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Novel distribution pattern of fibrinolytic components in rabbit tissues extract: a preliminary study

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第8期8卷 570-574页

作者： LU Xing-guo WU Xian-guo XU Xiao-hua gong Xu-bo ZHOU Xuan XU Gen-bo ZHU Lei ZHAO Xiao-ying Department of Haematology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Clinical Laboratory Diagnosis the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Objective: The purpose of this work was to investigate the distribution pattern of fibrinolytic factors and their inhibitors in rabbit tissues. Methods: The components of the fibrinolytic system in extracts from a variety of rabbit tissues, including tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), plasminogen (Plg), plasmin (Pl) and α2 plasmin inhibitor (α2PI), were determined by colorimetric assay. Results: The tissue extracts in renal, small intestine, lung, brain and spleen demonstrated strong fibrinolytic function, in which high activity of tPA, Plg and Pl was manifested; whereas in skeletal muscle, tongue and stomach, higher activity of PAI-1 and α2PI showed obviously. Also excellent linear correlations were found between levels of tPA and PAI-1, Pl and α2PI, Plg and Pl. In related tissues, renal cortex and renal marrow showed distinctly higher activity of tPA and lower activity of PAI-1, with the levels of Plg and Pl in renal cortex being higher than those in renal marrow, where the α2PI level was higher than that in renal cortex. Similarly, the levels of tPA, Plg and Pl in small intestine were higher than those in large intestine, but with respect to PAI-1 and α2PI, the matter was reverse. In addition, the fibrinolytic activity in muscle tissue was lower, however, the levels of tPA, Plg, and Pl in cardiac muscle were obviously higher than those in skeletal muscles, and the levels of PAI-1 and α2PI were significantly lower than those in skeletal muscle. Conclusion: Our data demonstrate that a remarkable difference of the fibrinolytic patterns exists in rabbit tissues, which has probable profound significance in understanding the relationship between the function of haemostasis or thrombosis and the physiologic function in tissues.

关键词： Tissue extract Fibrinolytic factors Fibrinolytic inhibitors

boosting kinetic separation of ethylene and ethane on microporous materials via crystal size control

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Chinese Journal of Chemical Engineering 2024年第1期65卷 85-91页

作者： Yixuan Ma Cong Yu Lifeng Yang Rimin You Yawen bo Qihan gong Huabin Xing Xili Cui Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310012China Fundamental Science&Advanced Technology Lab PetroChina Petrochemical Research InstituteChina National Petroleum CorporationBeijing 102200China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311200China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Hangzhou 310027China

The adsorptive separation of C_(2)H_(4)and C_(2)H_(6),as an alternative to distillation units consuming high energy,is a promising yet challenging *** great similarity in the molecular size of C_(2)H_(4)and C_(2)H_(6)brings challenges to the regulation of adsorbents to realize efficient dynamic ***,we reported the enhancement of the kinetic separation of C_(2)H_(4)/C_(2)H_(6)by controlling the crystal size of ZnAtzPO_(4)(Atz=3-amino-1,2,4-triazole)to amplify the diffusion difference of C_(2)H_(4)and C_(2)H_(6).Through adjusting the synthesis temperature,reactant concentration,and ligands/metal ions molar ratio,ZnAtzPO4 crystals with different sizes were *** single-component kinetic adsorption tests and binary-component dynamic breakthrough experiments confirmed the enhancement of the dynamic separation of C_(2)H_(4)/C_(2)H_(6)with the increase in the crystal size of ZnAtzPO_(4).The separation selectivity of C_(2)H_(4)/C_(2)H_(6)increased from 1.3 to 98.5 with the increase in the crystal size of ZnAtzPO_(4).This work demonstrated the role of morphology and size control of adsorbent crystals in the improvement of the C_(2)H_(4)/C_(2)H_(6)kinetic separation performance.

关键词： Adsorption Adsorbent Ethylene Binary mixture Crystal size control Kinetic separation

Sodium 4-phenylbutyrate ameliorates the effects of cataract-causing mutant gammaD-crystallin in cultured cells

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Sodium 4-phenylbutyrate ameliorates the effects of cataract-...

Study on Removal of Trace Lead from Nickel Sulphate Solution by Ion-exchange Method

中华医学会第九次全国检验医学学术会议暨中国医院协会临床检验管理专业委员会第六届全国临床检验实验室管理学术会议

作者： bo gong Sichuan people

Purpose gammaD-Crystallin(CRYGD) is a major structural lens crystallin and its mutations result in congenital cataract *** this study,we attempted to correct the altered protein features of G165fsX8 CRYGD protein with small chemical molecules. Methods Recombinant FLAG-tagged mutants (R15C,R15S,P24T,R61C and G165fsX8) CRYGD were expressed in COS-7 cells and treated

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来源： cnki会议评论

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Journal of Central South University 2000年第4期12卷 191-193页

作者： XIAO Lian-sheng ZHANG Gui-qing ZHANG Qi-xiu gong bo-fan MA Jing-xia LI Ji-zhong Zhu Rui-lun Metallurgical Separation Science and Engineering Lab. Central South UniversityChangsha 410083China Jinchuan Non-ferrousMetals Company Jinchuan737104China

By comparing the adsorption capacity of several kinds of resins, D363 resin is regarded as the most suitable one for removing lead from nickel sulphate electrolyte. The effects of pH, temperature and contact time on exchange adsorption during removing trace lead from industrial nickel sulphate solution with D363 large pore weak alkali anion exchange resin are discussed. Optimum conditions of adsorption of lead from nickel electrolyte by D363 resin are at room temperature, pH 1 2, contact time 30 min.

关键词： ion-exchange nickel sulphate lead

Synthesis and Efficiency of a SphericalMacroporous Epoxy-dicyandiamide ChelateResin for Preconcentrating and SeparatingTrace Au, Hg, Pd and Ru from Samples

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Chemical Research in Chinese Universities 2001年第2期17卷 168-174页

作者： gong bo-lin, LI Xue-qiang and WANG Feng-rong (Department of Chemistry, Ningxia University, Yinchuan 750021, China) CHANG Xi-jun (Department of Chemistry, Lanzhou University, Lanzhou 730000, China) 宁夏大学宁夏银川 750021 兰州大学甘肃兰州 730000

A novel spherical macroporous epoxy-dicyandiamide chelate resin was synthesized simply and rapidly from epoxy resin and used for the preconcentration and separation of trace amounts of Au (Ⅲ ), Hg (Ⅱ ), Pd (Ⅳ) and Ru (Ⅲ) ions from solution samples. The analyzed ions can be quantitatively concentrated by the resin at a flow rate of 2. 0 mL/min at pH 4, and can also be desorbed with 15 mL of 4 mol/L HCl + 0. 3 g thiourea from the resin column with recoveries of 96. 5%-99. 0%. After the chelate resin was reused for 7 times, the recoveries of these ions were still over 92%, and 400-1 000 times of excess of Fe(Ⅲ ), Al(Ⅲ ), Ni( II), Mn( Ⅱ ), Cr (Ⅲ ), Cu ( Ⅱ ), Cd (Ⅱ ) and Pb (Ⅱ ) caused little interference with the determination of these ions by an inductively coupled plasma optical emission spectrometer (ICP-OES ). The capacities of the resin for the analytes are in the range of 0. 35~0. 92 mmol/g. The RSDs of the proposed method are in the range of 1. 1 % ~4. 0% for each kind of the analyzed ions. The recoveries of a standard added in real solution samples are between 96. 5% and 98. 5%, and the results for the analyzed ions in a powder sample are in good agreement with their reported values.

关键词： Concentration Separation Macroporous epoxy-dicyandiamide chelate resin Gold Mercury Palladium and ruthenium.

Investigation into the structures and physicochemical properties of multi-component crystals of voriconazole

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Chinese Chemical Letters 2023年第6期34卷 504-511页

作者： Hong-Mei Yu Bao-Xi Zhang Wen-Hui Xing Mei-Ju Liu Feng-Feng Wang Ning-bo gong Li Zhang Yang Lu Guan-Hua Du Beijing Key Laboratory of Polymorphic Drugs Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China National Institutes for Food and Drug Control Beijing 102629China Beijing City Key Laboratory of Drug Target Identification and Drug Screening Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Voriconazole(VZL)is a second-generation and broad-spectrum triazole against fungal *** a BCS(biopharmaceutics classification system)class II compound,the poor aqueous solubility has limited its bioavailability and clinical *** to overcome this disadvantage,a cocrystallization strategy based on crystal engineering principles has resulted in five new multi-component crystals of VZL with maleic acid,L-tartaric,protocatechuic,gallic,and 3,5-dinitrobenzoic *** analysis revealed that the hydroxyl/carboxylic acid···triazole N_(3)hydrogen bonding interaction appears as a main supramolecular heterosynthon in the VZL multi-component crystals with organic *** VZL molecule has a flexible conformation in each of the five multi-component *** newly synthesized multi-component crystals showed impressive solubility improvement compared to that of the raw material of *** electrostatic potential surfaces(MEPS)analysis based on density functional(DFT)calculations revealed that hydrogen bond interactions in cocrystals mainly involved pairwise interactions in the global maxima and minima sites,but this rule is not always *** study indicates the potential of cocrystals to improve the solubility and dissolution rate of VZL.

关键词： Multi-component crystal Voriconazole Solubility Dissolution Stability

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塔式起重机非常规附着技术比选研究与应用

建筑技术开发 2024年第4期51卷 6-8页

作者：黄周敏陈磊祖公博黄宏林林宇静张铭中国建筑第二工程局有限公司华南分公司广东深圳518048

常见的刚性附着方式有双节点三杆式、双节点四杆式与三节点四杆式。本研究依托深圳某大型场馆工程,通过数值分析,对3种非常规附着形式进行定量研究,并考虑水平荷载作用方向的影响,以计算结果为依据进行附着优化,可为类似项目在非常规的... 详细信息

常见的刚性附着方式有双节点三杆式、双节点四杆式与三节点四杆式。本研究依托深圳某大型场馆工程,通过数值分析,对3种非常规附着形式进行定量研究,并考虑水平荷载作用方向的影响,以计算结果为依据进行附着优化,可为类似项目在非常规的塔式起重机附着布置方式比选中提供参考和借鉴。

关键词：塔式起重机非常规附着有限元分析

八子补肾胶囊延缓SAMP6小鼠增龄性胸腺退化的初探

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中国药理学通报 2024年第6期40卷 1186-1192页

作者：李兆栋陈银潇龚博炀徐喆于智先石悦暄彭雁飞边育红侯云龙王相玲赵舒武天津中医药大学中西医结合学院天津中医药大学医学技术学院天津301617 络病研究与创新中药国家重点实验室河北石家庄050035

目的探讨八子补肾胶囊对SAMP6小鼠胸腺退化的改善作用及其可能机制。方法20只12周龄雄性SAMP6小鼠随机分为模型组(SAMP6)和八子补肾治疗组(SAMP6+BZBS),10只SAMR1小鼠设为同源对照组(SAMR1)。SAMP6+BZBS组每日灌胃八子补肾胶囊混悬液(2.... 详细信息

目的探讨八子补肾胶囊对SAMP6小鼠胸腺退化的改善作用及其可能机制。方法20只12周龄雄性SAMP6小鼠随机分为模型组(SAMP6)和八子补肾治疗组(SAMP6+BZBS),10只SAMR1小鼠设为同源对照组(SAMR1)。SAMP6+BZBS组每日灌胃八子补肾胶囊混悬液(2.8 g·kg^(-1)),其余两组每日灌胃等量蒸馏水,给药9周后观察各组胸腺形态并计算胸腺指数;HE染色观察胸腺组织结构变化;SA-β-gal染色检测胸腺衰老情况;流式细胞术检测各组胸腺CD3+T细胞比例;Western blot检测胸腺中p16、Bax、Bcl-2、cleaved caspase-3蛋白水平;免疫荧光检测各组皮质胸腺上皮细胞比例;ELISA检测胸腺中IL-7水平。结果与SAMP6组小鼠比较,SAMP6+BZBS组胸腺指数明显提高(P<0.05);紊乱的胸腺结构得到明显改善;SA-β-gal染色阳性比例明显降低(P<0.01);CD3+T细胞比例明显提高(P<0.05);p16蛋白水平明显降低(P<0.05);Bcl-2蛋白水平明显增加(P<0.05),而cleaved caspase-3蛋白水平明显减少(P<0.05);皮质胸腺上皮细胞比例明显提高;IL-7水平明显升高(P<0.01)。结论八子补肾胶囊能够延缓SAMP6小鼠的胸腺退化、抑制胸腺中细胞凋亡、有助于胸腺细胞发育,可能与其提高皮质胸腺上皮细胞比例,促进IL-7分泌相关。

关键词：八子补肾胶囊胸腺退化免疫衰老胸腺上皮细胞 IL-7 SAMP6小鼠

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Gas-phase photocatalytic oxidation of benzene over titanium dioxide loaded on Bi_(12)TiO_(20)

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Chinese Chemical Letters 2007年第2期18卷 241-243页

作者： Tao Lin, Zhan Pi, Mao Chu gong, Jun bo Zhong, Jian Li Wang, Yao Qiang Chen College of Chemistry, Sichuan University, Chengdu 610064, China College of Chemistry Sichuan University Chengdu 610064 China

TiO2 was prepared by sol-gel method using tetrabutyl titanate as precursor. TiO2 was loaded on Bi12TiO20. The photocatalyst with different TiO2 loading was calcined at 723 K. The photocatalytic activity of decomposition gaseous benzene was investigated in a batch reactor. The prepared photocatalyst was characterized by UV-vis diffuse reflectance. The result showed that TiO2/Bi12TiO20 absorbed much more ultraviolet light than Ti02 in the ultraviolet light region and showed red shift. The results indicated that the prepared photocatalyst can greatly promote the photocatalytic activity. The 2.0% TiO2/Bi12TiO20 system exhibited the highest photocatalytic activity.

关键词： Titanium Bi_(12)TiO_(20) Benzene Photocatalytic oxidation