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Copper Metabolism and Cuproptosis:Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

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Current Medical Science 2024年第1期44卷 28-50页

作者： Xiao-xia BAN Hao WAN xin-xing WAN Ya-ting TAN Xi-min HU Hong-xia BAN xin-yu CHEN Kun HUANG qi ZHANG Kun XIONG Department of Human Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 430013China Department of Endocrinology Third Xiangya HospitalCentral South UniversityChangsha 430013China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 430013China Affiliated Hospital Inner Mongolia Medical UniversityHohhot 010050China Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikou 571199China Hunan Key Laboratory of Ophthalmology Changsha 430013China

Copper is an essential trace element,and plays a vital role in numerous physiological processes within the human *** normal metabolism,the human body maintains copper *** deficiency or excess can adversely affect cellular ***,copper homeostasis is stringently *** studies suggest that copper can trigger a specific form of cell death,namely,cuproptosis,which is triggered by excessive levels of intracellular *** induces the aggregation of mitochondrial lipoylated proteins,and the loss of iron-sulfur cluster *** neurodegenerative diseases,the pathogenesis and progression of neurological disorders are linked to copper *** review summarizes the advances in copper homeostasis and cuproptosis in the nervous system and neurodegenerative *** offers research perspectives that provide new insights into the targeted treatment of neurodegenerative diseases based on cuproptosis.

关键词： cuproptosis copper metabolism copper homeostasis neurodegeneration neurodegenerativedisease

A seven-crystal spectrometer for high-energy resolution X-ray spectroscopy at Shanghai Synchrotron Radiation Facility

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Nuclear Science and Techniques 2024年第9期35卷 82-91页

作者： Bing-Bao Mei Liang-xin Wang Song-qi Gu Xiao-Zhi Su Shuo Zhang Yao Wei Jing-Yuan Ma Zheng Jiang Fei Song Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201800China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026China

A Johann-type X-ray spectrometer was successfully developed at the hard X-ray branch(in-vacuum undulator with a 24-mm periodic length)of the energy material beamline(E-line)at the Shanghai Synchrotron Radiation Facility(SSRF).This spectrometer was utilized to implement X-ray emission spectroscopy(XES),high-energy resolution fluorescence-detected X-ray absorption spectroscopy(HERFD-XAS),and resonant inelastic X-ray *** spherically bent crystals were positioned on the respective vertical 500-mm-diameter Rowland circles,adopting an area detector to increase the solid angle to 1.75%of 4πsr,facilitating the study of low-concentrate systems under complex reaction *** under the atmosphere pressure,the spectrometer covers the energy region from 3.5 to 18 keV,with the Bragg angle ranging from 73°to 86°during vertical *** offers a promised energy resolution of sub-eV(XES)and super-eV(HERFD-XAS).Generally,these comprehensive core-level spectroscopy methods based on hard X-rays at the E-line with an extremely high photon flux can meet the crucial requirements of a green energy ***,they provide substantial support for scientific advances in fundamental research.

关键词： X-ray emission spectroscopy High-energy-resolution X-ray spectrometer Johann geometry Energy materials SSRF

Evaluating the thermal environment of urban land surfaces in Yakutsk,a city located in a region of continuous permafrost

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Advances in Climate Change Research 2024年第1期15卷 113-123页

作者： Xiang-Long LI Ze ZHANG Jin-xin LU Anatoli BROUCHKOV qing-Kai YAN qi-Hao YU Sheng-Rong ZHANG Andrey MELNIKOV School of Civil Engineering and Transportation Institute of Cold Regions Science and EngineeringPermafrost InstituteNortheast Forestry UniversityHarbin150040China China Railway qinghai-Tibet Group Company Xining 810000China Department of Geocryology Faculty of GeologyLomonosov Moscow State UniversityMoscow 119234Russian Federation State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco Envi ronment and Re sourcesChinese Academy of SciencesLanzhou 730000China Melnikov Permafrost Institute Siberian BranchRussian Academy of ScienceYakutsk 677010Russian Federation

Rapid urbanization has led to changes in the urban land surface thermal ***,there are still much unknown about the urban land surface thermal conditions in permafrost *** is a unique geological environment,changes in the urban land surface thermal environment may trigger geological disasters caused by permafrost *** study utilized remote sensing data and geographic de-tectors to identify the dynamic changes in land surface temperature(LST)and land use/land cover(LU/LC)in Yakutsk,as well as the potential factors contributing to LST *** 1992 and 2020,the built-up area in Yakutsk increased by 36%,and the annual average LST in Yakutsk has risen by 6.67℃,accompanied by an expansion of high-temperature *** ongoing greening efforts,rapid urbanization poses a threat to these green *** in the normalized difference built-up index(NDBI)and land use transfer(LDT)were identified as the primary drivers of urban LST *** integrating geographic detector technology and artificial neural network models,we optimized the selection of input factors in the prediction model and used it to explore the future changes in LST in *** average LST in Yakutsk is expected to reach 23.4℃ and 25.1℃ in 2030 and 2040,respectively,with a further increase in high-temperature *** study provides a reference for ecological,hydrological,and geological assessments of cities in permafrost regions.

关键词： Remote sensing Land surface temperature Land use/Land cover Permafrost Yakutsk

Liquid-metal microgrid stretchable electronics based on bionic leaf veins with ultra-stretchability and high conductivity

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Rare Metals 2024年第6期43卷 2747-2757页

作者： Xi-Di Sun Jun-Yang An Yi-qi Sun xin Guo Jing Wu Jiang-Bo Hua Meng-Rui Su Yi Shi Li-Jia Pan Collaborative Innovation Center of Advanced Microstructures School of Electronic Science and EngineeringNanjing UniversityNanjing 210093China

Stretchable electronics that monitor joint activity and treat diseases based on liquid metal could be used in the development of healthcare *** devices can be seamlessly integrated with human ***,most high-precision microstructures and complex patterns are difficult to fabricate due to the limitations of conventional fabrication solutions,resulting in suboptimal performance under practical ***,a liquid-metal stretchable system utilizing natural leaf veins was reported as microstructures,which was based on a biomimetic concept and utilized an all-solution process for the preparation of complex *** systems are ultra-high tensile(800%tensile strain),environmentally stable(20 days)and mechanically durable(300-cycle).The system can accurately recognize the wearer's finger bending level as well as simple gesture *** the same time,the system acts as a wearable heater,which can realize the fast heating behavior of heating up to 50℃in 3 min under the human body-safe voltage(1.5 V).The tensile stability is demonstrated by the heterogeneous integration of lasers(405 nm)with the system interconnects for a stretchable and wearable light source.

关键词： Stretchable electronics Liquid metal Stretchable conductor Vein Bionicist electronics

Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide

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Chinese Chemical Letters 2024年第9期35卷 223-226页

作者： gongcheng Ma qihang Ding Yuding Zhang Yue Wang Jingjing Xiang Mingle Li qi Zhao Saipeng Huang Ping gong Jong Seung Kim Guangdong Key Laboratory of Nanomedicine Shenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS-HK Joint Lab for BiomaterialsResearch Laboratory for Biomedical Optics and Molecular ImagingShenzhen Key Laboratory for Molecular ImagingCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Korea UniversitySeoul 02841South Korea School of Chemical Engineering Northwest UniversityXi’an 710069China Cancer Center Institute of Translational MedicineFaculty of Health SciencesUniversity of MacaoMacao 999078China State Key Laboratory of Fine Chemicals College of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China

Carbon monoxide(CO)is a vital intracellular gas messenger known for its cytoprotective and homeostatic *** plays a pivotal role in a myriad of biological ***,the precise detection of CO is of paramount importance in unraveling the intricacies of pathological mechanisms and advancing the development of disease *** herein introduce NFCOP,a state-of-the-art near-infrared(NIR)turn-on fluorescence(FL)probe that has been meticulously designed for highly sensitive,swift and selective imaging of *** NFCOP response occurred rapidly with CO,within just 10 s,and the calculated detection limit for CO was determined to be 0.32μmol/*** investigations conducted at the cellular level and in vivo demonstrated that NFCOP possesses high sensitivity and selectivity for imaging CO.

关键词： Palladium-free Chemoselective probe Fluorescence imaging Carbon monoxide Near-infrared

Effect of La on the Corrosion Behavior and Mechanism of 3Ni Weathering Steel in a Simulated Marine Atmospheric Environment

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 308-324页

作者： Gang Niu Rui Yuan R.D.K.Misra Na gong Zhi-Hui Zhang Hao-Xiu Chen Hui-Bin Wu Cheng-Jia Shang xin-Ping Mao Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083China Laboratory for Excellence in Advanced Steel Research Department of MetallurgicalMaterials and Biomedical EngineeringUniversity of Texas at El PasoEl PasoTX79968USA Institute of Materials Research and Engineering Agency for ScienceTechnologyand ResearchSingapore138634Singapore Department of Materials Science and Engineering University of TorontoTorontoONM5S 3E4Canada

The corrosion behavior and mechanism of 3Ni weathering steel in a simulated oceanic atmospheric environment are investigated in order to comprehend the impacts of La,as determined through electrochemical analysis and rust layer *** results of this study demonstrate that the addition of La enhances the corrosion resistance of 3Ni weathering steel in the marine atmospheric environment,thereby reducing the corrosion rate and improving the protection of the rust *** influence of La on corrosion resistance can be attributed to two primary ***,La functions as a grain refiner,minimizing the potential difference of the micro-regions on the substrate surface,thereby significantly reducing the corrosion of bare steel in the marine ***,La inhibits the process of Fe_(3)O_(4) oxidation back toγ-FeOOH during corrosion at the local site,thus decreasing the formation ofγ-FeOOH and enhancing the charge transfer *** research work may serve as a reference for expanding the application of rare earth elements in the field of weathering steel.

关键词： Weathering steel Rare earth Rust layer Corrosion behavior Corrosion resistance

Phase modulation of nickel-tin alloys in regulating electrocatalytic nitrogen reduction properties

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Rare Metals 2024年第6期43卷 2851-2858页

作者： Lin Wang Hang-Ning Liu xin Meng Chang-Hui Sun Hai-Dong Liu Liang-Yu gong Zhen-Hua Yan Jie Wang College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural UniversityQingdao 266109China Department of Chemistry-Angstrom Laboratory Uppsala University75121UppsalaSweden Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071China

Electrocatalytic nitrogen reduction reaction(NRR)is one of the attractive methods for ammonia(NH_(3))production at ambient conditions,but the catalytic performance largely depends on the physical properties of the ***,Ni-Sn alloy nanoparticles with well-controlled physical properties have been synthesized via a simple two-step method,which are applied as efficient electrocatalysts for the NRR.

关键词： alloys alloy nickel

Urban Spatial Form Optimization Strategies Based on the Principle of Climate Adaptability of Regional Architecture: A Case Study of Traditional Cave Dwelling Villages in Northern Shaanxi Province

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Journal of Landscape Research 2024年第3期16卷 1-7页

作者： qi Zizhuo YANG xin School of Architecture and Art North China University of TechnologyBeijing 100144China

A multitude of climate-adaptive design approaches are embedded in regional architecture,which have a positive impact on addressing the deformed development of urban spatial patterns and the dual challenges of climate and *** paper examines the principles of climate adaptability embedded in the site layout and spatial organization characteristics of traditional cave dwelling villages in northern Shaanxi *** extracted climate adaptability principles are summarized,and the resulting design strategies that are well-suited to the contemporary urban space form are *** analysis,it can be observed that traditional cave dwelling villages in northern Shaanxi are predominantly situated on south-facing slopes in proximity to water at low *** villages are characterized by compact building groups and east-west development,which is constrained by the elements of mountains and rivers.A two-level street system is generated,comprising streets parallel to the contour line and roadways perpendicular to the contour *** results in the formation of a courtyard form enclosed by *** site layout and spatial organization exhibit excellent climate adaptability with regard to heat,ventilation,and wind *** light of the aforementioned considerations,the following urban spatial form design strategies are put forth:①the topographic height difference can be exploited to obtain sufficient sunshine;②the group shape can be optimized in order to reduce building energy consumption;③the best orientation of the building can be chosen to take account of both winter and summer conditions;④the height and length can be combined in order to form natural masking;⑤the D/H ratio of streets and roadways should be controlled to achieve a balance between heat gain and cooling of groups;⑥vents should be set appropriately to optimize group ventilation;⑦climate buffers should be established to increase the level of climate response.

关键词： Traditional cave dwellings in northern Shaanxi Urban spatial form Outdoor thermal environment

Cetuximab combined with chemotherapy for simultaneous esophageal squamous cell carcinoma and colon adenocarcinoma:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2649-2654页

作者： xin-xin Luo Yu-Xuan Du qi-qing Zhang Lin Zhang Shu-Ying Zeng Zhi-Hong Yu Peng Shen Zheng-Quan Feng The Second School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou310053Zhejiang ProvinceChina Department of Oncology Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Medical Oncology The First Affiliated HospitalMedical College of Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Multiple primary carcinomas(MPCs)are defined as two or more independent primary cancers that occur simultaneously or sequentially in the same *** MPCs are rarer than solitary cancers or metachronous *** diagnoses of synchronous MPCs and the choice of treatment are critical for successful outcomes in these *** SUMMARY A 64-year-old patient presented with dysphagia,without obvious cause.A diagnosis of synchronous esophageal squamous cell carcinoma and colon adenocarcinoma with liver metastasis was confirmed based on examination and laboratory *** multi-disciplinary consultations,combination chemotherapy(a 3-wk cycle with oxaliplatin 212 mg administered on day 1 and capecitabine 1.5 g twice daily on days 1-14)and esophageal cancer radiotherapy were *** on the results of genetic testing,we switched to a regimen of leucovorin+fluorouracil+oxaliplatin and cetuximab regimen for 8 ***,capecitabine and bevacizumab were administered until the most recent follow-up,at which the tumor remained *** Successful cetuximab chemotherapy treatment provides a reference for the nonoperative and homogeneous treatment of different pathological types of synchronous MCPs.

关键词： Synchronous multiple primary carcinoma Esophageal squamous cell carcinoma Colon adenocarcinoma Cetuximab Chemotherapy Case report