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Therapeutic advances in atrial fibrillation based on animal models

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 135-152页

作者： qian gong Xuan LE Pengcheng YU Lenan ZHUANG Institute of Genetics and Reproduction College of Animal SciencesZhejiang UniversityHangzhou310058China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou310016China

Atrial fibrillation(AF)is the most prevalent sustained cardiac arrhythmia among humans,with its incidence increasing significantly with *** the high frequency of AF in clinical practice,its etiology and management remain *** develop effective treatment strategies,it is imperative to comprehend the underlying mechanisms of AF;therefore,the establishment of animal models of AF is vital to explore its *** spontaneous AF is rare in most animal species,several large animal models,particularly those of pigs,dogs,and horses,have proven as invaluable in recent years in advancing our knowledge of AF pathogenesis and developing novel therapeutic *** review aims to provide a comprehensive discussion of various animal models of AF,with an emphasis on the unique features of each model and its utility in AF research and *** data summarized in this review provide valuable insights into the mechanisms of AF and can be used to evaluate the efficacy and safety of novel therapeutic interventions.

关键词： Atrial fibrillation Animal model Therapeutic

LEACHING GOLD BY LOW CONCENTRATION THIOSULFATE SOLUTION

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Transactions of Nonferrous Metals Society of China 1992年第4期2卷 21-25页

作者： Cao Changlin Hu Jiexue gong qian Institute of Chemical Metallurgy Academia SinicaBeijing 100080China

The effects of the concentrations of thiosulfate,copper and ammonia on the extraction of gold from sulfide gold concentrate have been *** results show that it is possible to reduce thiosulfate *** than 95%of the gold could be extracted by a 0.2 mol/L thiosulfate leaching solution in two hours under suitable ***,the process of washing the residue was simplified,and the consumption and loss of thiosulfate carried by the washing residue were reduced.

关键词： gold extraction thiosulfate sulfide ore

Model test of the group piles foundation of a high-speed railway bridge in mined-out area

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Frontiers of Structural and Civil Engineering 2016年第4期10卷 488-498页

作者： Xin LIANG qian-gong CHENG Jiu-jiang WU Jian-ming CHEN Faculty of Geoseienees and Environmental Engineering Southwest Jiaotong University Chengdu 611756 China Faculty of Civil Engineering Guangxi University of Science and Technology Liuzhou 545006 China

The research on the mechanism of pile-soil-cap-goaf interaction and settlement of high-speed railway bridge located in mined-out area is still relatively rare. By taking the pile group of Guanshandi bridge foundation in Hefei- Fuzhou high-speed railway as the prototype, a model test is carried out. According to the similarity theory, the similar constant is derived and the similar model material is determined. Meanwhile, three types of data including the bearing behavior of piles, and the settlement law, and soil among piles are investigated. It can be found that： the influence of goaf on the bearing capacity of pile is inversely to the loading degree, the larger of loading degree, the smaller impact of goaf on the bearing capacity. There is no negative side friction can been found in pile body and the degree of downward tendency for the barycenter of side friction layout is obvious for piles in goaf. Although the bearing ratio of soil resistance under cap is relatively large, the cap effect is suggested be ignored considering the characteristic of goaf. There is a maximum critical value for the uneven settlement of pile group in goaf, and when the value is reached, the uneven settlement stop growing anymore. In addition, the formula for calculating bearing capacity and settlement of pile group in goaf based on test results, theory analysis and related standard is established.

关键词： high-speed railway mined-out areas goaf group piles foundation physical model test bearing capacity,settlement

OXIDATION OF GALENA IN AMMONIUM CARBONATE SOLUTION AND APPLIED REACTOR

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中国有色金属学会会刊：英文版 1995年第3期5卷 41-44页

作者： gong, qian gong, Yajun Cao, Changlin Lu, Keyuan(Institute of Chemical Metallurgy, Chinese Academy of Sciences, Beijing 100080) Chinese Acad of Sciences Beijing China

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关键词： galena carbonate reactor

A simplified method for the determination of vertically loaded pile-soil interface parameters in layered soil based on FLAC3D

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Frontiers of Structural and Civil Engineering 2016年第1期10卷 103-111页

作者： Jiu-jiang WU Yan LI qian-gong CHENG Hua WEN Xin LIAN School of Civil Engineering and Architecture Southwest University of Science and Technology Mianyang 621010 China Department of Geological Engineering Southwest Jiaotong University Chengdu 610031 China Faculty of Civil Engineering Guangxi University of Science and Technology Liuzhou 545006 China

The numerical analysis of pile-soil interaction commonly requires a lot of trial works to determine the interface parameters and the accuracy cannot be ensured normally. Considering this, this paper first conducts a sensitivity analysis to figure out the influence of interface parameters on the bearing behavior of a single pile in sand. Then, a simplified method for the determination of pile-soil interface parameters in layered soil is proposed based on the parameter studies. Finally, a filed loading test is used for the validation of the simplified method, and the calculated results agree well with the monitoring data. In general, the simplified method proposed in this paper works with higher accuracy and consumes less time compared with the traditional trial works, especially on the determinations ofinterfacial cohesive and interracial friction angle.

关键词： determination of interface parameters pile-soil interaction FLAC3D sensitivity analysis layered soil

Concentrations of copper, zinc and manganese in Tree Sparrow (Passer montanus) at Jixi, Heilongjiang Province, China

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Journal of Forestry Research 2012年第2期23卷 319-322页

作者： gong qian-qian Jin Zhi-min Zou Hong-fei Wildlife Resources College Northeast Forestry University Harbin 50040 China Department of Biology Mudanjiang Normal College Mudanjiang157012 China

Concentrations of copper （Cu）, zinc （Zn） and manganese （Mn） were measured in four tissues of Tree Sparrow （Passer montanus） from three sites in Heilongjiang province, China, during four seasons. Among the four measured tissues （primary feathers, liver, heart, and pectoral muscle）, the highest concentrations were found in feathers （Zn） or liver （Cu and Mn）, and the lowest concentrations were in muscle, except Cu. For Mn, mean concentrations of the birds from the three study sites were, in decreasing order： Didao mining area （DMA）〉 urban district of Jixi （UDJ）〉 Phoenix Mountain national nature reserve （PMR, the reference site）, but not for Zn and Cu. There were significant differences between metal concentrations at the three sites, but differences were not significant for Mn （in muscle and feathers） and Cu （in feathers）. For most elements, the mean concentrations were greatest in summer.

关键词： copper manganese mining tree sparrow zinc Jixi

Airblast evolution initiated by Wangjiayan landslides in the M_(s)8.0 Wenchuan earthquake and its destructive capacity analysis

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China Geology 2024年第2期7卷 237-247页

作者： Yu-feng Wang qian-gong Cheng Qi Zhu Department of Geological Engineering Southwest Jiaotong UniversityChengdu 610031China Sichuan Highway Planning SurveyDesign and Research Institute LtdChengdu 610041China

Airblasts,as one common phenomenon accompanied by rapid movements of landslides or rock/snow avalanches,commonly result in catastrophic damages and are attracting more and more scientific *** quantitatively analyze the intensity of airblast initiated by landslides,the Wangjiayan landslide,occurred in the Wenchuan earthquake,is selected here with the landslide propagation and airblast evolution being studied using FLUENT by introducing the Voellmy rheological *** results reveal that:(1)For the Wangjiayan landslide,its whole travelling duration is only 12 s with its maximum velocity reaching 36 m/s at t=10 s;(2)corresponding to the landslide propagation,the maximum velocity,28 m/s,of the airblast initiated by the landslide also appears at t=10 s with its maximum pressure reaching594.8 Pa,which is equivalent to violent storm;(3)under the attack of airblast,the load suffered by buildings in the airblast zone increases to 1300 Pa at t=9.4 s and sharply decreased to-7000 Pa as the rapid decrease of the velocity of the sliding mass at t=10 s,which is seriously unfavorable for buildings and might be the key reason for the destructive collapse of buildings in the airblast zone of the Wangjiayan landslide.

关键词： Landslide Voellmy rheological law 3D FLUENT simulation Airblast Intensity Building destructive collapse Wenchuan earthquake Geological hazards survey engineering

ELECTRODEPOSITION OF NICKEL FROM ALL CHLORIDE ELECTROLYTE

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Transactions of Nonferrous Metals Society of China 1992年第3期2卷 46-52页

作者： gong qian Liao Hong Yang Tao Hu Jiexue Fang Zhaoheng Institute of Chemical Metallurgy Academia SinicaBeijing 100080China

The optimum operating conditions for the electrodeposition of nickel from all-nickel chloride electrolytes were studied,based on measurements of conductivity,surface tension,viscosity of nickel chloride electrolytes at different temperatures and concentrations of nickel chloride as well as the experiments of electrodeposition arranged using experimental design in the normal *** studying cathode polarization and examination of physical features of cathodic nickel,the effects of trace Fe,Co,Pb..TBP and N-235 in all-nickel chloride electrolyte on cathode potentials,cell voltages,current efficiency and energy consumption as well as the morphology and the internal stress of cathodic nickel in electrodeposition of nickel were examined.

关键词： electrodeposition nickel chloride

Correlation among anxiety and depression,fear of disease progression,and social support in coronary heart disease

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World Journal of Psychiatry 2024年第11期14卷 1708-1717页

作者： Yan Xu Han-Xiang Ma Shan-Shui Liu qian gong Department of Cardiovascular Surgery Gaoxin CampusThe First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Cardiovascular Surgery Third Ward Gaoxin CampusThe First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Psychiatry The Fourth People’s Hospital of Hefei(Anhui Mental Health Center)Hefei 230022Anhui ProvinceChina

BACKGROUND The mental well-being of individuals with coronary heart disease(CHD)during the intensive care unit(ICU)transition period is a multifaceted and significant *** this phase,the individuals might encounter psychological challenges like anxiety and depression,which can impede their recuperation and potentially have lasting effects on their *** To investigate the correlation among psychological factors in CHD patients in the ICU transition *** A questionnaire survey was conducted with 119 patients admitted to the ICU after coronary artery bypass grafting between March and December *** in Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD),Fear of Progression Questionnaire-Short Form(Fop-Q-SF),and Social Support Rating Scale(SSRS)were collected and analyzed among diverse *** used Pearson’s correlation analysis to examine the *** linear regression analysis was used to explore whether these indicators influenced depression and anxiety in the *** The total scores for anxiety,depression,fear of disease progression,and social support were(7.50±1.41)points,(8.38±1.62)points,(35.19±8.14)points,and(36.34±7.08)points,respectively(P<0.05).Multivariate regression analysis showed that both the level of disease progression and social support affected the level of postoperative depression and anxiety in *** The anxiety and depression levels were positively related to each dimension of phobia disease progression and negatively related to each dimension of social support among patients with CHD.

关键词： Intensive care unit transition period Coronary heart disease Anxiety and depression Fear of disease progression Social support level