-OptoelectronicsBeijing Academy of Quantum Information SciencesPeking UniversityBeijing 100871China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Hefei National Laboratory Hefei 230088China College of Mathematics and Physics Beijing University of Chemical TechnologyBeijing 100029China

Nonreciprocal interlayer coupling is difcult to practically implement in bilayer non-Hermitian topological photonic *** this work,we identify a similarity transformation between the Hamiltonians of systems with nonreciprocal interlayer coupling and on-site gain/*** similarity transformation is widely applicable,and we show its application in one-and two-dimensional bilayer topological systems as *** bilayer non-Hermitian system with nonreciprocal interlayer coupling,whose topological number can be defned using the gauge-smoothed Wilson loop,is topologically equivalent to the bilayer system with on-site gain/*** also show that the topological number of bilayer non-Hermitian C6v-typed domaininduced topological interface states can be defned in the same way as in the case of the bilayer non-Hermitian Su–Schrieffer–Heeger *** results show the relations between two microscopic provenances of the non-Hermiticity and provide a universal and convenient scheme for constructing and studying nonreciprocal interlayer coupling in bilayer non-Hermitian topological *** scheme is useful for observation of non-Hermitian skin efect in three-dimensional systems.

关键词： Nonreciprocal bilayer Interlayer coupling Topological photonics

A DESIGN OF THREE-DIMENSIONAL SPATIAL DATA MODEL AND ITS DATA STRUCTURE IN GEOLOGICAL EXPLORATION ENGINEERING

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Geo-Spatial Information Science 1999年第1期2卷 78-85页

作者： Cheng Penggen gong Jianya Wang yandong Sui Haigang Notional Labocatory for Information Engineering in Surveying. Mapping and Remote Sensing WTUSM

The key to develop 3-D GISs is the study on 3-D data model and data structure. Some of the data models and data structures have been presented by scholars. because of the complexity of 3-D spatial phenomenon, there are no perfect data structures that can describe all spatial entities. Every data structure has its own advantages and disadvantages. It is difficult to design a single data structure to meet different needs. The important subject in the3-D data models is developing a data model that has integrated vector and raster data structures. A special 3-D spatial data model based on distributing features of spatial entities should be designed. We took the geological exploration engineering as the research background and designed an integrated data model whose data structures integrats vector and raster data byadopting object-oriented technique. Research achievements are presented in this paper.

关键词： geological exploration engineering geographic information system three dimensional data model data structure

DATA MODEL AND VISUALIZATION OF 3D CITY LANDSCAPE bASED ON INTEGRATED DATAbASES

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Geo-Spatial Information Science 1999年第1期2卷 21-25页

作者： Li Deren Wang yandong Zhu Qing gong Jianya National Laboratory for Information Engineering in Surveying Mspping and Remote Sensing WTUSM

Data acquisition and modeling are the two important, difficult and costful aspects in a Cybercity project. 2D-GIS is mature and can manage a lot of spatial data. Thus 3D-GIS should make the best of data and technology of 2D-GIS. Construction of a useful synthetic environment requires integration of multiple types of information like DEM, texture images and 3D representation of objects such as buildings. In this paper, the method for 3D city landscape data model and visualization based on integrated databases is presented. Since the data volume of raster are very huge, special strategies(for example, pyramid gridded method) must be adopted in order to manage raster data efficiently. Three different methods of data acquisition, the proper data structure and a simple modeling method are presented as well. At last, a pilot project of Shanghai Cybercity is illustrated.

关键词： 3D city landscape integrated databases modeling visualization

THE CNSDTF TOPOLOGICAL VECTOR MODEL AND STRUCTURE

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Geo-Spatial Information Science 1999年第1期2卷 104-108页

作者： Wang yandong gong Jianya Huang Juntao Deng Yuejin National Laboratory for Information Engineering in Surveying Mapping and Remote Sensing WTUSM

Geo-Spatial Data Transfer Standard is an important part of 'National Spatial Data Infrastructure(NSDI)' ,as well as a necessary means for data sharing. 'Chinese National Geo-Spatial Data Transfer Format (CNSDTF)' was approved by National Quality Technology Supervise bureau in 1999 with the standard serial number of 17798-1999. It is designed to support vector and raster spatial data. This paper describes the vector part of CNSDTF, including design ideas, main characters, conceptual model, definition of spatial object, and file structure.

关键词： GIS spatial data transfer format data sharing conceptual model

A Construction Schema for Provincial Spatial Database of China

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Geo-Spatial Information Science 2009年第1期12卷 25-32页

作者： WANG yandong gong Jianya State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing Wuhan University 129 Luoyu RoadWuhan 430079 China.

In order to provide a provincial spatial database, this paper presents a scheme for spatial database construction to meet the needs of China. The objective and overall technical route of spatial database construction are described. The logical and physical database models are designed. Key issues are addressed, such as integration of multi-scale heterogeneous spatial databases, spatial data version management based on metadata and integrative management of map cartography and spatial database.

关键词： spatial data database construction provincial